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View article: O-265 Cyclin-Dependent Kinase (CDK) Inhibitors are not detrimental to dormant follicles and steroidogenic function in human ovary
O-265 Cyclin-Dependent Kinase (CDK) Inhibitors are not detrimental to dormant follicles and steroidogenic function in human ovary Open
Study question Are CDK4/6 inhibitors gonadotoxic to human ovary? Summary answer No. The CDK inhibitor drugs ribociclib and palbociclib do not appear to have any gonadotoxic effects on dormant follicles and steroidogenic function in human o…
View article: P-385 Progestin-primed ovarian stimulation for oocyte/embryo freezing is not inferior to GnRH antagonist cycles in cancer patients for ovarian response and IVF characteristics
P-385 Progestin-primed ovarian stimulation for oocyte/embryo freezing is not inferior to GnRH antagonist cycles in cancer patients for ovarian response and IVF characteristics Open
Study question Does progestin-priming ovarian stimulation be an alternative to GnRH antagonist cycles in cancer patients for oocyte/embryo freezing? Summary answer Yes, PPOS is not inferior to antagonist cycles in terms of oocyte yield, ma…
View article: P-323 Endometriomas are extremely heterogenous for steroidogenic activity, functional FSH receptor expression and FSH-responsive aromatase transcript variants
P-323 Endometriomas are extremely heterogenous for steroidogenic activity, functional FSH receptor expression and FSH-responsive aromatase transcript variants Open
Study question Do all ovarian endometriomas uniformly express functional FSH receptors and the full cascade of steroidogenic enzymes? Summary answer No. They are extremely heterogenous for the expression of FSH receptors, in response to FS…
View article: Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system
Pharmacovigilance analysis of immune checkpoint inhibitor-related reproductive adverse effects based on the FDA adverse event reporting system Open
This study aims to investigate the adverse effects of immune checkpoint inhibitors (ICIs) on the female and male reproductive systems. In the FDA Adverse Event Reporting System (FAERS) database, adverse reactions under the "Reproductive sy…
View article: O-089 Association of pituitary suppression method with euploid blastocyst yield in preimplantation genetic testing for aneuploidy (PGT-A) cycles
O-089 Association of pituitary suppression method with euploid blastocyst yield in preimplantation genetic testing for aneuploidy (PGT-A) cycles Open
Study question Do progestin primed ovarian stimulation (PPOS) cycles have lower euploidy yield compared to pituitary suppression with gonadotropin releasing hormone (GnRH) antagonists? Summary answer The choice of pituitary suppression met…
View article: P-608 Cumulative live birth rates after 3 consecutive embryo transfers in freeze-all cycles following gonadotropin-releasing hormone antagonist protocol versus progesterone-primed ovarian stimulation
P-608 Cumulative live birth rates after 3 consecutive embryo transfers in freeze-all cycles following gonadotropin-releasing hormone antagonist protocol versus progesterone-primed ovarian stimulation Open
Study question Do cumulative live birth rates in freeze-all cycles differ between gonadotropin-releasing hormone (GnRH) antagonist protocol and progesterone-primed ovarian stimulation (PPOS)? Summary answer GnRH antagonist and PPOS protoco…
View article: O-299 Exposure of antral follicles to progestins during stimulation does not cause molecular perturbations in gonadotropin-responsiveness and steroidogenic function of granulosa cells in progestin-primed IVF cycles
O-299 Exposure of antral follicles to progestins during stimulation does not cause molecular perturbations in gonadotropin-responsiveness and steroidogenic function of granulosa cells in progestin-primed IVF cycles Open
Study question Does progestin exposure cause any molecular perturbations in the steroidogenic features and gonadotropin responsiveness of the granulosa cells in progestin-primed ovarian stimulation (PPOS) cycles? Summary answer No. PPOS cy…
View article: P-442 Genome edition in endometrial stroma cells leading to decreased expression of UDP-glucuronic acid decarboxylase I (UXS1) alters the molecular interactions of the implantation area
P-442 Genome edition in endometrial stroma cells leading to decreased expression of UDP-glucuronic acid decarboxylase I (UXS1) alters the molecular interactions of the implantation area Open
Study question Does UDP-glucuronic acid decarboxylase 1 (UXS1) expression in endometrial stroma cells have a direct effect on the early stages of implantation? Summary answer Decreased expression of UXS1 was found to alter adhesion, invasi…
View article: Discovery of autophagy as a universal mechanism for sex steroid synthesis in human ovary and testis
Discovery of autophagy as a universal mechanism for sex steroid synthesis in human ovary and testis Open
We recently discovered that lipophagy is a key mechanism to provide free cholesterol required for steroid biosynthesis in human ovary and testis. Pharmacological or genetic inhibition of autophagy by silencing of the autophagy-related (ATG…
View article: Progesterone signaling in the regulation of luteal steroidogenesis
Progesterone signaling in the regulation of luteal steroidogenesis Open
The corpus luteum is the major source of progesterone, the essential hormone for female reproductive function. While progesterone activity has been the subject of extensive research for decades, characterization of non-canonical progestero…
