Pirjo Mustonen
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View article: Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation: A nationwide cohort study
Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation: A nationwide cohort study Open
AUD is independently associated with markedly lower use of rhythm control therapies in AF patients. These disparities are most pronounced among socioeconomically disadvantaged individuals, highlighting the need for targeted interventions t…
View article: Finnish Healthcare Professionals' Online Searches for Paediatric Oral Antibiotics: <scp>COVID</scp> ‐19 Impact, 2017–2023
Finnish Healthcare Professionals' Online Searches for Paediatric Oral Antibiotics: <span>COVID</span> ‐19 Impact, 2017–2023 Open
Aim This study explores the trends in healthcare professionals' searches for children's oral suspension of antibiotics and antibiotic prescriptions, as well as COVID‐19 diagnoses in children under 5–6 years of age. Methods In Finland, Phys…
View article: Cost Differences Between Oral Anticoagulation Therapies in Patients with Atrial Fibrillation in Finland
Cost Differences Between Oral Anticoagulation Therapies in Patients with Atrial Fibrillation in Finland Open
EUPAS29845.
View article: Venous thromboembolisms and stroke risk in patients with atrial fibrillation: a nationwide cohort study
Venous thromboembolisms and stroke risk in patients with atrial fibrillation: a nationwide cohort study Open
Aims Little is known about the association of venous thromboembolisms (VTEs) on the risk of ischaemic stroke (IS) in patients with atrial fibrillation (AF). Nevertheless, both pulmonary embolism (PE) and deep venous thromboembolism (DVT) a…
View article: Factors associated with oral anticoagulant non-use at first ischemic stroke in atrial fibrillation: A nationwide study
Factors associated with oral anticoagulant non-use at first ischemic stroke in atrial fibrillation: A nationwide study Open
Background: Limited data exist on characteristics and patterns associated with patients with atrial fibrillation (AF) who encounter first-ever ischemic stroke (IS) while not on oral anticoagulation (OAC) therapy. Methods: From a nationwide…
View article: Quality of anticoagulation and outcomes after mechanical aortic valve replacement in patients with atrial fibrillation: a nationwide cohort study
Quality of anticoagulation and outcomes after mechanical aortic valve replacement in patients with atrial fibrillation: a nationwide cohort study Open
Aims Mechanical aortic valve replacement (AVR) remains the primary treatment for younger patients with severe aortic valve disease. However, limited information is available regarding the quality of the required lifelong vitamin K antagoni…
View article: Alcohol use disorder and initiation of oral anticoagulant therapy in patients with atrial fibrillation: a nationwide cohort study
Alcohol use disorder and initiation of oral anticoagulant therapy in patients with atrial fibrillation: a nationwide cohort study Open
Background Underuse of oral anticoagulant (OAC) therapy is prevalent among patients with atrial fibrillation (AF), and disparities in treatment are noted across various vulnerable demographic groups. Alcohol use disorders (AUD) are common …
View article: Reduced dose direct oral anticoagulants and time-in-therapeutic-range defined warfarin in new-onset atrial fibrillation: a report from the nationwide FinACAF study
Reduced dose direct oral anticoagulants and time-in-therapeutic-range defined warfarin in new-onset atrial fibrillation: a report from the nationwide FinACAF study Open
Aims Direct oral anticoagulants (DOACs) at reduced dosage regimens are the first choice of ischaemic stroke (IS) prevention for patients with atrial fibrillation (AF) and elevated bleeding risk or renal insufficiency. We compared the outco…
View article: Alcohol use disorder and initiation of oral anticoagulant therapy in patients with atrial fibrillation: A nationwide cohort study
Alcohol use disorder and initiation of oral anticoagulant therapy in patients with atrial fibrillation: A nationwide cohort study Open
AUDs are associated with a significantly lower rate of OAC initiation even after accounting for comorbidities that influence OAC initiation.
View article: Temporal trends of catheter ablation procedures in patients with atrial fibrillation and atrial flutter: A nationwide cohort study
Temporal trends of catheter ablation procedures in patients with atrial fibrillation and atrial flutter: A nationwide cohort study Open
The use of catheter ablation more than doubled during 2012-2018 and the increase was particularly seen in the elderly patients. Nevertheless, only a minority of AF and AFL patients were treated with catheter ablations.
