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View article: Influence of Starch-Granule Diameter on Lasing Thresholds of the Molecular Rotor Thioflavin T in a Dual-Cavity Fabry–Perot/Whispering Gallery Mode
Influence of Starch-Granule Diameter on Lasing Thresholds of the Molecular Rotor Thioflavin T in a Dual-Cavity Fabry–Perot/Whispering Gallery Mode Open
A dual-cavity lasing platform is reported in which thioflavin T (ThT), a rotor-sensitive molecular probe, is employed to map molecular-crowding effects within starch granules via coupled Fabry-Perot (FP) and whispering gallery mode (WGM) r…
View article: Thioflavin T Lasing Probe for Mucin Detection in Simulated Tears as a Targeting Strategy for Brain Tumors
Thioflavin T Lasing Probe for Mucin Detection in Simulated Tears as a Targeting Strategy for Brain Tumors Open
A novel optical approach for a noninvasive detection of mucins in tear fluid is proposed, aiming at the early diagnosis of brain tumors such as glioblastoma. Utilizing Thioflavin T (ThT) as a fluorescent probe, our study demonstrates that …
View article: Cavity Lasing of Thioflavin T in the Condensed Phase for Discrimination between Surface Interaction and β-Sheet Groove Binding in Alzheimer-Linked Peptides
Cavity Lasing of Thioflavin T in the Condensed Phase for Discrimination between Surface Interaction and β-Sheet Groove Binding in Alzheimer-Linked Peptides Open
This study investigates the lasing effects in a Fabry-Perot cavity to discern the binding interactions of thioflavin T (ThT) with various peptides associated with Alzheimer's disease, including Aβ(1-42), KLVFFA, and diphenylalanine (FF) in…
View article: Thioflavin T─a Reporter of Microviscosity in Protein Aggregation Process: The Study Case of α-Synuclein
Thioflavin T─a Reporter of Microviscosity in Protein Aggregation Process: The Study Case of α-Synuclein Open
Thioflavin T (ThT) informed microviscosity changes can be used to monitor protein aggregation. Steady-state, time-resolved and lasing spectroscopy were used to detect transient states in α-synuclein - a protein associated with Parkinson's …
View article: Role of Alkali Cations in DNA–Thioflavin T Interaction
Role of Alkali Cations in DNA–Thioflavin T Interaction Open
This study investigates the role of alkali cations in modulating the interaction between deoxyribonucleic acid (DNA) and Thioflavin T (ThT) in dilute and condensed phases. The emission characteristics of ThT were analyzed in the presence o…
View article: Photonics of Hydrothermally Treated β‐Lactoglobulin Amyloids
Photonics of Hydrothermally Treated β‐Lactoglobulin Amyloids Open
Increased temperature and high pressure are applied to β‐lactoglobulin fibrils in the autoclave, resulting in the acquisition of a composite material comprised of partially disassembled amyloid fibrils and carbon dots. Confirmation of the …
View article: Cavity Lasing Characteristics of Thioflavin T and Thioflavin X in Different Solvents and Their Interaction with DNA for the Controlled Reduction of a Light Amplification Threshold in Solid-State Biofilms
Cavity Lasing Characteristics of Thioflavin T and Thioflavin X in Different Solvents and Their Interaction with DNA for the Controlled Reduction of a Light Amplification Threshold in Solid-State Biofilms Open
The lasing characteristics of Thioflavin T (ThT) and Thioflavin X (ThX) dyes were investigated in solvents with increasing viscosity: water, ethanol, butanol, ethylene glycol, and glycerol and three forms of DNA (double-helix natural, frag…
View article: One- and two-photon lasing from a TCF-based AIE dye
One- and two-photon lasing from a TCF-based AIE dye Open
The aggregation of a TCF-based dye exhibiting AIE is used to enhance the random lasing emission intensity up to 170 times. The transition from small aggregates to crystals forms a second lasing band and is responsible for 2-photon pumped l…
View article: Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase
Laser Emission of Thioflavin T Uncovers Protein Aggregation in Amyloid Nucleation Phase Open
There is currently no definitive test for early detection of neurodegeneration which is linked with protein aggregation. Finding methods capable of detecting intermediate states of protein aggregates, named oligomers, is critical for the e…
View article: Air–Water Interface Assembly of Protein Nanofibrils Promoted by Hydrophobic Additives
Air–Water Interface Assembly of Protein Nanofibrils Promoted by Hydrophobic Additives Open
Herein we demonstrate a novel way of modifying the colloidal stability of proteins by the presence of hydrophobic molecules. A protein capable of self-assembly into protein nanofibrils (PNFs) is milled with a hydrophobic molecular material…
View article: Identification of Thioflavin T Binding Modes to DNA: A Structure-Specific Molecular Probe for Lasing Applications
