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View article: Optimizing filamentous fungi identification by MALDI-TOF MS: A comparative analysis of key factors
Optimizing filamentous fungi identification by MALDI-TOF MS: A comparative analysis of key factors Open
Purpose The identification of filamentous fungi in clinical microbiology laboratories remains a challenging task. Although matrix-assisted laser desorption/ionization–time of flight mass spectrometry (MALDI-TOF MS) has revolutionized micro…
View article: The effect of oral ferrous sulfate use in different posology on laboratory values and clinical findings related to iron metabolism in anemia due to iron deficiency
The effect of oral ferrous sulfate use in different posology on laboratory values and clinical findings related to iron metabolism in anemia due to iron deficiency Open
Iron deficiency anemia (IDA) is a common general health problem in daily clinical practice. A large amount of iron in the body is used for hemoglobin (Hb) synthesis and iron is critical for many biological functions such as cell proliferat…
View article: Fractalkine and Neuroinflammation in Autism Spectrum Disorder: A Novel Perspective
Fractalkine and Neuroinflammation in Autism Spectrum Disorder: A Novel Perspective Open
Our study is the first to evaluate serum fractalkine levels in ASD in early childhood. Our findings suggest that fractalkine may play a role in the etiopathogenesis of ASD in early life and may be a potential biomarker for ASD.
View article: Exploring the Sensitivity of Peripheral ADA Levels Measurement in Establishing Psychosis Susceptibility
Exploring the Sensitivity of Peripheral ADA Levels Measurement in Establishing Psychosis Susceptibility Open
Studies on the relationship between the adenosinergic system and schizophrenia have been released, but none has explored the relationship between adenosine deaminase and psychosis risk. Our primary objective is to investigate the sensitivi…
View article: Is Hemoglobin, Albumin, Lymphocyte, and Platelet Score a Prognostic Indicator in Metastatic Squamous Cell Lung Cancer?
Is Hemoglobin, Albumin, Lymphocyte, and Platelet Score a Prognostic Indicator in Metastatic Squamous Cell Lung Cancer? Open
Aim: We aimed to determine the prognosis by using the HALP score as a prognostic marker in patients followed in our clinic due to metastatic lung squamous cell carcinoma (SCC). Methods: The study retrospectively reviewed 35 patients diagno…
View article: Evaluation of Changes in Clinicopathological Features and Prognosis in Patients with Thyroid Cancer
Evaluation of Changes in Clinicopathological Features and Prognosis in Patients with Thyroid Cancer Open
Background: In this study, we evaluated the changes in clinicopathological features and prognosis in patients with thyroid cancer in the last two decades using the Surveillance, Epidemiology, and End Results Database (SEER) data. Methods: …
View article: Complement system dysfunction in autism spectrum disorder: evidence for altered C1q and C3 levels (complement system dysfunction in ASD)
Complement system dysfunction in autism spectrum disorder: evidence for altered C1q and C3 levels (complement system dysfunction in ASD) Open
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterised by impairments in social communication, repetitive behaviours, and restricted interests. Emerging evidence suggests that immune system dysregulation, particular…
View article: Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study
Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study Open
Highly selective inhibitors of cyclin-dependent kinase 4 and 6 (CDK4/6is) have emerged as a standart of care for first- and second-line therapies in combination with endocrine therapy (ET) for HR+/HER2- metastatic breast cancer (MBC) patie…
View article: Hypoxic Responses in Periodontal Tissues: Influence of Smoking and Periodontitis
Hypoxic Responses in Periodontal Tissues: Influence of Smoking and Periodontitis Open
Aim This study aimed to investigate the hypoxic changes in periodontal tissues resulting from smoking and periodontitis by assessing levels of hypoxia‐inducible factors (HIF‐1α, HIF‐2α, HIF‐3α) and vascular endothelial growth factor (VEGF)…
