P. Brandon Bookstaver
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View article: A review of antibiotic safety in pregnancy—2025 update
A review of antibiotic safety in pregnancy—2025 update Open
Antibiotics constitute the majority of prescriptions for women during pregnancy. Common bacterial infections, including urinary tract infections, skin and soft tissue infections, and upper and lower respiratory tract infections, are expect…
View article: Association Between Reporting Antimicrobial Use and Clostridioides difficile Standardized Infection Ratios in South Carolina Hospitals
Association Between Reporting Antimicrobial Use and Clostridioides difficile Standardized Infection Ratios in South Carolina Hospitals Open
The Centers for Disease Control and Prevention have been encouraging hospitals in the United States to report antimicrobial use (AU) to the National Healthcare Safety Network (NHSN). This retrospective cohort study examines the association…
View article: Impact of a pharmacist-led asthma clinic in a high-risk pediatric population at a federally qualified health center within a medically underserved area
Impact of a pharmacist-led asthma clinic in a high-risk pediatric population at a federally qualified health center within a medically underserved area Open
View article: P-1102. Real-World Effectiveness of Dalbavancin for Invasive Gram-Positive Bacterial Infections
P-1102. Real-World Effectiveness of Dalbavancin for Invasive Gram-Positive Bacterial Infections Open
Background Emerging data suggest dalbavancin (DAL) may be used in complicated infections including bacteremia, prosthetic joints, osteomyelitis, and endovascular infections. The purpose of this study was to evaluate the real-world effectiv…
View article: P-877. Effectiveness of Oral Step-down Antibiotic Therapy in Uncomplicated <i>Enterococcus faecalis</i> Bloodstream Infection
P-877. Effectiveness of Oral Step-down Antibiotic Therapy in Uncomplicated <i>Enterococcus faecalis</i> Bloodstream Infection Open
Background The transition from intravenous (IV) to oral antibiotic therapy is a common strategy in the management of uncomplicated bloodstream infection (BSI). However, the role of oral step-down therapy in uncomplicated Enterococcus faeca…
View article: Appropriateness of ambulatory antibiotic prescribing in South Carolina, 2012–2017
Appropriateness of ambulatory antibiotic prescribing in South Carolina, 2012–2017 Open
This population-based cohort study examines the appropriateness of antibiotic prescribing in South Carolina via aggregated pharmacy claims data matched with diagnosis codes from medical claims. Inappropriate antibiotic prescribing decrease…
View article: A Cost Analysis of Opioid/Acetaminophen Therapy Versus a Multidrug, Opioid-Free Multimodal Postoperative Pain Control Regimen
A Cost Analysis of Opioid/Acetaminophen Therapy Versus a Multidrug, Opioid-Free Multimodal Postoperative Pain Control Regimen Open
Background: Opioids are often part of the post-operative pain regimen after orthopaedic surgery. Novel multimodal post-operative pain control regimens have been developed to decrease the amount of opioid usage due to their negative side ef…
View article: Oral switch antibiotic therapy in uncomplicated <i>Enterococcus faecalis</i> bloodstream infection
Oral switch antibiotic therapy in uncomplicated <i>Enterococcus faecalis</i> bloodstream infection Open
Background The role of oral switch antibiotic therapy in uncomplicated Enterococcus faecalis bloodstream infection (BSI) remains unclear. This retrospective cohort study examines the effectiveness of oral switch compared with standard intr…
View article: Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics
Rationale and Logistics of Continuous Infusion Cephalosporin Antibiotics Open
Cephalosporins have traditionally been administered as an intermittent infusion. With the knowledge that cephalosporins demonstrate a time-dependent pharmacodynamic profile, administration via continuous infusion may provide more effective…
View article: A comprehensive survey of penicillin allergy education among United States Colleges and Schools of Pharmacy
A comprehensive survey of penicillin allergy education among United States Colleges and Schools of Pharmacy Open
Background Pharmacy students should be prepared to evaluate, manage, and de‐label penicillin allergies. It is unknown if, and to what extent, education about allergy management is included within the curriculum of United States Colleges an…
View article: Missed Opportunities for Early De-Escalation of Antipseudomonal Beta-Lactam Antimicrobial Therapy in Enterobacterales Bloodstream Infection
Missed Opportunities for Early De-Escalation of Antipseudomonal Beta-Lactam Antimicrobial Therapy in Enterobacterales Bloodstream Infection Open
Background: Antipseudomonal β-lactams (APBL) are commonly used for empirical therapy of Gram-negative bloodstream infections (BSI). This retrospective cohort study examines risk factors for prolonged APBL use (≥48 h) in patients with Enter…
View article: Missed Opportunities for Early De-Escalation of Antipseudomonal Beta-Lactam Antimicrobial Therapy in Enterobacterales Bloodstream Infection
Missed Opportunities for Early De-Escalation of Antipseudomonal Beta-Lactam Antimicrobial Therapy in Enterobacterales Bloodstream Infection Open
Background: Antipseudomonal β-lactams (APBL) are commonly used for empirical therapy of Gram-negative bloodstream infections (BSI). This retrospective cohort study examines risk factors for prolonged APBL use (≥48 h) in patients with Enter…
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View article: Incidence and predictors of complications in Gram-negative bloodstream infection
Incidence and predictors of complications in Gram-negative bloodstream infection Open
Background The incidence of metastatic complications in Gram-negative bloodstream infection (GN-BSI) remains undefined. This retrospective cohort study examines the incidence and predictors of complications within 90 days of GN-BSI. Method…
View article: Issue Information
Issue Information Open
A qualitative study exploring patient experiences and opinions of warfarin patient self
View article: Issue Information
Issue Information Open
View article: A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2022
A Baker's Dozen of Top Antimicrobial Stewardship Intervention Publications in 2022 Open
