Peter Natesan Pushparaj
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View article: Correction: Alzahrani et al. Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy. Cancers 2025, 17, 1470
Correction: Alzahrani et al. Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy. Cancers 2025, 17, 1470 Open
In the original publication [...]
View article: Investigating the Potential of Propranolol as an Anti-Tumor Agent in Colorectal Cancer Cell Lines
Investigating the Potential of Propranolol as an Anti-Tumor Agent in Colorectal Cancer Cell Lines Open
The incidence and mortality of colorectal cancer (CRC) have increased globally. Several therapeutic approaches have been suggested to address this health issue, in addition to classical methods. Propranolol (PRO) is a beta-blocker that was…
View article: A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications
A narrative review of research advancements in pharmacogenetics of cardiovascular disease and impact on clinical implications Open
Pharmacogenetics can enhance cardiovascular disease (CVD) treatment by tailoring drug therapy to genetic profiles and minimising trial-and-error approaches. Genetic variability influences responses to common CVD drugs, including antiplatel…
View article: Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy
Propranolol and Capecitabine Synergy on Inducing Ferroptosis in Human Colorectal Cancer Cells: Potential Implications in Cancer Therapy Open
Background/Objectives: Colorectal cancer (CRC) is a significant global health issue with rising incidence and mortality rates. In oncology, drug repurposing has emerged as a promising therapeutic strategy in conjunction with conventional t…
View article: Development of quick and accurate methods for identifying human pathogenic yeast by targeting the phospholipase B gene, topoisomerase II gene, Candida drug resistance gene, and species-specific ITS 2
Development of quick and accurate methods for identifying human pathogenic yeast by targeting the phospholipase B gene, topoisomerase II gene, Candida drug resistance gene, and species-specific ITS 2 Open
Candida species are a major cause of mortality in immune-compromised patients with head and neck cancer. The early detection and classification of Candida species isolated from clinical samples is crucial because of their diverse antifunga…
View article: Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer
Evaluation of potential substrates and inhibitors of MRP2 transporter to predict effective combinatorial chemotherapeutic agents for treating MRP2-associated non-responsive colorectal cancer Open
Colorectal cancer (CRC) is a significant cause of death globally, due to the emergence of multidrug resistance (MDR), which limits the effectiveness of conventional chemotherapy. Multidrug resistance-associated protein 2 (MRP2) plays a cri…
View article: Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia
Effect of novel IL-8 gene mutation on its protein structure and stability among ovarian cancer patients in Saudi Arabia Open
Despite advancements in therapeutics, early diagnosis of ovarian cancer (OC) remains a challenge due to its asymptomatic progression and it is often diagnosed at an advanced stage. Interleukin-8 (IL-8), a pro-inflammatory chemokine with an…
View article: Interleukin-33 mediated regulation of microRNAs in human cord blood-derived mast cells: Implications for infection, immunity, and inflammation
Interleukin-33 mediated regulation of microRNAs in human cord blood-derived mast cells: Implications for infection, immunity, and inflammation Open
Mast cell (MCs) activation is the driving force of immune responses in several inflammatory diseases, including asthma and allergies. MCs are immune cells found throughout the body and are equipped with numerous surface receptors that allo…
View article: Evaluation of serum biomarkers after intra-articular injection of rat bone marrow-derived mesenchymal stem cells in a rat model of knee osteoarthritis
Evaluation of serum biomarkers after intra-articular injection of rat bone marrow-derived mesenchymal stem cells in a rat model of knee osteoarthritis Open
Cartilage damage leads to an increase in inflammatory cytokine levels and is associated with an increase in serum biomarkers related to cartilage degradation. Intra-articular administration of MSCs showed beneficial effects, including rege…
View article: Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells
Acute and chronic impact of interleukin-33 stimulation on chemokines and growth factors in human cord blood-derived mast cells Open
Background Mast cells (MCs) are multifaceted immune cells that are capable of recognizing and responding to various stimuli by releasing an array of cytokines. We aimed to use human cord blood-derived mast cells (hCBMCs) as a model to eval…
View article: The discovery and simulation analysis of a novel mutation c.40 G < T (V14F) in the NRAS gene in patients with colorectal cancer in Saudi Arabia
The discovery and simulation analysis of a novel mutation c.40 G < T (V14F) in the NRAS gene in patients with colorectal cancer in Saudi Arabia Open
Background: Colorectal cancer (CRC) is the most diagnosed cancer in men and the second most common cancer in women and remains associated with high morbidity and mortality in Saudi Arabia. The current understanding of genetic heterogeneity…
View article: Discovery of a novel mutation F184S (c.551T>C) in GATA4 gene causing congenital heart disease in a consanguineous Saudi family
Discovery of a novel mutation F184S (c.551T>C) in GATA4 gene causing congenital heart disease in a consanguineous Saudi family Open
The variant identified in GATA4 appears to cause recessive CHD in the family. In silico analysis suggested that this variant was damaging and caused multiple structural and functional aberrations. This study may support prenatal screening …
View article: Deciphering gene expression signatures in liver metastasized colorectal cancer in stage IV colorectal cancer patients
Deciphering gene expression signatures in liver metastasized colorectal cancer in stage IV colorectal cancer patients Open
