Peter Kim
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View article: Bump hunting by topological data analysis
Bump hunting by topological data analysis Open
A topological data analysis approach is taken to the challenging problem of finding and validating the statistical significance of local modes in a data set. As with the SIgnificance of the ZERo (SiZer) approach to this problem, statistica…
View article: Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy
Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy Open
View article: Feeding a low-protein diet exacerbates the susceptibility to Citrobacter rodentium and Dextran Sulfate Sodium-induced intestinal injury in mice
Feeding a low-protein diet exacerbates the susceptibility to Citrobacter rodentium and Dextran Sulfate Sodium-induced intestinal injury in mice Open
Globally, almost half of all early childhood deaths are linked to severe undernutrition, herein referred to as severe malnutrition. Mortality in severely malnourished children is often attributed to common infectious diseases, including en…
View article: A scoping review of Coxiella burnetii transmission models in ruminants
A scoping review of Coxiella burnetii transmission models in ruminants Open
Coxiella burnetii is a highly infectious zoonotic bacterium that causes Q fever in humans and coxiellosis in animals. C. burnetii is mainly transmitted from infectious ruminants, particularly during parturition or abortions, to susceptible…
View article: The State of American Epidemiologic Research on Palliative Care and Hospice in Pancreatic Cancer
The State of American Epidemiologic Research on Palliative Care and Hospice in Pancreatic Cancer Open
View article: Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework
Modelling Immune Dynamics in Locally Advanced MSI-H/dMMR Colorectal Cancer with Neoadjuvant Pembrolizumab Treatment: From Differential Equations to an Agent-Based Framework Open
Colorectal cancer (CRC) is the third most common malignancy worldwide, and accounts for approximately 10% of all cancers and an estimated 850,000 deaths annually. Within CRC, MSI-H/dMMR tumours are highly immunogenic due to their high muta…
View article: Dehydration promotes intracellular lipid synthesis and accumulation
Dehydration promotes intracellular lipid synthesis and accumulation Open
Lipids can be considered a water reservoir used to offset dehydration stress as their oxidation by the mitochondria generates water. However, whether dehydration directly regulates lipid synthesis is unknown, which is the focus of this stu…
View article: Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations Open
Colorectal cancer (CRC) poses a major public health challenge due to its increasing prevalence, particularly among younger populations. Microsatellite instability-high (MSI-H) CRC and deficient mismatch repair (dMMR) CRC constitute 15 % of…
View article: Reducing surgical site infections in patients undergoing pancreatic resection: a quality improvement initiative
Reducing surgical site infections in patients undergoing pancreatic resection: a quality improvement initiative Open
Background Surgical site infections (SSIs) represent a significant source of morbidity during pancreaticoduodenectomy. The use of piperacillin–tazobactam (pip–tazo) has been shown to significantly reduce the incidence of SSI in this patien…
View article: Sensitivity analysis-guided model reduction of a mathematical model of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer
Sensitivity analysis-guided model reduction of a mathematical model of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer Open
Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide and the leading cause of cancer-related deaths in adults under 55, involving a complex interplay of biological processes such as dendritic cell (DC) maturation a…
View article: Optimisation of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
Optimisation of pembrolizumab therapy for de novo metastatic MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations Open
Colorectal cancer (CRC), the third most commonly diagnosed cancer worldwide, presents a growing public health concern, with 20% of new diagnoses involving de novo metastatic disease and up to 80% of these patients presenting with unresecta…
View article: Half as high for twice as long: male bias in the fertile-age sex ratio
Half as high for twice as long: male bias in the fertile-age sex ratio Open
Humans are distinguished from our closest living relatives, other great apes, by our extended postmenopausal longevity, later first births, and shorter birth intervals. Those features likely evolved as ancestral grandmothers’ foraging subs…
View article: Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood
Rapid enrichment of progenitor exhausted neoantigen-specific CD8 T cells from peripheral blood Open
Neoantigen-reactive peripheral blood lymphocytes (NeoPBL) are tumor-specific T cells found at ultra-low frequencies in the blood. Unlike tumor-infiltrating lymphocytes (TIL), NeoPBL exist in a favorable less dysfunctional phenotypic state …
View article: Evolution of Human Pair Bonds as a Consequence of Male-Biased Mating Sex Ratios?
Evolution of Human Pair Bonds as a Consequence of Male-Biased Mating Sex Ratios? Open
Compared to our closest primate relatives, human life history involves greater longevity, which includes a distinctive postmenopausal life stage. Given mammalian reproductive physiology in which females build a finite stock of cells that c…
View article: A Scoping Review of <i>Coxiella burnetii</i> Transmission Models in Ruminants
A Scoping Review of <i>Coxiella burnetii</i> Transmission Models in Ruminants Open
View article: Can collagen production be re-programmed in ageing skin?
