M. Cooke
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View article: Up and down quark structure of the proton
Up and down quark structure of the proton Open
We report an improved measurement of the valence u and d quark distributions from the forward-backward asymmetry in the Drell-Yan process using 8.6 fb−1 of data collected with the D0 detector in pp¯ collisions at s=1.96. This analysis pro…
View article: A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis
A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis Open
Current therapies for anthrax include the use of antibiotics (i.e., doxycycline, and ciprofloxacin), an anthrax vaccine (BioThrax) and Bacillus anthracis -specific, monoclonal antibody (mAb) (i.e., Raxibacumab and obiltoxaximab). In this s…
View article: Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Discovery of ASTX029, A Clinical Candidate Which Modulates the Phosphorylation and Catalytic Activity of ERK1/2 Open
Aberrant activation of the mitogen-activated protein kinase pathway frequently drives tumor growth, and the ERK1/2 kinases are positioned at a key node in this pathway, making them important targets for therapeutic intervention. Recently, …
View article: How’re Things? Some Observations about Things, Non-Things and Serial Things
How’re Things? Some Observations about Things, Non-Things and Serial Things Open
Recently, I ran into a friend of mine on a street in New Plymouth.We hadn't seen each other for a few years, so we walked to the park and found a tree to sit under for a catch-up.He used to paint these amazing amorphous abstractions, so I …
View article: A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates
A Single Dose of CD117 Antibody Drug Conjugate Enables Hematopoietic Stem Cell Based Gene Therapy in Nonhuman Primates Open
Autologous hematopoietic stem cell transplantation (Auto-HSCT) with gene-modification represents a potential cure for multiple genetic diseases, but its broad curative potential, is limited because of morbidity/mortality from cytotoxic che…
View article: Studies of $X(3872)$ and $\psi(2S)$ production in $p\bar{p}$ collisions at 1.96 TeV
Studies of $X(3872)$ and $\psi(2S)$ production in $p\bar{p}$ collisions at 1.96 TeV Open
We present various properties of the production of the $X(3872)$ and $ψ(2S)$ states based on $10.4 fb^{−1}$ collected by the D0 experiment in Tevatron $p\bar{p}$ collisions at $\sqrt{s}=1.96 TeV$. For both states, we measure the nonprompt …
View article: A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant
A CD117-Amanitin Antibody Drug Conjugate (ADC) Effectively Depletes Human and Non-Human Primate Hematopoietic Stem and Progenitor Cells (HSPCs): targeted Non-Genotoxic Conditioning for Bone Marrow Transplant Open
Current regimens for patient preparation, or conditioning, prior to bone marrow transplantation (BMT) limit the use of this curative procedure due to regimen-related mortality and morbidities. To address this, we developed a CD117-ADC to s…
View article: Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2
Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2 Open
Aberrant activation of the MAPK pathway drives cell proliferation in multiple cancers. Inhibitors of BRAF and MEK kinases are approved for the treatment of BRAF mutant melanoma, but resistance frequently emerges, often mediated by increase…
View article: Combination of D0 measurements of the top quark mass
Combination of D0 measurements of the top quark mass Open
We present a combination of measurements of the top quark mass by the D0 experiment in the lepton+jets and dilepton channels. We use all the data collected in Run I (1992–1996) at √s=1.8 TeV and Run II (2001–2011) at √s = 1.96 TeV of the T…
View article: Measurement of the top quark mass using the matrix element technique in dilepton final states
Measurement of the top quark mass using the matrix element technique in dilepton final states Open
We present a measurement of the top quark mass in p (p) over bar collisions at a center-of-mass energy of 1.96 TeV at the Fermilab Tevatron collider. The data were collected by the D0 experiment corresponding to an integrated luminosity of…
View article: Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide
Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide Open
Small molecule Toll-like receptor 7 (TLR7) agonists have been used as vaccine adjuvants by enhancing innate immune activation to afford better adaptive response. Localized TLR7 agonists without systemic exposure can afford good adjuvantici…
View article: Precise measurement of the top quark mass in dilepton decays using optimized neutrino weighting
Precise measurement of the top quark mass in dilepton decays using optimized neutrino weighting Open
We measure the top quark mass in dilepton final states of t (t) over bar events in p (p) over bar collisions at root s = 1.96 TeV, using data corresponding to an integrated luminosity of 9.7 fb(-1) at the Fermilab Tevatron Collider. The an…
View article: Simultaneous measurement of forward-backward asymmetry and top polarization in dilepton final states from<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>t</mml:mi><mml:mover accent="true"><mml:mi>t</mml:mi><mml:mo stretchy="false">¯</mml:mo></mml:mover></mml:math>production at the Tevatron
Simultaneous measurement of forward-backward asymmetry and top polarization in dilepton final states fromproduction at the Tevatron Open
We present a simultaneous measurement of the forward-backward asymmetry and the top-quark polarization in tt¯ production in dilepton final states using 9.7 fb−1 of proton-antiproton collisions at s√=1.96 TeV with the D0 detector. To recons…
View article: A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells
A new TLR2 agonist promotes cross-presentation by mouse and human antigen presenting cells Open
Cross-presentation is the process by which professional APCs load peptides from an extracellularly derived protein onto class I MHC molecules to trigger a CD8(+) T cell response. The ability to enhance this process is therefore relevant fo…