Background: Colorectal cancer (CRC) liver metastasis (CRLM) is a clinical challenge, and optimizing treatment strategies is crucial for improving patient outcomes. This study aimed to identify gene expression signatures associated with CRL…
View article: Acute and prolonged effects of interleukin-33 on cytokines in human cord blood-derived mast cells
Acute and prolonged effects of interleukin-33 on cytokines in human cord blood-derived mast cells Open
Mast cells are multifaceted cells localized in tissues and possess various surface receptors that allow them to respond to inner and external threat signals. Interleukin-33 (IL-33) is a cytokine released by structural cells in response to …
View article: Dengue virus infection: potential applications of "Omics" based approaches
Dengue virus infection: potential applications of "Omics" based approaches Open
Dengue, caused by the dengue virus (DENV), a member of the flavivirus family, continues to pose a significant threat to populations worldwide, despite advances in technology. Nearly half of the global population is at risk of contracting t…
View article: Current genetic models for studying congenital heart diseases: Advantages and disadvantages
Current genetic models for studying congenital heart diseases: Advantages and disadvantages Open
Congenital heart disease (CHD) encompasses a diverse range of structural and functional anomalies that affect the heart and the major blood vessels. Epidemiological studies have documented a global increase in CHD prevalence, which can be …
View article: Synthesis and molecular docking analysis of MBH adducts' derived amides as potential β-lactamase inhibitors
Synthesis and molecular docking analysis of MBH adducts' derived amides as potential β-lactamase inhibitors Open
Humans suffer from various diseases that require more specific drugs to target them. Among the different potent agents, β-lactamases serve as good antibacterial agents; however, β-lactamases are resistant to such antibiotics. The present s…
View article: KDM3A knockdown regulates COMP, LOX, COL8A1 and ACOT1 genes in myocardial fibrosis
KDM3A knockdown regulates COMP, LOX, COL8A1 and ACOT1 genes in myocardial fibrosis Open
Cardiovascular disease (CVD) is one of the main causes of death in Saudi Arabia. Cardiac remodeling plays a critical role in the pathophysiology of heart failure. Major focus of our study was to identify crucial genes involved in the patho…
View article: Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update
Screening, awareness and challenges for colorectal cancer treatment in Saudi Arabia: an update Open
Colorectal cancer (CRC) is the second most common cancer in the world. In Saudi Arabia, CRC is the most common cancer in males and the third most common in females, and its incidence rate is rising as the country continues to develop. Howe…
View article: Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer
Expression pattern, prognostic value and potential microRNA silencing of FZD8 in breast cancer Open
Breast cancer (BC) is one of the most widespread types of cancer affecting females, and therefore, early diagnosis is critical. BC is a complex heterogeneous disease affected by several key pathways. Among these, WNT proteins and their fri…
View article: Characterization of human umbilical cord blood-derived mast cells using high-throughput expression profiling and next-generation knowledge discovery platforms
Characterization of human umbilical cord blood-derived mast cells using high-throughput expression profiling and next-generation knowledge discovery platforms Open
Mast cells (MCs) are tissue-resident innate immune cells that express the high-affinity receptor for immunoglobulin E and are responsible for host defense and an array of diseases related to immune system. We aimed in this study to charact…
View article: Herpesvirus entry mediator as a potential biomarker in breast cancer compared with conventional cytotoxic T‑lymphocyte‑associated antigen 4
Herpesvirus entry mediator as a potential biomarker in breast cancer compared with conventional cytotoxic T‑lymphocyte‑associated antigen 4 Open
Breast cancer (BC) is the most common cancer in women worldwide, with 2.3 million cases recorded in 2020. Despite improvements in cancer treatment, patients with BC still succumb to the disease, due to regional and distant metastases when …
View article: Communicate your audience through Virtual Influencer: A Systematic Literature Review
Communicate your audience through Virtual Influencer: A Systematic Literature Review Open
In the era of Bot and ChatGPT, virtual influencers on social and digital media have taken the position of many celebrities. Artificial humans are having several followers and they are influencing their following by communicating with diffe…
View article: Exploration of potential molecular mechanisms and genotoxicity of anti-cancer drugs using next generation knowledge discovery methods
Exploration of potential molecular mechanisms and genotoxicity of anti-cancer drugs using next generation knowledge discovery methods Open
Background & Objectives: Accurate identification of molecular and toxicological functions of potential drug candidates is crucial for drug discovery and development. This may aid in the evaluation of the risks of genotoxicity and carcinoge…
View article: Corrigendum: Human Wharton’s Jelly stem cell (hWJSC) extracts inhibit ovarian cancer cell lines OVCAR3 and SKOV3 in vitro by inducing cell cycle arrest and apoptosis
Corrigendum: Human Wharton’s Jelly stem cell (hWJSC) extracts inhibit ovarian cancer cell lines OVCAR3 and SKOV3 in vitro by inducing cell cycle arrest and apoptosis Open
[This corrects the article DOI: 10.3389/fonc.2018.00592.].
View article: The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis
The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritis Open
Introduction Clusterin is a moonlighting protein that has many functions. It is a multifunctional holdase chaperone glycoprotein that is present intracellularly and extracellularly in almost all bodily fluids. Clusterin is involved in lipi…