Peter S. Conti
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View article: Oral Inhaled Cromolyn for Mild-to-Moderate Amyotrophic Lateral Sclerosis: A Randomized, Open Label Phase 2a Study
Oral Inhaled Cromolyn for Mild-to-Moderate Amyotrophic Lateral Sclerosis: A Randomized, Open Label Phase 2a Study Open
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder of the motor neuron system for which there is currently no effective treatment. This study aims to evaluate the safety and efficacy of two doses of oral inhale…
View article: Unresectable Metastatic Solid Pseudopapillary Pancreatic Neoplasm Treated With Liver Transplantation
Unresectable Metastatic Solid Pseudopapillary Pancreatic Neoplasm Treated With Liver Transplantation Open
We present a 49-year-old woman requiring living donor liver transplantation after liver metastasis from a pancreatic solid pseudopapillary tumor. After identifying a pancreatic mass and liver lesions, she underwent extensive surgical resec…
View article: Clinical outcomes and treatment patterns in REASSURE: planned interim analysis of a real-world observational study of radium-223 in metastatic castration-resistant prostate cancer
Clinical outcomes and treatment patterns in REASSURE: planned interim analysis of a real-world observational study of radium-223 in metastatic castration-resistant prostate cancer Open
Bayer HealthCare.
View article: Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same
Cage-like bifunctional chelators, copper-64 radiopharmaceuticals and PET imaging using the same Open
Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) an…
View article: Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 62K, Table S1. Humanized MAb159 Pharmacokinetics in mouse. Table S2. Toxicology study of humanized MAb159 in mouse.
View article: Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 121K
View article: Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Methods from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 121K
View article: Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Tables 1 - 2 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 62K, Table S1. Humanized MAb159 Pharmacokinetics in mouse. Table S2. Toxicology study of humanized MAb159 in mouse.
View article: Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 736K, Fig. S1. Generation and characterization of MAb159. Fig. S2. MAb159 induces GRP78 endocytosis through clathrin mediated pathway. Fig. S3. MAb159 induces apoptosis of tumor cells in vitro. Fig. S4. Surface GRP78 Forms Compl…
View article: Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosphoinosit…
View article: Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Data from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
Purpose: The ER chaperone GRP78 translocates to the surface of tumor cells and promotes survival, metastasis, and resistance to therapy. An oncogenic function of cell surface GRP78 has been attributed to the activation of the phosphoinosit…
View article: Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis
Supplementary Figures 1 - 9 from Monoclonal Antibody against Cell Surface GRP78 as a Novel Agent in Suppressing PI3K/AKT Signaling, Tumor Growth, and Metastasis Open
PDF file - 736K, Fig. S1. Generation and characterization of MAb159. Fig. S2. MAb159 induces GRP78 endocytosis through clathrin mediated pathway. Fig. S3. MAb159 induces apoptosis of tumor cells in vitro. Fig. S4. Surface GRP78 Forms Compl…
View article: Supplementary Methods from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice
Supplementary Methods from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice Open
Supplementary Methods from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice
View article: Supplementary Table 1 from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice
Supplementary Table 1 from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice Open
Supplementary Table 1 from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice
View article: Data from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice
Data from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice Open
Colorectal cancer, one of the most common human malignancies in the Western world, is often subdivided based on tumor location in either the distal or proximal colon. Several mouse models have been developed to study human colorectal cance…
View article: Supplementary Table 1 from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice
Supplementary Table 1 from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice Open
Supplementary Table 1 from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice
View article: Supplementary Methods from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice
Supplementary Methods from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice Open
