P. David Rogers
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View article: Acquired amphotericin B resistance attributed to a mutated <i>ERG3</i> in <i>Candidozyma auris</i>
Acquired amphotericin B resistance attributed to a mutated <i>ERG3</i> in <i>Candidozyma auris</i> Open
First identified in 2009, Candidozyma auris (formerly Candida auris ) is an emerging multidrug-resistant fungus that can cause invasive infections with a crude mortality rate ranging from 30 to 60%. Currently, 30–50% of C. auris isolates a…
View article: Mutations in <i>TAC1B</i> drive increased <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>Candida auris</i>
Mutations in <i>TAC1B</i> drive increased <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>Candida auris</i> Open
Candida auris has emerged as a fungal pathogen of particular concern owing in part to its propensity to exhibit antifungal resistance, especially to the commonly prescribed antifungal fluconazole. A mutation in TAC1B , which encodes a zinc…
View article: Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in <i>Candida auris</i> ( <i>Candidozyma auris</i> ), <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> )
Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in <i>Candida auris</i> ( <i>Candidozyma auris</i> ), <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> ) Open
The fungal pathogen Candida auris is of global concern due to high levels of multidrug resistance and its propensity to cause infectious outbreaks. Over 90% of isolates are resistant to fluconazole, the most commonly prescribed antifungal …
View article: Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in <i>Candida auris</i> , <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> )
Mutations in transcription factors that confer fluconazole resistance also confer reduced susceptibility to manogepix in <i>Candida auris</i> , <i>Candida albicans</i> , <i>Candida parapsilosis</i> , and <i>Candida glabrata</i> ( <i>Nakaseomyces glabratus</i> ) Open
The fungal pathogen Candida auris is of global concern due to high levels of multidrug resistance and its propensity to cause infectious outbreaks. Over 90% of isolates are resistant to fluconazole, the most commonly prescribed antifungal …
View article: Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i>
Acquired Amphotericin B Resistance Attributed to a Mutated <i>ERG3</i> in <i>Candidozyma auris</i> Open
First identified in 2009, Candidozyma auris (formerly Candida auris ) is an emerging multidrug resistant fungus that can cause invasive infections with a crude mortality rate ranging from 30-60%. Currently, 30-50% of C. auris isolates are …
View article: Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>C. auris</i>
Mutations in <i>TAC1B</i> drive <i>CDR1</i> and <i>MDR1</i> expression and azole resistance in <i>C. auris</i> Open
Objective Candida auris has emerged as a fungal pathogen of particular concern owing in part to its propensity to exhibit antifungal resistance, especially to the commonly prescribed antifungal fluconazole. In this work we aimed to determi…
View article: Probing gene function in <i>Candida albicans</i> wild-type strains by Cas9-facilitated one-step integration of two dominant selection markers: a systematic analysis of recombination events at the target locus
Probing gene function in <i>Candida albicans</i> wild-type strains by Cas9-facilitated one-step integration of two dominant selection markers: a systematic analysis of recombination events at the target locus Open
The adaptation of gene deletion methods based on the CRISPR-Cas9 system has facilitated the genetic manipulation of the pathogenic yeast Candida albicans , because homozygous mutants of this diploid fungus can now be generated in a single …
View article: The zinc cluster transcription factor Znc1 regulates Rta3-dependent miltefosine resistance in <i>Candida albicans</i>
The zinc cluster transcription factor Znc1 regulates Rta3-dependent miltefosine resistance in <i>Candida albicans</i> Open
Zinc cluster transcription factors (ZCFs) are a family of transcription regulators that are almost exclusively found in the fungal kingdom. Activating mutations in the ZCFs Mrr1, Tac1, and Upc2 frequently cause acquired resistance to the w…
View article: Analysis of clinical <i>Candida parapsilosis</i> isolates reveals copy number variation in key fluconazole resistance genes
Analysis of clinical <i>Candida parapsilosis</i> isolates reveals copy number variation in key fluconazole resistance genes Open
We used whole-genome sequencing to analyze a collection of 35 fluconazole-resistant and 7 susceptible Candida parapsilosis isolates together with coverage analysis and GWAS techniques to identify new mechanisms of fluconazole resistance. P…
View article: Analysis of clinical<i>Candida parapsilosis</i>isolates reveals copy number variation in key fluconazole resistance genes
Analysis of clinical<i>Candida parapsilosis</i>isolates reveals copy number variation in key fluconazole resistance genes Open
We used whole-genome sequencing to analyse a collection of 35 fluconazole resistant and 7 susceptible Candida parapsilosis isolates together with coverage analysis and GWAS techniques to identify new mechanisms of fluconazole resistance. P…
View article: The sterol C-24 methyltransferase encoding gene,<i>erg6</i>, is essential for viability of<i>Aspergillus</i>species
The sterol C-24 methyltransferase encoding gene,<i>erg6</i>, is essential for viability of<i>Aspergillus</i>species Open
Ergosterol is a critical component of fungal plasma membranes. Although many currently available antifungal compounds target the ergosterol biosynthesis pathway for antifungal effect, current knowledge regarding ergosterol synthesis remain…
View article: <i>hapE</i> and <i>hmg1</i> Mutations Are Drivers of <i>cyp51A</i> -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate
