Osamu Handa
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View article: Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After Helicobacter pylori Eradication: A Prospective Multicenter Observational Study
Kyoto Classification-Based Predictive Factors Associated with the Development of Gastric Cancer After Helicobacter pylori Eradication: A Prospective Multicenter Observational Study Open
Background/Objectives: This study aimed to identify specific endoscopic findings associated with the development of GC following successful H. pylori eradication. Methods: This prospective multicenter observational study included patients …
View article: Fecal Microbiota Transplantation Using Donor Stool Obtained from Exercised Mice Suppresses Colonic Tumor Development Induced by Azoxymethane in High-Fat Diet-Induced Obese Mice
Fecal Microbiota Transplantation Using Donor Stool Obtained from Exercised Mice Suppresses Colonic Tumor Development Induced by Azoxymethane in High-Fat Diet-Induced Obese Mice Open
The gut microbiota plays an important role in the development of colorectal tumors. However, the underlying mechanisms remain unclear. In this study, we examined the effects of fecal microbiota transplantation (FMT) on azoxymethane (AOM)-i…
View article: The Relationship Between Bacterial Flora in Saliva and Esophageal Mucus and Endoscopic Severity in Patients with Eosinophilic Esophagitis
The Relationship Between Bacterial Flora in Saliva and Esophageal Mucus and Endoscopic Severity in Patients with Eosinophilic Esophagitis Open
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease characterized by esophageal dysfunction and eosinophilic inflammation of the esophageal mucosa. In this study, we investigated the bacterial flora in saliva and esophageal mu…
View article: Endoscopic risk factors to inform early detection of gastric cancer after <i>Helicobacter pylori</i> eradication: Meta‐analysis and systematic review
Endoscopic risk factors to inform early detection of gastric cancer after <i>Helicobacter pylori</i> eradication: Meta‐analysis and systematic review Open
Objectives Helicobacter pylori eradication reduces but cannot eliminate the risk of gastric cancer (GC). The prevalence of post‐eradication GC has been rising. Characterization of the endoscopic findings of post‐eradication GC may facilita…
View article: P1333 Trajectory analyses to optimise third booster COVID-19 vaccination in patients with Inflammatory Bowel Disease: final analyses of the J-COMBAT trial
P1333 Trajectory analyses to optimise third booster COVID-19 vaccination in patients with Inflammatory Bowel Disease: final analyses of the J-COMBAT trial Open
Background Even after resolving pandemic, the verification of COVID-19 vaccination is important to optimise vaccination against next crisis.1,2 Methods Data at 39 institutes were prospectively acquired at eight predetermined timepoints bef…
View article: Ulcerative Colitis in Pregnancy: A Japanese Multicenter Cohort Study Focusing on Their Mutual Influence
Ulcerative Colitis in Pregnancy: A Japanese Multicenter Cohort Study Focusing on Their Mutual Influence Open
Objective To investigate the clinical course of ulcerative colitis (UC) during pregnancy, focusing on their mutual influence. Methods We retrospectively reviewed the medical records of 58 patients with UC who had 73 pregnancies and 3 patie…
View article: Characteristics of Mucosa-Associated Microbiota in Ulcerative Colitis Patients with 5-Aminosalicylic Acid Intolerance
Characteristics of Mucosa-Associated Microbiota in Ulcerative Colitis Patients with 5-Aminosalicylic Acid Intolerance Open
Background/Objectives: 5-Aminosalicylic acid (5-ASA) is a first-line therapy for ulcerative colitis (UC). This study examined the mucosa-associated microbiota (MAM) in UC patients, distinguishing between those who were 5-ASA tolerant and i…