View article: Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis
Autophagy regulates sex steroid hormone synthesis through lysosomal degradation of lipid droplets in human ovary and testis Open
Autophagy is an evolutionarily conserved process that aims to maintain the energy homeostasis of the cell by recycling long-lived proteins and organelles. Previous studies documented the role of autophagy in sex steroid hormone biosynthesi…
View article: Data from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve
Data from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve Open
Many chemotherapeutic agents, especially of the alkylating family, alter fertility in premenopausal females. However, it is not practically possible to quantify and characterize the impact of cancer drugs on ovarian reserve in a clinical s…
View article: Supplementary Table 1, Figure 1 from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve
Supplementary Table 1, Figure 1 from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve Open
Supplementary Table 1, Figure 1 from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve
View article: Supplementary Table 1, Figure 1 from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve
Supplementary Table 1, Figure 1 from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve Open
Supplementary Table 1, Figure 1 from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve
View article: Data from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve
Data from A Novel Ovarian Xenografting Model to Characterize the Impact of Chemotherapy Agents on Human Primordial Follicle Reserve Open
Many chemotherapeutic agents, especially of the alkylating family, alter fertility in premenopausal females. However, it is not practically possible to quantify and characterize the impact of cancer drugs on ovarian reserve in a clinical s…
View article: IVF characteristics and the molecular luteal features of random start IVF cycles are not different from conventional cycles in cancer patients
IVF characteristics and the molecular luteal features of random start IVF cycles are not different from conventional cycles in cancer patients Open
STUDY QUESTION Are the IVF parameters and the steroidogenic luteal characteristics of random-start IVF cycles different from conventional cycles in cancer patients? SUMMARY ANSWER No; controlled ovarian stimulation cycles randomly started …
View article: There is a cycle to cycle variation in ovarian response and pre-hCG serum progesterone level: an analysis of 244 consecutive IVF cycles
There is a cycle to cycle variation in ovarian response and pre-hCG serum progesterone level: an analysis of 244 consecutive IVF cycles Open
We aimed to answer one key question, that was not previously addressed as to whether serum progesterone (P 4-hCG day) and its co-variates (estradiol (E 2-hCG day ) and the number of retrieved oocytes) of a given cycle can be predictive of …
View article: Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway
Terminal differentiation of human granulosa cells as luteinization is reversed by activin-A through silencing of Jnk pathway Open
Molecular mechanisms underlying luteinization (terminal differentiation of granulosa and theca cells after ovulation) and luteolysis (demise of corpus luteum) are poorly understood in human ovary. Here we report that activin-A, after bindi…
View article: hCG Improves Luteal Function and Promotes Progesterone Output through the Activation of JNK Pathway in the Luteal Granulosa Cells of the Stimulated IVF Cycles†
hCG Improves Luteal Function and Promotes Progesterone Output through the Activation of JNK Pathway in the Luteal Granulosa Cells of the Stimulated IVF Cycles† Open
Human chorionic gonadotropin (hCG) is a luteotropic hormone that promotes the survival and steroidogenic activity of corpus luteum (CL) by acting through luteinizing hormone receptors (LHRs) expressed on luteinized theca and granulosa cell…
View article: The mammalian target of rapamycin protein expression in human granulosa cell tumors
The mammalian target of rapamycin protein expression in human granulosa cell tumors Open
mTOR expression is observed in various degrees in 90%, and p-mTOR expression is observed in only 10% of patients with granulosa cell ovarian carcinoma. Rapamycin caused a dose-dependent growth arrest and apoptosis in COV434 mitotic granulo…
View article: Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome
Spontaneous and in vitro fertilization pregnancies have comparable first trimester screening profiles for Down syndrome Open
These results support the notion that uncomplicated singleton IVF pregnancies have similar first trimester screening profiles to spontaneous conceptions.
View article: The mammalian target of rapamycin protein expression in human granulosa cell tumors
The mammalian target of rapamycin protein expression in human granulosa cell tumors Open
Objective: To investigate the role of Mammalian Target of Rapamycin (mTOR) in human granulosa cell ovarian tumors and the therapeutic effect of rapamycin in COV434 mitotic granulosa cell lines.Methods: A retrospective evaluation of the med…
View article: Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles
Luteal granulosa cells from natural cycles are more capable of maintaining their viability, steroidogenic activity and LH receptor expression than those of stimulated IVF cycles Open
This study was funded by the School of Medicine, the Graduate School of Health Sciences of Koc University and Koç University Research Center for Translational Medicine (KUTTAM), equally funded by the Republic of Turkey Ministry of Developm…