Dhanji P. Rajani
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View article: Antimicrobial Efficacy of 1,2,3-Triazole-Incorporated Indole-Pyrazolone against Drug-Resistant ESKAPE Pathogens: Design and Synthesis
Antimicrobial Efficacy of 1,2,3-Triazole-Incorporated Indole-Pyrazolone against Drug-Resistant ESKAPE Pathogens: Design and Synthesis Open
In the current study, we report the synthesis of novel 4-((1-((1H-1,2,3-triazole-4-yl)methyl)-1H-indol-3-yl)methylene)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazole-3-one derivatives 5a-o. The compounds were prepared through a Knoevenagel cond…
View article: Antimycobacterial Activity of Solid Lipid Microparticles Loaded with Ursolic Acid and Oleanolic Acid: In Vitro, In Vivo, and Toxicity Assessments
Antimycobacterial Activity of Solid Lipid Microparticles Loaded with Ursolic Acid and Oleanolic Acid: In Vitro, In Vivo, and Toxicity Assessments Open
Ursolic acid (UA) and oleanolic acid (OA) are hydrophobic triterpenoid isomers with demonstrated anti-mycobacterial (Mtb) and immune-regulatory properties, although their poor solubility limits clinical use. We report the development of so…
View article: New Amino Acids Naphthalene Scaffolds as Potent Antimicrobial Agents: <i>In Vitro</i> Assay and <i>In Silico</i> Molecular Docking Study
New Amino Acids Naphthalene Scaffolds as Potent Antimicrobial Agents: <i>In Vitro</i> Assay and <i>In Silico</i> Molecular Docking Study Open
The development of innovative antifungal medications to address the issues of indiscriminate antifungal use contributes to certain antifungal drug resistance. To tackle this issue, we have designed and synthesized novel amino acids naphtha…
View article: Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4(2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study
Cs2CO3-promoted one-pot synthesis of novel tetrahydrobenzofuran-4(2H)-ones: In vitro antimicrobial, antimalarial activity and in silico docking study Open
A diverse set of tetrahydrobenzofuran-4(2H)-one derivative 4(a-o) were synthesized using a one-pot treatment of dimedone, 3-(1H-imidazol-1-yl)benzaldehyde, and different phenacyl bromide by utilizing cesium carbonate as a cost-effective ca…
View article: CCDC 2315011: Experimental Crystal Structure Determination
CCDC 2315011: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Exploration of quinazoline-tethered hydroxamic acid derivatives as HDAC inhibitors for anticancer activity: Design, synthesis, molecular docking, and biological evaluation
Exploration of quinazoline-tethered hydroxamic acid derivatives as HDAC inhibitors for anticancer activity: Design, synthesis, molecular docking, and biological evaluation Open
In the past two decades, targeted cancer therapy has emerged as a novel class of anticancer therapeutics, besides traditional chemotherapy, surgery, and radiotherapy. Inhibition of HDACs represents a promising avenue for cancer therapeutic…
View article: Design, synthesis, molecular docking, molecular dynamic simulation, and MMGBSA analysis of 7-O-substituted 5-hydroxy flavone derivatives
Design, synthesis, molecular docking, molecular dynamic simulation, and MMGBSA analysis of 7-O-substituted 5-hydroxy flavone derivatives Open
A series of chrysin derivatives were designed, synthesized, and evaluated for their antibacterial activity against four different bacterial strains. We have synthesized new propyl-substituted and butyl-substituted chrysin-piperazine deriva…
View article: Two Dimensional Quantitative Structure Activity Relationship Prediction and Synthesis of Bioactive Newer 1 2 4-Triazole-Isoniazid Conjugates
Two Dimensional Quantitative Structure Activity Relationship Prediction and Synthesis of Bioactive Newer 1 2 4-Triazole-Isoniazid Conjugates Open
1,2,4-triazole and Schiff bases are active against antimicrobial and antitubercular activities. Isoniazid itself reacts as antitubercular drug. The two dimensional quantitative structure activity relationship study was used to predicts the…
View article: CCDC 1970503: Experimental Crystal Structure Determination
CCDC 1970503: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Crystal structure, antibacterial and antifungal evaluation of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1<i>H</i>)-(thi)ones
Crystal structure, antibacterial and antifungal evaluation of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1<i>H</i>)-(thi)ones Open
Herein, a solvent-free synthesis of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1H)-(thi)ones was explored. The main advantages of this study are that pure products are readily obtained through an easy workup and without using any separ…
View article: International Multicentre Study of Candida auris Infections
International Multicentre Study of Candida auris Infections Open