Identification of Thioflavin T Binding Modes to DNA: A Structure-Specific Molecular Probe for Lasing Applications Open
The binding mechanism of thioflavin T (ThT) to DNA was studied using polarized light spectroscopy and fluorescence-based techniques in solutions and in solid films. Linear dichroism measurements showed that ThT binds to DNA duplex by inter…
View article: Two‐photon excited lasing of Coumarin 307 for lysozyme amyloid fibrils detection
Two‐photon excited lasing of Coumarin 307 for lysozyme amyloid fibrils detection Open
Amyloid fibrils are a well‐recognized hallmark of neurodegeneration. A common approach to detect amyloid fibrils is staining with organic molecules and monitoring optical properties using fluorescence spectroscopy. However, the structural …
View article: Two‐photon excited lasing of Coumarin 307 for lysozyme amyloid fibrils detection
Two‐photon excited lasing of Coumarin 307 for lysozyme amyloid fibrils detection Open
Amyloid fibrils are a well‐recognized hallmark of neurodegeneration. A common approach to detect amyloid fibrils is staining with organic molecules and monitoring optical properties using fluorescence spectroscopy. However, the structural …
View article: Surface patterns of insulin fibrils revealed by time-resolved spectroscopy measurements of fluorescent probes
Surface patterns of insulin fibrils revealed by time-resolved spectroscopy measurements of fluorescent probes Open
Amyloid fibrils are a hallmark of neurodegeneration. The structural diversity of amyloids necessitates sensitive methods and probes that can be reliably used to characterize them. Here, we study insulin fibrils and its polymorphs seeded wi…
View article: Assessment of the quality of life of women with breast cancer depending on the surgical treatment method used
Assessment of the quality of life of women with breast cancer depending on the surgical treatment method used Open
Background. Women treated for breast cancer undergo traumatic experiences that significantly reduce their quality of life. Modern medicine is constantly looking for the best solutions in the field of surgical treatment. The choice of surg…
View article: Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils
Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils Open
Protein aggregation is associated with numerous devastating diseases such as Alzheimer’s, Parkinson’s, and prion diseases. Development of therapeutics would benefit from knowledge of the structural organization of protein molecules in thes…
View article: Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils
Ultrafast Time-Resolved Studies on Fluorescein for Recognition Strands Architecture in Amyloid Fibrils Open
Protein aggregation is associated with numerous devastating diseases such as Alzheimer's, Parkinson's, and prion diseases. Development of therapeutics would benefit from knowledge of the structural organization of protein molecules in thes…
View article: Important to Forensic Medicine Trends in Hospital Admissions Due to Intoxications with Narcotic Substances (T40 ICD-10) in the Lower Silesia Region of Poland in the Years 2006-2012
Important to Forensic Medicine Trends in Hospital Admissions Due to Intoxications with Narcotic Substances (T40 ICD-10) in the Lower Silesia Region of Poland in the Years 2006-2012 Open
Being aware of the importance of statistical structure of poisonings for directing of toxicological analyses both in clinical and especially forensic medicine, the study was aimed at finding current incidence of narcotic substances intoxic…
View article: Review of Changes in Amount of Hospitalizations Related to Poisoning by Chosen Psychotropic Drugs (T43 ICD-10) in Lower Silesia Region of Poland in Years 2006-2012
Review of Changes in Amount of Hospitalizations Related to Poisoning by Chosen Psychotropic Drugs (T43 ICD-10) in Lower Silesia Region of Poland in Years 2006-2012 Open
Poisonings by psychotropic drugs in various manners pose a serious public health, forensic and clinical medicine problem -especially for the medical staff of toxicology, intensive care and anesthesiology wards.Data on hospital admissions s…
View article: Changes in Hospital Admissions due to Toxic Effects of Alcohols (T51 ICD-10) in the Lower Silesia Region of Poland in the Years 2006-2012 Significant for Emergency Medicine, Medical Intensive Care and Anesthesia
Changes in Hospital Admissions due to Toxic Effects of Alcohols (T51 ICD-10) in the Lower Silesia Region of Poland in the Years 2006-2012 Significant for Emergency Medicine, Medical Intensive Care and Anesthesia Open
Intoxications -both acute and chronic -with different alcohols constitute an important problem of public health and clinical medicine, including intensive care and anesthesiology, in modern societies, also in Poland.A statistical evaluatio…