Sheba M.J. MohanKumar
YOU?
Author Swipe
View article: Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring
Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring Open
Significance Women are at increased risk for mood disorders, which may be partly attributed to exposure to endocrine-disrupting chemicals (EDCs) during sensitive periods such as pregnancy. Exposure during these times can impact brain devel…
View article: Prenatal stress mediates tissue specific programming of 11β-hydroxysteroid dehydrogenase type 1 expression in diet-induced obese and dietary resistant rats
Prenatal stress mediates tissue specific programming of 11β-hydroxysteroid dehydrogenase type 1 expression in diet-induced obese and dietary resistant rats Open
Background The link between uterine stress and fetal programming of metabolic diseases in the offspring is well established. However, susceptibility to prenatal stress-induced programming of metabolic diseases is not uniform across populat…
View article: Prenatal Exposure to Bisphenol A and/or Diethylhexyl Phthalate Impacts Brain Monoamine Levels in Rat Offspring
Prenatal Exposure to Bisphenol A and/or Diethylhexyl Phthalate Impacts Brain Monoamine Levels in Rat Offspring Open
This study examines the sex-specific effects of gestational exposure (days 6–21) to endocrine-disrupting chemicals such as bisphenol A (BPA), diethylhexyl phthalate (DEHP), or their combination on brain monoamine levels that play an import…
View article: Prenatal exposure to bisphenol A and/or diethylhexyl phthalate alters stress responses in rat offspring in a sex- and dose-dependent manner
Prenatal exposure to bisphenol A and/or diethylhexyl phthalate alters stress responses in rat offspring in a sex- and dose-dependent manner Open
Background: Prenatal exposures to endocrine disrupting chemicals (EDCs) are correlated with adverse behavioral outcomes, but the effects of combinations of these chemicals are unclear. The aim of this study was to determine the dose-depend…
View article: Role of cytokines and reactive oxygen species in brain aging
Role of cytokines and reactive oxygen species in brain aging Open
View article: Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits
Branched-Chain Amino Acids Are Linked with Alzheimer’s Disease-Related Pathology and Cognitive Deficits Open
Alzheimer’s disease (AD) is an irreversible neurodegenerative disorder with a complex pathophysiology. Type 2 diabetes (T2D) is a strong risk factor for AD that shares similar abnormal features including metabolic dysregulation and brain p…
View article: RF22 | PMON03 Sex-specific Effects of Bisphenol-A and its Analogs on Monoamine Levels in the Paraventricular Nucleus
RF22 | PMON03 Sex-specific Effects of Bisphenol-A and its Analogs on Monoamine Levels in the Paraventricular Nucleus Open
Bisphenol A (BPA) is known to produce adverse effects on fertility, cardiovascular, and metabolic health. The constraints placed on BPA production led companies to switch to BPA's structural analogs, Bisphenol S (BPS) and Bisphenol F (BPF)…
View article: RF22 | PMON04 Sex- and Dose-Dependent Effects of In Utero Endocrine Disruptor Exposure on Offspring Behavior and Brain Monoamines
RF22 | PMON04 Sex- and Dose-Dependent Effects of In Utero Endocrine Disruptor Exposure on Offspring Behavior and Brain Monoamines Open
Exposure to endocrine disruptors (EDs), including the well-known plasticizers bisphenol A (BPA) and di(2-Ethylhexyl) phthalate (DEHP), during the highly sensitive gestational period, can produce long-lasting behavioral changes in offspring…
View article: Prenatal Exposure to Diethylhexyl Phthalate Impairs the Recovery of Spatial Memory Post-traumatic Brain Injury in a Sex-specific Manner
Prenatal Exposure to Diethylhexyl Phthalate Impairs the Recovery of Spatial Memory Post-traumatic Brain Injury in a Sex-specific Manner Open
Background Diethyl hexyl phthalate (DEHP) is a chemical plasticizer that causes significant neurological impairments after prenatal exposure. The impact of these exposures on cognitive recovery after severe traumatic brain injury (sTBI) ha…
View article: Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats
Evaluation of the Central Effects of Systemic Lentiviral-Mediated Leptin Delivery in Streptozotocin-Induced Diabetic Rats Open
Type 1 diabetes (T1D) is characterized by hyperphagia, hyperglycemia and activation of the hypothalamic–pituitary–adrenal (HPA) axis. We have reported previously that daily leptin injections help to alleviate these symptoms. Therefore, we …