View article: Exercise Affects Mucosa-Associated Microbiota and Colonic Tumor Formation Induced by Azoxymethane in High-Fat-Diet-Induced Obese Mice
Exercise Affects Mucosa-Associated Microbiota and Colonic Tumor Formation Induced by Azoxymethane in High-Fat-Diet-Induced Obese Mice Open
The only reliable factor that reduces the risk of colorectal carcinogenesis is physical activity. However, the underlying mechanisms remain unclear. In this study, we examined the effects of physical activity against gut microbiota, includ…
View article: Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study
Background factors of idiopathic peptic ulcers and optimal treatment methods: a multicenter retrospective Japanese study Open
This study investigated the trends in idiopathic peptic ulcers, examined the characteristics of refractory idiopathic peptic ulcer, and identified the optimal treatment. The characteristics of 309 patients with idiopathic peptic ulcer were…
View article: Serial Changes in Intestinal Stenotic Stiffness in Patients with Crohn’s Disease Treated with Biologics: A Pilot Study Using Ultrasound Shear Wave Elastography
Serial Changes in Intestinal Stenotic Stiffness in Patients with Crohn’s Disease Treated with Biologics: A Pilot Study Using Ultrasound Shear Wave Elastography Open
BACKGROUND/AIMS: Intestinal strictures represent an important serious complication of Crohn’s disease. Shear wave elastography is a promising noninvasive ultrasound technique for assessing tissue stiffness. This study aimed to evaluate sti…
View article: Reduction of butyric acid-producing bacteria in the ileal mucosa-associated microbiota is associated with the history of abdominal surgery in patients with Crohn’s disease
Reduction of butyric acid-producing bacteria in the ileal mucosa-associated microbiota is associated with the history of abdominal surgery in patients with Crohn’s disease Open
Fecal microbiota is a significant factor determining the cause, course, and prognosis of Crohn's disease (CD). However, the factors affecting mucosa-associated microbiota (MAM) remain unclear. This retrospective study examined the differen…
View article: Linked Color Imaging for Stomach
Linked Color Imaging for Stomach Open
Image-enhanced endoscopy (IEE) plays an important role in the detection and further examination of gastritis and early gastric cancer (EGC). Linked color imaging (LCI) is also useful for detecting and evaluating gastritis, gastric intestin…
View article: Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients
Reduced abundance of butyric acid-producing bacteria in the ileal mucosa-associated microbiota of ulcerative colitis patients Open
Compositional changes in the microbiota are associated with various inflammatory diseases, including ulcerative colitis (UC). Aim: This study aimed to investigate the mucosa-associated microbiota (MAM) in patients with UC and its differenc…
View article: Safety and efficacy of capsule endoscopy for patients with newly diagnosed Crohn’s disease: A multicenter retrospective study
Safety and efficacy of capsule endoscopy for patients with newly diagnosed Crohn’s disease: A multicenter retrospective study Open
Crohn’s disease (CD) is a chronic inflammatory disease that develops at a young age and frequently leads to intestinal resection. Capsule endoscopy (CE) can directly and non-invasively inspect the entire small bowel mucosa. We suspected th…
View article: Current status of noninvasive endoscopic assessment of gastric cancer risk and future perspective
Current status of noninvasive endoscopic assessment of gastric cancer risk and future perspective Open
This Editorial refers to the article by M. Kawamura et al., p 508‐516 of this issue DEN 34:3 .