View article: Sex- and age-specific differences in the use of antiarrhythmic therapies among atrial fibrillation patients: a nationwide cohort study
Sex- and age-specific differences in the use of antiarrhythmic therapies among atrial fibrillation patients: a nationwide cohort study Open
Aims Atrial fibrillation (AF) patients frequently require active rhythm control therapy to maintain sinus rhythm and reduce symptom burden. Our study assessed whether antiarrhythmic therapies (AATs) are used disproportionately between men …
View article: Vascular disease and ischemic stroke in patients with atrial fibrillation: Temporal trends and age-related differences
Vascular disease and ischemic stroke in patients with atrial fibrillation: Temporal trends and age-related differences Open
The association between vascular diseases and IS has remained stable over time and vascular diseases were independently associated with higher incidence of IS particularly in patients with AF under the age of 65.
View article: Temporal trends in mortality and causes of death in patients with incident atrial fibrillation: a nationwide register study from 2010 to 2018
Temporal trends in mortality and causes of death in patients with incident atrial fibrillation: a nationwide register study from 2010 to 2018 Open
Objectives Atrial fibrillation (AF) is associated with increased mortality. Previous studies have reported conflicting results in temporal trends of mortality after AF diagnosis. We aim to address this disparity by investigating the 1-year…
View article: Time-in-therapeutic-range defined warfarin and direct oral anticoagulants in atrial fibrillation: a Nationwide Cohort Study
Time-in-therapeutic-range defined warfarin and direct oral anticoagulants in atrial fibrillation: a Nationwide Cohort Study Open
The outcome was unsatisfactory in the two lowest TTR quartiles - in half of the patients treated with warfarin. The differences between the high TTR groups and standard dose DOACs were absent or modest.
View article: Thromboembolic and bleeding complications after elective cardioversion of atrial fibrillation: a nationwide cohort study
Thromboembolic and bleeding complications after elective cardioversion of atrial fibrillation: a nationwide cohort study Open
Aims Elective cardioversion (ECV) is routinely used in atrial fibrillation (AF) to restore sinus rhythm. However, it includes a risk of thromboembolism even during adequate oral anticoagulation treatment. The aim of this study was to evalu…
View article: Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease
Repaired coarctation of the aorta does not affect four-dimensional flow metrics in bicuspid aortic valve disease Open
OBJECTIVES The objective of this study was primarily to compare four-dimensional flow magnetic resonance imaging metrics in the ascending aorta (AA) of patients with right–left fusion type bicuspid aortic valve (RL-BAV) and repaired coarct…
View article: #1923 Anticoagulation and risk of stroke in patients with incident atrial fibrillation and CKD stages 4-5—results from the nationwide FinACAF study
#1923 Anticoagulation and risk of stroke in patients with incident atrial fibrillation and CKD stages 4-5—results from the nationwide FinACAF study Open
Background and Aims Atrial fibrillation (AF) is common in patients with chronic kidney disease (CKD). It is well known that CKD in AF patients increases the risk of thromboembolic complications, and also bleeding. However, there is lack of…
View article: Ischaemic stroke in women with atrial fibrillation: temporal trends and clinical implications
Ischaemic stroke in women with atrial fibrillation: temporal trends and clinical implications Open
Background and Aims Female sex has been linked with higher risk of ischaemic stroke (IS) in atrial fibrillation (AF), but no prior study has examined temporal trends in the IS risk associated with female sex. Methods The registry-linkage F…
View article: Temporal trends in hypertension-related ischaemic stroke risk in atrial fibrillation from 2007 to 2018: a nationwide cohort study
Temporal trends in hypertension-related ischaemic stroke risk in atrial fibrillation from 2007 to 2018: a nationwide cohort study Open
View article: Ischemic Stroke Temporally Associated With New-Onset Atrial Fibrillation: A Population-Based Registry-Linkage Study
Ischemic Stroke Temporally Associated With New-Onset Atrial Fibrillation: A Population-Based Registry-Linkage Study Open
