Explanipedia

Impact of P2Y12 inhibitor pretreatment on periprocedural (type 4a) myocardial infarction and bleeding in NSTEMI Open

Matteo Armillotta, Pasquale Paolisso, Damiano Fedele, Sara Amicone, Khrystyna Ryabenko , et al. · 2025

Impact of glucometabolic status on type 4a myocardial infarction in patients with non–ST-segment elevation myocardial infarction: the role of stress hyperglycemia ratio Open

Matteo Armillotta, Luca Bergamaschi, Francesco Angeli, Marta Belmonte, Marcello Casuso Alvarez , et al. · 2025

PCSK9 Inhibitors “Fast Track” Use Versus “Stepwise” Lipid-Lowering Therapy in Patients with Acute Coronary Syndrome: A Retrospective Single-Center Study in a “Real-World” Population Open

Davide D’Andrea, Valentina Capone, Alessandro Bellis, Rossana Castaldo, Monica Franzese , et al. · 2025

Background: The “fast track” addition (within 48 h) of proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) to the optimized oral lipid-lowering therapy (LLT) during hospitalization for acute coronary syndrome (ACS) has been s…

Unveiling the invisible culprit: a multimodality approach for myocardial infarction with non-obstructive coronary arteries diagnosis—a case report Open

Riccardo Terzi, Pasquale Paolisso, Francesca Di Lenarda, Edoardo Conte, Emanuele Gallinoro · 2025

Background Myocardial infarction with non-obstructive coronary arteries (MINOCA) affects up to 10% of patients undergoing coronary angiography for acute myocardial infarction. Despite the lack of obstructive lesions, these patients face si…

Prognostic Relevance of Type 4a Myocardial Infarction and Periprocedural Myocardial Injury in Patients With Non–ST-Segment–Elevation Myocardial Infarction Open

Matteo Armillotta, Luca Bergamaschi, Pasquale Paolisso, Marta Belmonte, Francesco Angeli , et al. · 2025

BACKGROUND: Periprocedural myocardial injury (PMI) with or without type 4a myocardial infarction (MI) might occur in patients with non–ST-segment–elevation MI (NSTEMI) after percutaneous coronary intervention (PCI). This study investigated…

Utility of Cardiovascular CT in Ischemic Heart Disease Open

Davide Marchetti, M. Gallazzi, Giulia Nemola, M Stracqualursi, Blanca Prestini , et al. · 2025

Cardiac computed tomography angiography (CCTA) has acquired a pivotal role in modern cardiology. It represents the gold standard for noninvasive coronary imaging. Moreover, CCTA permits a comprehensive evaluation of atheromatic burden and …

Hallmarks of Left Ventricular Apical Cardiac Mass in a Young Patient Open

Francesco Angeli, Luca Bergamaschi, Pasquale Paolisso, Matteo Armillotta, Carmine Pizzi · 2025

Comprehensive Non-invasive Versus Invasive Approach to Evaluate Cardiac Allograft Vasculopathy in Heart Transplantation: The CCTA-HTx Study Open

Marta Belmonte, Pasquale Paolisso, Michele Mattia Viscusi, Monika Beles, Luca Bergamaschi , et al. · 2025

BACKGROUND: Coronary computed tomography angiography (CCTA) is emerging as a valuable tool for noninvasive surveillance of cardiac allograft vasculopathy (CAV) in patients with heart transplant (HTx). We assessed the diagnostic performance…

Pathological findings at invasive assessment in MINOCA: a systematic review and meta-analysis Open

Damiano Fedele, Daniele Cavallo, Francesca Bodega, Nicole Suma, Lisa Canton , et al. · 2024

Background Pathological mechanisms of myocardial infarction with non-obstructive coronary arteries (MINOCA) are heterogeneous, with an unknown impact on prognosis, and often remain unrecognised in clinical practice. This study aimed to eva…

Multimodality Imaging in the Diagnostic Work-Up of Patients With Cardiac Masses Open

Francesco Angeli, Francesca Bodega, Luca Bergamaschi, Matteo Armillotta, Sara Amicone , et al. · 2024

Cardiac masses encompass a diverse range of benign and malignant tumors as well as pseudotumors. Accurate histologic identification is essential for guiding appropriate treatment, yet the diagnostic process remains challenging. Although bi…

