Pallavi Balte
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View article: Self-Reported Resilience During the COVID-19 Pandemic
Self-Reported Resilience During the COVID-19 Pandemic Open
IMPORTANCE: Identifying factors associated with resilience during the COVID-19 pandemic can inform targeted interventions and resource allocation for groups disproportionately affected by systemic inequities. OBJECTIVE: To examine factors …
View article: Self-Reported Resilience During the COVID-19 Pandemic
Self-Reported Resilience During the COVID-19 Pandemic Open
Importance Identifying factors associated with resilience during the COVID-19 pandemic can inform targeted interventions and resource allocation for groups disproportionately affected by systemic inequities. Objective To examine factors as…
View article: COVID-19 and Cognitive Change in a Community-Based Cohort
COVID-19 and Cognitive Change in a Community-Based Cohort Open
Importance: SARS-CoV-2 infection has been linked to neurotoxic effects and cognitive deficits. Objective: To determine whether decreases in cognitive function were accelerated after SARS-CoV-2 infection compared with individuals not infect…
View article: COVID-19 and Cognitive Change in a Community-Based Cohort
COVID-19 and Cognitive Change in a Community-Based Cohort Open
Importance SARS-CoV-2 infection has been linked to neurotoxic effects and cognitive deficits. Objective To determine whether decreases in cognitive function were accelerated after SARS-CoV-2 infection compared with individuals not infected…
View article: Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study
Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study Open
Rationale: Increased risk of coronavirus disease (COVID-19) hospitalization and death has been reported among patients with clinical lung disease. Objective: To test the association of objective measures of prepandemic lung function and st…
View article: Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study
Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study Open
Despite the availability of effective vaccines and a recent decrease in annual deaths, coronavirus disease-2019 (COVID-19) remains a leading cause of death. Serological studies provide insights into host immunobiology of adaptive immune re…
View article: Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans
Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans Open
BACKGROUND: Treatment and preventative advances for chronic obstructive pulmonary disease (COPD) have been slow due, in part, to limited subphenotypes. We tested if unsupervised machine learning on CT images would discover CT emphysema sub…
View article: Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study
Demographic and Clinical Factors Associated With SARS-CoV-2 Anti-Nucleocapsid Antibody Response Among Previously Infected US Adults: The C4R Study Open
Despite the availability of effective vaccines and a recent decrease in annual deaths, COVID-19 remains a leading cause of death. Serological studies provide insights into host immunobiology of adaptive immune response to infection, which …
View article: Associations of metabolic syndrome with lung function decline and clinical respiratory outcomes: the NHLBI Pooled Cohort Study
Associations of metabolic syndrome with lung function decline and clinical respiratory outcomes: the NHLBI Pooled Cohort Study Open
Background Whether metabolic syndrome (MetS) increases the risk of chronic lung diseases remains uncertain. We aimed to test whether MetS was associated with lung function and clinical respiratory outcomes. Methods Data were harmonised fro…
View article: Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study
Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study Open
RATIONALE: Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established method to validate endpoints for clinical t…
View article: Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study
Classifying COVID-19 hospitalizations in epidemiology cohort studies: The C4R study Open
Rationale Robust COVID-19 outcomes classification is important for ongoing epidemiology research on acute and post-acute COVID-19 conditions. Protocolized medical record review is an established method to validate endpoints for clinical tr…
View article: Whole Genome Sequence Analysis of Pulmonary Function and COPD in 44,287 Multi-ancestry Participants
Whole Genome Sequence Analysis of Pulmonary Function and COPD in 44,287 Multi-ancestry Participants Open
Background Whole genome sequence (WGS) data in multi-ancestry samples provide the opportunity to identify low-frequency or population-specific genetic variants associated with chronic obstructive pulmonary disease (COPD) and lung function.…
View article: Epidemiologic Features of Recovery From SARS-CoV-2 Infection
Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open
Importance: Persistent symptoms and disability following SARS-CoV-2 infection, known as post-COVID-19 condition or "long COVID," are frequently reported and pose a substantial personal and societal burden. Objective: To determine time to r…
