Peter M.T. Deen
YOU?
Author Swipe
View article: A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression
A Vasopressin-Induced Change in Prostaglandin Receptor Subtype Expression Explains the Differential Effect of PGE2 on AQP2 Expression Open
Arginine vasopressin (AVP) stimulates the concentration of renal urine by increasing the principal cell expression of aquaporin-2 (AQP2) water channels. Prostaglandin E 2 (PGE 2 ) and prostaglandin 2α (PGF 2α ) increase the water absorptio…
View article: Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas
Succinate Mediates Tumorigenic Effects via Succinate Receptor 1: Potential for New Targeted Treatment Strategies in Succinate Dehydrogenase Deficient Paragangliomas Open
Paragangliomas and pheochromocytomas (PPGLs) are chromaffin tumors associated with severe catecholamine-induced morbidities. Surgical removal is often curative. However, complete resection may not be an option for patients with succinate d…
View article: Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics
Loss of sdhb in zebrafish larvae recapitulates human paraganglioma characteristics Open
Pheochromocytomas and paragangliomas (PPGLs) caused by mutations in the B-subunit of the succinate dehydrogenase ( SDHB ) have the highest metastatic rate among PPGLs, and effective systemic therapy is lacking. To unravel underlying pathog…
View article: Genes Involved in Energy Metabolism Are Differentially Expressed During the Day–Night Cycle in Murine Retinal Pigment Epithelium
Genes Involved in Energy Metabolism Are Differentially Expressed During the Day–Night Cycle in Murine Retinal Pigment Epithelium Open
Our transcriptome data suggest that the highest energy demand of RPE cells is at night, whereas POS phagocytosis and degradation take place in the morning. Furthermore, we identified genes involved in fatty acid and glycerophospholipid syn…
View article: The metabolite receptor SUCNR1 in oxidative stress-induced age-related macular degeneration
The metabolite receptor SUCNR1 in oxidative stress-induced age-related macular degeneration Open
Age-related macular degeneration (AMD) is the leading cause of vision impairment in elderly people. AMD is a multifactorial disease which is characterised by complex interactions between metabolic and environmental factors as well as multi…
View article: Differential day-night expression of tight junction components in murine retinal pigment epithelium
Differential day-night expression of tight junction components in murine retinal pigment epithelium Open
Strong communication and interaction between the retinal pigment epithelium (RPE) and the photoreceptor (PR) cells is essential for vision. RPE cells are essential for supporting and maintaining PR cells by transporting nutrients, waste pr…
View article: Structural Insights into AQP2 Targeting to Multivesicular Bodies
Structural Insights into AQP2 Targeting to Multivesicular Bodies Open
Vasopressin-dependent trafficking of AQP2 in the renal collecting duct is crucial for the regulation of water homeostasis. This process involves the targeting of AQP2 to the apical membrane during dehydration as well as its removal when hy…
View article: Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice
Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice Open
Significance Statement Lithium causes nephrogenic diabetes insipidus and hypercalcemia in 20% and 10% of patients, respectively, and may lead to metabolic acidosis. To determine the potential role of genetic predisposition in these adverse…
View article: Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470
Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470 Open
Oxidative stress is a feature of many common diseases. It leads to excessive formation and subsequent release of the mitochondrial metabolite succinate, which acts as a signalling molecule through binding the succinate receptor (SUCNR1). R…
View article: Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470
Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470 Open
Oxidative stress is a feature of many common diseases. It leads to excessive formation and subsequent release of the mitochondrial metabolite succinate, which acts as a signalling molecule through binding the succinate receptor (SUCNR1). R…
View article: Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470
Single nucleotide polymorphism rs13079080 is associated with differential regulation of the succinate receptor 1 (SUCNR1) gene by miRNA-4470 Open
Oxidative stress is a feature of many common diseases. It leads to excessive formation and subsequent release of the mitochondrial metabolite succinate, which acts as a signalling molecule through binding the succinate receptor (SUCNR1). R…
View article: Impact of acute<i>versus</i>prolonged exercise and dehydration on kidney function and injury
Impact of acute<i>versus</i>prolonged exercise and dehydration on kidney function and injury Open
Exercise and dehydration may be associated with a compromised kidney function and potential signs of kidney injury. However, the kidney responses to exercise of different durations and hypohydration levels are not yet known. Therefore, we …
View article: MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis
MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis Open
Fine-tuning of the body’s water balance is regulated by vasopressin (AVP), which induces the expression and apical membrane insertion of aquaporin-2 water channels and subsequent water reabsorption in the kidney. Here we demonstrate that s…
View article: Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice
Lithium reduces blood glucose levels, but aggravates albuminuria in BTBR-ob/ob mice Open
Glycogen synthase kinase 3 (GSK3) plays an important role in the development of diabetes mellitus and renal injury. GSK3 inhibition increases glucose uptake in insulin-insensitive muscle and adipose tissue, while it reduces albuminuria and…
View article: Impact of acute versus repetitive moderate intensity endurance exercise on kidney injury markers
Impact of acute versus repetitive moderate intensity endurance exercise on kidney injury markers Open
Exercise may lead to kidney injury through several mechanisms. Urinary Kidney Injury Molecule-1 (uKIM1) and Neutrophil Gelatinase-Associated Lipocalin (uNGAL) are known biomarkers for acute kidney injury, but their response to repetitive e…
View article: NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation
NDFIP allows NEDD4/NEDD4L-induced AQP2 ubiquitination and degradation Open
Regulation of our water homeostasis is fine-tuned by dynamic translocation of Aquaporin-2 (AQP2)-bearing vesicles to and from the plasma membrane of renal principal cells. Whereas binding of vasopressin to its type-2 receptor initiates a c…
View article: Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5
Phosphorylation of human aquaporin 2 (AQP2) allosterically controls its interaction with the lysosomal trafficking protein LIP5 Open
The interaction between the renal water channel aquaporin-2 (AQP2) and the lysosomal trafficking regulator-interacting protein LIP5 targets AQP2 to multivesicular bodies and facilitates lysosomal degradation. This interaction is part of a …
View article: AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70
AQP2 Abundance is Regulated by the E3-Ligase CHIP Via HSP70 Open
Background/Aims: AQP2 expression is mainly controlled by vasopressin-dependent changes in protein abundance which is in turn regulated by AQP2 ubiquitylation and degradation, however the proteins involved in these processes are largely unk…
View article: Lithium in the Kidney: Friend and Foe?
Lithium in the Kidney: Friend and Foe? Open
Trace amounts of lithium are essential for our physical and mental health, and administration of lithium has improved the quality of life of millions of patients with bipolar disorder for >60 years. However, in a substantial number of pati…
View article: Acetazolamide Attenuates Lithium–Induced Nephrogenic Diabetes Insipidus
Acetazolamide Attenuates Lithium–Induced Nephrogenic Diabetes Insipidus Open
To reduce lithium–induced nephrogenic diabetes insipidus (lithium-NDI), patients with bipolar disorder are treated with thiazide and amiloride, which are thought to induce antidiuresis by a compensatory increase in prourine uptake in proxi…