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View article: Beyond Staphylococcus: The Cutaneous Microbiome in Itch Pathobiology
Beyond Staphylococcus: The Cutaneous Microbiome in Itch Pathobiology Open
Background: Pruritus is burdensome across dermatoses. Beyond Staphylococcus, broader components of the cutaneous microbiome—bacteria, fungi, and viruses—and their products shape itch via barrier disruption, immune polarization, and direct …
View article: The Central Role of Th2 Immune Response in Inflammatory Dermatoses: From Pathogenesis to Targeted Therapies
The Central Role of Th2 Immune Response in Inflammatory Dermatoses: From Pathogenesis to Targeted Therapies Open
T helper 2 (Th2)-mediated dermatoses are inflammatory skin diseases driven by CD4+ Th2 cells that produce interleukin (IL)-4, IL-5, IL-13, and IL-31, promoting immunoglobulin E (IgE) class switching, eosinophil recruitment, mast cell degra…
View article: From north to south: exploring Italian sun-exposure habits through the “Save your skin” campaign
From north to south: exploring Italian sun-exposure habits through the “Save your skin” campaign Open
Sun exposure is the main external risk factor for skin cancer, affecting melanoma and non-melanoma differently. Although increased awareness of sun-induced skin damage and appropriate photoprotection has helped to reduce melanoma incidence…
View article: Synchronous Melanoma and Follicular Lymphoma in the Same Nodal Basin: A Diagnostic and Therapeutic Challenge
Synchronous Melanoma and Follicular Lymphoma in the Same Nodal Basin: A Diagnostic and Therapeutic Challenge Open
Background The incidence of both malignant melanoma (MM) and non‐Hodgkin lymphoma (NHL) has risen in recent decades, with studies suggesting a potential bidirectional association. Nonetheless, synchronous presentation of active disease in …
View article: Nodes of concern? Prediction of nodal burden from radiological imaging in CTCL, findings from the PROCLIPI study
Nodes of concern? Prediction of nodal burden from radiological imaging in CTCL, findings from the PROCLIPI study Open
View article: Melanoma Clues Beyond Dermoscopic Patterns: Lesion Orientation to Langer’s Lines as a Predictor on the Trunk
Melanoma Clues Beyond Dermoscopic Patterns: Lesion Orientation to Langer’s Lines as a Predictor on the Trunk Open
Background/Objectives: The diagnosis of melanocytic lesions on the trunk is challenging due to a high frequency of atypical features in benign nevi, leading to a high rate of unnecessary excisions. This study aimed to identify robust dermo…
View article: Melanoma in Primary Care: A Narrative Review of Training Interventions and the Role of Telemedicine in Medical Education
Melanoma in Primary Care: A Narrative Review of Training Interventions and the Role of Telemedicine in Medical Education Open
General practitioners play a crucial role in the early detection and prevention of cutaneous melanoma. However, structured training on skin cancer diagnosis and management is often lacking. This narrative review aims to map the current edu…
View article: Monoclonal Antibodies and Small-Molecule Therapies for Lichen Planus: Targeted Immunomodulation and Emerging Evidence
Monoclonal Antibodies and Small-Molecule Therapies for Lichen Planus: Targeted Immunomodulation and Emerging Evidence Open
Background/Objectives: Lichen planus (LP) is a chronic inflammatory disease of autoimmune origin, affecting the skin and mucous membranes. While corticosteroids and immunosuppressants are traditionally used, many cases remain refractory or…
View article: Cutaneous and Lymphangitic Infection Caused by Purpureocillium lilacinum in Immunocompromised Patients: A Case Report with a Narrative Review of the Literature
Cutaneous and Lymphangitic Infection Caused by Purpureocillium lilacinum in Immunocompromised Patients: A Case Report with a Narrative Review of the Literature Open
Background: Purpureocillium lilacinum (P. lilacinum) is an emerging filamentous fungus known to cause opportunistic infections, particularly in immunocompromised patients. Formerly known as Paecilomyces lilacinus, this pathogen is widespre…
View article: Hormonal Therapies in Cosmetic Dermatology: Mechanisms, Clinical Applications, and Future Perspectives
Hormonal Therapies in Cosmetic Dermatology: Mechanisms, Clinical Applications, and Future Perspectives Open
Background: Hormonal fluctuations significantly influence skin physiology, affecting collagen production, sebum regulation, pigmentation, and tissue repair. Hormonal therapies are increasingly used in cosmetic dermatology to address age-re…
View article: Cosmeceuticals for Anti-Aging: Mechanisms, Clinical Evidence, and Regulatory Insights—A Comprehensive Review
