P. Hemachandra Reddy
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View article: Efficiency of Artificial Intelligence in Three-Dimensional Reconstruction of Medical Imaging
Efficiency of Artificial Intelligence in Three-Dimensional Reconstruction of Medical Imaging Open
View article: Retraction notice to "Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease" [Pharmacol. Res., Vol. 174 (2021) 105973]
Retraction notice to "Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease" [Pharmacol. Res., Vol. 174 (2021) 105973] Open
View article: Harnessing artificial intelligence for transforming dementia care: Innovations in early detection and treatment
Harnessing artificial intelligence for transforming dementia care: Innovations in early detection and treatment Open
View article: Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars
Cell culture research in aging and Alzheimer's disease: The strategic use/reuse of untreated controls and savings people's tax dollars Open
Cell culture is an essential tool in both fundamental and translational research, particularly for understanding complex diseases like Alzheimer's disease (AD). The use of cell lines provides the advantage of genetic homogeneity, ensuring …
View article: A Case Report of Phenotypic Discrepancy in Sex Determination and Implications for Genetic Testing and Counseling
A Case Report of Phenotypic Discrepancy in Sex Determination and Implications for Genetic Testing and Counseling Open
This case report presents an extraordinary instance of a 7-month-old male infant with an XX chromosomal pattern—a genetic configuration typically associated with females—while displaying characteristic male physical traits. This anomaly ch…
View article: An experimental study to evaluate the effectiveness of lecture cum demonstration on knowledge and practice on basic life support among lay person
An experimental study to evaluate the effectiveness of lecture cum demonstration on knowledge and practice on basic life support among lay person Open
: Basic Life Support (BLS) refers to a set of emergency procedures that assist individuals experiencing cardiac arrest, respiratory distress, or airway obstruction. Cardiopulmonary resuscitation (CPR) and other BLS techniques serve as cruc…
View article: Steroidogenic acute regulatory protein mediated variations of gender-specific sex neurosteroids in Alzheimer’s disease: Relevance to hormonal and neuronal imbalance
Steroidogenic acute regulatory protein mediated variations of gender-specific sex neurosteroids in Alzheimer’s disease: Relevance to hormonal and neuronal imbalance Open
The steroidogenic acute regulatory (StAR) protein mediates the rate-liming step in neuro/steroid biosynthesis. Multifaceted and delicate changes during aging, disrupting hormonal and neuronal homeostasis, constitute human senescence, an in…
View article: Sleep deprivation in dementia comorbidities: focus on cardiovascular disease, diabetes, anxiety/depression and thyroid disorders
Sleep deprivation in dementia comorbidities: focus on cardiovascular disease, diabetes, anxiety/depression and thyroid disorders Open
Sleep disturbances are a significant concern in individuals with dementia, affecting their overall health and quality of life, as well as that of their family members and caregivers. Dementia, a progressive neurodegenerative condition mark…
View article: Serotonin in depression and Alzheimer’s disease: Focus on SSRI’s beneficial effects
Serotonin in depression and Alzheimer’s disease: Focus on SSRI’s beneficial effects Open
View article: Acetylation of Steroidogenic Acute Regulatory Protein Sensitizes 17β-Estradiol Regulation in Hormone-Sensitive Breast Cancer Cells
Acetylation of Steroidogenic Acute Regulatory Protein Sensitizes 17β-Estradiol Regulation in Hormone-Sensitive Breast Cancer Cells Open
An imbalance in estrogen signaling is a critical event in breast tumorigenesis. The majority of breast cancers (BCs) are hormone-sensitive; they majorly express the estrogen receptor (ER+) and are activated by 17β-estradiol (E2). The stero…
View article: Harnessing Artificial Intelligence for the Detection and Management of Colorectal Cancer Treatment
Harnessing Artificial Intelligence for the Detection and Management of Colorectal Cancer Treatment Open
Currently, eight million people in the United States suffer from cancer and it is a major global health concern. Early detection and interventions are urgently needed for all cancers, including colorectal cancer. Colorectal cancer is the t…
View article: Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease
Effects of sleep deprivation on brain atrophy in individuals with mild cognitive impairment and Alzheimer's disease Open
View article: Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching
Small molecule inhibitor DDQ-treated hippocampal neuronal cells show improved neurite outgrowth and synaptic branching Open
JOURNAL/nrgr/04.03/01300535-202509000-00024/figure1/v/2024-12-31T000210Z/r/image-tiff The process of neurite outgrowth and branching is a crucial aspect of neuronal development and regeneration. Axons and dendrites, sometimes referred to a…
View article: Correction: Digital Interventions for Relapse Prevention, Illness Self‑Management, and Health Promotion In Schizophrenia: Recent Advances, Continued Challenges, and Future Opportunities
Correction: Digital Interventions for Relapse Prevention, Illness Self‑Management, and Health Promotion In Schizophrenia: Recent Advances, Continued Challenges, and Future Opportunities Open
View article: Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease Open
Alzheimer's disease (AD) is a age-related neurodegenerative disease and is a major public health concern both in Texas, US and Worldwide. This neurodegenerative disease is mainly characterized by amyloid-beta (Aβ) and phosphorylated Tau (p…
View article: Corrigendum to ‘Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease’ [Pharmacol Res. 174 (2021) 105973]
Corrigendum to ‘Mitophagy enhancers against phosphorylated Tau-induced mitochondrial and synaptic toxicities in Alzheimer disease’ [Pharmacol Res. 174 (2021) 105973] Open
View article: A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation
A Combinational Therapy for Preventing and Delaying the Onset of Alzheimer’s Disease: A Focus on Probiotic and Vitamin Co-Supplementation Open
Alzheimer’s disease is a progressive neurodegenerative disorder with a complex etiology, and effective interventions to prevent or delay its onset remain a global health challenge. In recent years, there has been growing interest in the po…
View article: Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells 2023, 12, 1646
Correction: Reddy et al. Rlip Reduction Induces Oxidative Stress and Mitochondrial Dysfunction in Mutant Tau-Expressed Immortalized Hippocampal Neurons: Mechanistic Insights. Cells 2023, 12, 1646 Open
The authors wish to make the following changes to their paper [...]
