Roopika Menon
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View article: Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors Open
View article: Expanding Role of SBRT in Primary Bladder Cancer – Is It Ready for Prime Time?
Expanding Role of SBRT in Primary Bladder Cancer – Is It Ready for Prime Time? Open
View article: Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer
Somatic rearrangements causing oncogenic ectodomain deletions of FGFR1 in squamous cell lung cancer Open
The discovery of frequent 8p11-p12 amplifications in squamous cell lung cancer (SQLC) has fueled hopes that FGFR1, located inside this amplicon, might be a therapeutic target. In a clinical trial, only 11% of patients with 8p11 amplificati…
View article: Supplementary text from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary text from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Text for supplement: Supplementary methods, supplementary figure legends
View article: Supplementary Figures 1-11 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary Figures 1-11 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Supplementary Figures 1-11
View article: Supplementary Tables from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Supplementary Tables from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
XLSX file 75K, This is an excel file containing 9 sheets, one for each of the 9 supplementary tables (S1 to S9) mentioned in the main text
View article: Supplementary Figures from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Supplementary Figures from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
PDF file 234K, This is a file containing the list of supplementary tables, the list of supplementary figures, as well as the 7 supplementary figures (S1 to S7) and their correspondent legends, mentioned in the main text
View article: Data from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Data from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Small cell lung cancer (SCLC) patient-derived xenografts (PDX) can be generated from biopsies or circulating tumor cells (CTC), though scarcity of tissue and low efficiency of tumor growth have previously limited these approaches. Applying…
View article: Supplementary Figures 1-11 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary Figures 1-11 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Supplementary Figures 1-11
View article: Supplementary Tables S3-S8 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary Tables S3-S8 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Supplementary Tables S3-S8
View article: Data from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Data from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
We discovered a novel somatic gene fusion, CD74–NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional …
View article: Data from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Data from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Small cell lung cancer (SCLC) patient-derived xenografts (PDX) can be generated from biopsies or circulating tumor cells (CTC), though scarcity of tissue and low efficiency of tumor growth have previously limited these approaches. Applying…
View article: Data from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Data from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
We discovered a novel somatic gene fusion, CD74–NRG1, by transcriptome sequencing of 25 lung adenocarcinomas of never smokers. By screening 102 lung adenocarcinomas negative for known oncogenic alterations, we found four additional …
View article: Supplementary Tables S1-S2 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary Tables S1-S2 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Supplementary Tables S1-S2
View article: Supplementary Tables from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Supplementary Tables from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
XLSX file 75K, This is an excel file containing 9 sheets, one for each of the 9 supplementary tables (S1 to S9) mentioned in the main text
View article: Supplementary Tables S3-S8 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary Tables S3-S8 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Supplementary Tables S3-S8
View article: Supplementary Tables S1-S2 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary Tables S1-S2 from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Supplementary Tables S1-S2
View article: Supplementary text from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts
Supplementary text from Genomic and Functional Fidelity of Small Cell Lung Cancer Patient-Derived Xenografts Open
Text for supplement: Supplementary methods, supplementary figure legends
View article: Supplementary Figures from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma
Supplementary Figures from <i>CD74–NRG1</i> Fusions in Lung Adenocarcinoma Open
PDF file 234K, This is a file containing the list of supplementary tables, the list of supplementary figures, as well as the 7 supplementary figures (S1 to S7) and their correspondent legends, mentioned in the main text
View article: Supplementary Figures 1-5 from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer
Supplementary Figures 1-5 from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer Open
Supplementary Figure 1 Short Tandem Repeat Analysis for H1581 and DMS114 Cells; Supplementary Figure 2 Genomic Alteration Validation of NRAS and DUSP6; Supplementary Figure 3 Genomic Differences in DMS114 and DMS114_BGJp Cells; Supplementa…
View article: Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients
Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients Open
Purpose: We sought to investigate the clinical response to MET inhibition in patients diagnosed with structural MET alterations and to characterize their functional relevance in cellular models.Experimental Design: Patients w…
View article: Supplementary Figures 1-5 from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer
Supplementary Figures 1-5 from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer Open
Supplementary Figure 1 Short Tandem Repeat Analysis for H1581 and DMS114 Cells; Supplementary Figure 2 Genomic Alteration Validation of NRAS and DUSP6; Supplementary Figure 3 Genomic Differences in DMS114 and DMS114_BGJp Cells; Supplementa…
View article: Supplementary Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients
Supplementary Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients Open
Supplementary Methods Supplementary Figure S1. Characterization of KIF5B- and STARD3NL-MET rearrangements. A) IGV screenshots of next-generation sequencing reads from breakpoint regions of KIF5B- and STARD3NL-MET positive patient tissue. D…
View article: Supplementary Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients
Supplementary Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients Open
Supplementary Methods Supplementary Figure S1. Characterization of KIF5B- and STARD3NL-MET rearrangements. A) IGV screenshots of next-generation sequencing reads from breakpoint regions of KIF5B- and STARD3NL-MET positive patient tissue. D…
View article: Data from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer
Data from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer Open
Purpose: The 8p12-p11 locus is frequently amplified in squamous cell lung cancer (SQLC); the receptor tyrosine kinase fibroblast growth factor receptor 1 (FGFR1) being one of the most prominent targets of this amplification. Thus, s…
View article: Data from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer
Data from Mechanisms of Primary Drug Resistance in <i>FGFR1</i>-Amplified Lung Cancer Open
Purpose: The 8p12-p11 locus is frequently amplified in squamous cell lung cancer (SQLC); the receptor tyrosine kinase fibroblast growth factor receptor 1 (FGFR1) being one of the most prominent targets of this amplification. Thus, s…
View article: Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients
Data from Structural Alterations of MET Trigger Response to MET Kinase Inhibition in Lung Adenocarcinoma Patients Open
Purpose: We sought to investigate the clinical response to MET inhibition in patients diagnosed with structural MET alterations and to characterize their functional relevance in cellular models.Experimental Design: Patients w…
View article: Clinical Impact of Immune Checkpoint Inhibitor (ICI) Response, DNA Damage Repair (DDR) Gene Mutations and Immune-Cell Infiltration in Metastatic Melanoma Subtypes
Clinical Impact of Immune Checkpoint Inhibitor (ICI) Response, DNA Damage Repair (DDR) Gene Mutations and Immune-Cell Infiltration in Metastatic Melanoma Subtypes Open
Molecular and histopathological analysis of melanoma subtypes has revealed distinct epidemiological, genetic, and clinical features. However, immunotherapy for advanced metastatic melanoma patients does not differ based on subtype. Respons…
View article: Cell-free tumor DNA, CA125 and HE4 for the objective assessment of tumor burden in patients with advanced high-grade serous ovarian cancer
Cell-free tumor DNA, CA125 and HE4 for the objective assessment of tumor burden in patients with advanced high-grade serous ovarian cancer Open
Background The present prospective study aimed at determining the impact of cell-free tumor DNA (ct-DNA), CA125 and HE4 from blood and ascites for quantification of tumor burden in patients with advanced high-grade serous epithelial ovaria…
View article: Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing
Neuroblastoma Risk Assessment and Treatment Stratification with Hybrid Capture-Based Panel Sequencing Open
For many years, the risk-based therapy stratification of children with neuroblastoma has relied on clinical and molecular covariates. In recent years, genome analysis has revealed further alterations defining risk, tumor biology, and thera…