Philippa C. Matthews
YOU?
Author Swipe
View article: Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice
Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice Open
The potential for hepatitis B reactivation must be considered when switching people with HIV and prior hepatitis B exposure away from tenofovir-containing combined anti-retroviral therapy. Four cases of hepatitis B reactivation from the Un…
View article: “It would be better for those of us who have the disease not to be ashamed”: Insights from people living with chronic hepatitis B virus infection and healthcare workers providing HBV care in Kilifi, Kenya
“It would be better for those of us who have the disease not to be ashamed”: Insights from people living with chronic hepatitis B virus infection and healthcare workers providing HBV care in Kilifi, Kenya Open
Chronic hepatitis B infection (CHB) causes over 1 million deaths annually, with a large burden of morbidity and mortality in the WHO-African Region (WHO-AFRO) where <5% of people are diagnosed and 0.2% are on treatment. Studies have shown …
View article: Hepatitis B Virus ( <scp>HBV</scp> ) Treatment Eligibility in the <scp>UK</scp> : Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines
Hepatitis B Virus ( <span>HBV</span> ) Treatment Eligibility in the <span>UK</span> : Retrospective Longitudinal Cohort Data to Explore the Impact of Changes in Clinical Guidelines Open
Nucleos/tide analogue (NA) drugs are used for long‐term treatment of chronic hepatitis B virus (HBV) infection, with treatment eligibility criteria changing rapidly amidst globally evolving clinical guidelines. We aimed to quantify the pre…
View article: HepB-Boost: Implementation of free of charge healthcare worker hepatitis B testing and vaccination at Kilifi County Referral Hospital, Kenya
HepB-Boost: Implementation of free of charge healthcare worker hepatitis B testing and vaccination at Kilifi County Referral Hospital, Kenya Open
Objective Healthcare workers (HCWs) are at high risk of HBV exposure due to contact with blood and bodily fluids. In Kenya, HCWs are rarely fully vaccinated against HBV. During 2024, Kilifi County Referral Hospital (KCRH) on the Kenyan coa…
View article: Evaluation of Hepatitis B core-related antigen (HBcrAg) as a biomarker in cohorts from the United Kingdom and South Africa
Evaluation of Hepatitis B core-related antigen (HBcrAg) as a biomarker in cohorts from the United Kingdom and South Africa Open
HBcrAg correlated with VL, but less so with liver disease. Use of this biomarker needs tailoring for use in diverse populations.
View article: Is health, growth and development impaired in children who are Hepatitis B-exposed but uninfected?
Is health, growth and development impaired in children who are Hepatitis B-exposed but uninfected? Open
An estimated 254 million people are living with chronic hepatitis B virus (HBV) infection worldwide. Many infants are born to mothers with HBV but do not themselves acquire the infection. It is unclear whether this exposure to HBV in early…
View article: Social behaviours and contact patterns across the 2020/21, 2021/22 and 2022/23 winter seasons in the UK, and associations with symptoms
Social behaviours and contact patterns across the 2020/21, 2021/22 and 2022/23 winter seasons in the UK, and associations with symptoms Open
The SARS-CoV-2 pandemic had a large impact on social mixing in the UK. This study analysed data from the Office for National Statistics Coronavirus Infection Survey to examine changes in contact patterns and self-reported symptoms through …
View article: Conserved recombination patterns across hepatitis B genotypes: a retrospective study
Conserved recombination patterns across hepatitis B genotypes: a retrospective study Open
Hepatitis B virus (HBV) infection is a major public health concern, as chronic HBV infection can lead to liver cirrhosis and increase a person's risk of developing hepatocellular carcinoma (HCC). HBV has been classified into ten genotypes …
View article: Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study
Next-Generation Sequencing Methods for Sensitive Hepatitis B Viral Genome Analysis: A European Study Open
Objectives This multicentre study investigated the utility of next-generation sequencing (NGS) to detect and generate hepatitis B virus (HBV) genomes in samples of low viral load (from 0.2 to 6207 IU/ml). Methods 23 HBV DNA positive plasma…
View article: HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa
HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa Open
Sexual reproductive health and PrEP programmes provide an opportunity for HBV testing and treatment. However, attrition from the care cascade at each step highlights the pressing need for interventions that address barriers to sustainable …
View article: Community engagement and chronic viral hepatitis public health interventions: a systematic review, meta-analysis, and complementary crowdsourcing open call
Community engagement and chronic viral hepatitis public health interventions: a systematic review, meta-analysis, and complementary crowdsourcing open call Open
National Natural Science Foundation of China.
