Pilar Carranza‐Rosales
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View article: Untargeted Chemical Profile, Antioxidant, and Enzyme Inhibition Activity of Physalis angulata L. from the Peruvian Amazon: A Contribution to the Validation of Its Pharmacological Potential
Untargeted Chemical Profile, Antioxidant, and Enzyme Inhibition Activity of Physalis angulata L. from the Peruvian Amazon: A Contribution to the Validation of Its Pharmacological Potential Open
Physalis angulata is a plant of great value in traditional medicine known for its content of bioactive compounds, such as physalins and withanolides, which possess diverse biological activities. In this study, the chemical profile, antioxi…
View article: Antioxidant and Biological Activity of Mexican Madroño Fruit (Arbutus arizonica)
Antioxidant and Biological Activity of Mexican Madroño Fruit (Arbutus arizonica) Open
The fruit of the Mexican madroño (Arbutus arizonica) has been consumed since pre-Columbian times by North American tribes and native groups in Mexico. Despite this, reports on its chemical composition and biological activity are limited. T…
View article: Cordycepin Triphosphate as a Potential Modulator of Cellular Plasticity in Cancer via cAMP-Dependent Pathways: An In Silico Approach
Cordycepin Triphosphate as a Potential Modulator of Cellular Plasticity in Cancer via cAMP-Dependent Pathways: An In Silico Approach Open
Cordycepin, or 3′-deoxyadenosine, is an adenosine analog with a broad spectrum of biological activity. The key structural difference between cordycepin and adenosine lies in the absence of a hydroxyl group at the 3′ position of the ribose …
View article: Adverse cardiovascular, obstetric and perinatal events during pregnancy and puerperium in patients with heart disease
Adverse cardiovascular, obstetric and perinatal events during pregnancy and puerperium in patients with heart disease Open
severe complications were found during pregnancy and postpartum in patients with heart disease, which is why preconception evaluation and close surveillance are vital.
View article: Green synthesis of ethyl cinnamates under microwave irradiation: photophysical properties, cytotoxicity, and cell bioimaging
Green synthesis of ethyl cinnamates under microwave irradiation: photophysical properties, cytotoxicity, and cell bioimaging Open
A simple and green method for the synthesis of six ethyl cinnamates was performed via Horner–Wadsworth–Emmons reaction under microwave irradiation.
View article: Breast Cancer Tissue Explants: An Approach to Develop Personalized Therapy in Public Health Services
Breast Cancer Tissue Explants: An Approach to Develop Personalized Therapy in Public Health Services Open
Breast cancer is one of the main causes of death worldwide. Lately, there is great interest in developing methods that assess individual sensitivity and/or resistance of tumors to antineoplastics to provide personalized therapy for patient…
View article: Frank's sign associated with the severity of ischemic heart disease in patients under 65 years old
Frank's sign associated with the severity of ischemic heart disease in patients under 65 years old Open
There is an independent association between Frank's sign with the presence of severe CAD in patients ≤ 65 years old, which may be useful for screening and prevention.
View article: Metformin May Alter the Metabolic Reprogramming in Cancer Cells by Disrupting the L-Arginine Metabolism: A Preliminary Computational Study
Metformin May Alter the Metabolic Reprogramming in Cancer Cells by Disrupting the L-Arginine Metabolism: A Preliminary Computational Study Open
Metabolic reprogramming in cancer is considered to be one of the most important hallmarks to drive proliferation, angiogenesis, and invasion. AMP-activated protein kinase activation is one of the established mechanisms for metformin’s anti…
View article: Protective Effect of <i>Hedeoma drummondii</i> against Formaldehyde‐Induced Testicular Toxicity and Genotoxicity in Wistar Rats
Protective Effect of <i>Hedeoma drummondii</i> against Formaldehyde‐Induced Testicular Toxicity and Genotoxicity in Wistar Rats Open
Formaldehyde (FA) is an oxidative stress inducer and a known carcinogen. Hedeoma drummondii has been shown to have potential as a chemopreventive agent. The aim of this study was to assess the protective effect of H. drummondii on FA‐induc…
View article: Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico
Comparative Biomonitoring of Arsenic Exposure in Mothers and Their Neonates in Comarca Lagunera, Mexico Open
Multiple comorbidities related to arsenic exposure through drinking water continue to be public problems worldwide, principally in chronically exposed populations, such as those in the Comarca Lagunera (CL), Mexico. In addition, this relat…
View article: Author Correction: Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure
Author Correction: Transgenerational effects in DNA methylation, genotoxicity and reproductive phenotype by chronic arsenic exposure Open
Rats chronically exposed to arsenic in drinking water (1 mg As 2 O 3 /mL) (F0) were mated to produce the arsenic lineage (F1, F2, and F3)." now reads: "Rats chronically exposed to arsenic in drinking water (1 mg As 2 O 3 /L) (F0) were mate…
View article: Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits Ehretia tinifolia and Sideroxylon lanuginosum
Phenolic Profiles and Biological Activities of Extracts from Edible Wild Fruits Ehretia tinifolia and Sideroxylon lanuginosum Open
Ehretia tinifolia Linnaeus (Boraginacea) and Sideroxylon lanuginosum Michaux (Sapotaceae) are wild fruits consumed in North America and are appreciated for their pleasant flavor and sweet taste. However, details regarding their composition…
View article: Ex vivo infection of murine precision-cut lung tissue slices with Mycobacterium abscessus: a model to study antimycobacterial agents
Ex vivo infection of murine precision-cut lung tissue slices with Mycobacterium abscessus: a model to study antimycobacterial agents Open
Background Multidrug-resistant infections due to Mycobacterium abscessus often require complex and prolonged regimens for treatment. Here, we report the evaluation of a new ex vivo antimicrobial susceptibility testing model using organotyp…
View article: Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii
Antimycobacterial Activity of Laurinterol and Aplysin from Laurencia johnstonii Open
Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to their large variety and functions derived from natural selection, marine natural products may allow the i…
View article: Antimycobacterial Activity of Laurinterol and Aplysin from <i>Laurencia johnstonii</i>
Antimycobacterial Activity of Laurinterol and Aplysin from <i>Laurencia johnstonii</i> Open
Marine environments represent a great opportunity for the discovery of compounds with a wide spectrum of bioactive properties. Due to the privileged conditions of natural selection, marine natural products are subject to overcome the press…
View article: Curcumin Attenuates the Pathogenicity of Entamoeba histolytica by Regulating the Expression of Virulence Factors in an Ex-Vivo Model Infection
Curcumin Attenuates the Pathogenicity of Entamoeba histolytica by Regulating the Expression of Virulence Factors in an Ex-Vivo Model Infection Open
Infection with the enteric protozoan Entamoeba histolytica is still a serious public health problem, especially in developing countries. Amoebic liver abscess (ALA) is the most common extraintestinal manifestation of the amoebiasis, and it…
View article: Protective effects of phenolic acids on mercury-induced DNA damage in precision-cut kidney slices.