View article: Intestinal stiffness in Crohn’s disease treated by biologics: Comparison of ustekinumab and infliximab using ultrasound shear wave elastography
Intestinal stiffness in Crohn’s disease treated by biologics: Comparison of ustekinumab and infliximab using ultrasound shear wave elastography Open
Background : Intestinal strictures represent an important serious complication of Crohn’s disease (CD). Shear wave elastography (SWE) is one of the promising noninvasive ultrasound techniques for assessing tissue stiffness. This study was …
View article: DOP24 Japan prospective multicenter study for optimization of COVID-19 vaccinations based on the immune response and safety profile in Inflammatory Bowel Disease patients: Interim analyses of the J-COMBAT trial
DOP24 Japan prospective multicenter study for optimization of COVID-19 vaccinations based on the immune response and safety profile in Inflammatory Bowel Disease patients: Interim analyses of the J-COMBAT trial Open
Background Immune responses to the SARS-CoV-2 vaccination may be influenced by immunomodulatory drugs (IMDs). We investigated the immune responses and safety in fully vaccinated Japanese patients with IBD. Methods IBD patients and control …
View article: P2Y12 Inhibitors Exacerbate Low-dose Aspirin-induced Small Bowel Injury in Dual Antiplatelet Therapy
P2Y12 Inhibitors Exacerbate Low-dose Aspirin-induced Small Bowel Injury in Dual Antiplatelet Therapy Open
Objective Antithrombotic drugs are being used increasingly frequently to prevent cardiovascular diseases. Few studies have evaluated small bowel mucosal injury induced by dual antiplatelet therapy (DAPT). The aim of the present study was t…
View article: Comparison of mucosa-associated microbiota in Crohn’s disease patients with and without anti-tumor necrosis factor-α therapy
Comparison of mucosa-associated microbiota in Crohn’s disease patients with and without anti-tumor necrosis factor-α therapy Open
Most studies on the gut microbiome of Crohn's disease have been conducted using feces, instead of intestinal mucus to analyze the mucosa-associated microbiota. To investigate the characteristics of mucosa-associated microbiota in Crohn's d…
View article: Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis
Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis Open
PHGG partially prevented NAFLD development in mice through the gut-liver axis by modulating microbiota and downstream SCFA profiles.
View article: Evaluation of Performance in Colon Capsule Endoscopy Reading by Endoscopy Nurses
Evaluation of Performance in Colon Capsule Endoscopy Reading by Endoscopy Nurses Open
Background . Although there are papers reporting on the accuracy of colon capsule endoscopy (CCE) compared with colonoscopy (CS), there are few reports on the detection rates of significant lesions by endoscopy nurses. We previously report…
View article: Supplementary Material for: Mucosa-Associated Microbiota in Patients with Irritable Bowel Syndrome: A Comparison of Subtypes
Supplementary Material for: Mucosa-Associated Microbiota in Patients with Irritable Bowel Syndrome: A Comparison of Subtypes Open
Background: Most studies on gut microbiome of irritable bowel syndrome (IBS) have focused on fecal microbiota, instead of mucosa-associated microbiota (MAM). Aims: The aim of this study wasto investigate the MAM in IBS patients including t…
View article: Supplementary Material for: Efficacy and Feasibility of Magnifying Blue Laser Imaging without Biopsy Confirmation for the Diagnosis of the Demarcation of Gastric Tumors: A Randomized Controlled Study
Supplementary Material for: Efficacy and Feasibility of Magnifying Blue Laser Imaging without Biopsy Confirmation for the Diagnosis of the Demarcation of Gastric Tumors: A Randomized Controlled Study Open
Background: Accurate diagnosis of the demarcation line (DL) of gastric tumors is essential for curative complete resection by endoscopic submucosal dissection (ESD). It is controversial to perform only magnifying endoscopy for diagnosing t…
View article: Nutrients and probiotics: current trends in their use to eradicate <i>Helicobacter pylori</i>
Nutrients and probiotics: current trends in their use to eradicate <i>Helicobacter pylori</i> Open
Helicobacter pylori is a well-known bacterium that infects the human gastric mucosa and causes gastric inflammation, ultimately resulting in gastric cancer. To reduce the incidence of gastric cancer, eradication therapy is important. Howev…
View article: Effectiveness of including probiotics to <i>Helicobacter pylori</i> eradication therapies
Effectiveness of including probiotics to <i>Helicobacter pylori</i> eradication therapies Open
The eradication rate of Helicobacter pylori (H. pylori) with proton pump inhibitors, amoxicillin, and clarithromycin has reportedly decreased. Some studies have found probiotics to be useful in eradicating H. pylori, but these effects have…
View article: Self-study of the non-extension sign in an e-learning program improves diagnostic accuracy of invasion depth of early gastric cancer
Self-study of the non-extension sign in an e-learning program improves diagnostic accuracy of invasion depth of early gastric cancer Open
Background and study aims We developed an e-learning program for endoscopic diagnosis of invasion depth of early gastric cancer (EGC) using a simple diagnostic criterion called non-extension sign, and the contribution of self-study quizzes…