Aditya Gupta
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View article: THE GENOMIC LANDSCAPE OF JUVENILE MYELOMONOCYTIC LEUKEMIA ON WHOLE EXOME SEQUENCING
THE GENOMIC LANDSCAPE OF JUVENILE MYELOMONOCYTIC LEUKEMIA ON WHOLE EXOME SEQUENCING Open
View article: SH2B3 GENE MUTATION IN JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) –A FREQUENT CO-EXISTING MUTATION WITH RAS MUTATIONS
SH2B3 GENE MUTATION IN JUVENILE MYELOMONOCYTIC LEUKEMIA (JMML) –A FREQUENT CO-EXISTING MUTATION WITH RAS MUTATIONS Open
View article: Dual Preconditioned Mesenchymal Stem Cells-Derived Culture Conditioned Media Augment Immunomodulation and Drive Metabolic Reprogramming in Acute Graft-versus-Host Disease
Dual Preconditioned Mesenchymal Stem Cells-Derived Culture Conditioned Media Augment Immunomodulation and Drive Metabolic Reprogramming in Acute Graft-versus-Host Disease Open
Background The toxicity associated with conventional conditioning regimens limits treatment outcomes in autoimmune disorders such as acute graft-versus-host disease (aGVHD). Developing effective adjunctive interventions to restore immune b…
View article: QLENS: Towards A Quantum Perspective of Language Transformers
QLENS: Towards A Quantum Perspective of Language Transformers Open
In natural language processing, current methods for understanding Transformers are successful at identifying intermediate predictions during a model's inference. However, these approaches function as limited diagnostic checkpoints, lacking…
View article: Dose-response immunomodulatory effects of Mesenchymal stem cell-derived culture-conditioned media in acute Graft-versus-Host Disease
Dose-response immunomodulatory effects of Mesenchymal stem cell-derived culture-conditioned media in acute Graft-versus-Host Disease Open
These results emphasize the critical role of optimizing CCM collection timing and concentration to maximize therapeutic potential. Our study paves the way for the development of standardized, scalable, and effective cell-free therapies for…
View article: A retrospective cohort study on impact of Covid-19 outbreak on out-of-hospital cardiac arrest (OHCA) in Telangana, India: mortality trends, contributing factors, and research imperatives
A retrospective cohort study on impact of Covid-19 outbreak on out-of-hospital cardiac arrest (OHCA) in Telangana, India: mortality trends, contributing factors, and research imperatives Open
Background Out-of-hospital cardiac arrest (OHCA) poses considerable issues, notably in the context of the COVID-19 outbreak. The objective of this study is to assess the differences in incidence rates and clinical outcomes of OHCA in Telan…
View article: Navigating the Future of Cybersecurity: A Strategic Approach to Crypto Agility for Modern Enterprises
Navigating the Future of Cybersecurity: A Strategic Approach to Crypto Agility for Modern Enterprises Open
View article: DrugProtAI: A machine learning-driven approach for predicting protein druggability through feature engineering and robust partition-based ensemble methods.
DrugProtAI: A machine learning-driven approach for predicting protein druggability through feature engineering and robust partition-based ensemble methods. Open
Drug design and development are central to clinical research, yet 90% of drugs fail to reach the clinic, often due to inappropriate selection of drug targets. Conventional methods for target identification lack precision and sensitivity. W…
View article: Laparoscopic Removal of Retained Bullet in Penetrating Retroperitoneal Gunshot Injury
Laparoscopic Removal of Retained Bullet in Penetrating Retroperitoneal Gunshot Injury Open
Gunshot wounds (GSWs) to the abdomen often necessitate open surgical exploration due to the potential for critical visceral and vascular injuries. In hemodynamically stable patients without major intra-abdominal trauma, laparoscopy is incr…
View article: Performance evaluation of Recron fibre and glass wool fibre reinforced self-compacting mortar at elevated temperature: A comparative study
Performance evaluation of Recron fibre and glass wool fibre reinforced self-compacting mortar at elevated temperature: A comparative study Open
View article: Oral Cryotherapy for the Prevention of Oral Mucositis in Children With Hematolymphoid Malignancies Receiving IV Methotrexate‐Based Chemotherapy: A Randomized Controlled Trial
Oral Cryotherapy for the Prevention of Oral Mucositis in Children With Hematolymphoid Malignancies Receiving IV Methotrexate‐Based Chemotherapy: A Randomized Controlled Trial Open
Background and Aims Oral mucositis (OM) is a debilitating adverse effect of many chemotherapeutic drugs. Oral cryotherapy using ice cubes/chips is used to prevent oral mucositis in adults post 5‐fluorouracil (5‐FU)/melphalan administration…
View article: Elevating Identity Security: A Strategic Framework for Assessment and Transformation
Elevating Identity Security: A Strategic Framework for Assessment and Transformation Open
View article: RNA Sequencing Identifies WT1 Overexpression as a Predictor of Poor Outcomes in Acute Myeloid Leukemia
RNA Sequencing Identifies WT1 Overexpression as a Predictor of Poor Outcomes in Acute Myeloid Leukemia Open
Background/Objectives: AML is a heterogeneous hematological malignancy distinguished by the clonal expansion of immature myeloid progenitor cells. Despite advances in therapy, relapse rates remain high, and outcomes are poor. The WT1 gene …
View article: The cell with a signet: When histology tells a more sinister story
The cell with a signet: When histology tells a more sinister story Open
View article: X linked- ALD: Should Loes score be the only benchmark for HSCT eligibility?
