Per Kristian Eide
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View article: A method for measuring first glymphatic influx of a cerebrospinal fluid tracer in the human brain
A method for measuring first glymphatic influx of a cerebrospinal fluid tracer in the human brain Open
Introduction The glymphatic system is a brain-wide perivascular transport route for fluids and solutes in which cerebrospinal fluid (CSF) serves as a conduit for solute transport and clearance of brain waste. Intrathecal contrast-enhanced …
View article: Arginine vasopressin deficiency after surgical ligation of an unruptured anterior communicating artery aneurysm – a case report and literature review
Arginine vasopressin deficiency after surgical ligation of an unruptured anterior communicating artery aneurysm – a case report and literature review Open
Introduction Plasma osmolality is maintained within a narrow range by secretion of arginine vasopressin (AVP). AVP deficiency (formerly known as central diabetes insipidus) is a rare complication of surgery in the hypothalamic and pituitar…
View article: Cranial nerves as pathways for human cerebrospinal fluid efflux: In vivo evidence
Cranial nerves as pathways for human cerebrospinal fluid efflux: In vivo evidence Open
In vivo evidence for cerebrospinal fluid (CSF) efflux along cranial nerves in humans is scarce. This study investigated whether the trigeminal, facial, and vestibulocochlear nerves serve as efflux routes for CSF in humans. A magnetic reson…
View article: Correction: Cognitive profile and frailty in patients with idiopathic normal pressure hydrocephalus
Correction: Cognitive profile and frailty in patients with idiopathic normal pressure hydrocephalus Open
[This corrects the article DOI: 10.3389/fneur.2025.1644507.].
View article: The impact of human brain geometry on the transport of an intrathecal tracer
The impact of human brain geometry on the transport of an intrathecal tracer Open
Background: Intrathecal contrast-enhanced magnetic resonance imaging (MRI), utilizing the contrast agent gadobutrol as cerebrospinal fluid (CSF) tracer is emerging as a useful method to study glymphatic function in the human brain. A consi…
View article: Cognitive profile and frailty in patients with idiopathic normal pressure hydrocephalus
Cognitive profile and frailty in patients with idiopathic normal pressure hydrocephalus Open
Background Cognition and frailty are sparsely studied in patients with idiopathic normal pressure hydrocephalus (iNPH). We aimed to describe the preoperative cognitive function compared with normative data and frailty profile in iNPH patie…
View article: Geometry Reduced Order Modeling (GROM) with application to modeling of glymphatic function
Geometry Reduced Order Modeling (GROM) with application to modeling of glymphatic function Open
Computational modeling of the brain has become a key part of understanding how the brain clears metabolic waste, but patient-specific modeling on a significant scale is still out of reach with current methods. We introduce a novel approach…
View article: Heterogeneity in human brain clearance adds resilience against tauopathy – a computational model informed by glymphatic MRI
Heterogeneity in human brain clearance adds resilience against tauopathy – a computational model informed by glymphatic MRI Open
Neurotoxic protein fragments such as amyloid-beta and tau accumulate in characteristic staging patterns in Alzheimer’s disease (AD). The brain clears such metabolic substances via multiple different systems, including via the glymphatic (e…
View article: U‐Net‐Based Prediction of Cerebrospinal Fluid Distribution and Ventricular Reflux Grading
U‐Net‐Based Prediction of Cerebrospinal Fluid Distribution and Ventricular Reflux Grading Open
Previous work indicates evidence that cerebrospinal fluid (CSF) plays a crucial role in brain waste clearance processes and that altered flow patterns are associated with various diseases of the central nervous system. In this study, we in…
View article: Evidence for cellular and solute passage between the brain and skull bone marrow across meninges: A systematic review
Evidence for cellular and solute passage between the brain and skull bone marrow across meninges: A systematic review Open
A potential two-way passage of cells and substances between the brain and skull bone marrow may open for new insights into neurological disease. The arachnoid membrane was traditionally considered to restrict cells and larger molecules in …
View article: U-net based prediction of cerebrospinal fluid distribution and ventricular reflux grading
U-net based prediction of cerebrospinal fluid distribution and ventricular reflux grading Open
Previous work indicates evidence that cerebrospinal fluid (CSF) plays a crucial role in brain waste clearance processes, and that altered flow patterns are associated with various diseases of the central nervous system. In this study, we i…
View article: Risk Variants Associated With Normal Pressure Hydrocephalus
Risk Variants Associated With Normal Pressure Hydrocephalus Open
We identified 6 loci significantly associated with NPH in the thus far largest GWAS in chronic hydrocephalus. The genes near the top loci have previously been associated with blood-brain barrier and blood-CSF barrier function and with incr…
View article: Neurosurgery and the glymphatic system
Neurosurgery and the glymphatic system Open
The discovery of the glymphatic system has fundamentally altered our comprehension of cerebrospinal fluid transport and the removal of waste from brain metabolism. In the past decade, since its initial characterization, research on the gly…
View article: Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood
Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood Open
Over the last decade, it has become evident that cerebrospinal fluid (CSF) plays a pivotal role in brain solute clearance through perivascular pathways and interactions between the brain and meningeal lymphatic vessels. Whereas most of thi…
View article: Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans
Glymphatic-lymphatic coupling: assessment of the evidence from magnetic resonance imaging of humans Open
The discoveries that cerebrospinal fluid participates in metabolic perivascular exchange with the brain and further drains solutes to meningeal lymphatic vessels have sparked a tremendous interest in translating these seminal findings from…
View article: Functional analysis of the human perivascular subarachnoid space
Functional analysis of the human perivascular subarachnoid space Open
The human subarachnoid space harbors the cerebrospinal fluid, which flows within a landscape of blood vessels and trabeculae. Functional implications of subarachnoid space anatomy remain far less understood. This study of 75 patients utili…
View article: Glymphatic-stagnated edema induced by traumatic brain injury
Glymphatic-stagnated edema induced by traumatic brain injury Open
Traumatic brain injury (TBI) outcomes are notably affected by brain edema. A recent report by Hussain et al. unveils a unique form, glymphatic-stagnated brain edema, that stems from impaired glymphatic and lymphatic drainage induced by nor…
View article: Preoperative estimation of intracranial compliance in symptomatic children with Chiari malformation type 1: impact on outcome and risk of complications
Preoperative estimation of intracranial compliance in symptomatic children with Chiari malformation type 1: impact on outcome and risk of complications Open
Background The role of reduced intracranial compliance (ICC) in the outcome after foramen magnum decompression (FMD) was demonstrated in adults with Chiari malformation Type 1 (CMI). However, similar observations from children treated for …
View article: A woman in her forties with ear pain
A woman in her forties with ear pain Open
Glossopharyngeal neuralgia is a rare condition characterised by intermittent, unilateral pain in the base of the tongue, oropharynx, and/or angle of the mandible which radiates to the ipsilateral ear. The condition should be treated medica…
View article: In vivo distribution of cerebrospinal fluid tracer in human upper spinal cord and brain stem
In vivo distribution of cerebrospinal fluid tracer in human upper spinal cord and brain stem Open
BACKGROUNDIntrathecal injection is an attractive route through which drugs can be administered and directed to the spinal cord, restricted by the blood-spinal cord barrier. However, in vivo data on the distribution of cerebrospinal fluid (…