View article: The effects of plerixafor on the hemostatic system in patients undergoing stem cell mobilization
The effects of plerixafor on the hemostatic system in patients undergoing stem cell mobilization Open
Despite numerous reports on the procoagulant activities of G-CSF, the effect of plerixafor on the hemostatic system is not clearly understood. This study aims to evaluate the effects of plerixafor on the hemostatic system when used for aut…
View article: Immature platelet fraction as a systemic inflammation marker in patients with chronic obstructive pulmonary disease
Immature platelet fraction as a systemic inflammation marker in patients with chronic obstructive pulmonary disease Open
Introduction Recently, there has been an increasing interest to find a simple, low cost, widely available biomarker for outcome predictors in chronic obstructive pulmonary disease (COPD). Methods Absolute immature platelet count (AIPC), th…
View article: Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder
Investigation of Liver X Receptor Gene Variants and Oxysterol Dysregulation in Autism Spectrum Disorder Open
The NR1H2 gene produces the Liver X Receptor Beta (LXRB) protein, which is crucial for brain cholesterol metabolism and neuronal development. However, its involvement in autism spectrum disorder (ASD) remains largely unexplored, aside from…
View article: Oxysterol Metabolism Balance as a Candidate Biomarker in Autism Spectrum Disorder
Oxysterol Metabolism Balance as a Candidate Biomarker in Autism Spectrum Disorder Open
Our findings suggest that alterations in oxysterol levels, commonly associated with neurodegenerative processes, can also be observed in ASD and may serve as a potential candidate biomarker for the disorder.
View article: SOCIAL COGNITION AND OXIDATIVE STRESS IN SCHIZOPHRENIA PATIENTS AND FIRST-DEGREE RELATIVES OF PATIENTS
SOCIAL COGNITION AND OXIDATIVE STRESS IN SCHIZOPHRENIA PATIENTS AND FIRST-DEGREE RELATIVES OF PATIENTS Open
It was concluded that social cognition and working memory and GPx level may be used as endophenotypes and social cognition, working memory, and general intellectual skills are different but strongly related constructs. Endophenotypes guide…
View article: Zonulin is not Useful for the Diagnosis of Intestinal Permeability in Cirrhotic
Zonulin is not Useful for the Diagnosis of Intestinal Permeability in Cirrhotic Open
Objectives: Increased intestinal permeability is an important cause of serious complications in cirrhotic.In addition, intestinal permeability can promote impaired liver functions.Zonulin, well-known intestinal permeability marker, has nev…
View article: Ghrelin and impulsivity relationship in alcohol-dependent patients and healthy individuals
Ghrelin and impulsivity relationship in alcohol-dependent patients and healthy individuals Open
Aims: Abundant research indicates that ghrelin hormone levels are associated with alcohol use and addiction. One of the mediators of this association may be impulsivity, which is one of the common traits observed in alcohol addiction and s…
View article: Serum Chitotriosidase Activity in Bronchopulmonary Dysplasia: A Cross-Sectional Study
Serum Chitotriosidase Activity in Bronchopulmonary Dysplasia: A Cross-Sectional Study Open
Amaç: Serum kitotriozidaz (CHIT1), hava yolu ve akciğer hastalıkları dahil olmak üzere enflamatuvar hastalıklarda kullanılan yeni bir biyobelirteçtir.Bugüne kadar, bronkopulmoner displazi (BPD) hastalarında enflamasyonu belirlemek için ser…
View article: The Relation of Hepcidin, Vitamin D and Inflammatory Parameters, and Effects on Intensive Care Unit Outcome in Critically Ill COVID-19 Patients
The Relation of Hepcidin, Vitamin D and Inflammatory Parameters, and Effects on Intensive Care Unit Outcome in Critically Ill COVID-19 Patients Open
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View article: Cord blood anti-Müllerian hormone levels are higher in female newborns from women with polycystic ovary syndrome (PCOS) when compared to non-PCOS controls, irrespective of body mass index; a prospective case-control study