<i>hapE</i> and <i>hmg1</i> Mutations Are Drivers of <i>cyp51A</i> -Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate Open
Triazole resistance is an important cause of treatment failure and high mortality rates for A. fumigatus human infections. Although Cyp51A-associated mutations are frequently identified as the cause of A. fumigatus triazole resistance, the…
View article: Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance
Candida parapsilosis Mdr1B and Cdr1B Are Drivers of Mrr1-Mediated Clinical Fluconazole Resistance Open
Candida parapsilosis is a common cause of invasive candidiasis worldwide and is the most commonly is7olated Candida species among pediatric and neonatal populations. Previous work has demonstrated that nonsynonymous mutations in the gene e…
View article: Loss-of-Function <i>ROX1</i> Mutations Suppress the Fluconazole Susceptibility of <i>upc2A</i> Δ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis
Loss-of-Function <i>ROX1</i> Mutations Suppress the Fluconazole Susceptibility of <i>upc2A</i> Δ Mutation in Candida glabrata, Implicating Additional Positive Regulators of Ergosterol Biosynthesis Open
Candida glabrata is one of the most important human fungal pathogens and has reduced susceptibility to azole-class inhibitors of ergosterol biosynthesis. Although ergosterol is the target of two of the three classes of antifungal drugs, re…
View article: Delineation of the Direct Contribution of Candida auris <i>ERG11</i> Mutations to Clinical Triazole Resistance
Delineation of the Direct Contribution of Candida auris <i>ERG11</i> Mutations to Clinical Triazole Resistance Open
Candida auris is an emerging multidrug-resistant and health care-associated pathogen of urgent clinical concern. The triazoles are the most widely prescribed antifungal agents worldwide and are commonly utilized for the treatment of invasi…
View article: Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i>Δ mutation in <i>Candida glabrata</i>, implicating additional positive regulators of ergosterol biosynthesis
Loss-of-function <i>ROX1</i> mutations suppress the fluconazole susceptibility of <i>upc2A</i>Δ mutation in <i>Candida glabrata</i>, implicating additional positive regulators of ergosterol biosynthesis Open
Two of the major classes of antifungal drugs in clinical use target ergosterol biosynthesis. Despite its importance, our understanding of the transcriptional regulation of ergosterol biosynthesis genes in pathogenic fungi is essentially li…
View article: <i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i>
<i>In vivo</i> emergence of high-level resistance during treatment reveals the first identified mechanism of amphotericin B resistance in <i>Candida auris</i> Open
Candida auris has emerged as a healthcare-associated and multidrug-resistant fungal pathogen of great clinical concern. While as much as 50% of C. auris clinical isolates are reported to be resistant to amphotericin B, to date, no mechanis…
View article: The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways
The Candida glabrata Upc2A transcription factor is a global regulator of antifungal drug resistance pathways Open
The most commonly used antifungal drugs are the azole compounds, which interfere with biosynthesis of the fungal-specific sterol: ergosterol. The pathogenic yeast Candida glabrata commonly acquires resistance to azole drugs like fluconazol…
View article: Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in<i>Candida glabrata</i>
Azole resistance is mediated by integration of sterol gene regulation and membrane transporter production by the zinc cluster-containing transcription factor Upc2A in<i>Candida glabrata</i> Open
The most commonly used antifungal drugs are the azole compounds that interfere with biosynthesis of the fungal-specific sterol: ergosterol. The pathogenic yeast Candida glabrata commonly acquires resistance to azole drugs like fluconazole …
View article: Mechanisms of triazole resistance in <i>Aspergillus fumigatus</i>
Mechanisms of triazole resistance in <i>Aspergillus fumigatus</i> Open
Summary The ubiquitous fungal pathogen Aspergillus fumigatus is the primary cause of opportunistic mould infections in humans. Aspergilli disseminate via asexual conidia passively travelling through air currents to germinate within a broad…
View article: Mutations in <i>TAC1B</i> : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris
Mutations in <i>TAC1B</i> : a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris Open
Candida auris is an emerging multidrug-resistant pathogen of global concern, known to be responsible for outbreaks on six continents and to be commonly resistant to antifungals. While the vast majority of clinical C. auris isolates are hig…
View article: Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae
Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae Open
One mechanism behind drug resistance is altered export out of the cell. This work is a multifaceted analysis of membrane efflux transporters in the human fungal pathogen A. fumigatus . Bioinformatics evidence infers that there is a relativ…
View article: Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections
Lyophilized Iron Oxide Nanoparticles Encapsulated in Amphotericin B: A Novel Targeted Nano Drug Delivery System for the Treatment of Systemic Fungal Infections Open
We formulated and tested a targeted nanodrug delivery system to help treat life-threatening invasive fungal infections, such as cryptococcal meningitis. Various designs of iron oxide nanoparticles (IONP) (34–40 nm) coated with bovine serum…
View article: Mutations in<i>TAC1B</i>: a novel genetic determinant of clinical fluconazole resistance in<i>C. auris</i>
Mutations in<i>TAC1B</i>: a novel genetic determinant of clinical fluconazole resistance in<i>C. auris</i> Open
Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, yet it remains unknown what…