Pedro A. José
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View article: Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target
Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target Open
View article: Correction: LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
Correction: LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis Open
Corrected article: https://www.bjbms.org/ojs/index.php/bjbms/article/view/7225 In the published article [Qu S, et al. LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis. Bosn J Basic Med Sci. 2022; DOI: 10.17305/bj…
View article: Role of NLRP3 activation in salt sensitive blood pressure regulation, effect of ND-13
Role of NLRP3 activation in salt sensitive blood pressure regulation, effect of ND-13 Open
Background and Objectives High salt intake is a major contributor to the development and exacerbation of hypertension, partly by inducing an inflammatory response through immune cell dysfunction. Inflammasomes, key components of the innate…
View article: SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling
SNX19 Interacts with Caveolin-1 and Flotillin-1 to Regulate D1R Endocytosis and Signaling Open
Background: Sorting nexin 19 (SNX19) is important in the localization and trafficking of the dopamine D1 receptor (D1R) to lipid raft microdomains. However, the interaction between SNX19 and the lipid raft components caveolin-1 or flotilli…
View article: Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway
Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway Open
The Gastrin/CCKBR axis is essential for inhibiting intestinal sodium absorption, but its effects on intestinal glucose metabolism remain elusive. This study aims to determine the role of intestinal Gastrin/CCKBR on glucose absorption in th…
View article: Genetic variants of accessory proteins and G proteins in human genetic disease
Genetic variants of accessory proteins and G proteins in human genetic disease Open
We present a series of three articles on the genetics and pharmacogenetics of G protein- coupled receptors (GPCR). In the first article, we discuss genetic variants of the G protein subunits and accessory proteins that are associated with …
View article: Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation
Reversing metabolic reprogramming by CPT1 inhibition with etomoxir promotes cardiomyocyte proliferation and heart regeneration via DUSP1 ADP-ribosylation-mediated p38 MAPK phosphorylation Open
View article: Effect of mitochondrial translocator protein TSPO on LPS-induced cardiac dysfunction
Effect of mitochondrial translocator protein TSPO on LPS-induced cardiac dysfunction Open
View article: Irisin‐Encapsulated Mitochondria‐Targeted Biomimetic Nanotherapeutics for Alleviating Acute Kidney Injury
Irisin‐Encapsulated Mitochondria‐Targeted Biomimetic Nanotherapeutics for Alleviating Acute Kidney Injury Open
Acute kidney injury (AKI) is the sudden decrease in renal function that can be attributed to dysregulated reactive oxygen species (ROS) production and impaired mitochondrial function. Irisin, a type I membrane protein secreted by skeletal …
View article: Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice
Single-Nucleus RNA Sequencing Reveals Loss of Distal Convoluted Tubule 1 Renal Tubules in HIV Viral Protein R Transgenic Mice Open
View article: Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure
Renal autocrine neuropeptide FF (NPFF) signaling regulates blood pressure Open
The kidney and brain play critical roles in the regulation of blood pressure. Neuropeptide FF (NPFF), originally isolated from the bovine brain, has been suggested to contribute to the pathogenesis of hypertension. However, the roles of NP…
View article: G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets
G protein-coupled receptor kinases in hypertension: physiology, pathogenesis, and therapeutic targets Open
View article: Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial
Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial Open
View article: Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53
Irisin attenuates type 1 diabetic cardiomyopathy by anti-ferroptosis via SIRT1-mediated deacetylation of p53 Open
Background Diabetic cardiomyopathy (DCM) is a serious complication in patients with type 1 diabetes mellitus (T1DM), which still lacks adequate therapy. Irisin, a cleavage peptide off fibronectin type III domain-containing 5, has been show…
View article: Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction
Semaglutide attenuates doxorubicin-induced cardiotoxicity by ameliorating BNIP3-Mediated mitochondrial dysfunction Open
View article: Poly-(ADP-ribose) polymerases inhibition by olaparib attenuates activities of the NLRP3 inflammasome and of NF-κB in THP-1 monocytes
Poly-(ADP-ribose) polymerases inhibition by olaparib attenuates activities of the NLRP3 inflammasome and of NF-κB in THP-1 monocytes Open
Poly-(ADP-ribose) polymerases (PARPs) are a protein family that make ADP-ribose modifications on target genes and proteins. PARP family members contribute to the pathogenesis of chronic inflammatory diseases, including atherosclerosis, in …
View article: Assessing Global, Regional, and National Time Trends and Associated Risk Factors of the Mortality in Ischemic Heart Disease Through Global Burden of Disease 2019 Study: Population-Based Study
