Celia J. A. Morgan
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View article: Practitioner perspectives on extended difficulties and optimal support strategies following psychedelic experiences: a qualitative analysis
Practitioner perspectives on extended difficulties and optimal support strategies following psychedelic experiences: a qualitative analysis Open
Background As the use of psychedelics increases in both therapeutic and non-clinical settings, reports of extended post-experience difficulties have also emerged. While many individuals integrate their experiences effectively, others face …
View article: Assessing behavioural economic demand for morphine after an acute dose in individuals with- and without childhood trauma: a double-blind, randomised, controlled trial
Assessing behavioural economic demand for morphine after an acute dose in individuals with- and without childhood trauma: a double-blind, randomised, controlled trial Open
Background Childhood trauma is associated with positive subjective responses to acute opioids in the laboratory. Yet, its impact on behavioural economic demand for opioids remains unclear. Because demand can predict future use and misuse, …
View article: Recommendations for the Neurophysiological Assessment of Conditioned Pain Modulation: A Systematic Review of Nociceptive Blink Reflex and Nociceptive Withdrawal Reflex Protocols
Recommendations for the Neurophysiological Assessment of Conditioned Pain Modulation: A Systematic Review of Nociceptive Blink Reflex and Nociceptive Withdrawal Reflex Protocols Open
Background and Objective The nociceptive blink reflex (NBR) and nociceptive withdrawal reflex (NWR) are increasingly used as neurophysiological test stimuli to assess conditioned pain modulation (CPM). However, methodological inconsistenci…
View article: Self-treatment of psychiatric conditions using ketamine: Patterns, characteristics, and retrospective insights
Self-treatment of psychiatric conditions using ketamine: Patterns, characteristics, and retrospective insights Open
Background: While research on novel therapeutic applications of ketamine is expanding, particularly in controlled settings, there is limited exploration of its consumption related to self-treatment of psychiatric conditions. This study inv…
View article: A long, strange trip: Ketamine treatment in psychiatry
A long, strange trip: Ketamine treatment in psychiatry Open
View article: MDMA-assisted psychotherapy for AUD: Bayesian analysis of WHO drinking risk level and exploratory analysis of drinking behavior and psychosocial functioning at 3 months follow-up
MDMA-assisted psychotherapy for AUD: Bayesian analysis of WHO drinking risk level and exploratory analysis of drinking behavior and psychosocial functioning at 3 months follow-up Open
Aims Safety and tolerability data from the first open-label feasibility study of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychotherapy for alcohol use disorder was recently published. This paper presents a Bayesian analysis of th…
View article: Practitioner perspectives on extended difficulties and optimal support strategies following psychedelic experiences: A qualitative analysis
Practitioner perspectives on extended difficulties and optimal support strategies following psychedelic experiences: A qualitative analysis Open
Background As the use of psychedelics increases in both therapeutic and non-clinical settings, reports of extended post-experience difficulties have also emerged. While many individuals integrate their experiences effectively, others face …
View article: The landscape of ketamine use disorder: Patient experiences and perspectives on current treatment options
The landscape of ketamine use disorder: Patient experiences and perspectives on current treatment options Open
Aims To report the symptoms and aetiology of ketamine use disorder (KUD), gauge the effectiveness of current treatment services and identify strategies to enhance patient access and outcomes. Design Mixed‐methods, cross‐sectional questionn…
View article: Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview
Learning from Boundlessness: Psychedelic induced awe and epistemic shifts towards a holistic worldview Open
Psychedelic substances are increasingly recognized for their potential to catalyse transformative shifts in worldviews. Central to these transformations are states of awe, a self-transcendent, epistemic emotion. This mixed-methods study ex…
View article: How to set up a psychedelic study: Unique considerations for research involving human participants
How to set up a psychedelic study: Unique considerations for research involving human participants Open
Setting up a psychedelic study can be a long, arduous, and kafkaesque process. This rapidly-developing field poses several unique challenges for researchers, necessitating a range of considerations that have not yet been standardised. Many…
View article: EXPLORING THE NEUROBIOLOGICAL AND PSYCHOLOGICAL MECHANISMS OF KETAMINE IN PROBLEMATIC GAMBLING: A MECHANISTIC STUDY
EXPLORING THE NEUROBIOLOGICAL AND PSYCHOLOGICAL MECHANISMS OF KETAMINE IN PROBLEMATIC GAMBLING: A MECHANISTIC STUDY Open
Background Ketamine, an NMDA-receptor antagonist approved for depression treatment, exhibits a wide spectrum of applicability in psychiatric disorders. With established efficacy in addressing substance addictions1, ketamine's potential cou…
View article: Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial)
Protocol of an open-label safety and feasibility pilot study of ketamine-assisted psychotherapy for methamphetamine use disorder (the KAPPA trial) Open
Introduction Methamphetamine use disorder is a significant public health concern. No pharmacological treatment options currently exist for methamphetamine use disorder, and psychotherapy is only moderately effective. Preliminary evidence s…
View article: Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems
Esketamine combined with a mindfulness-based intervention for individuals with alcohol problems Open
Background: Alcohol use disorder (AUD) is a major public health issue, posing harmful consequences for individuals and society. Recent advances in addiction research have highlighted the therapeutic potential of ketamine-assisted therapy f…
View article: The Metaphysics Matrix Questionnaire: the development of an accessible measure of belief change for the general population
The Metaphysics Matrix Questionnaire: the development of an accessible measure of belief change for the general population Open
Anecdotal and empirical evidence suggests that people may undergo substantial shifts in their Metaphysical beliefs (MPBs) following non-ordinary states of consciousness induced by experiences such as meditation, breathwork, near-death, and…
View article: Commentary on Keyes and Patrick: Changes in psychedelic use in the United States may require changes in our narrative of psychedelic harms
Commentary on Keyes and Patrick: Changes in psychedelic use in the United States may require changes in our narrative of psychedelic harms Open
Given the shifting public perception of psilocybin and associated legal changes, the increase in use observed by Keyes and Patrick is not surprising. The conclusion that this is a rising health concern is not justified by the data, particu…
View article: Corrigendum: Ceremonial ayahuasca in amazonian retreats—mental health and epigenetic outcomes from a six-month naturalistic study
Corrigendum: Ceremonial ayahuasca in amazonian retreats—mental health and epigenetic outcomes from a six-month naturalistic study Open
[This corrects the article DOI: 10.3389/fpsyt.2021.687615.].