Cord blood anti-Müllerian hormone levels are higher in female newborns from women with polycystic ovary syndrome (PCOS) when compared to non-PCOS controls, irrespective of body mass index; a prospective case-control study Open
The cord blood anti-Müllerian hormone levels were higher in female newborns of women with polycystic ovary syndrome when compared to non-polycystic ovary syndrome controls. The effect of polycystic ovary syndrome seems to be greater than b…
View article: Investigation of Neutrophil Volume, Conductivity, and Light-Scattering Parameters for Early Diagnosis of Bacterial Infections
Investigation of Neutrophil Volume, Conductivity, and Light-Scattering Parameters for Early Diagnosis of Bacterial Infections Open
Aim: Early diagnosis of bacterial infections is crucial in planning treatment. Thus, it is important to determine the gram staining property of bacteria as well as the presence of bacterial infection. The acute bacterial infection leads to…
View article: Fibroblast Growth Factor 21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children
Fibroblast Growth Factor 21 Levels and Bone Mineral Density in Metabolically Healthy and Metabolically Unhealthy Obese Children Open
BMD-z-score was increased in obese children compared to healthy control. Moreover, BMD-z-score tended to be higher when more metabolic risk factors were present. However, there was no significant relationship between FGF21 levels and BMD z…
View article: The Effects of Modified Ketogenic Diet on Blood Parameters of Patients with Glioblastoma: A Retrospective Study
The Effects of Modified Ketogenic Diet on Blood Parameters of Patients with Glioblastoma: A Retrospective Study Open
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View article: Kynurenine pathway in Coronavirus disease (COVID‐19): Potential role in prognosis
Kynurenine pathway in Coronavirus disease (COVID‐19): Potential role in prognosis Open
Background It is known that inflammatory responses play an important role in the pathophysiology of COVID‐19. Aims In this study, we aimed to examine the role of kynurenine (KYN) metabolism on the severity of COVID‐19 disease AQ5. Material…
View article: Association of pro-ghrelin leu72met polymorphism with acylated ghrelin level and alcohol use disorder: a preliminary study
Association of pro-ghrelin leu72met polymorphism with acylated ghrelin level and alcohol use disorder: a preliminary study Open
Objective: Multiple environmental and genetic factors contribute to the progression of alcohol use disorder (AUD). Ghrelin is one of the important elements of the brain-gut axis that has been believed to involve in the pathophysiology of a…
View article: Response to Letter to the Editor: “First Admission Neutrophil–Lymphocyte Ratio May Indicate Acute Prognosis of Ischemic Stroke”
Response to Letter to the Editor: “First Admission Neutrophil–Lymphocyte Ratio May Indicate Acute Prognosis of Ischemic Stroke” Open
We have carefully read and evaluated the letter writ¬ten by Drs Mungmunpuntipantip and Wiwanitkit regarding our article published in the July issue of Rambam Maimonides Medical Journal.
View article: Comparison of nitric oxide and adrenomedullin levels of children with attention deficit hyperactivity disorder and anxiety disorder
Comparison of nitric oxide and adrenomedullin levels of children with attention deficit hyperactivity disorder and anxiety disorder Open
Objectives Many studies show that adrenomedullin (ADM) is associated with nitric oxide (NO) and various mechanisms and is involved in the etiopathogenesis of schizophrenia, bipolar disorder and autism by oxidative stress and HPA axis dsyre…
View article: First Admission Neutrophil–Lymphocyte Ratio May Indicate Acute Prognosis of Ischemic Stroke
First Admission Neutrophil–Lymphocyte Ratio May Indicate Acute Prognosis of Ischemic Stroke Open
Objectives: Our study aimed to determine the relationship between serum periostin levels, and the neutrophil–lymphocyte ratio (NLR) with ischemic stroke subtypes, clinical stroke scales, and acute prognosis in patients with acute ischemic …