Assessing Global, Regional, and National Time Trends and Associated Risk Factors of the Mortality in Ischemic Heart Disease Through Global Burden of Disease 2019 Study: Population-Based Study Open
Background Ischemic heart disease (IHD) is the leading cause of death among noncommunicable diseases worldwide, but data on current epidemiological patterns and associated risk factors are lacking. Objective This study assessed the global,…
View article: The Role of Dopamine D2 receptors and Oxidative Stress in the Pathogenesis of Hypertension
The Role of Dopamine D2 receptors and Oxidative Stress in the Pathogenesis of Hypertension Open
Globally, hypertension is the number one risk factor for death, affecting more than 1 billion people. Hypertension is the result of the interactions among genetics, epigenetics, environment, and lifestyle. The long-term regulation of blood…
View article: β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury
β-aminoisobutyrics acid, a metabolite of BCAA, activates the AMPK/Nrf-2 pathway to prevent ferroptosis and ameliorates lung ischemia-reperfusion injury Open
Background Lung ischemia-reperfusion (I/R) injury is a serious clinical problem without effective treatment. Enhancing branched-chain amino acids (BCAA) metabolism can protect against cardiac I/R injury, which may be related to bioactive m…
View article: Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na <sup>+</sup> excretion and insulin resistance
Thrombospondin 2 is a novel biomarker of essential hypertension and associated with nocturnal Na <sup>+</sup> excretion and insulin resistance Open
Our study suggests for the first time that the circulating levels of TSP2 may be a novel potential biomarker for essential hypertension. The association between TSP2 and blood pressure may be, at least in part, related to the regulation of…
View article: Anti-Inflammatory Effects of Peripheral Dopamine
Anti-Inflammatory Effects of Peripheral Dopamine Open
Dopamine is synthesized in the nervous system where it acts as a neurotransmitter. Dopamine is also synthesized in a number of peripheral organs as well as in several types of cells and has organ-specific functions and, as demonstrated mor…
View article: Developing Protocols for the Propagation and Multiplication of <i>Baccaurea courtallensis</i> (Wight) Mull. Arg. for Domestication – a Wild Edible Fruit Tree of the Western Ghats, India
Developing Protocols for the Propagation and Multiplication of <i>Baccaurea courtallensis</i> (Wight) Mull. Arg. for Domestication – a Wild Edible Fruit Tree of the Western Ghats, India Open
View article: LA INTERVENCIÓN DE LA FUERZA ARMADA NACIONAL BOLIVARIANA EN APOYO A CATÁSTROFES Y LOS DERECHOS HUMANOS
LA INTERVENCIÓN DE LA FUERZA ARMADA NACIONAL BOLIVARIANA EN APOYO A CATÁSTROFES Y LOS DERECHOS HUMANOS Open
Según lo prescribe el Artículo 328 de la Constitución de la República Bolivariana de Venezuela y en el Artículo N.º 29 de la Ley Orgánica de la Fuerza Armada Nacional Bolivariana, los Componentes Militares se complementan con la Milicia Bo…
View article: Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages
Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages Open
Myocardial dysfunction is the most serious complication of sepsis. Sepsis-induced myocardial dysfunction (SMD) is often associated with gastrointestinal dysfunction, but its pathophysiological significance remains unclear. The present stud…
View article: Dopamine Receptor D1R and D3R and GRK4Interaction in Hypertension
Dopamine Receptor D1R and D3R and GRK4Interaction in Hypertension Open
Essential hypertension is caused by the interaction of genetic, behavioral, and environmental factors. Abnormalities in the regulation of renal ion transport cause essential hypertension. The renal dopaminergic system, which inhibits sodiu…
View article: Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway
Selenium deficiency causes hypertension by increasing renal AT1 receptor expression via GPx1/H2O2/NF-κB pathway Open
View article: HIV viral protein R induces loss of DCT1-type renal tubules
HIV viral protein R induces loss of DCT1-type renal tubules Open
Hyponatremia and salt wasting is a common occurance in patients with HIV/AIDS, however, the understanding of its contributing factors is limited. HIV viral protein R (Vpr) contributes to HIV-associated nephropathy. To investigate the effec…
View article: Long‐Term High‐Fat Diet Decreases Renal Insulin‐Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway
Long‐Term High‐Fat Diet Decreases Renal Insulin‐Degrading Enzyme Expression and Function by Inhibiting the PPARγ Pathway Open
Scope Long‐term high‐fat diet (HFD) causes insulin resistance, which is a primary etiological factor in the development of obesity and type 2 diabetes mellitus. Impaired insulin clearance is not only a consequence but also a cause of insul…
View article: Polystyrene Microplastics Exposure Causes Glomerulonephritis via Crosstalk between Glomerular Endothelial and Mesangial Cells
Polystyrene Microplastics Exposure Causes Glomerulonephritis via Crosstalk between Glomerular Endothelial and Mesangial Cells Open
View article: Intrarenal Dopaminergic System Is Dysregulated in SS-Resp18mutant Rats
Intrarenal Dopaminergic System Is Dysregulated in SS-Resp18mutant Rats Open
The genetic and molecular basis of developing high blood pressure and renal disease are not well known. Resp18mutant Dahl salt-sensitive (SS-Resp18mutant) rats fed a 2% NaCl diet for six weeks have high blood pressure, increased renal fibr…