View article: Metformin effectively restores the HPA axis function in diet-induced obese rats
Metformin effectively restores the HPA axis function in diet-induced obese rats Open
View article: SAT-719 Prenatal Exposure to Bisphenol A, S and F Increases Blood Pressure in Female Rats
SAT-719 Prenatal Exposure to Bisphenol A, S and F Increases Blood Pressure in Female Rats Open
Cardiovascular diseases are the leading causes of mortality among men and women. With the new blood pressure guidelines from the American Heart Association, almost half of the United States population has hypertension (45.6%). The reasons …
View article: SAT-717 Region-Specific Effects of the Exposome on Brain Monoamine Levels in Female Rats
SAT-717 Region-Specific Effects of the Exposome on Brain Monoamine Levels in Female Rats Open
Prenatal programming with endocrine disrupting chemicals (EDCs), in particular the ubiquitous plasticizers bisphenol A (BPA) and di(2-ethylhexyl) phthalate (DEHP), can induce long-lasting behavioral changes in rats. Additionally, changes i…
View article: Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats
Responsiveness of hypothalamo-pituitary-adrenal axis to leptin is impaired in diet-induced obese rats Open
Background/objectives Diet-induced obese (DIO) rats have altered stress (HPA) axis activity compared to diet-resistant (DR) rats when chronically exposed to a high-fat (HF) diet. Since stress axis is tightly regulated by leptin, an adipocy…
View article: Data for: Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists
Data for: Leptin and HPA axis activity in diabetic rats: Effects of adrenergic agonists Open
This study explores the effect of diabetes on norepinephrine release in the paraventricular nucleus of the hypothalamus and its relationship to circulating corticosterone. Leptin treatment helps to partially reverse the increase in noradre…
View article: Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging
Chronic estrogen affects TIDA neurons through IL-1β and NO: effects of aging Open
Women are chronically exposed to estrogens through oral contraceptives, hormone replacement therapy or environmental estrogens. We hypothesized that chronic exposure to low levels of estradiol-17β (E2) can induce inflammatory and degenerat…
View article: Chronic Estradiol exposure-harmful effects on behavior, cardiovascular and reproductive functions
Chronic Estradiol exposure-harmful effects on behavior, cardiovascular and reproductive functions Open
Estradiol (E2) is a female hormone that is produced largely by the ovaries, but also by the adrenal glands, fat and liver. It is present in the circulation of both males and females. Many studies in the literature have described how E2 is …
View article: Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1
Chronic exposure to low doses of estradiol-17ß increases blood pressure in young female rats: A possible role for central Endothelin-1 Open
Previously, we demonstrated that chronic exposure to low levels of estradiol-17β (E2) increases mean arterial pressure (MAP) in young female Sprague-Dawley (SD) rats, however, the underlying mechanisms are unclear. Since endothelin-1 (ET-1…
View article: Effects of prenatal bisphenol-A exposure and postnatal overfeeding on cardiovascular function in female sheep
Effects of prenatal bisphenol-A exposure and postnatal overfeeding on cardiovascular function in female sheep Open
Bisphenol-A (BPA) is a widely used endocrine-disrupting chemical. Prenatal exposure to BPA is known to affect birth weight, but its impact on the cardiovascular system has not been studied in detail. In this study, we investigated the effe…
View article: Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats
Differential effects of prenatal stress on metabolic programming in diet-induced obese and dietary-resistant rats Open
Stress during pregnancy is a known contributing factor for the development of obesity in the offspring. Since maternal obesity is on the rise, we wanted to identify the effects of prenatal stress in the offspring of diet-induced obese (DIO…
View article: Liraglutide Improves Hypertension and Metabolic Perturbation in a Rat Model of Polycystic Ovarian Syndrome
Liraglutide Improves Hypertension and Metabolic Perturbation in a Rat Model of Polycystic Ovarian Syndrome Open
Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in women of reproductive age, with a prevalence of 5-8%. Type 2 diabetes and cardiovascular disease (CVD) are its long-term complications. Targeted therapies addressi…