P. Jacob Bueno de Mesquita
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View article: Comparison of Viral Aerosol Shedding by Mild and Moderately Symptomatic Community‐Acquired and Nasally Inoculated Influenza A(H3) Infection
Comparison of Viral Aerosol Shedding by Mild and Moderately Symptomatic Community‐Acquired and Nasally Inoculated Influenza A(H3) Infection Open
Background Nasally inoculated influenza cases reported milder symptoms and shed lower viral RNA load in exhaled breath aerosols (EBA) than people with classic influenza‐like illness in a previous study. Whether nasally inoculated influenza…
View article: Revolutionising indoor air quality to stop pandemics with Germicidal Ultraviolet (GUV) technology
Revolutionising indoor air quality to stop pandemics with Germicidal Ultraviolet (GUV) technology Open
Revolutionising indoor air quality to stop pandemics with Germicidal Ultraviolet (GUV) technology Indoor air quality is a silent public health crisis, harbouring pathogens that contribute to billions of illnesses annually. Addressing this …
View article: Introductory Chapter: New Directions for Tuberculosis Elimination
Introductory Chapter: New Directions for Tuberculosis Elimination Open
There is perhaps no other disease that has caused and continues to cause as much devastation to human society as tuberculosis (TB). An ancient scourge, we have archaeological evidence of tuberculosis from across the globe, dating back thou…
View article: Influenza A (H3) viral aerosol shedding in nasally inoculated and naturally infected cases
Influenza A (H3) viral aerosol shedding in nasally inoculated and naturally infected cases Open
Nasally inoculated influenza cases reported milder symptoms and shed lower viral RNA load in exhaled breath aerosols (EBA) than people with classic influenza-like illness including fever, in a previous study. Whether nasally inoculated inf…
View article: Airborne Transmission and Control of Influenza and Other Respiratory Pathogens
Airborne Transmission and Control of Influenza and Other Respiratory Pathogens Open
Despite uncertainty about the specific transmission risk posed by airborne, spray-borne, and contact modes for influenza, SARS-CoV-2, and other respiratory viruses, there is evidence that airborne transmission via inhalation is important a…
View article: Control of airborne infectious disease in buildings: Evidence and research priorities
Control of airborne infectious disease in buildings: Evidence and research priorities Open
The evolution of SARS-CoV-2 virus has resulted in variants likely to be more readily transmitted through respiratory aerosols, underscoring the increased potential for indoor environmental controls to mitigate risk. Use of tight-fitting fa…
View article: Intrahost-diversity of influenza A virus in upper and lower respiratory tract derived samples from a college community
Intrahost-diversity of influenza A virus in upper and lower respiratory tract derived samples from a college community Open
Motivation Influenza is a rapidly mutating RNA virus responsible for annual epidemics causing substantial morbidity, mortality, and economic loss. Characterizing influenza virus mutational diversity and evolutionary processes within and be…
View article: Reviews of "SARS-CoV-2 Aerosol Transmission in Schools: The Effectiveness of Different Interventions"
Reviews of "SARS-CoV-2 Aerosol Transmission in Schools: The Effectiveness of Different Interventions" Open
Reviewers: Jacob Bueno de Mesquita, Ph.D (UC Berkeley) | 📗📗📗📗◻️ • Richard M. Lynch, Ph.D (Preferred Management Corporation) | 📗📗📗📗◻️ • Brian Pavilonis (CUNY School of Public Health) | 📒📒📒 ◻️◻️
View article: Viral RNA and Infectious Influenza Virus on Mobile Phones of Patients With Influenza in Hong Kong and the United States
Viral RNA and Infectious Influenza Virus on Mobile Phones of Patients With Influenza in Hong Kong and the United States Open
Mobile phones are among the most highly touched personal objects. As part of a broader study on the contribution of fomites to influenza transmission, between 2017 and 2019, we swabbed mobile phones from 138 patients with influenza in 2 lo…
View article: Infectious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection
Infectious Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemiology implicates airborne transmission; aerosol infectiousness and impacts of masks and variants on aerosol shedding are not well understood. Methods We recruit…
View article: Infectious SARS-CoV-2 in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection
Infectious SARS-CoV-2 in Exhaled Aerosols and Efficacy of Masks During Early Mild Infection Open
Background SARS-CoV-2 epidemiology implicates airborne transmission; aerosol infectiousness and impacts of masks and variants on aerosol shedding are not well understood. Methods We recruited COVID-19 cases to give blood, saliva, mid-turbi…
View article: High confidence identification of intra-host single nucleotide variants for person-to-person influenza transmission tracking in congregate settings
High confidence identification of intra-host single nucleotide variants for person-to-person influenza transmission tracking in congregate settings Open
Influenza within-host viral populations are the source of all global influenza diversity and play an important role in driving the evolution and escape of the influenza virus from human immune responses, antiviral treatment, and vaccines, …
View article: The effect of COVID‐19 stay‐at‐home order and campus closure on the prevalence of acute respiratory infection symptoms in college campus cohorts
The effect of COVID‐19 stay‐at‐home order and campus closure on the prevalence of acute respiratory infection symptoms in college campus cohorts Open
Evaluation of population‐based COVID‐19 control measures informs strategies to quell the current pandemic and reduce the impact of those yet to come. Effective COVID‐19 control measures may simultaneously reduce the incidence of other acut…
View article: Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases
Influenza A (H3) illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases Open
Background It has long been known that nasal inoculation with influenza A virus produces asymptomatic to febrile infections. Uncertainty persists about whether these infections are sufficiently similar to natural infections for studying hu…
View article: Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment
Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment Open
Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowled…
View article: Quantitative aerobiologic analysis of an influenza human challenge‐transmission trial
Quantitative aerobiologic analysis of an influenza human challenge‐transmission trial Open
Despite evidence that airborne transmission contributes to influenza epidemics, limited knowledge of the infectiousness of human influenza cases hinders pandemic preparedness. We used airborne viral source strength and indoor CO2 monitorin…
View article: Influenza A illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases
Influenza A illness and viral aerosol shedding from symptomatic naturally infected and experimentally infected cases Open
Background: It has long been known that nasal inoculation with influenza A virus produces asymptomatic to febrile infections. Uncertainty persists about whether these infections are sufficiently similar to natural infections for studying h…
View article: Analysis of RNA Concentration of Influenza and other Respiratory Viruses from Dormitory Air Sampling
Analysis of RNA Concentration of Influenza and other Respiratory Viruses from Dormitory Air Sampling Open
Making accurate exposure assessments of airborne disease transmission is an integral part of a proactive response to outbreak events and can help track the pathway of transmission. This study aimed to assess the use of the rebreathed air e…
View article: Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment
Minimal transmission in an influenza A (H3N2) human challenge-transmission model within a controlled exposure environment Open
Uncertainty about the importance of influenza transmission by airborne droplet nuclei generates controversy for infection control. Human challenge-transmission studies have been supported as the most promising approach to fill this knowled…
View article: Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community
Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community Open
Significance Lack of human data on influenza virus aerosol shedding fuels debate over the importance of airborne transmission. We provide overwhelming evidence that humans generate infectious aerosols and quantitative data to improve mathe…
View article: Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community
Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community Open
Little is known about the amount and infectiousness of influenza virus shed into exhaled breath. This contributes to uncertainty about the importance of airborne influenza transmission. We screened 355 symptomatic volunteers with acute res…
View article: A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis
A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis Open
Vitamin D is implicated in the etiology of cancers of the gastrointestinal tract, usually characterized by alteration in the APC/β-catenin/TCF tumor suppressor pathway. The vitamin D receptor (VDR) is also implicated in cardiovascular and …