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View article: Figure S1 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S1 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma Open
Validation of HOXA10-specific antibody
View article: Table S3 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma
Table S3 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma Open
Enriched genes in STS
View article: Figure S3 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S3 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma Open
CIBERSORT analysis for HOXA10 and its driven signature
View article: Table S4 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma
Table S4 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma Open
PDAC cohort validated genes
View article: Figure S4 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S4 from A Novel <i>HOXA10</i>-Associated 5-Gene–Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma Open
CIBERSORT analysis for T cell exhaustion markers
View article: Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S5 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 5. MUC5AC silencing inhibits cMET and CD44v6 expression and Astrocytes induce MUC5AC expression in breast cancer cells. A-B. Western blots showing knockdown of MUC5AC in MDA-231BR HER2 (A) and MUC5AC knockout in HCC195…
View article: Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S6 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 6. PLB1001 inhibit cMET and CD44v6 expression. A. Representative IHC images showing MUC5AC expression in G5-3 PDXs B. Representative fluorescence microscopy images showing GFP+ in G5-3 PDXs C. Representative IHC images…
View article: Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S4 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 4. MUC5AC silencing inhibits brain metastasis. A. Fluorescence microscopy images showing Cytokeratin 8/18 and MUC5AC in the brain tissue sections of the mice intracardially injected with shSCR and shMUC5AC KD MDA-231BR…
View article: Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Data from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Purpose:Breast cancer brain metastasis remains a significant clinical problem. Mucins have been implicated in metastasis; however, whether they are also involved in breast cancer brain metastasis remains unknown. We queried databases of pa…
View article: Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S1 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 1. Expression of MUC5AC is high in breast cancer brain metastasis. A. Heatmap showing the expression of upregulated genes in BC BrM cells as compared to primary BC cells (MDA-231BR vs MDA-231P). B. Comparison of MUC5AC…
View article: Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S2 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 2. MUC5AC IHC staining using Aperio Digital Imaging revealed MUC5AC strong to medium scores in BrM patient samples. Tumor areas were defined by annotations (green color) and necrotic areas or areas not corresponding to…
View article: Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6
Supplementary Figure S3 from Mucin 5AC Promotes Breast Cancer Brain Metastasis through cMET/CD44v6 Open
Supplementary Figure 3. MUC5AC promotes brain metastasis. A. Western blot for HER2 expression in MDA-231BR HER2 cells. B. Western blot showing knockout of MUC5AC in the HCC1954BR cells. C-F. Wound healing assay and quantification showing r…
View article: Data from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Data from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Purpose: Despite the significant association of molecular subtypes with poor prognosis in pancreatic ductal adenocarcinoma (PDAC) patients, little effort has been made to identify the underlying pathway(s) responsible for this prognosis. I…
View article: Figure S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
CIBERSORT analysis for HOXA10 and its driven signature
View article: Figure S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
CIBERSORT analysis for T cell exhaustion markers
View article: Table S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
PDAC cohort validated genes
View article: Table S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Enriched genes in STS
View article: Figure S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Human Protein Atlas pathology for the 5-gene prognostic signature in PDAC
View article: Table S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
HOXA10-driven gene set
View article: Figure S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Validation of HOXA10-specific antibody
View article: Table S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Enriched genes in STS
View article: Figure S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Human Protein Atlas pathology for the 5-gene prognostic signature in PDAC
View article: Table S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
PDAC cohort validated genes
View article: Figure S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S4 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
CIBERSORT analysis for T cell exhaustion markers
View article: Figure S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
Validation of HOXA10-specific antibody
View article: Table S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
GSEA gene sets enriched in STS PDAC patients
View article: Figure S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Figure S3 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
CIBERSORT analysis for HOXA10 and its driven signature
View article: Table S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S2 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
HOXA10-driven gene set
View article: Table S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma
Table S1 from A Novel HOXA10-Associated 5 Gene-Based Prognostic Signature for Stratification of Short-Term Survivors of Pancreatic Ductal Adenocarcinoma Open
GSEA gene sets enriched in STS PDAC patients
View article: Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma
Connectivity mapping-based identification of pharmacological inhibitor targeting HDAC6 in aggressive pancreatic ductal adenocarcinoma Open
Pancreatic ductal adenocarcinoma (PDAC) remains highly lethal due to limited therapeutic options and expensive/burdensome drug discovery processes. Utilizing genomic-data-driven Connectivity Mapping (CMAP) to identify a drug closer to real…