Cosmeceuticals for Anti-Aging: Mechanisms, Clinical Evidence, and Regulatory Insights—A Comprehensive Review Open
Products with biologically active ingredients have emerged as a powerful category within the skincare and anti-aging sectors. Bridging the gap between pharmaceuticals and cosmetics, they offer therapeutic benefits supported by scientific e…
View article: Quality and duration of responses with mogamulizumab in cutaneous T‐cell lymphomas: Insights into long‐lasting outcomes
Quality and duration of responses with mogamulizumab in cutaneous T‐cell lymphomas: Insights into long‐lasting outcomes Open
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View article: Consider the unexpected! An overlooked, elusive, rare but dramatic diagnosis: anorectal melanoma
Consider the unexpected! An overlooked, elusive, rare but dramatic diagnosis: anorectal melanoma Open
Background: Anorectal melanoma (AM) is a rare and aggressive malignancy, often misdiagnosed due to its clinical resemblance to benign anorectal conditions. Early diagnosis remains challenging, with a poor prognosis and high rates of metast…
View article: Management of Erythrodermic Psoriasis with Systemic Therapies: A Systematic Review
Management of Erythrodermic Psoriasis with Systemic Therapies: A Systematic Review Open
View article: Postnatal determinants of testicular germ cell tumor by histological subtypes: The <scp>EPSAM1</scp> and <scp>EPSAM2</scp> studies
Postnatal determinants of testicular germ cell tumor by histological subtypes: The <span>EPSAM1</span> and <span>EPSAM2</span> studies Open
The EPSAM study is an ongoing case–control study evaluating the postnatal risk factors for testicular germ‐cell tumor (TGCT). We aimed at updating the risk estimates for factors identified in previous EPSAM analyses and studying heterogene…
View article: Dermoscopy of Melanoma According to Age Groups: A Retrospective Monocentric Study on 285 Patients
Dermoscopy of Melanoma According to Age Groups: A Retrospective Monocentric Study on 285 Patients Open
Background/Objectives: Melanoma is an aggressive skin cancer with increasing incidence worldwide. Dermoscopy has revolutionized early melanoma detection, but most studies have focused on the general adult population. This study aims to ana…
View article: European Organisation for Research and Treatment of Cancer, United States Cutaneous Lymphoma Consortium and International Society for Cutaneous Lymphomas consensus recommendations for management and treatment of cutaneous lymphoproliferative disorders
European Organisation for Research and Treatment of Cancer, United States Cutaneous Lymphoma Consortium and International Society for Cutaneous Lymphomas consensus recommendations for management and treatment of cutaneous lymphoproliferative disorders Open
In recent classifications several cutaneous lymphomas were reclassified as lymphoproliferative disorder (LPDs). These include primary cutaneous CD4+ small/medium T-cell LPD (PCSM-TCLPD), primary cutaneous acral CD8+ T-cell LPD (acral CD8+ …
View article: Effectiveness and Safety of Tildrakizumab in Elderly and Frail Elderly Psoriatic Patients Up to 2 years
Effectiveness and Safety of Tildrakizumab in Elderly and Frail Elderly Psoriatic Patients Up to 2 years Open
Tildrakizumab showed good safety and effectiveness at 2 years in the elderly population with or without frailty, confirming it as a possible treatment of choice in psoriatic patients with significant comorbidities and older frail patients …
View article: The Epidemiology of Syphilis Worldwide in the Last Decade
The Epidemiology of Syphilis Worldwide in the Last Decade Open
Background/Objectives: Syphilis, a re-emerging global public health issue, has shown increasing incidence over the past decade, particularly among key populations such as men who have sex with men (MSM), people living with HIV, and pregnan…
View article: Strahlentherapie bei kutanen Lymphomen: Empfehlungen der EORTC-Arbeitsgruppe für kutane Lymphome
Strahlentherapie bei kutanen Lymphomen: Empfehlungen der EORTC-Arbeitsgruppe für kutane Lymphome Open
Die Zahl der Patienten mit primär kutanem Lymphom, die eine niedrigdosierte Strahlentherapie erhalten, nimmt zu, obwohl kontrollierte klinische Studien zur Festlegung der Standard-Strahlendosis für jede spezifische Entität noch nicht abges…
View article: Drug survival, effectiveness and safety of risankizumab for moderate-to-severe psoriasis for up to 4 years
Drug survival, effectiveness and safety of risankizumab for moderate-to-severe psoriasis for up to 4 years Open
