Philip Palade
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View article: Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications
Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications Open
Type 2 diabetes (T2D) is a prevalent metabolic disorder characterized by persistent hyperglycemia, hyperinsulinemia, and long-term cardiovascular complications. Another hallmark of T2D is disrupted hormonal homeostasis—marked by elevated l…
View article: Uncovering immune pathways for therapeutic targeting of hypertension
Uncovering immune pathways for therapeutic targeting of hypertension Open
Targeting these inter-organ immune circuits, especially activation and infiltration of T cells and inflammasome, will provide precise immunomodulatory strategies poised to deliver enduring blood-pressure control and cardiovascular protecti…
View article: The pleiotropic effects of PCSK9 in cardiovascular diseases beyond cholesterol metabolism
The pleiotropic effects of PCSK9 in cardiovascular diseases beyond cholesterol metabolism Open
Cardiovascular diseases (CVD) are the leading cause of morbidity and mortality globally, with elevated low‐density lipoprotein cholesterol (LDL‐C) levels being a major risk factor. Proprotein convertase subtilisin/kexin type 9 (PCSK9) play…
View article: Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels
Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels Open
Rlip76 (Rlip) is a multifunctional membrane protein that facilitates the high metabolic rates of cancer cells through the efflux of toxic metabolites and other functions. Rlip inhibition or depletion results in broad-spectrum anti-cancer e…
View article: Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells
Anticancer Activity of Ω-6 Fatty Acids through Increased 4-HNE in Breast Cancer Cells Open
Her2-amplified breast cancers resistant to available Her2-targeted therapeutics continue to be a challenge in breast cancer therapy. Dox is the mainstay of chemotherapy of all types of breast cancer, but its usefulness is limited by cumula…
View article: RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease Open
The purpose of our study is to understand the role of the RALBP1 gene in oxidative stress (OS), mitochondrial dysfunction and cognition in Alzheimer’s disease (AD) pathogenesis. The RALPB1 gene encodes the 76 kDa protein RLIP76 (Rlip). Rli…
View article: Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease
Role of RALBP1 in Oxidative Stress and Mitochondrial Dysfunction in Alzheimer’s Disease Open
The purpose of our study is to understand the role of the Ralbp1 gene in oxidative stress (OS), mitochondrial dysfunction and cognition in Alzheimer’s disease (AD) pathogenesis. The Ralbp1 gene encodes the 76 kDa protein Rlip ( aka RLIP76)…
View article: Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis
Haploinsufficiency Interactions between RALBP1 and p53 in ERBB2 and PyVT Models of Mouse Mammary Carcinogenesis Open
We recently reported that loss of one or both alleles of Ralbp1, which encodes the stress-protective protein RLIP76 (Rlip), exerts a strong dominant negative effect on both the inherent cancer susceptibility and the chemically inducible ca…
View article: Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling
Sulforaphane prevents age‐associated cardiac and muscular dysfunction through Nrf2 signaling Open
Age‐associated mitochondrial dysfunction and oxidative damage are primary causes for multiple health problems including sarcopenia and cardiovascular disease (CVD). Though the role of Nrf2, a transcription factor that regulates cytoprotect…
View article: Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice
Multi-Omic Analysis Reveals Different Effects of Sulforaphane on the Microbiome and Metabolome in Old Compared to Young Mice Open
Dietary factors modulate interactions between the microbiome, metabolome, and immune system. Sulforaphane (SFN) exerts effects on aging, cancer prevention and reducing insulin resistance. This study investigated effects of SFN on the gut m…
View article: Multi-omic analysis reveals the anti-aging impact of sulforaphane on the microbiome and metabolome
Multi-omic analysis reveals the anti-aging impact of sulforaphane on the microbiome and metabolome Open
Background Dietary factors may modulate many complex interactions between the microbiome, metabolome, and immune system and can have an impact on the functional status of older adults. Sulforaphane (SFN), a natural compound and Nrf2-relate…
View article: Rlip Depletion Suppresses Growth of Breast Cancer
Rlip Depletion Suppresses Growth of Breast Cancer Open
RLIP76 (RAL-binding protein-1, Rlip) is a stress-protective mercapturic-acid-pathway transporter protein that also plays a key role in regulating clathrin-dependent endocytosis as a Ral effector. Targeted inhibition or depletion of Rlip ca…
View article: Chromosomal alterations of pediatric malignancy in a West Texas population
Chromosomal alterations of pediatric malignancy in a West Texas population Open
Background: Comparative genomic hybridization (CGH) microarrays are used forgenome-wide evaluation of copy number variations (CNV) of known prognostic significance;however, unannotated variants of uncertain significance (VUS) are frequentl…
View article: Topical 2′-Hydroxyflavanone for Cutaneous Melanoma
Topical 2′-Hydroxyflavanone for Cutaneous Melanoma Open
2′-hydroxyflavanone (2HF) is a dietary flavonoid with anticancer activity towards multiple cancers. Here, we report that topically applied 2HF inhibits the growth of intradermal implants of melanoma in immunocompetent mice. 2HF induced apo…
View article: Oxidative stress in intensive care unit patients: a review of glutathione linked metabolism and lipid peroxidation
Oxidative stress in intensive care unit patients: a review of glutathione linked metabolism and lipid peroxidation Open
Despite clear evidence of increased oxidative stress in the blood and tissues of critically ill intensive care unit patients, consistent beneficial effects of many different antioxidants have not been observed, and antioxidant therapy has …