Protective effects of phenolic acids on mercury-induced DNA damage in precision-cut kidney slices. Open
This is the first time that a modification of the comet assay technique is reported as a tool to visualize the comets from kidney tissue slices in a clear and simple way. The phenolic compounds tested in this study provided protection agai…
View article: Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants
Antitumoral Effect of Laurinterol on 3D Culture of Breast Cancer Explants Open
Macroalgae represent an important source of bioactive compounds with a wide range of biotechnological applications. Overall, the discovery of effective cytotoxic compounds with pharmaceutical potential is a significant challenge, mostly be…
View article: Telomere length analysis in residents of a community exposed to arsenic
Telomere length analysis in residents of a community exposed to arsenic Open
Differentiated cells telomere length is an indicator of senescence or lifespan; however, in peripheral blood leukocytes the relative shortening of the telomere has been considered as a biological marker of aging, and lengthening telomere a…
View article: Evaluation of the Coating with TiO<sub>2</sub> Nanoparticles as an Option for the Improvement of the Characteristics of NiTi Archwires: Histopathological, Cytotoxic, and Genotoxic Evidence
Evaluation of the Coating with TiO<sub>2</sub> Nanoparticles as an Option for the Improvement of the Characteristics of NiTi Archwires: Histopathological, Cytotoxic, and Genotoxic Evidence Open
For the EPD, different voltages and different times were used. Male rats were used in four groups () with different treatments. The blood sample was obtained for genotoxic analysis and liver and kidney organs were removed for histopatholog…
View article: Expression of NK Cell Surface Receptors in Breast Cancer Tissue as Predictors of Resistance to Antineoplastic Treatment
Expression of NK Cell Surface Receptors in Breast Cancer Tissue as Predictors of Resistance to Antineoplastic Treatment Open
Background: Currently, one of the most used strategies for the treatment of newly diagnosed patients with breast cancer is neoadjuvant chemotherapy based on the application of taxanes and anthracyclines. However, despite the high number of…
View article: Stereochemical preference toward oncotarget: Design, synthesis and<i>in vitro</i>anticancer evaluation of diastereomeric β-lactams
Stereochemical preference toward oncotarget: Design, synthesis and<i>in vitro</i>anticancer evaluation of diastereomeric β-lactams Open
Stereochemical preferences of the cis-β-lactams over their trans-counterparts, toward the molecular target β-tubulin, was confirmed by docking studies and in vitro anticancer evaluation. Apoptosis was identified as the cause of cell death.…
View article: Cytological effects of pulsed electromagnetic fields and static magnetic fields induced by a therapeutic device on <i>in vivo</i> exposed rats
Cytological effects of pulsed electromagnetic fields and static magnetic fields induced by a therapeutic device on <i>in vivo</i> exposed rats Open
Background: There is a trend towards the use of magnetic fields in medicine. Pulsed electromagnetic fields (PEMFs) technology was based upon 20 years of fundamental studies on the electromechanical properties of bone and other connective t…
View article: CYTOLOGICAL EFFECTS OF PULSED ELECTROMAGNETIC FIELDS AND STATIC MAGNETIC FIELDS INDUCED BY A THERAPEUTIC DEVICE ON IN VIVO EXPOSED RATS.
CYTOLOGICAL EFFECTS OF PULSED ELECTROMAGNETIC FIELDS AND STATIC MAGNETIC FIELDS INDUCED BY A THERAPEUTIC DEVICE ON IN VIVO EXPOSED RATS. Open
Background: There is a trend towards the use of magnetic fields in medicine. Pulsed electromagnetic fields (PEMFs) technology was based
upon 20 years of fundamental studies on the electromechanical properties of bone and other connective …
View article: Sperm chromatin dispersion by formaldehyde in Wistar rats
Sperm chromatin dispersion by formaldehyde in Wistar rats Open
Formaldehyde (FA) is an environmental xenobiotic, which is genotoxic and carcinogenic to humans and animals; it induces DNA damage, mutations, and clastogenicity during critical cytogenetic events. FA-mediated oxidative stress is an import…