Background Numerous randomized controlled trials and real-life studies have shown risankizumab to be safe and effective for the treatment of psoriasis. However, real-life data on treatment for up to 4 years are lacking. Objectives We aimed…
View article: Impact of Disease Activity-Guided Dose Reduction on IL-17 and IL-23 Inhibitors in Psoriasis: A Real-World Assessment of Efficacy, Safety, and Economic Benefits
Impact of Disease Activity-Guided Dose Reduction on IL-17 and IL-23 Inhibitors in Psoriasis: A Real-World Assessment of Efficacy, Safety, and Economic Benefits Open
Introduction: Psoriasis is a chronic inflammatory multisystem disease for which IL-17 and IL-23 inhibitors have transformed treatment. However, high costs, and the possibility of overtreatment in patients with excellent and sustained respo…
View article: Advantages of Mohs Surgery in the Treatment of NMSC in the Head and Neck District
Advantages of Mohs Surgery in the Treatment of NMSC in the Head and Neck District Open
This narrative review examines the efficacy, cost-effectiveness, and aesthetic outcomes of Mohs micrographic surgery (MMS) compared to standard excision for treating non-melanoma skin cancers (NMSCs). A comprehensive literature search was …
View article: O11 A patchy prognosis: identification of prognostic factors associated with progression in early-stage mycosis fungoides and first-line treatment selection
O11 A patchy prognosis: identification of prognostic factors associated with progression in early-stage mycosis fungoides and first-line treatment selection Open
Advanced mycosis fungoides (MF) and Sézary syndrome typically have a poor prognosis of < 5 years’ survival. In addition, over 25% of patients with early-stage MF progress to having advanced disease. The current European Organisation for…
View article: Psoriasis vulgaris in patients with a recent history of neoplasia: safety of interleukin-23 inhibitors. A multicentre retrospective study
Psoriasis vulgaris in patients with a recent history of neoplasia: safety of interleukin-23 inhibitors. A multicentre retrospective study Open
Background The management of psoriasis in patients with a history of cancer remains debated, especially for the limited literature available. Given the lack of large, well-designed studies focused on this patient group, real-world clinical…
View article: Dose modulation strategies in patients with psoriasis: real-world comparison between secukinumab and brodalumab for up to 1 year after dose spacing
Dose modulation strategies in patients with psoriasis: real-world comparison between secukinumab and brodalumab for up to 1 year after dose spacing Open
Background Modulating the regimen of biologics is of increasing interest in patients with psoriasis. This includes dose reduction (de-escalation) and dose augmentation (escalation). De-escalation strategies include reducing the single ther…
View article: Germline Non-CDKN2A Variants in Melanoma and Associated Hereditary Cancer Syndromes
Germline Non-CDKN2A Variants in Melanoma and Associated Hereditary Cancer Syndromes Open
The etiology of melanoma is multifactorial and arises from the interplay of genetic, phenotypic, and environmental factors. The genetic predisposition to melanoma is influenced by a complex interaction among genes exhibiting varying levels…
View article: Combined immunotherapy with nivolumab and ipilimumab with and without sequential or concomitant stereotactic radiotherapy in patients with melanoma brain metastasis: An international retrospective study
Combined immunotherapy with nivolumab and ipilimumab with and without sequential or concomitant stereotactic radiotherapy in patients with melanoma brain metastasis: An international retrospective study Open
Our results suggest a better OS in patients who receive SRT plus COMBO, regardless of timing of SRT. Prospective studies are needed to validate our findings.
View article: Verlängerung der Dosierungsintervalle von IL‐17‐ und IL‐23‐Inhibitoren bei erwachsenen Patienten mit Psoriasis: eine Pilotstudie aus der Praxis
Verlängerung der Dosierungsintervalle von IL‐17‐ und IL‐23‐Inhibitoren bei erwachsenen Patienten mit Psoriasis: eine Pilotstudie aus der Praxis Open
Zusammenfassung Hintergrund und Ziele Deeskalationsstrategien für Biologika bei der Behandlung von Psoriasis sind in der klinischen Praxis weit verbreitet. Die Verlängerung des Dosierungsintervalls beinhaltet die Deeskalation der Zeitspann…
View article: 396 | ONGOING PHASE 2, OPEN‐LABEL, MULTICENTER, SINGLE‐ARM STUDY ASSESSING AN EVERY‐4‐WEEK DOSING SCHEDULE OF MOGAMULIZUMAB IN CUTANEOUS T‐CELL LYMPHOMA: PRELIMINARY RESULTS
396 | ONGOING PHASE 2, OPEN‐LABEL, MULTICENTER, SINGLE‐ARM STUDY ASSESSING AN EVERY‐4‐WEEK DOSING SCHEDULE OF MOGAMULIZUMAB IN CUTANEOUS T‐CELL LYMPHOMA: PRELIMINARY RESULTS Open