Background:Candida auris has emerged globally as a multi-drug resistant yeast and is commonly associated with nosocomial outbreaks in ICUs. Methods: We conducted a retrospective observational multicentre study to determine the epidemiology…
View article: Crystal structure and Biological evolution of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1H)-thi(ones)
Crystal structure and Biological evolution of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1H)-thi(ones) Open
Herein, Solvent-free synthesis of 5-bromothiophene based 3,4-dihydropyrimidin-2-(1 H )-thi(ones) was explored. The main advantages of this study are that pure product comes in hand with easy workup and without using any separation techniqu…
View article: Molecular Docking and QSAR Study of Chalcone and Pyrimidine Derivatives as Potent Anti-Malarial Agents against <i>Plasmodium falciparum</i>
Molecular Docking and QSAR Study of Chalcone and Pyrimidine Derivatives as Potent Anti-Malarial Agents against <i>Plasmodium falciparum</i> Open
A data set of chalcone and pyrimidine derivatives with anti-malarial activity against Plasmodium falciparum was employed in investigating the quantitative structure-activity relationship (QSAR). Molecular docking study was performed for pl…
View article: Molecular Docking and QSAR Study of Chalcone and Pyrimidine Derivatives as Potent Anti-Malarial Agents against <i>Plasmodium falciparum</i>
Molecular Docking and QSAR Study of Chalcone and Pyrimidine Derivatives as Potent Anti-Malarial Agents against <i>Plasmodium falciparum</i> Open
A data set of chalcone and pyrimidine derivatives with anti-malarial activity against Plasmodium falciparum was employed in investigating the quantitative structure-activity relationship (QSAR). Molecular docking study was performed for pl…
View article: CCDC 1872027: Experimental Crystal Structure Determination
CCDC 1872027: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1838423: Experimental Crystal Structure Determination
CCDC 1838423: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1871669: Experimental Crystal Structure Determination
CCDC 1871669: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1837016: Experimental Crystal Structure Determination
CCDC 1837016: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1837695: Experimental Crystal Structure Determination
CCDC 1837695: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 1838422: Experimental Crystal Structure Determination
CCDC 1838422: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: ANTIMICROBIAL AND ANTIMALARIAL ACTIVITIES OF SOME SELECTED ETHNO-MEDICINAL PLANTS USED BY TRIBAL COMMUNITIES OF TAPI DISTRICT, GUJARAT, INDIA
ANTIMICROBIAL AND ANTIMALARIAL ACTIVITIES OF SOME SELECTED ETHNO-MEDICINAL PLANTS USED BY TRIBAL COMMUNITIES OF TAPI DISTRICT, GUJARAT, INDIA Open
In the present study, eight medicinal plants which are traditionally used by tribal communities of Tapi District, Gujarat were studied for antimicrobial and antimalarial activity.Acetone, ethyl acetate, hexane, petroleum ether and chlorofo…
View article: Synthesis and Antimicrobial Evaluation of Novel Benzene Sulfonamide Pyrazole Linked [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole Derivatives
Synthesis and Antimicrobial Evaluation of Novel Benzene Sulfonamide Pyrazole Linked [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazole Derivatives Open
A novel series of benzene sulfonamide pyrazole linked [1,2,4]-triazolo[3,4-b][1,3,4]thiadiazole derivatives have been synthesized by reaction of 4-(3-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl)-5- (3-fluoro-4-methoxyphenyl)-1H-pyrazol-1-yl)…
View article: Synthesis of N'-(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies
Synthesis of N'-(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies Open
A wide range of 4-chloro-3,4-dihydroquinazolines hybrid isoniazid derivatives were synthesised efficiently via reaction of 4-chloro-3,4-dihydroquinazolines with isoniazid in the presence of catalytic amount of N,N-diisopropylethylamine (DI…
View article: CCDC 1471153: Experimental Crystal Structure Determination
CCDC 1471153: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction
Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction Open
A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting…
View article: Supplementary material from "Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction"
Supplementary material from "Green approach for synthesis of bioactive Hantzsch 1,4-dihydropyridine derivatives based on thiophene moiety via multicomponent reaction" Open
A novel green and efficient one-pot multicomponent reaction of dihydropyridine derivatives was reported as having good to excellent yield. In the presence of the catalyst ceric ammonium nitrate (CAN), different 1,3-diones and same starting…