Coronary Artery Disease, Family History, and Screening Perspectives: An Up-to-Date Review Open

Francesca Di Lenarda, Angela Balestrucci, Riccardo Terzi, P Lopes, Giuseppe Ciliberti , et al. · 2024

Family history for CAD (coronary artery disease) is an established cardiovascular (CV) risk factor and it is progressively acquiring importance in patients’ CV risk stratification. Numerous studies have demonstrated that individuals with a…

Micro-nanoplastics and cardiovascular diseases: evidence and perspectives Open

Francesco Prattichizzo, Antonio Ceriello, Valeria Pellegrini, Rosalba La Grotta, Laura Graciotti , et al. · 2024

Emerging evidence indicates that chemical exposures in the environment are overlooked drivers of cardiovascular diseases (CVD). Recent evidence suggests that micro- and nanoplastic (MNP) particles derived largely from the chemical or mecha…

2024 ESC Guidelines for the management of chronic coronary syndromes Open

Christiaan Vrints, Felicita Andreotti, Konstantinos C. Koskinas, Xavier Rosselló, Marianna Adamo , et al. · 2024

Role of Cardiac Magnetic Resonance in Inflammatory and Infiltrative Cardiomyopathies: A Narrative Review Open

Davide Marchetti, Federica Buzzi, Riccardo Di Febo, Sara Modugno, Matteo Schillaci , et al. · 2024

Cardiac magnetic resonance (CMR) has acquired a pivotal role in modern cardiology. It represents the gold standard for biventricular volume and systolic function assessment. Moreover, CMR allows for non-invasive myocardial tissue evaluatio…

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events Open

Raffaele Marfella, Francesco Prattichizzo, Celestino Sardu, Gianluca Fulgenzi, Laura Graciotti , et al. · 2024

In this study, patients with carotid artery plaque in which MNPs were detected had a higher risk of a composite of myocardial infarction, stroke, or death from any cause at 34 months of follow-up than those in whom MNPs were not detected. …

Characterisation of coronary microvascular dysfunction in patients with severe aortic stenosis undergoing TAVI Open

Roberto Scarsini, Emanuele Gallinoro, Marco Ancona, Leonardo Portolan, Pasquale Paolisso , et al. · 2024

In this observational, hypothesis-generating study, CMD was associated with extravalvular cardiac damage and a low-flow phenotype in patients with severe AS undergoing TAVI.

Cardiac Magnetic Resonance to Predict Cardiac Mass Malignancy: The CMR Mass Score Open

Pasquale Paolisso, Luca Bergamaschi, Francesco Angeli, Marta Belmonte, Alberto Foà , et al. · 2024

BACKGROUND: Multimodality imaging is currently suggested for the noninvasive diagnosis of cardiac masses. The identification of cardiac masses’ malignant nature is essential to guide proper treatment. We aimed to develop a cardiac magnetic…

Myocardial sodium–glucose cotransporter <span>2</span> expression and cardiac remodelling in patients with severe aortic stenosis: The <span>BIO‐AS</span> study Open

Lucia Scisciola, Pasquale Paolisso, Marta Belmonte, Emanuele Gallinoro, Leen Delrue , et al. · 2024

Aim Cardiac remodelling plays a major role in the prognosis of patients with aortic stenosis (AS) and could impact the benefits of aortic valve replacement. Our study aimed to evaluate the expression of sodium–glucose cotransporter 2 (SGLT…

Predicting Cardiac Mass Malignancy Through Multiparametric Cardiac Magnetic Resonance Open

Pasquale Paolisso, Anna Giulia Pavon, Luca Bergamaschi, Francesco Angeli, Marta Belmonte , et al. · 2024

Contemporary Echocardiographic Evaluation of Mitral Regurgitation and Guidance for Percutaneous Mitral Valve Repair Open

Davide Marchetti, Francesca Di Lenarda, Maria Laura Novembre, Pasquale Paolisso, Matteo Schillaci , et al. · 2023

Mitral valve regurgitation (MR) is a multifaceted valvular heart disease. Echocardiography plays a central role in etiology assessment, severity quantification, treatment candidacy, outcome evaluation, and patient follow-up. In this review…

Multimodality imaging in cardiac masses Open

Francesca Bodega, Francesco Angeli, Luca Bergamaschi, Pasquale Paolisso, Matteo Armillotta , et al. · 2023