Can collagen production be re-programmed in ageing skin? Open
View article: Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations
Optimisation of neoadjuvant pembrolizumab therapy for locally advanced MSI-H/dMMR colorectal cancer using data-driven delay integro-differential equations Open
Colorectal cancer (CRC) poses a major public health challenge due to its increasing prevalence, particularly among younger populations. Microsatellite instability-high (MSI-H) CRC and deficient mismatch repair (dMMR) CRC constitute 15% of …
View article: Flexible Development Programs for Antibacterial Drugs to Address Unmet Medical Needs
Flexible Development Programs for Antibacterial Drugs to Address Unmet Medical Needs Open
The US Food and Drug Administration recognizes the unmet medical need for antibacterial drugs to treat serious bacterial diseases caused by resistant pathogens for which effective therapies are limited or lacking. The agency also recognize…
View article: pHoenix score: development and validation of a novel approach to decrease the number of inconclusive GERD diagnoses
pHoenix score: development and validation of a novel approach to decrease the number of inconclusive GERD diagnoses Open
Background The Johnson–DeMeester composite score (DMS) is the historical gold standard for diagnosing gastroesophageal reflux disease (GERD). The Lyon Consensus outlines criteria for diagnosing GERD by pH monitoring, defining normal acid e…
View article: Target regimen profiles for tuberculosis treatment
Target regimen profiles for tuberculosis treatment Open
Simpler, shorter, safer and more effective treatments for tuberculosis that are easily accessible to all people with tuberculosis are desperately needed. In 2016, the World Health Organization (WHO) developed target regimen profiles for th…
View article: Modelling the evolution of human postmenopausal longevity using ordinary differential equations
Modelling the evolution of human postmenopausal longevity using ordinary differential equations Open
We present two simple ODE systems based on the mathematical model in Le et al. (2022) investigating how human postmenopausal longevity could have evolved. Specifically, our ODE systems address a fairly recent and provocative hypothesis tha…
View article: Targeting CD38 with isatuximab and a novel CD38/CD3×CD28 trispecific T-cell engager in older patients with acute myeloid leukemia
Targeting CD38 with isatuximab and a novel CD38/CD3×CD28 trispecific T-cell engager in older patients with acute myeloid leukemia Open
View article: Tripeptide-Assisted Gold Nanocluster Formation for Fe3+ and Cu2+ Sensing
Tripeptide-Assisted Gold Nanocluster Formation for Fe3+ and Cu2+ Sensing Open
Fluorescent gold nanoclusters (AuNCs) have shown promise as metal ion sensors. Further research into surface ligands is crucial for developing sensors that are both selective and sensitive. Here, we designed simple tripeptides to form fluo…
View article: Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy
Label-free structural imaging of plant roots and microbes using third-harmonic generation microscopy Open
Root biology is pivotal in addressing global challenges including sustainable agriculture and climate change. However, roots have been relatively understudied among plant organs, partly due to the difficulties in imaging root structures in…
View article: Exploration of a Potential DOOR Endpoint for Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia Using Six Registrational Trials for Antibacterial Drugs
Exploration of a Potential DOOR Endpoint for Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia Using Six Registrational Trials for Antibacterial Drugs Open
Background Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single…
View article: Evolution of human pair bonds as a consequence of male-biased mating sex ratios?
Evolution of human pair bonds as a consequence of male-biased mating sex ratios? Open
Compared to our closest primate relatives, human life history involves greater longevity, which includes a distinctive postmenopausal life stage. The extension of the human lifes-pan (and continued fertility in old males) without lengtheni…
View article: Are coastal residents turning blue in the blue economy?
Are coastal residents turning blue in the blue economy? Open
AThe World Bank (2017) defined the blue economy (BE) as a strategy that seeks to promote economic growth, social inclusion, and the protection or improvement of livelihoods while ensuring the environmental sustainability of ocean and coast…
View article: Ten-Year Trends of Inflammatory Bowel disease and Total Parental Nutrition Use: Nationwide study from 2010-2020
Ten-Year Trends of Inflammatory Bowel disease and Total Parental Nutrition Use: Nationwide study from 2010-2020 Open
Background This study examined total parenteral nutrition (TPN) usage trends over the last 10 years, including their nationwide patterns, and the outcomes of the utilization of TPN in patients admitted with inflammatory bowel disease. Meth…
View article: Bifurcations of a Cancer Immunotherapy Model Explaining Thetransient Delayed Response and Various Other Responses
Bifurcations of a Cancer Immunotherapy Model Explaining Thetransient Delayed Response and Various Other Responses Open
View article: ACTIV trials: cross-trial lessons learned for master protocol implementation
ACTIV trials: cross-trial lessons learned for master protocol implementation Open
The United States Government (USG) public-private partnership “Accelerating COVID-19 Treatment Interventions and Vaccines” (ACTIV) was launched to identify safe, effective therapeutics to treat patients with Coronavirus Disease 2019 (COVID…