View article: Hepatitis B virus resistance to nucleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field
Hepatitis B virus resistance to nucleos(t)ide analogue therapy: WHO consultation on questions, challenges, and a roadmap for the field Open
In this Review, we summarise outputs from a multidisciplinary consultation convened by WHO between July 11 and 13, 2023, to discuss hepatitis B virus (HBV) drug resistance (HBVDR). Treatment of chronic HBV infection with highly effective n…
View article: Eligibility for hepatitis B virus (HBV) treatment and prevalence of drug resistance in a Ugandan population cohort
Eligibility for hepatitis B virus (HBV) treatment and prevalence of drug resistance in a Ugandan population cohort Open
Background The World Health Organization (WHO) 2024 Hepatitis B virus (HBV) treatment guidelines expand eligibility for nucleos(t)ide analogue treatment in individuals with chronic HBV infection. For countries to implement these guidelines…
View article: Liver, cardiovascular and metabolic factors as predictors of all-cause mortality in a rural Ugandan Cohort
Liver, cardiovascular and metabolic factors as predictors of all-cause mortality in a rural Ugandan Cohort Open
Markers of liver and metabolic disease have not been well described for many populations in Africa, but could be important to inform individual and public health interventions that reduce morbidity and mortality. We studied longitudinal da…
View article: Infecting minds: socio-contextual drivers of vaccine perceptions and attitudes among young and older adults living in urban and rural areas in KwaZulu-Natal, South Africa
Infecting minds: socio-contextual drivers of vaccine perceptions and attitudes among young and older adults living in urban and rural areas in KwaZulu-Natal, South Africa Open
Background We investigated how social and contextual factors, including a pandemic, shape vaccine perceptions and attitudes among people living in KwaZulu-Natal in South Africa. We assessed how participants’ views, acceptance, and uptake o…
View article: Impact of metformin on HBV replication: No evidence of suppression in vitro
Impact of metformin on HBV replication: No evidence of suppression in vitro Open
In HepAD38 cells, HBV replication is not impacted by metformin treatment. This contrasts with prior in vitro data but is in line with clinical evidence that suggests metformin acts through an influence on liver disease progression rather t…
View article: Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya
Hepatitis B Core-Related Antigen Point-of-Care Tests as a Risk Stratification Tool for Treatment Eligibility: Experience From Kenya Open
We undertook a point-of-care test for hepatitis B core-related antigen in adults with hepatitis B virus in Kilifi, Kenya. A positive test identified all individuals with a hepatitis B viral load >200 000 IU/mL and who were hepatitis B e…
View article: A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults
A putative hepatitis B virus sequence motif associated with hepatocellular carcinoma in South African adults Open
In this setting, HBV sequence polymorphisms and deletions are associated with HCC, and 'non-T53 + G1764A' represents a putative signature motif for HCC. Additional investigations are needed to disaggregate the impact of other demographic, …
View article: Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms
Whole genome sequencing of hepatitis B virus using tiled amplicon (HEPTILE) and probe based enrichment on Illumina and Nanopore platforms Open
Hepatitis B virus (HBV) whole genome sequencing (WGS) is currently limited as the DNA viral loads (VL) of many clinical samples are below the threshold required to generate full genomes using current sequencing methods. We developed two pa…
View article: Knowledge, attitudes and practices to hepatitis B among South African primary healthcare staff
Knowledge, attitudes and practices to hepatitis B among South African primary healthcare staff Open
Background: Hepatitis B virus (HBV), a significant cause of liver disease globally, is recognised as a 2030 elimination target by the World Health Organization (WHO). Healthcare workers (HCWs) require appropriate HBV knowledge to identify,…
View article: Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study
Using Laboratory Test Results for Surveillance During a New Outbreak of Acute Hepatitis in 3-Week- to 5-Year-Old Children in the United Kingdom, the Netherlands, Ireland, and Curaçao: Observational Cohort Study Open
Background In March 2022, a concerning rise in cases of unexplained pediatric hepatitis was reported in multiple countries. Cases were defined as acute hepatitis with serum transaminases >500 U/L (aspartate transaminase [AST] or alanine tr…
View article: HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa
HIV PrEP programmes as a framework for diagnosing and treating HBV infection in adolescents and young adults in KwaZulu-Natal, South Africa Open
Background Hepatitis B virus (HBV) is a neglected public health threat with poor community awareness and access to prevention, despite having a safe and effective vaccine. There are still gaps in diagnosis and treatment, particularly in th…
View article: Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines
Hepatitis B Virus (HBV) treatment eligibility in the UK: retrospective longitudinal cohort data to explore the impact of changes in clinical guidelines Open
Objective Nucleos/tide analogue (NA) drugs are used for the long-term treatment of chronic hepatitis B virus (HBV) infection. In a landscape of changing clinical recommendations, we set out to quantify the prescription of NA drugs to date,…
View article: “I think it would be better for those of us who have the disease not to be ashamed”. Insights from people living with chronic hepatitis B virus infection and healthcare workers providing HBV care in Kilifi, Kenya
“I think it would be better for those of us who have the disease not to be ashamed”. Insights from people living with chronic hepatitis B virus infection and healthcare workers providing HBV care in Kilifi, Kenya Open
Chronic hepatitis B infection (CHB) causes over 1 million deaths annually, with a large burden of morbidity and mortality in the WHO-African Region (WHO-AFRO) where <5% of people are diagnosed and 0.2% are on treatment. Studies have shown …