Patrick J. Babin
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View article: Structure, Oligomerization, and Thermal Stability of a Recently Discovered Old Yellow Enzyme
Structure, Oligomerization, and Thermal Stability of a Recently Discovered Old Yellow Enzyme Open
The Old Yellow Enzyme from Ferrovum sp. JA12 (FOYE) displays an unusual thermal stability for an enzyme isolated from a mesophilic organism. We determined the crystal structure of this enzyme and performed bioinformatic characterization to…
View article: An optimized zebrafish obesogenic test protocol with an artificial intelligence-based analysis software for screening obesogens and anti-obesogens
An optimized zebrafish obesogenic test protocol with an artificial intelligence-based analysis software for screening obesogens and anti-obesogens Open
Obesity is defined as a disease in which abnormal excessive body fat accumulation causes adverse effects on health. One proposed contributing factor to the rise in obesity is the exposure to endocrine disruptors acting as obesogens. Semitr…
View article: New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project
New approach methods to assess developmental and adult neurotoxicity for regulatory use: a PARC work package 5 project Open
In the European regulatory context, rodent in vivo studies are the predominant source of neurotoxicity information. Although they form a cornerstone of neurotoxicological assessments, they are costly and the topic of ethical debate. While …
View article: A cognitive and sensory approach based on workshops using the zebrafish model promotes the discovery of life sciences in the classroom
A cognitive and sensory approach based on workshops using the zebrafish model promotes the discovery of life sciences in the classroom Open
The main objective of the ZebraCool programme was to create a positive attitude and curiosity towards science by bringing experimental activities within schools using an introductory cognitive and sensory approach. This innovative programm…
View article: Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors Open
The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic ( in vivo , in vitro and in silico ) toxicology ha…
View article: Corrigendum to “Obesity II: Establishing causal links between chemical exposures and obesity” [Biochem. Pharmacol. 199 (2022) 115015]
Corrigendum to “Obesity II: Establishing causal links between chemical exposures and obesity” [Biochem. Pharmacol. 199 (2022) 115015] Open
VoR
View article: Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project
Integrative Strategy of Testing Systems for Identification of Endocrine Disruptors Inducing Metabolic Disorders—An Introduction to the OBERON Project Open
Exposure to chemical substances that can produce endocrine disrupting effects represents one of the most critical public health threats nowadays. In line with the regulatory framework implemented within the European Union (EU) to reduce th…
View article: Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5
Plasma oxysterols: biomarkers for diagnosis and treatment in spastic paraplegia type 5 Open
The hereditary spastic paraplegias are an expanding and heterogeneous group of disorders characterized by spasticity in the lower limbs. Plasma biomarkers are needed to guide the genetic testing of spastic paraplegia. Spastic paraplegia ty…
View article: CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56
CYP2U1 activity is altered by missense mutations in hereditary spastic paraplegia 56 Open
Hereditary spastic paraplegia (HSP) is an inherited disorder of the central nervous system mainly characterized by gradual spasticity and weakness of the lower limbs. SPG56 is a rare autosomal recessive early onset complicated form of HSP …
View article: Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models
Caffeic acid and hydroxytyrosol have anti-obesogenic properties in zebrafish and rainbow trout models Open
Some natural products, known sources of bioactive compounds with a wide range of properties, may have therapeutic values in human health and diseases, as well as agronomic applications. The effect of three compounds of plant origin with we…
View article: Correction: Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning
Correction: Corrigendum: Zebrafish Models for Human Acute Organophosphorus Poisoning Open
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more recently, in the Syri…