X linked- ALD: Should Loes score be the only benchmark for HSCT eligibility? Open
Hematopoietic stem cell transplant(HSCT) is the only modality that, if performed in the early- stages of cerebral X-linked adrenoleukodystrophy(X-ALD) can lead to good outcomes. Loes- score, calculated based on the findings of the magnetic…
View article: The Impact of Artificial Intelligence on Teenagers/Adolescents: A Comprehensive Analysis
The Impact of Artificial Intelligence on Teenagers/Adolescents: A Comprehensive Analysis Open
This research paper explores the multifaceted effects of Artificial Intelligence (AI) on teenagers, encompassing cognitive development, social dynamics, and ethical considerations. I took an interdisciplinary approach, to investigate how t…
View article: Cybersecurity Platformization: Transforming Enterprise Security in an AI-Driven, Threat-Evolving Digital Landscape
Cybersecurity Platformization: Transforming Enterprise Security in an AI-Driven, Threat-Evolving Digital Landscape Open
View article: An ambispective cross-sectional descriptive study to characterise the cutaneous and histological features of pediatric Langerhans cell histiocytosis (LCH)
An ambispective cross-sectional descriptive study to characterise the cutaneous and histological features of pediatric Langerhans cell histiocytosis (LCH) Open
Background Langerhans cell histiocytosis (LCH) is an idiopathic disorder characterised by the presence of pathological Langerhans cells derived from myeloid precursor cells. There is a scarcity of data regarding its diverse cutaneous and h…
View article: Predictive Modeling of Acute Graft-versus-Host-Disease using Machine Learning on Immune Cell and Cytokine Profiles at Engraftment
Predictive Modeling of Acute Graft-versus-Host-Disease using Machine Learning on Immune Cell and Cytokine Profiles at Engraftment Open
Background Acute Graft-versus-Host-Disease (aGvHD) is a major immune complication following allogenic hematopoietic stem cell transplantation (Allo-HSCT), initiated by conditioning regimen-associated tissue damage. It involves the complex …
View article: Management and Genetics of Alopecia Areata within the USA: A Cross-Sectional Study of All of Us
Management and Genetics of Alopecia Areata within the USA: A Cross-Sectional Study of All of Us Open
Introduction: Alopecia areata (AA) is a difficult to treat and appearance altering disorder affecting up to 2% of people during their lifetime. Understanding current management trends will help in improving patient outcomes. The aim of thi…
View article: Mitral Transcatheter Edge-to-Edge Repair and Mandatory Mechanical Circulatory Support in Patients With Structural Shock
Mitral Transcatheter Edge-to-Edge Repair and Mandatory Mechanical Circulatory Support in Patients With Structural Shock Open
View article: Dose-Response Immunomodulatory Effects of Mesenchymal Stem Cells-Derived Culture-Conditioned Media in Acute Graft-versus-Host-Disease
Dose-Response Immunomodulatory Effects of Mesenchymal Stem Cells-Derived Culture-Conditioned Media in Acute Graft-versus-Host-Disease Open
Background: Mesenchymal stem cell-based therapy faces challenges that have driven interest in MSCs-derived culture-conditioned media (CCM) as a cell-free alternative. Our study aims to optimize the dose, and collection timing of CCM to enh…
View article: PREVALENCE OF HYPOCALCEMIA DUE TO PHOTOTHERAPY IN NEWBORNS WITH NEONATAL JAUNDICE IN A TERTIARY CARE CENTER OF SOUTHERN RAJASTHAN
PREVALENCE OF HYPOCALCEMIA DUE TO PHOTOTHERAPY IN NEWBORNS WITH NEONATAL JAUNDICE IN A TERTIARY CARE CENTER OF SOUTHERN RAJASTHAN Open
Objective: Neonatal jaundice is a prevalent condition affecting approximately 60–80% of newborns, with phototherapy being a widely utilized treatment. While double surface phototherapy (DSPT) offers enhanced efficacy, it has been associate…
View article: Clinical characteristics and genetic spectrum of pediatric cancer predisposition syndromes: Insights from an Indian cohort
Clinical characteristics and genetic spectrum of pediatric cancer predisposition syndromes: Insights from an Indian cohort Open
View article: A quality improvement initiative to optimize time to blood transfusion in the pediatric emergency room: Determinants and impact on short-term outcomes in children with malignancy
A quality improvement initiative to optimize time to blood transfusion in the pediatric emergency room: Determinants and impact on short-term outcomes in children with malignancy Open
View article: Clinical, cyto-molecular spectrum and outcomes of myeloid sarcoma in children
Clinical, cyto-molecular spectrum and outcomes of myeloid sarcoma in children Open
View article: A case series on pediatric nonrhabdomyosarcoma soft tissue sarcoma: Clinicopathologic features and treatment outcomes from a tertiary cancer center in India
A case series on pediatric nonrhabdomyosarcoma soft tissue sarcoma: Clinicopathologic features and treatment outcomes from a tertiary cancer center in India Open
View article: Exploring the role of procalcitonin and proadrenomedullin in pediatric acute leukemia: Biomarkers for infection and beyond
Exploring the role of procalcitonin and proadrenomedullin in pediatric acute leukemia: Biomarkers for infection and beyond Open
View article: Development of the Integrated CPS Trigger Score (ICTS) for prioritizing genetic testing in childhood cancer in India: A derivation study
Development of the Integrated CPS Trigger Score (ICTS) for prioritizing genetic testing in childhood cancer in India: A derivation study Open
View article: Improving the outcome of pediatric ALL by transitioning from nonuniform chemotherapy regimens to a uniform multicentric protocol: A comprehensive experience from an Indian center on the ICiCLe protocol
Improving the outcome of pediatric ALL by transitioning from nonuniform chemotherapy regimens to a uniform multicentric protocol: A comprehensive experience from an Indian center on the ICiCLe protocol Open