Cameron Casey
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View article: Longitudinal study of single-pulse TMS in infants with perinatal brain injury: safety and feasibility
Longitudinal study of single-pulse TMS in infants with perinatal brain injury: safety and feasibility Open
Introduction Perinatal brain injury is a leading cause of cerebral palsy. Single-pulse transcranial magnetic stimulation (spTMS) provides a non-invasive method for investigating motor pathway development; however, data on the safety and fe…
View article: Reliability of motor evoked potential identification in pediatric populations
Reliability of motor evoked potential identification in pediatric populations Open
MEP identification using a rater-based scoring protocol is feasible in pediatric cohorts but presents greater challenges in infants due to distinct neurophysiological and behavioral factors. Despite these difficulties, good reliability can…
View article: White-Matter Connectivity and General Movements in Infants with Perinatal Brain Injury
White-Matter Connectivity and General Movements in Infants with Perinatal Brain Injury Open
Background/Objectives: Cerebral palsy (CP), often caused by early brain injury such as perinatal stroke or hemorrhage, is the most common lifelong motor disability. Early identification of at-risk infants and timely access to rehabilitatio…
View article: 491 Safety and feasibility of transcranial magnetic stimulation in infants with perinatal brain injury: A step toward early clinical translation
491 Safety and feasibility of transcranial magnetic stimulation in infants with perinatal brain injury: A step toward early clinical translation Open
Objectives/Goals: To determine the safety and feasibility of single-pulse transcranial magnetic stimulation (spTMS) for assessing corticospinal tract (CST) excitability and integrity in infants with perinatal brain injury, bridging foundat…
View article: Preservation of Bilateral Corticospinal Projections from Injured Hemisphere After Perinatal Stroke
Preservation of Bilateral Corticospinal Projections from Injured Hemisphere After Perinatal Stroke Open
Background: Perinatal brain injury is a leading cause of developmental disabilities, including cerebral palsy. However, further work is needed to understand early brain development in the presence of brain injury. In this case report, we e…
View article: Moving from a pilot study to large pragmatic trial in primary care settings: A study on acute rhinosinusitis
Moving from a pilot study to large pragmatic trial in primary care settings: A study on acute rhinosinusitis Open
Background: Acute rhinosinusitis is one of the most common conditions seen in primary care. One in seven adults are diagnosed with ARS annually, resulting in one in five of all antibiotic prescriptions. Yet there has been limited research …
View article: NOSES (Nasal Steroids, Nasal Irrigation, Oral Antibiotics and Subgroup Targeting for Effective Management of Sinusitis) Trial
NOSES (Nasal Steroids, Nasal Irrigation, Oral Antibiotics and Subgroup Targeting for Effective Management of Sinusitis) Trial Open
CONTEXT: Acute rhinosinusitis (ARS) is so prevalent that it affects 15% of the adult population annually, and accounts for 20% of all antibiotics prescribed to adults in the outpatient setting. Evidence is needed to demonstrate the most ef…
View article: Risk of Acute Rhinosinusitis Progression Based on Duration of Symptoms, Method of Care, and Setting of Care
Risk of Acute Rhinosinusitis Progression Based on Duration of Symptoms, Method of Care, and Setting of Care Open
CONTEXT: One of the most common primary care illnesses is acute rhinosinusitis (ARS). Guidelines currently suggest treating ARS with antibiotics when persistent symptoms or double sickening occur. OBJECTIVE: To identify the factors associa…
View article: Adjunctive Saline Nasal Irrigation for Acute Rhinosinusitis: Results of a Randomized Pilot Study
Adjunctive Saline Nasal Irrigation for Acute Rhinosinusitis: Results of a Randomized Pilot Study Open
CONTEXT: Acute rhinosinusitis (ARS) affects 15% of the adult population annually, and accounts for 20% of adult outpatient antibiotic prescriptions. Evidence is needed to clarify effectiveness of standard treatment, which includes antibiot…
View article: Association between substance use and acute rhinosinusitis in a multisite trial pilot study
Association between substance use and acute rhinosinusitis in a multisite trial pilot study Open
CONTEXT: Substance use may contribute to sinusitis frequency and severity by weakening the immune system or irritating and damaging nasal tissue. A pilot trial of the NOSES study was conducted to assess the feasibility for a full-scale tri…
View article: Single-pulse transcranial magnetic stimulation for assessment of motor development in infants with early brain injury
Single-pulse transcranial magnetic stimulation for assessment of motor development in infants with early brain injury Open
Single-pulse TMS has demonstrated safety and feasibility in infants with perinatal brain injury and may provide insight into neuromotor development and potential cerebral palsy diagnosis. Additional research in larger sample sizes will mor…
View article: Translating electrophysiological signatures of awareness into thalamocortical mechanisms by inverting systems-level computational models across arousal states
Translating electrophysiological signatures of awareness into thalamocortical mechanisms by inverting systems-level computational models across arousal states Open
While consciousness never fades during wakefulness, there is a paradoxical coexistence of consciousness during dreaming states. It’s also possible for sensory awareness to be either present or absent when awakened from seemingly-identical …
View article: Translating electrophysiological signatures of awareness into thalamocortical mechanisms by inverting systems-level computational models across arousal states
Translating electrophysiological signatures of awareness into thalamocortical mechanisms by inverting systems-level computational models across arousal states Open
While consciousness never fades during wakefulness, there is a paradoxical coexistence of consciousness during dreaming states. It’s also possible for sensory awareness to be either present or absent when awakened from seemingly-identical …
View article: Delirium is associated with loss of feedback cortical connectivity
Delirium is associated with loss of feedback cortical connectivity Open
INTRODUCTION Post‐operative delirium (POD) is associated with increased morbidity and mortality but is bereft of treatments, largely due to our limited understanding of the underlying pathophysiology. We hypothesized that delirium reflects…
View article: Control of contextual memory through interneuronal α5-GABAA receptors
Control of contextual memory through interneuronal α5-GABAA receptors Open
γ-Aminobutyric acid type A receptors that incorporate α5 subunits (α5-GABAARs) are highly enriched in the hippocampus and are strongly implicated in control of learning and memory. Receptors located on pyramidal neuron dendrites have long …