Pei‐Jer Chen
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View article: Global burden of vision impairment due to smoking-related cataract: A descriptive study of spatiotemporal trends based on GBD secondary data and projections to 2050
Global burden of vision impairment due to smoking-related cataract: A descriptive study of spatiotemporal trends based on GBD secondary data and projections to 2050 Open
Despite a declining age-standardized burden globally, the absolute burden is increasing due to population growth and aging, presenting ongoing challenges, particularly for low- and middle-income countries. Strengthening tobacco control and…
View article: Dual immune modulation of microglia in viral encephalitis: current understanding and future perspectives
Dual immune modulation of microglia in viral encephalitis: current understanding and future perspectives Open
Viral encephalitis, characterized by inflammation of the brain parenchyma, poses a significant threat to public health due to its high rates of morbidity and mortality. Microglia, the central nervous system’s resident immune cells, are cru…
View article: #110 Association between relapse and long-term kidney outcomes in IgA nephropathy
#110 Association between relapse and long-term kidney outcomes in IgA nephropathy Open
Background and Aims Relapse in IgA nephropathy (IgAN) remains under-researched. This study investigates the incidence of IgAN relapse, its association with adverse outcomes, and its risk factors within a prospective cohort. Method We analy…
View article: Novel therapies improve prognosis of IgAN and limit the applicability of the International IgA Nephropathy Prediction Tool
Novel therapies improve prognosis of IgAN and limit the applicability of the International IgA Nephropathy Prediction Tool Open
Background The International IgA Nephropathy Prediction Tools using clinical variables and the Oxford MEST scores were developed in outdated cohorts. External validation is required to assess the tool's applicability in predicting progress…
View article: Optical fogging is an effective method of reducing overestimation of myopia
Optical fogging is an effective method of reducing overestimation of myopia Open
Optical fogging effectively suppresses unnecessary accommodative responses in young adults, significantly reducing myopic overestimation, with particularly pronounced effects in those with notable myopic overestimation. Although optical fo…
View article: Association of systemic inflammatory response index with serum uric acid levels, hyperuricemia, and gout in adults aged 20 years and older in the United States: A cross-sectional study
Association of systemic inflammatory response index with serum uric acid levels, hyperuricemia, and gout in adults aged 20 years and older in the United States: A cross-sectional study Open
This study aimed to explore the association between the systemic inflammatory response index (SIRI) and the prevalence of gout, hyperuricemia, and serum uric acid (SUA) levels with the help of the National health and nutrition examination …
View article: Behaviors of hydrogen diffusion in 18Cr2Ni4Wa
Behaviors of hydrogen diffusion in 18Cr2Ni4Wa Open
The hydrogen diffusion coefficient is a key factor affecting the sensitivity of hydrogen embrittlement in steels and the sensitivity of high-strength steel. Studying diffusion behaviors in steels is of great significance for the study of h…
View article: Tradeoffs between proliferation and transmission in virus evolution– insights from evolutionary and functional analyses of SARS-CoV-2
Tradeoffs between proliferation and transmission in virus evolution– insights from evolutionary and functional analyses of SARS-CoV-2 Open
To be successful, a virus must maintain high between-host transmissibility while also effectively adapting within hosts. The impact of these potentially conflicting demands on viral genetic diversity and adaptation remains largely unexplor…
View article: Effect of mild hypercapnia during the recovery period on the emergence time from total intravenous anesthesia: a randomized controlled trial
Effect of mild hypercapnia during the recovery period on the emergence time from total intravenous anesthesia: a randomized controlled trial Open
Background: Intraoperative hypercapnia reduces the time to emergence from volatile anesthetics, but few clinical studies have explored the effect of hypercapnia on the emergence time from intravenous (IV) anesthesia. We investigated the ef…
View article: Native epitranscriptome sequencing reveals Hepatitis B virus RNA stability protected by heavy m<sup>6</sup>A modification
Native epitranscriptome sequencing reveals Hepatitis B virus RNA stability protected by heavy m<sup>6</sup>A modification Open
Although the RNA of Hepatitis B virus (HBV) is known to be regulated by the epitranscriptomic modification N 6 -methyladenosine (m 6 A), it remains controversial whether if m 6 A is beneficial or detrimental for viral replication. Here, we…
View article: Sequential combination with ropeginterferon alfa-2b and anti-PD-1 treatment as adjuvant therapy in HBV-related HCC: a phase 1 dose escalation trial
Sequential combination with ropeginterferon alfa-2b and anti-PD-1 treatment as adjuvant therapy in HBV-related HCC: a phase 1 dose escalation trial Open
Background/purpose Post-operative recurrence is a major clinical challenge with hepatocellular carcinoma (HCC). While currently unapproved, anti-programmed cell death 1 (PD-1) and anti-vascular endothelial growth factor combination adjuvan…
View article: Evolution of qHBsAg levels in HBV/HCV co-infected patients with low serum HBV DNA: Comparison between treated versus untreated
Evolution of qHBsAg levels in HBV/HCV co-infected patients with low serum HBV DNA: Comparison between treated versus untreated Open
In HBV/HCV co-infected patients with low serum HBV DNA, favorable HBsAg dynamics was found post-interferon/ribavirin therapy. These findings supported further investigations of interferon-based therapy in this clinical setting.