View article: Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas
Is Effective Recruitment Strategy Critical to Assess Brain Cognitive Function of Super Agers in Rural West Texas Open
Our commentary aims to elucidate the importance of participant recruitment strategy in healthy brain aging study, particularly in rural West Texas, where more than 50% of the population are Hispanics and Latinos. The objective of our healt…
View article: Use and Reuse of Animal Behavioral, Molecular, and Biochemical Data in Alzheimer’s Disease Research: Focus on 3Rs and Saving People’s Tax Dollars
Use and Reuse of Animal Behavioral, Molecular, and Biochemical Data in Alzheimer’s Disease Research: Focus on 3Rs and Saving People’s Tax Dollars Open
Several decades of research on cell and animal models contributed tremendously to understanding human diseases. Particularly, research on rodents and non-human primates revealed that animal research is a major and important component in bi…
View article: Circulating Cell Free DNA and DNA Double-Strand Breakage in Alzheimer’s Disease
Circulating Cell Free DNA and DNA Double-Strand Breakage in Alzheimer’s Disease Open
Alzheimer’s disease (AD) is an age-related neurodegenerative disease that is characterized by memory loss and multiple cognitive impairments. AD is pathologically characterized by age-dependent accumulation of amyloid-β protein and the pho…
View article: Caring for Individuals with Alzheimer’s Disease: A Spotlight on Hispanic Caregivers
Caring for Individuals with Alzheimer’s Disease: A Spotlight on Hispanic Caregivers Open
A caregiver is a constantly evolving role that an individual most likely undertakes at some point in their lifetime. With discoveries and research in increasing life expectancy, the prevalence of neurological-related diseases, such as Alzh…
View article: Creating Cultural and Lifestyle Awareness About Dementia and Co-morbidities
Creating Cultural and Lifestyle Awareness About Dementia and Co-morbidities Open
Dementia is a major health concern in society, particularly in the aging population. It is alarmingly increasing in ethnic minorities such as Native Americans, African Americans, Hispanics/Latinos, and to some extent Asians. With increasin…
View article: Comparative Study of Risk Factors Associated with Normal Cognition and Cognitive Impairment in Rural West Elderly Texans
Comparative Study of Risk Factors Associated with Normal Cognition and Cognitive Impairment in Rural West Elderly Texans Open
Background: Alzheimer’s disease (AD) is related to one or more chronic illnesses, which may develop cognitive decline and dementia. Cognitive impairment is increasing, and public health officials must address risk factors for AD to improve…
View article: Cell-Free DNA As Peripheral Biomarker of Alzheimer’s Disease
Cell-Free DNA As Peripheral Biomarker of Alzheimer’s Disease Open
Alzheimer's disease (AD) and Alzheimer's disease-related disorders (ADRD) are progressive neurodegenerative diseases without cure. Alzheimer's disease occurs in 2 forms, early-onset familial AD and late-onset sporadic AD. Early-onset AD is…
View article: Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers
Alzheimer's disease and Alzheimer’s disease-related dementias in Hispanics: Identifying influential factors and supporting caregivers Open
View article: Epigenetic Dysregulation and Its Correlation with the Steroidogenic Machinery Impacting Breast Pathogenesis: Data Mining and Molecular Insights into Therapeutics
Epigenetic Dysregulation and Its Correlation with the Steroidogenic Machinery Impacting Breast Pathogenesis: Data Mining and Molecular Insights into Therapeutics Open
Breast cancer (BC) is a heterogeneous condition and comprises molecularly distinct subtypes. An imbalance in the levels of epigenetic histone deacetylases (HDACs), modulating estrogen accumulation, especially 17β-estradiol (E2), promotes b…
View article: Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases
Role of diet and exercise in aging, Alzheimer’s disease, and other chronic diseases Open
View article: Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer
Amino acid transporter SLC38A5 is a tumor promoter and a novel therapeutic target for pancreatic cancer Open
View article: Healthy brain aging and delayed dementia in Texas rural elderly
Healthy brain aging and delayed dementia in Texas rural elderly Open