Supplementary Methods from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of ApcMin/+ Mice
View article: Data from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice
Data from Smad3 Deficiency Promotes Tumorigenesis in the Distal Colon of <i>Apc<sup>Min/+</sup></i> Mice Open
Colorectal cancer, one of the most common human malignancies in the Western world, is often subdivided based on tumor location in either the distal or proximal colon. Several mouse models have been developed to study human colorectal cance…
View article: Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same
Boron-based dual imaging probes, compositions and methods for rapid aqueous F-18 labeling, and imaging methods using same Open
A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: ##STR00001## wherein R.sub.1-R.sub.7 may be independently selected from hydrogen, halogen, …
View article: Synthesis of 2'-deoxy-2'-[.sup.18F]fluoro-5-methyl-1-B-D-arabinofuranosyluracil (.sup.18F-FMAU)
Synthesis of 2'-deoxy-2'-[.sup.18F]fluoro-5-methyl-1-B-D-arabinofuranosyluracil (.sup.18F-FMAU) Open
The present invention relates to methods of synthesizing .sup.18F-FMAU. In particular, .sup.18F-FMAU is synthesized using one-pot reaction conditions in the presence of Friedel-Crafts catalysts. The one-pot reaction conditions are incorpor…
View article: Near-infrared Spectroscopy of Ultracompact H ii Regions in W51A with NIFS/ALTAIR*
Near-infrared Spectroscopy of Ultracompact H ii Regions in W51A with NIFS/ALTAIR* Open
W51A is the most active star formation region of the giant H ii region W51. It harbors the two massive protoclusters W51e and W51 IRS2, which are very rare in the Galaxy. We aim to identify the newborn massive stars and ultracompact H ii r…
View article: Exploring Solvent Effects in the Radiosynthesis of <sup>18</sup>F-Labeled Thymidine Analogues toward Clinical Translation for Positron Emission Tomography Imaging
Exploring Solvent Effects in the Radiosynthesis of <sup>18</sup>F-Labeled Thymidine Analogues toward Clinical Translation for Positron Emission Tomography Imaging Open
Thymidine analogues, 5-substituted 2'-deoxy-2'-[18F]fluoro-arabinofuranosyluracil derivatives, are promising positron emission tomography (PET) tracers being evaluated for noninvasive imaging of cancer cell proliferation and/or reporter ge…
View article: Relationships between cerebrovascular health and tau PET uptake are associated with global cognition
Relationships between cerebrovascular health and tau PET uptake are associated with global cognition Open
Background Brain accumulation of tau and cerebrovascular dysfunction are both important contributors to AD pathogenesis, but associations between vascular health and tau levels, and their effects on clinical outcome, are poorly understood.…
View article: Improved Metabolic Stability for 18 F PET Probes Rapidly Constructed via Tetrazine trans -Cyclooctene Ligation
Improved Metabolic Stability for 18 F PET Probes Rapidly Constructed via Tetrazine trans -Cyclooctene Ligation Open
The fast kinetics and bioorthogonal nature of the tetrazine trans-cyclooctene (TCO) ligation makes it a unique tool for PET probe construction. In this study, we report the development of an 18F-labeling system based on a CF3-substituted d…
View article: Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid
Associations between Vascular Function and Tau PET Are Associated with Global Cognition and Amyloid Open
Tau pathology and vascular dysfunction are important contributors to Alzheimer's disease (AD), but vascular–tau associations and their effects on cognition are poorly understood. We investigated these associations in male and female humans…
View article: A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema
A Pre-clinical Animal Model of Secondary Head and Neck Lymphedema Open
Head and neck lymphedema (HNL) is a disfiguring disease affecting over 90% of patients treated for head and neck cancer. Animal models of lymphedema are used to test pharmacologic and microsurgical therapies; however, no animal model for H…
View article: Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions
Developing Effective Alzheimer’s Disease Therapies: Clinical Experience and Future Directions Open
Alzheimer’s disease (AD) clinical trials, focused on disease modifying drugs and conducted in patients with mild to moderate AD, as well as prodromal (early) AD, have failed to reach efficacy endpoints in improving cognitive function in mo…
View article: PET Imaging of Adenosine Receptors in Diseases
PET Imaging of Adenosine Receptors in Diseases Open
Adenosine receptors (ARs) are a class of purinergic G-protein-coupled receptors (GPCRs). Extracellular adenosine is a pivotal regulation molecule that adjusts physiological function through the interaction with four ARs: A1R, A2AR, A2BR, a…