Ryan P. O’Connell
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View article: Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma
Format-tuning of in vivo-launched bispecific T cell engager enhances efficacy against renal cell carcinoma Open
Background Advanced clear cell renal cell carcinoma (ccRCC) is a prevalent kidney cancer for which long-term survival rates are abysmal, though immunotherapies are showing potential. Not yet clinically vetted are bispecific T cell engagers…
View article: Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy Open
In the absence of cell surface cancer-specific antigens, immunotherapies such as chimeric antigen receptor (CAR) T cells, monoclonal antibodies, or bispecific T cell engagers typically target lineage antigens. Currently, such immunotherapi…
View article: Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape
Multivalent in vivo delivery of DNA-encoded bispecific T cell engagers effectively controls heterogeneous GBM tumors and mitigates immune escape Open
View article: A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy
A mAb against surface-expressed FSHR engineered to engage adaptive immunity for ovarian cancer immunotherapy Open
Despite advances in ovarian cancer (OC) therapy, recurrent OC remains a poor-prognosis disease. Because of the close interaction between OC cells and the tumor microenvironment (TME), it is important to develop strategies that target tumor…
View article: In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme
In vivo DNA-launched bispecific T cell engager targeting IL-13Rα2 controls tumor growth in an animal model of glioblastoma multiforme Open
Glioblastoma is an aggressive tumor with poor survival rates. Bispecific T cell engagers (BTEs) against different cancers are in various stages of clinical development. Toxicity resulting from cytokine release syndrome and the short half-l…
View article: Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk
Abnormal myocardial expression of SAP97 is associated with arrhythmogenic risk Open
The gene encoding SAP97 ( DLG1) joins a growing list of genes encoding ion channel interacting proteins (ChIPs) identified as potential channelopathy-susceptibility genes because of their ability to regulate the trafficking, targeting, and…
View article: Functionally conservative substitutions at cardiac troponin I S43/45
Functionally conservative substitutions at cardiac troponin I S43/45 Open
View article: Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular Architecture
Free Fatty Acid Effects on the Atrial Myocardium: Membrane Ionic Currents Are Remodeled by the Disruption of T-Tubular Architecture Open
SA disrupts t-tubular architecture and remodels properties of membrane ionic currents in sheep atrial myocytes, with potential implications in arrhythmogenesis.