Keeping abreast of the antimicrobial stewardship–related articles published each year is challenging. The Southeastern Research Group Endeavor identified antimicrobial stewardship–related, peer-reviewed literature that detailed an actionab…
View article: Evaluation of the diagnostic utility of metagenomic next-generation sequencing testing for pathogen identification in infected hosts: a retrospective cohort study
Evaluation of the diagnostic utility of metagenomic next-generation sequencing testing for pathogen identification in infected hosts: a retrospective cohort study Open
Background: Metagenomic next-generation sequencing (mNGS) testing identifies thousands of potential pathogens in a single blood test, though data on its real-world diagnostic utility are lacking. Objectives: Determine the diagnostic utilit…
View article: The prevalence of gram-negative bacteria with difficult-to-treat resistance and utilization of novel β-lactam antibiotics in the southeastern United States
The prevalence of gram-negative bacteria with difficult-to-treat resistance and utilization of novel β-lactam antibiotics in the southeastern United States Open
Objective: To evaluate temporal trends in the prevalence of gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR) in the southeastern United States. Secondary objective was to examine the use of novel β-lactams for GNB with…
View article: Investigating the Prevalence and Types of Clinical Services Offered by Pharmacists in Federally Qualified Health Centers in South Carolina: A Qualitative, Cross-Sectional Survey
Investigating the Prevalence and Types of Clinical Services Offered by Pharmacists in Federally Qualified Health Centers in South Carolina: A Qualitative, Cross-Sectional Survey Open
Purpose: To investigate the prevalence and type of clinical pharmacy services offered within South Carolina Federally Qualified Health Centers (SC FQHCs) and identify existing implementation barriers. Methods: This study was a cross-sectio…
View article: The top 10 papers on the treatment of invasive fungal infections, 2018–2023
The top 10 papers on the treatment of invasive fungal infections, 2018–2023 Open
Background: Invasive fungal infections are responsible for a large number of infections in hospitalized patients annually and are responsible for high morbidity and mortality. Familiarity with novel agents or strategies in this area can be…
View article: 1286. Evaluating Dalbavancin Suppression Therapy in Patients at High Risk for Recurrent Infections
1286. Evaluating Dalbavancin Suppression Therapy in Patients at High Risk for Recurrent Infections Open
Background Dalbavancin is a long-acting lipoglycopeptide used off-label in the treatment of deep-seated infections. An emerging potential niche for dalbavancin is chronic suppressive therapy in patients with retained sources. Limited data …
View article: 2763. Evaluating the Safety and Effectiveness of Long-term Antibiotic Suppression in Patients with Left Ventricular Assist Devices
2763. Evaluating the Safety and Effectiveness of Long-term Antibiotic Suppression in Patients with Left Ventricular Assist Devices Open
Background The utilization of left ventricular assist devices (LVADs) as a bridge to transplantation or destination therapy for non-transplant candidates continues to rise. Unfortunately, infection remains one of the most common complicati…
View article: Application of Precision Medicine Concepts in Ambulatory Antibiotic Management of Acute Pyelonephritis
Application of Precision Medicine Concepts in Ambulatory Antibiotic Management of Acute Pyelonephritis Open
Acute pyelonephritis (APN) is a relatively common community-acquired infection, particularly in women. The early appropriate antibiotic treatment of this potentially life-threatening infection is associated with improved outcomes. The inte…
View article: Optimization of Empirical Antimicrobial Therapy in Enterobacterales Bloodstream Infection Using the Extended-Spectrum Beta-Lactamase Prediction Score
Optimization of Empirical Antimicrobial Therapy in Enterobacterales Bloodstream Infection Using the Extended-Spectrum Beta-Lactamase Prediction Score Open
Clinical tools for the prediction of antimicrobial resistance have been derived and validated without examination of their implementation in clinical practice. This study examined the impact of utilization of the extended-spectrum beta-lac…
View article: Successful use of nafcillin and ceftaroline combination therapy for persistent MSSA bacteraemia and endocarditis: a case series
Successful use of nafcillin and ceftaroline combination therapy for persistent MSSA bacteraemia and endocarditis: a case series Open
View article: Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation
Cefazolin in the treatment of central nervous system infections: A narrative review and recommendation Open
Infections of the central nervous system (CNS) are complex to treat and associated with significant morbidity and mortality. Historically, antistaphylococcal penicillins such as nafcillin were recommended for the treatment of methicillin‐s…
View article: 338. Epidemiology and Treatment of Invasive <i>Bartonella spp.</i> Infections
338. Epidemiology and Treatment of Invasive <i>Bartonella spp.</i> Infections Open
Background Serology and PCR testing methods have increased ability to diagnose Bartonella spp. invasive infections. Current treatment recommendations are based primarily on case series and aging data published before newly available diagno…
View article: 1422. A Multi-Center Evaluation of Omadacycline for Multi-Drug Resistant Infections
1422. A Multi-Center Evaluation of Omadacycline for Multi-Drug Resistant Infections Open
Background Multi-drug resistant (MDR) pathogens are a continuously evolving threat for which there are limited effective treatment modalities. Omadacycline (OMC) is a novel oral and intravenously administered aminomethylcycline with potent…
View article: 408. Benchmarking the Use of New β-lactams Utilizing a Novel Metric of Microbiological Burden
408. Benchmarking the Use of New β-lactams Utilizing a Novel Metric of Microbiological Burden Open
Background Several methods are used to account for various hospital characteristics when comparing antimicrobial use (AU) between heterogenous hospitals. Recently, a new antimicrobial stewardship metric that adjusts AU by microbiological b…