View article: High potency cannabis use, mental health symptoms and cannabis dependence: Triangulating the evidence
High potency cannabis use, mental health symptoms and cannabis dependence: Triangulating the evidence Open
Users of cannabis who preferred high potency types might be at increased risk of problematic cannabis use. This should be considered with caution as we were not able to triangulate these results with an objective measure of cannabis potenc…
View article: Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder
Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder Open
Cannabidiol (CBD) has shown promise in treating psychiatric disorders, including cannabis use disorder – a major public health burden with no approved pharmacotherapies. However, the mechanisms through which CBD acts are poorly understood.…
View article: Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder
Effect of four-week cannabidiol treatment on cognitive function: secondary outcomes from a randomised clinical trial for the treatment of cannabis use disorder Open
View article: Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder
Adjunctive Ketamine With Relapse Prevention–Based Psychological Therapy in the Treatment of Alcohol Use Disorder Open
This study demonstrated that treatment with three infusions of ketamine was well tolerated in patients with alcohol use disorder and was associated with more days of abstinence from alcohol at 6-month follow-up. The findings suggest a poss…
View article: Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review – CORRIGENDUM
Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review – CORRIGENDUM Open
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View article: Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review
Ketamine for the treatment of mental health and substance use disorders: comprehensive systematic review Open
Background In the past two decades, subanaesthetic doses of ketamine have been demonstrated to have rapid and sustained antidepressant effects, and accumulating research has demonstrated ketamine's therapeutic effects for a range of psychi…
View article: “This Is Something That Changed My Life”: A Qualitative Study of Patients' Experiences in a Clinical Trial of Ketamine Treatment for Alcohol Use Disorders
“This Is Something That Changed My Life”: A Qualitative Study of Patients' Experiences in a Clinical Trial of Ketamine Treatment for Alcohol Use Disorders Open
Background: The therapeutic benefits of ketamine have been demonstrated for a variety of psychiatric disorders. However, the role of ketamine induced psychoactive experiences in mediating the therapeutic effects is unclear. Despite the gro…
View article: Brain volume in chronic ketamine users — relationship to sub-threshold psychotic symptoms and relevance to schizophrenia
Brain volume in chronic ketamine users — relationship to sub-threshold psychotic symptoms and relevance to schizophrenia Open
View article: A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine
A randomised, double‐blind study investigating the relationship between early childhood trauma and the rewarding effects of morphine Open
Experiences of childhood trauma (abuse and neglect) are disproportionately higher in those with opioid use disorder (OUD). Childhood trauma may affect the reinforcing and rewarding properties of opioid drugs and responses to pain, potentia…
View article: Ceremonial Ayahuasca in Amazonian Retreats—Mental Health and Epigenetic Outcomes From a Six-Month Naturalistic Study
Ceremonial Ayahuasca in Amazonian Retreats—Mental Health and Epigenetic Outcomes From a Six-Month Naturalistic Study Open
Ayahuasca is a natural psychoactive brew, used in traditional ceremonies in the Amazon basin. Recent research has indicated that ayahuasca is pharmacologically safe and its use may be positively associated with improvements in psychiatric …
View article: The acute effects of alcohol on state rumination in the laboratory
The acute effects of alcohol on state rumination in the laboratory Open
View article: Does variation in trait schizotypy and frequency of cannabis use influence the acute subjective, cognitive and psychotomimetic effects of delta-9-tetrahydrocannabinol? A mega-analysis
Does variation in trait schizotypy and frequency of cannabis use influence the acute subjective, cognitive and psychotomimetic effects of delta-9-tetrahydrocannabinol? A mega-analysis Open
Background: While the acute effects of cannabis are relatively benign for most users, some individuals experience significant adverse effects. This study aimed to identify whether variation in schizotypal personality traits and frequency o…
View article: Cost recovery in production sharing contracts: a comparative review of Southeast Asian jurisdictions
Cost recovery in production sharing contracts: a comparative review of Southeast Asian jurisdictions Open
While the current macro factors (such as the COVID-19 pandemic’s impact on oil and gas demand and lower crude prices) suggest a challenging period lies ahead, the oil and gas industry remains important to a number of Southeast Asian countr…
View article: Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial
Cannabidiol for the treatment of cannabis use disorder: a phase 2a, double-blind, placebo-controlled, randomised, adaptive Bayesian trial Open