James P. Coxon
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View article: Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women
Effects of a probiotic fermented dairy product on hippocampal metabolites, structure and function: an 8-week randomised, placebo-controlled trial in healthy women Open
Background Fermented foods are a promising yet underexplored intervention for influencing brain function and mental health through the gut–brain axis. Objective The objective of this study was to evaluate the impact of a dairy product ferm…
Generalisation between motor and declarative memory sequences: A conceptual replication of Mosha & Robertson (2016) Open
Motor and declarative memory systems have been traditionally considered distinct. However, a study by Mosha and Robertson (2016) reported striking evidence of ‘generalisation’ between motor and declarative learning. Specifically, learning …
View article: Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study Open
Learning new motor skills is a fundamental process that involves the sequencing of actions. Skill develops with practice and time and manifests as performance that is fast and accurate. Although we know that learning can occur through an i…
View article: High-Intensity Exercise and Hippocampal Integrity in Adults With Cannabis Use Disorder
High-Intensity Exercise and Hippocampal Integrity in Adults With Cannabis Use Disorder Open
Importance Cannabis is the most commonly used illicit drug, with 10% to 30% of regular users developing cannabis use disorder (CUD), a condition linked to altered hippocampal integrity. Evidence suggests high-intensity interval training (H…
High frequency oscillations and the 1/f slope vary across a spectrum of depression severity Open
Depression is a highly prevalent mental disorder that impacts an individual’s functioning, societal productivity, and quality of life. It is associated with disrupted neural activity (e.g., balance of excitation-inhibition) across networks…
The role of human intraparietal sulcus in evidence accumulation revealed by EEG and model-informed fMRI Open
Sequential sampling models propose that the repeated sampling of sensory information is a fundamental component of perceptual decision-making. Electroencephalographic investigations in humans have demonstrated motor-independent representat…
View article: Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study
Default mode and motor networks facilitate early learning of implicit motor sequences: a multimodal MR spectroscopy and fMRI study Open
Learning new motor skills is a fundamental process that involves the sequencing of actions. Skill develops with practice and time, and manifests as performance that is fast and accurate. Although we know that learning can occur through an …
Disinhibition across Secondary Motor Cortical Regions during Motor Sequence Learning: A TMS-EEG Study Open
Secondary motor cortical regions, such as the supplementary motor area (SMA), are involved in planning and learning motor sequences; however, the neurophysiological mechanisms across these secondary cortical networks remain poorly understo…
The Effect of Congruent versus Incongruent Distractor Positioning on Electrophysiological Signals during Perceptual Decision-Making Open
Key event-related potentials (ERPs) of perceptual decision-making such as centroparietal positivity (CPP) elucidate how evidence is accumulated toward a given choice. Furthermore, this accumulation can be impacted by visual target selectio…
Using TMS-EEG to study the intricate interplay between GABAergic inhibition and glutamatergic excitation during reactive and proactive motor inhibition Open
Transcranial magnetic stimulation (TMS) studies have provided insight into the neurotransmission underlying motor inhibition but are limited to the primary motor cortex (M1). To investigate γ-aminobutyric acid (GABA) and glutamatergic neur…
View article: Exercise‐induced cortical disinhibition mediates the relationship between fitness and memory in older adults
Exercise‐induced cortical disinhibition mediates the relationship between fitness and memory in older adults Open
Regular exercise benefits learning and memory in older adults, but the neural mechanisms mediating these effects remain unclear. Evidence in young adults indicates that acute exercise creates a favourable environment for synaptic plasticit…
View article: White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis
White matter alterations associated with chronic cannabis use disorder: a structural network and fixel-based analysis Open
Cannabis use disorder (CUD) is associated with adverse mental health effects, as well as social and cognitive impairment. Given prevalence rates of CUD are increasing, there is considerable efforts, and need, to identify prognostic markers…
View article: Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition
Dopamine D2 Receptor Modulates Exercise Related Effect on Cortical Excitation/Inhibition and Motor Skill Acquisition Open
Exercise is known to benefit motor skill learning in health and neurological disease. Evidence from brain stimulation, genotyping, and Parkinson's disease studies converge to suggest that the dopamine D2 receptor, and shifts in the cortica…
Micro-consolidation occurs when learning an implicit motor sequence, but is not influenced by HIIT exercise Open
We investigated if micro-consolidation, a phenomenon recently discovered during the brief rest periods between practice when learning an explicit motor sequence, generalises to learning an implicit motor sequence task. We demonstrate micro…
9 Creating a palliative care emergency simulation session for a large oncology department Open
Background The role of simulation to develop skills around managing complex palliative care emergencies has already been established in training post-graduate doctors. Following several palliative care emergencies on a busy oncology ward, …
Supplementary motor area disinhibition during motor sequence learning: A TMS-EEG study Open
Background In primary motor cortex, changes in excitatory and inhibitory neurotransmission (E:I balance) accompany motor sequence learning. In particular, there is an early reduction in inhibition (i.e., disinhibition). The supplementary m…
View article: High-intensity acute exercise impacts motor learning in healthy older adults
High-intensity acute exercise impacts motor learning in healthy older adults Open
Healthy aging is associated with changes in motor sequence learning, with some studies indicating decline in motor skill learning in older age. Acute cardiorespiratory exercise has emerged as a potential intervention to improve motor learn…
View article: Ageing attenuates exercise‐enhanced motor cortical plasticity
Ageing attenuates exercise‐enhanced motor cortical plasticity Open
Cardiorespiratory exercise is known to modulate motor cortical plasticity in young adults, but the influence of ageing on this relationship is unknown. Here, we compared the effects of a single session of cardiorespiratory exercise on moto…
View article: The effect of dopamine D2 receptor blockade on human motor skill learning
The effect of dopamine D2 receptor blockade on human motor skill learning Open
Rationale: Dopamine signalling supports motor skill learning in a variety of ways, including through an effect on cortical and striatal plasticity. One neuromodulator that has been consistently linked to motor skill learning is dopamine. H…
View article: Ageing attenuates exercise-enhanced motor cortical plasticity
Ageing attenuates exercise-enhanced motor cortical plasticity Open
Cardiorespiratory exercise is known to modulate motor cortical plasticity in young adults, but the influence of ageing on this relationship is unknown. Here, we compared the effects of a single session of cardiorespiratory exercise on moto…
View article: High-intensity acute exercise impacts motor learning in healthy older adults
High-intensity acute exercise impacts motor learning in healthy older adults Open
Healthy aging is associated with a decline in motor sequence learning. Acute cardiorespiratory exercise has emerged as a potential intervention to improve motor learning, however research in healthy older adults is limited. The current stu…
Micro-consolidation occurs during implicit motor sequence learning, but is not influenced by HIIT exercise Open
We investigated if micro-consolidation, a phenomenon recently discovered during the brief rest periods between practice when learning an explicit motor sequence, generalises to implicit motor sequence learning. We demonstrate micro-consoli…
View article: A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease
A single bout of moderate-intensity aerobic exercise improves motor learning in premanifest and early Huntington’s disease Open
Introduction Cardiorespiratory exercise has emerged as a promising candidate to modify disease progression in Huntington’s disease (HD). In animal models, exercise has been found to alter biomarkers of neuroplasticity and delay evidence of…