View article: Greater pericardial and visceral adiposity increase risk of hospitalization or death from SARS-CoV-2 infection in community dwelling adults: A C4R Study
Greater pericardial and visceral adiposity increase risk of hospitalization or death from SARS-CoV-2 infection in community dwelling adults: A C4R Study Open
Importance Higher body mass index (BMI) increases risk of respiratory failure and death from SARS-CoV-2 infection. BMI is imprecise and fails to account for adipose tissue distribution. Objective To determine whether pericardial adipose ti…
View article: Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes
Non-cigarette tobacco products, aryl-hydrocarbon receptor repressor gene methylation and smoking-related health outcomes Open
Introduction Cigarette smoking leads to altered DNA methylation at the aryl-hydrocarbon receptor repressor (AHRR) gene. However, it remains unknown whether pipe or cigar smoking is associated with AHRR methylation. We evaluated association…
View article: Epidemiologic Features of Recovery From SARS-CoV-2 Infection
Epidemiologic Features of Recovery From SARS-CoV-2 Infection Open
Importance Persistent symptoms and disability following SARS-CoV-2 infection, known as post–COVID-19 condition or “long COVID,” are frequently reported and pose a substantial personal and societal burden. Objective To determine time to rec…
View article: A Dyadic Growth Modeling Approach for Examining Associations between Weight Gain and Lung Function Decline
A Dyadic Growth Modeling Approach for Examining Associations between Weight Gain and Lung Function Decline Open
The relationship between body weight and lung function is complex. Using a dyadic multilevel linear modeling approach, treating body mass index (BMI; weight (kg)/height (m)2) and lung function as paired, within-person outcomes, we tested t…
View article: Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants
Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants Open
Chronic obstructive pulmonary disease (COPD), diagnosed by reduced lung function, is a leading cause of morbidity and mortality. We performed whole genome sequence (WGS) analysis of lung function and COPD in a multi-ethnic sample of 11,497…
View article: Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol
Familial Hypercholesterolemia Variant and Cardiovascular Risk in Individuals With Elevated Cholesterol Open
Importance Familial hypercholesterolemia (FH) is a genetic disorder that often results in severely high low-density lipoprotein cholesterol (LDL-C) and high risk of premature coronary heart disease (CHD). However, the impact of FH variants…
View article: Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction
Investigating Associations of Omega-3 Fatty Acids, Lung Function Decline, and Airway Obstruction Open
Rationale: Inflammation contributes to lung function decline and the development of chronic obstructive pulmonary disease. Omega-3 fatty acids have antiinflammatory properties and may benefit lung health. Objectives: To investigate associa…
View article: Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans
Pulmonary emphysema subtypes defined by unsupervised machine learning on CT scans Open
Background Treatment and preventative advances for chronic obstructive pulmonary disease (COPD) have been slow due, in part, to limited subphenotypes. We tested if unsupervised machine learning on CT images would discover CT emphysema subt…
View article: Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease
Association of Severe Hypercholesterolemia and Familial Hypercholesterolemia Genotype With Risk of Coronary Heart Disease Open
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View article: Association of Symptoms After COVID-19 Vaccination With Anti–SARS-CoV-2 Antibody Response in the Framingham Heart Study
Association of Symptoms After COVID-19 Vaccination With Anti–SARS-CoV-2 Antibody Response in the Framingham Heart Study Open
This cohort study examines the association of self-reported postvaccination symptoms with anti–SARS-CoV-2 antibody response among Framingham Heart Study participants contributing to the Collaborative Cohort of Cohorts for COVID-19 Research…
View article: <i>MUC5B</i>, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study
<i>MUC5B</i>, telomere length and longitudinal quantitative interstitial lung changes: the MESA Lung Study Open
Background The MUC5B promoter variant (rs35705950) and telomere length are linked to pulmonary fibrosis and CT-based qualitative assessments of interstitial abnormalities, but their associations with longitudinal quantitative changes of th…
View article: Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study
Lung function impairment and risk of incident heart failure: the NHLBI Pooled Cohorts Study Open
Aims The aim is to evaluate associations of lung function impairment with risk of incident heart failure (HF). Methods and results Data were pooled across eight US population-based cohorts that enrolled participants from 1987 to 2004. Part…