P. Lassen
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View article: Mutational profile of oropharyngeal squamous cell carcinoma in relation to HPV, tobacco smoking and prognosis with validation in the DAHANCA 19 randomized trial
Mutational profile of oropharyngeal squamous cell carcinoma in relation to HPV, tobacco smoking and prognosis with validation in the DAHANCA 19 randomized trial Open
Background and purpose: This study investigated prognostic biomarkers in oropharyngeal squamous cell carcinoma (OPSCC), with a focus on tumors related to human papillomavirus (HPV) infection and potential molecular effects of tobacco smoki…
View article: Subsite variation of HPV-related p16-expression in oropharynx cancer: Incidence and prognostic impact in a population-based DAHANCA cohort 1986–2020
Subsite variation of HPV-related p16-expression in oropharynx cancer: Incidence and prognostic impact in a population-based DAHANCA cohort 1986–2020 Open
p16-expression are implemented in the TNM8 classification of oropharyngeal cancer (OPSCC). Based on a nationwide cohort, we provide a detailed description of subsite variation in the age-standardised incidence-rates of OPSCC alongside an e…
View article: Initial cosmetic outcome six months after kilovoltage therapy of facial basal cell carcinoma: A Danish national prospective study of 932 patients
Initial cosmetic outcome six months after kilovoltage therapy of facial basal cell carcinoma: A Danish national prospective study of 932 patients Open
Kilovoltage therapy is a valid treatment option for basal cell carcinomas (BCC), resulting in tumor control rates and cosmetic outcomes comparable to surgery. The aim was to report patient reported satisfaction as well as professional eval…
View article: Potential of E-Learning Interventions and Artificial Intelligence–Assisted Contouring Skills in Radiotherapy: The ELAISA Study
Potential of E-Learning Interventions and Artificial Intelligence–Assisted Contouring Skills in Radiotherapy: The ELAISA Study Open
PURPOSE Most research on artificial intelligence–based auto-contouring as template (AI-assisted contouring) for organs-at-risk (OARs) stem from high-income countries. The effect and safety are, however, likely to depend on local factors. T…
View article: HPV testing versus p16 immunohistochemistry in oropharyngeal squamous cell carcinoma: results from the DAHANCA 19 study
HPV testing versus p16 immunohistochemistry in oropharyngeal squamous cell carcinoma: results from the DAHANCA 19 study Open
In the present study, HPV DNA testing or typing in a Danish OPSCC cohort did not add additional information to p16 IHC, the most widely used and accepted prognostic indicator.
View article: Socioeconomic position and the pre-diagnostic interval among patients diagnosed with head and neck squamous cell carcinoma - a population-based study from DAHANCA
Socioeconomic position and the pre-diagnostic interval among patients diagnosed with head and neck squamous cell carcinoma - a population-based study from DAHANCA Open
The socioeconomic differences in survival are pronounced for patients diagnosed with head and neck cancer; disease stage at diagnosis is suggested to be a main driver of this association. This nationwide, population-based study investigate…
View article: Association of Smoking, Comorbidity, Clinical Stage, and Treatment Intent With Socioeconomic Differences in Survival After Oropharyngeal Squamous Cell Carcinoma in Denmark
Association of Smoking, Comorbidity, Clinical Stage, and Treatment Intent With Socioeconomic Differences in Survival After Oropharyngeal Squamous Cell Carcinoma in Denmark Open
Importance The socioeconomic gap in survival after cancer is pronounced among patients with head and neck cancer. Understanding the mechanisms of this gap is crucial to target intervention strategies. Objective To investigate socioeconomic…
View article: Treatment outcomes and survival following definitive (chemo)radiotherapy in <scp>HPV</scp>‐positive oropharynx cancer: Large‐scale comparison of <scp>DAHANCA</scp> vs <scp>PMH</scp> cohorts
Treatment outcomes and survival following definitive (chemo)radiotherapy in <span>HPV</span>‐positive oropharynx cancer: Large‐scale comparison of <span>DAHANCA</span> vs <span>PMH</span> cohorts Open
We compare outcomes in two large‐scale contemporaneously treated HPV‐positive (HPV+) oropharynx cancer (OPC) cohorts treated with definitive radiotherapy/chemoradiotherapy (RT/CRT). p16‐confirmed HPV+ OPC treated between 2007 and 2015 at P…
View article: Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study
Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study Open
Incidence, location of metastases and prognosis of primary metastatic (M1) or post-treatment metastatic (DM) disease in pharyngeal and laryngeal squamous cell carcinoma are similar in this register-based study.
View article: Correlation and prognostic impact of human papilloma virus and p16-expression in advanced hypopharynx and larynx cancer treated with definitive radiotherapy
Correlation and prognostic impact of human papilloma virus and p16-expression in advanced hypopharynx and larynx cancer treated with definitive radiotherapy Open
Human papilloma virus (HPV) is a well-established aetiological factor in oropharynx cancer (OPC) [1,2] and the global variation in the incidence of HPV + OPC is considerable. Countries with high ag...
View article: Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study
Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study Open
In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding out…
View article: Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study
Distant metastases in squamous cell carcinoma of the pharynx and larynx: a population-based DAHANCA study Open
In head and neck cancer, distant metastases may be present at diagnosis (M1) or occur after treatment (DM). It is unknown whether M1 and DM follow the same clinical development and share prognosis, as population-based studies regarding out…
View article: Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts
Characterization and radiosensitivity of HPV-related oropharyngeal squamous cell carcinoma patient-derived xenografts Open
Background: Oropharyngeal squamous cell carcinomas (OPSCC) are rising rapidly in incidence due to Human Papillomavirus (HPV) and/or tobacco smoking. Prognosis is better for patients with HPV-positive disease, but may also be influenced by …
View article: Characterization and Radiosensitivity of HPV-Related Oropharyngeal Squamous Cell Carcinoma Patient-Derived Xenografts
Characterization and Radiosensitivity of HPV-Related Oropharyngeal Squamous Cell Carcinoma Patient-Derived Xenografts Open
Background: Oropharyngeal squamous cell carcinomas (OPSCC) are rising rapidly in incidence due to Human Papillomavirus (HPV) and/or tobacco smoking. Prognosis is better for patients with HPV-positive disease, but may also be influenced by …
View article: Laparoscopic surgery for early endometrial cancer
Laparoscopic surgery for early endometrial cancer Open
Introduction The purpose of the present study was to evaluate learning curves and short‐term outcomes following laparoscopic surgery for early endometrial cancer in women of different body mass index ( BMI ) classes. Material and methods D…