Background Cardiac masses (CM) are an extremely heterogeneous clinical scenario, including benign and malignant neoformations. After a first echocardiographic assessment, Cardiac Computed Tomography (CCT) together with Cardiac Magnetic Res…

Diagnostic agreement between echocardiography and second-level imaging techniques in patients with cardiac masses Open

Nicole Suma, Sara Amicone, Francesca Bodega, Angelo Sansonetti, Domenico Maria Cavallo , et al. · 2023

Background Cardiac masses (CMs) are a diagnostic dilemma in clinical practice and require multimodality imaging to assess malignancy, which is essential to guide the proper treatment. Aim To define diagnostic accuracy and agreement between…

Comparison of non-invasive and invasive cardiac damage staging in patients with clinically significant aortic stenosis Open

Marta Belmonte, Pasquale Paolisso, Dario Tino Bertolone, Michele Mattia Viscusi, Emanuele Gallinoro , et al. · 2023

Background Cardiac damage staging derived from transthoracic echocardiography (TTE) is an additive clinical tool to enhance risk stratification and therapeutic decision making in patients with clinically significant (i.e. ≥moderate) aortic…

Predictors for and the role of abnormal mapping values at cardiac magnetic resonance in myocardial infarction with non-obstructive coronary arteries Open

Andrea Impellizzeri, Francesca Bodega, Khrystyna Ryabenko, Francesco Pio Tattilo, Nicole Suma , et al. · 2023

Background Cardiovascular magnetic resonance (CMR) plays a crucial role in the diagnostic approach of Myocardial infarction with non-obstructive coronary arteries (MINOCA), as a result of its ability to perform myocardial tissue characteri…

Endotypes of coronary microvascular dysfunction in patients with and without Diabetes Mellitus Open

Emanuele Gallinoro, Pasquale Paolisso, Dario Tino Bertolone, Marta Belmonte, Giuseppe Esposito , et al. · 2023

Background Coronary microvascular dysfunction (CMD) is an early feature of diabetic cardiomyopathy, which usually precedes the onset of ventricular dysfunction. Continuous intracoronary thermodilution allows an accurate and reproducible as…

Impact of SGLT2-inhibitors on contrast-induced acute kidney injury in diabetic patients with acute myocardial infarction: data from SGLT2-I AMI PROTECT Registry Open

Pasquale Paolisso, Luca Bergamaschi, Arturo Cesaro, Emanuele Gallinoro, Felice Gragnano , et al. · 2023

Background Diabetes patients presenting with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have an increased risk of contrast induced-acute kidney injury (CI-AKI). It has been shown that SGLT…

Incidence and predictors of heart failure in a cohort of MINOCA patients Open

Khrystyna Ryabenko, Domenico Fedele, Alberto Foà, Luca Bergamaschi, Pasquale Paolisso , et al. · 2023

Background/Introduction A higher risk of death and major cardiovascular events, including Heart Failure (HF), after a Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) has been described. In particular, HF has a negativ…

Microvascular Resistance Reserve assessed by bolus and continuous thermodilution Open

Emanuele Gallinoro, Dario Tino Bertolone, Marta Belmonte, Pasquale Paolisso, Takuya Mizukami , et al. · 2023

Aim The main limitation of Coronary flow reserve (CFR) as an index to assess coronary microvascular function, is that it is influenced by epicardial resistance. Microvascular Resistance Reserve (MRR) has been recently introduced as a metri…

Prognostic role of late gadolinium enhancement and abnormal mapping values in myocardial infarction with non-obstructive coronary arteries Open

Matteo Armillotta, Luca Bergamaschi, Sara Amicone, Domenico Fedele, Andrea Impellizzeri , et al. · 2023

Background Myocardial infarction with non-obstructive coronary arteries (MINOCA) represents an extremely heterogeneous clinical entity, as multiple pathophysiological mechanisms may result in variable outcomes. Cardiac magnetic resonance (…

Impact of gender-related differences in outcomes in acute myocardial infarction: non-obstructive coronary arteries versus obstructive coronary arteries Open

Domenico Fedele, Lisa Canton, Matteo Armillotta, Francesco Pio Tattilo, Ornella Di Iuorio , et al. · 2023

Background Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) represents 6-10% of acute myocardial infarction (AMI) and is more prevalent in females. The impact of gender on the outcomes of MINOCA patients has been poorl…

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