Frank Larkin
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View article: The Ashkenazi-Centric G334R Variant of <i>TP53</i> is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model
The Ashkenazi-Centric G334R Variant of <i>TP53</i> is Severely Impaired for Transactivation but Retains Tumor Suppressor Function in a Mouse Model Open
Mutations in the TP53 tumor suppressor gene are the most abundant genetic occurrences in cancer. Some of these mutations lead to loss of function of p53 protein, some are gain of function, and some variants are hypomorphic (partially funct…
View article: Belantamab Mafodotin Plus Cyclophosphamide and Dexamethasone for Patients with Relapsed or Refractory Multiple Myeloma: Interim Results from the UK Myeloma Research Alliance Prommise Clinical Trial
Belantamab Mafodotin Plus Cyclophosphamide and Dexamethasone for Patients with Relapsed or Refractory Multiple Myeloma: Interim Results from the UK Myeloma Research Alliance Prommise Clinical Trial Open
Introduction: Belantamab Mafodotin (Belamaf) is a BCMA targeted antibody drug conjugate with a multi-modal mechanism of action including direct MMAF induced cellular cytotoxicity as well as immunogenic cell death. It has demonstrated super…
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High-risk factors for zonular complications during cataract surgery in eyes with pseudoexfoliation syndrome (see page 1193) High-risk factors for intraoperative zonular complications due to pre-existing zonular dehiscence in eyes with pseu…
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Cataract surgery workload estimates in Theni district, India (see page 915) In Theni district, India, based on current utilisation of eye care services and prevalence of vision impairment, a 5-year goal of eliminating vision impairment wou…
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Navigation guided transcaruncular orbital optic canal decompression in indirect traumatic optic neuropathy: long term outcomes (see page 779)No therapeutic modality has an established role in traumatic optic neuropathy.Minimally invasive n…
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Incidence and epidemiology of conjunctival squamous cell carcinoma in relation to the HIV epidemic in South Africa: a 25-year analysis of the National Cancer Registry (1994-2018) (see page 175) There have been considerable changes in conju…
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Risk factors for corneal ulcers: a population-based matched case-control study in Nepal (see page 1771) This population-based matched casecontrol study in Nepal evaluated risk factors for corneal ulcer.We found that ocular injury, manual l…
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Associations between visual impairment, incident falls and fall frequency among older Asians: longitudinal findings from the Singapore Epidemiology of Eye Diseases Study (see page 1590) Baseline bilateral but not unilateral visual impairme…
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Extending the utility of anterior corneal buttons through refrigeration and glycerol cryopreservation: utility rate and outcome analysis (see page 1415) Glycerol cryopreservation can safely extend the utility of donor anterior corneal graf…
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Ocular adverse events associated with chimeric antigen receptor T-cell therapy: a case series and review (see page 901) Ocular complications associated with CAR-T therapy at a comprehensive cancer centre were identified and corroborated wi…