View article: Long-term evaluation of the timing of corticosteroid therapy in an IgA nephropathy cohort
Long-term evaluation of the timing of corticosteroid therapy in an IgA nephropathy cohort Open
Background Current proposed KDIGO guidelines suggest systemic corticosteroid therapy to reduce glomerular inflammation in immunoglobulin A nephropathy (IgAN), however the optimal timing for initiating steroid treatment remains a topic of d…
View article: HBV polymerase recruits the phosphatase PP1 to dephosphorylate HBc-Ser170 to complete encapsidation
HBV polymerase recruits the phosphatase PP1 to dephosphorylate HBc-Ser170 to complete encapsidation Open
The HBV core (HBc) protein contains an N-terminal domain (NTD) for capsid assembly and an arginine-rich C-terminal domain (CTD) for pregenomic RNA (pgRNA) encapsidation. Phosphorylation of the HBc CTD, especially at Ser162 and Ser170, is e…
View article: Interacting topological magnons in the Kitaev-Heisenberg honeycomb ferromagnet with the Dzyaloshinskii-Moriya interaction
Interacting topological magnons in the Kitaev-Heisenberg honeycomb ferromagnet with the Dzyaloshinskii-Moriya interaction Open
The study of the Heisenberg-Kitaev honeycomb ferromagnets has recently drawn attention because of their rich topological properties. Topological phase transitions may arise when there exist two or more distinct topological phases, and they…
View article: HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC
HBV DNA integration and somatic mutations in HCC patients with HBV-HCV dual infection reveals profiles intermediate between HBV- and HCV-related HCC Open
Background In regions with a high prevalence of chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections, coinfected patients face a heightened risk of developing hepatocellular carcinoma (HCC), termed HBV/HCV-related HCC (HB…
View article: Long-term serum ferritin dynamics in patients receiving antiviral treatment for hepatitis C virus infection
Long-term serum ferritin dynamics in patients receiving antiviral treatment for hepatitis C virus infection Open
Patients achieving SVR12, irrespective of types of treatment, exhibited more favorable long-term ferritin dynamics compared to those not achieving SVR12. Absence of MASLD may help improve long-term ferritin dynamics among patients achievin…
View article: Accurate diagnosis of high-risk pulmonary nodules using a non-invasive epigenetic biomarker test
Accurate diagnosis of high-risk pulmonary nodules using a non-invasive epigenetic biomarker test Open
Background Accurate non-invasive tests to improve the early detection and diagnosis of lung cancer are urgently needed, given that large tumors may metastasize or be resistant to treatment. However, no regulatory-approved blood tests are a…
View article: Diffusion-based Visual Anagram as Multi-task Learning
Diffusion-based Visual Anagram as Multi-task Learning Open
Visual anagrams are images that change appearance upon transformation, like flipping or rotation. With the advent of diffusion models, generating such optical illusions can be achieved by averaging noise across multiple views during the re…
View article: Optical Fogging is an Effective Method of Reducing Overestimation of Myopia
Optical Fogging is an Effective Method of Reducing Overestimation of Myopia Open
Background To evaluate the effectiveness of optical fogging in reducing overestimation of myopia using an open-field auto-refractor and partial coherence interferometry. METHODS The study recruited 144 young adults with an age range of 17-…
View article: Tradeoffs between proliferation and transmission in virus evolution – insights from evolutionary and functional analyses of SARS-CoV-2
Tradeoffs between proliferation and transmission in virus evolution – insights from evolutionary and functional analyses of SARS-CoV-2 Open
To be successful a virus must maintain high between-host transmissibility while also effectively adapting within hosts. The impact of these potentially conflicting demands on viral genetic diversity and adaptation remains largely unexplore…
View article: Addition of neutrophil-to-lymphocyte ratio to Pre-DAA FIB-4 does not increase prediction value for de novo liver complications in hepatitis C
Addition of neutrophil-to-lymphocyte ratio to Pre-DAA FIB-4 does not increase prediction value for de novo liver complications in hepatitis C Open
The overall incidence of de novo liver complications after SVR is low during short-term follow-up. Elevated pre-DAA FIB-4 is associated with de novo liver complications after SVR, whereas the addition of pre-DAA NLR does not increase the p…
View article: Clinical care guidance in patients with diabetes and metabolic dysfunction–associated steatotic liver disease: A joint consensus
Clinical care guidance in patients with diabetes and metabolic dysfunction–associated steatotic liver disease: A joint consensus Open
Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease worldwide, affecting >30% of the global population. Metabolic dysregulation, particularly insulin resistance and its subsequent ma…
View article: Efficacy, safety, and pharmacokinetics of CPL-01, an investigational long-acting ropivacaine, in bunionectomy: Results of a phase 2b study
Efficacy, safety, and pharmacokinetics of CPL-01, an investigational long-acting ropivacaine, in bunionectomy: Results of a phase 2b study Open
CPL-01 (ropivacaine extended-release injection) is formulated to safely provide postoperative analgesia and reduce opioid use. Participants undergoing unilateral distal first metatarsal bunionectomy with osteotomy were randomized to receiv…