BACKGROUND: Limited data exist on the temporal relationship between new-onset atrial fibrillation (AF) and ischemic stroke and its impact on patients’ clinical characteristics and mortality. METHODS: A population-based registry-linkage dat…
View article: Temporal Relation Between Myocardial Infarction and New-Onset Atrial Fibrillation: Results from a Nationwide Registry Study
Temporal Relation Between Myocardial Infarction and New-Onset Atrial Fibrillation: Results from a Nationwide Registry Study Open
Myocardial infarction (MI) and atrial fibrillation (AF) are commonly seen in the same patient. In this study, we evaluated the temporal relations and prognosis of MI and AF. This is a substudy of the nationwide registry-based Finnish Antic…
View article: Anticoagulation therapy in patients with atrial fibrillation and active cancer
Anticoagulation therapy in patients with atrial fibrillation and active cancer Open
Background Atrial fibrillation (AF) is common among cancer patients. Oral anticoagulation therapy (OAT) is important to prevent stroke in AF patients, but active cancer may also predispose to bleeding. Current knowledge on the use of OAT a…
View article: Haemorrhagic stroke among patients with atrial fibrillation: preceding oral anticoagulation use and 30-day case fatality over 10 years
Haemorrhagic stroke among patients with atrial fibrillation: preceding oral anticoagulation use and 30-day case fatality over 10 years Open
Background and purpose Oral anticoagulation (OAC) is the cornerstone of thromboprophylaxis in atrial fibrillation (AF) yet complicated by elevated bleeding risk. We examined the temporal evolution of OAC treatment on 30-day fatality in pat…
View article: Oral anticoagulant therapy and risk of admission to long-term care in patients with atrial fibrillation: a nationwide cohort study
Oral anticoagulant therapy and risk of admission to long-term care in patients with atrial fibrillation: a nationwide cohort study Open
Background The impact of oral anticoagulants (OACs) on outcomes in patients with atrial fibrillation (AF) has been a focus of extensive research in the past decades, but there is a complete paucity of information about their effect on the …
View article: Lower dose direct oral anticoagulation and warfarin in atrial fibrillation. Ischemic stroke, intracranial hemorrhage and mortality in a nationwide registry study
Lower dose direct oral anticoagulation and warfarin in atrial fibrillation. Ischemic stroke, intracranial hemorrhage and mortality in a nationwide registry study Open
Background and aims Direct oral anticoagulants (DOACs) have replaced Vitamin-K antagonists as the primary choice of oral anticoagulation (OAC) in atrial fibrillation (AF). However, after several years of experience with DOACs, no studies h…
View article: Time-in-therapeutic-range defined warfarin and standard dose direct oral anticoagulants in atrial fibrillation: Ischemic stroke, intracranial hemorrhage and death in a nationwide registry study
Time-in-therapeutic-range defined warfarin and standard dose direct oral anticoagulants in atrial fibrillation: Ischemic stroke, intracranial hemorrhage and death in a nationwide registry study Open
Background and aims Direct oral anticoagulants (DOACs) have almost replaced warfarin in stroke prevention of patients with atrial fibrillation (AF). However, little is known whether DOACs are more efficacious or safer than warfarin having …
View article: Quality of anticoagulation and outcomes after mechanical aortic valve replacement in patients with atrial fibrillation: a nationwide cohort study
Quality of anticoagulation and outcomes after mechanical aortic valve replacement in patients with atrial fibrillation: a nationwide cohort study Open
Background Mechanical aortic valve replacement (AVR) remains predominant treatment approach for younger patients in need of aortic valve operation. However, little is known about the success of the required Vitamin K Antagonist (VKA) treat…
View article: Temporal trends of gender disparities in oral anticoagulant use in patients with atrial fibrillation
Temporal trends of gender disparities in oral anticoagulant use in patients with atrial fibrillation Open
Aims To investigate sex‐specific temporal trends in the initiation of oral anticoagulant (OAC) therapy among patients diagnosed with atrial fibrillation (AF) in Finland between 2007 and 2018. Methods The registry‐linkage Finnish AntiCoagul…