Paul Enright
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View article: Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos)
Spirometry Reference Equations from the HCHS/SOL (Hispanic Community Health Study/Study of Latinos) Open
RATIONALE: Accurate reference values for spirometry are important because the results are used for diagnosing common chronic lung diseases such as asthma and chronic obstructive pulmonary disease, estimating physiologic impairment, and pre…
View article: Gas Exchange Impairment During COVID-19 Recovery
Gas Exchange Impairment During COVID-19 Recovery Open
Subjects who recovered from severe COVID-19 pneumonia continued to have abnormal lung function and abnormal radiologic findings.
View article: Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study
Prevalence and Population-Attributable Risk for Chronic Airflow Obstruction in a Large Multinational Study Open
Rationale: The Global Burden of Disease program identified smoking and ambient and household air pollution as the main drivers of death and disability from chronic obstructive pulmonary disease (COPD). Objectives: To estimate the attributa…
View article: APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema
APOM and high-density lipoprotein cholesterol are associated with lung function and per cent emphysema Open
Chronic obstructive pulmonary disease (COPD) is linked to cardiovascular disease; however, there are few studies on the associations of cardiovascular genes with COPD.
View article: Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function
Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function Open
Measurements of lung function by spirometry are heritable traits that reflect respiratory health and predict morbidity and mortality. We meta-analyzed genome-wide association studies for two clinically important measures, forced expiratory…
View article: A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research
A Brief Targeted Review of Susceptibility Factors, Environmental Exposures, Asthma Incidence, and Recommendations for Future Asthma Incidence Research Open
Relative to research on effects of environmental exposures on exacerbation of existing asthma, little research on incident asthma and environmental exposures has been conducted. However, this research is needed to better devise strategies …
View article: Induction of Asthma and the Environment: What We Know and Need to Know
Induction of Asthma and the Environment: What We Know and Need to Know Open
The prevalence of asthma has increased dramatically over the last 25 years in the United States and in other nations as a result of ill-defined changes in living conditions in modern society. On 18 and 19 October 2004 the U.S. Environmenta…
View article: A global history in a global world? Human rights in history education in the Global North and South
A global history in a global world? Human rights in history education in the Global North and South Open
In this study, we analyse similarities and differences in 957 students’ perceptions of the
\nhistory of human rights in six countries: England, India, New Zealand, South Africa, Sweden and
\nthe United States of America. This is investigat…
View article: Classifying Chronic Lower Respiratory Disease Events in Epidemiologic Cohort Studies
Classifying Chronic Lower Respiratory Disease Events in Epidemiologic Cohort Studies Open
Rationale: One in 12 adults has chronic obstructive pulmonary disease or asthma. Acute exacerbations of these chronic lower respiratory diseases (CLRDs) are a major cause of morbidity and mortality. Valid approaches to classifying cases an…
View article: Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults
Association of Nonobstructive Chronic Bronchitis With Respiratory Health Outcomes in Adults Open
The findings suggest that nonobstructive chronic bronchitis is associated with adverse respiratory health outcomes, particularly in ever smokers, and may be a high-risk phenotype suitable for risk stratification and targeted therapies.
View article: Harmonization of Respiratory Data From 9 US Population-Based Cohorts
Harmonization of Respiratory Data From 9 US Population-Based Cohorts Open
Chronic lower respiratory diseases (CLRDs) are the fourth leading cause of death in the United States. To support investigations into CLRD risk determinants and new approaches to primary prevention, we aimed to harmonize and pool respirato…
View article: Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study
Associations between emphysema-like lung on CT and incident airflow limitation: a general population-based cohort study Open
Emphysema on CT is associated with accelerated lung function decline in heavy smokers and patients with COPD; however, in the general population, it is not known whether greater emphysema-like lung on CT is associated with incident COPD. W…
View article: Long-Term Stability of a Portable Carbon Monoxide Single-Breath Diffusing Capacity Instrument
Long-Term Stability of a Portable Carbon Monoxide Single-Breath Diffusing Capacity Instrument Open
Measurements of DLCO were stable over the 3-y period without any need for manual recalibration of the instrument. The biological control was as good as the DLCO simulator to evaluate this kind of device in a long-term laboratory quality co…
View article: High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study
High attenuation areas on chest computed tomography in community-dwelling adults: the MESA study Open
Evidence suggests that lung injury, inflammation and extracellular matrix remodelling precede lung fibrosis in interstitial lung disease (ILD). We examined whether a quantitative measure of increased lung attenuation on computed tomography…
View article: Oxygen desaturation during a 6-min walk identifies a COPD phenotype with an increased risk of morbidity and mortality
Oxygen desaturation during a 6-min walk identifies a COPD phenotype with an increased risk of morbidity and mortality Open
M. Waatevik and co-investigators from Bergen, Norway, have added to the evidence that smokers with airflow limitation who have oxygen desaturation during a 6-min walk test (6MWT) are: 50% more likely to have respiratory exacerbations; more…
View article: Classifying Chronic Lower Respiratory Disease Events in Epidemiologic Cohort Studies
Classifying Chronic Lower Respiratory Disease Events in Epidemiologic Cohort Studies Open
CLRD cases and severe exacerbations without preceding documentation of airflow limitation are identified frequently in population-based cohorts of persons. A primary discharge diagnosis of CLRD is specific but insensitive for defining exac…
View article: Per cent emphysema is associated with respiratory and lung cancer mortality in the general population: a cohort study
Per cent emphysema is associated with respiratory and lung cancer mortality in the general population: a cohort study Open
Quantitatively assessed emphysema on CT is associated with greater respiratory disease and lung cancer mortality, even among persons without traditional risk factors.