Rajeshwar P. Sinha
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View article: Screening mycosporine-like amino acids (MAAs) as potential inhibitors of a malaria-associated cysteine protease falcipain-2
Screening mycosporine-like amino acids (MAAs) as potential inhibitors of a malaria-associated cysteine protease falcipain-2 Open
The results derived from these studies on FP2 inhibition by MAAs suggest that these metabolites possess a significant antimalarial activity by impeding the target enzyme's active site, thereby providing significant insights in playing cruc…
View article: Antioxidant profiling of cyanobacterial bioactive compounds
Antioxidant profiling of cyanobacterial bioactive compounds Open
Antioxidant compounds may be useful as dietary supplements that protect from oxidative stress-related diseases. Different organisms produce antioxidants as a defense mechanism to counteract the damaging effects of free radicals. Reactive o…
View article: Cyanobacteria as a Biocatalyst for Sustainable Production of Biofuels and Chemicals
Cyanobacteria as a Biocatalyst for Sustainable Production of Biofuels and Chemicals Open
The combustion of fossil fuels constitutes a significant catalyst for climate change, resulting in the annual release of about two billion tonnes of carbon dioxide (CO2). The increase in CO2 emission is directly linked to a heightened occu…
View article: The Radiant World of Cyanobacterial Phycobiliproteins: Examining Their Structure, Functions, and Biomedical Potentials
The Radiant World of Cyanobacterial Phycobiliproteins: Examining Their Structure, Functions, and Biomedical Potentials Open
Phycobiliproteins (PBPs) are accessory light-harvesting pigment complexes found in cyanobacteria, red algae, and certain types of cryptophytes. The unique spectral features (strong absorbance and fluorescence), proteinaceous nature, and so…
View article: Algal biofertilizers as plant growth stimulants for sustainable agriculture
Algal biofertilizers as plant growth stimulants for sustainable agriculture Open
Population of the Earth has been projected to reach ~9.7 billion by 2050 and Asia and Africa would be the major contributors to this enhanced population. This increased population is directly related with higher demand of food security in …
View article: Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress
Resilience and Mitigation Strategies of Cyanobacteria under Ultraviolet Radiation Stress Open
Ultraviolet radiation (UVR) tends to damage key cellular machinery. Cells may adapt by developing several defence mechanisms as a response to such damage; otherwise, their destiny is cell death. Since cyanobacteria are primary biotic compo…
View article: Cyanobacterial Biofuel: A Platform for Green Energy
Cyanobacterial Biofuel: A Platform for Green Energy Open
Cyanobacteria have great potential as a platform for biofuel production because of their fast growth, ability to fix CO2 gas, and genetic tractability. They also preserve the sustainability of an ecosystem without harming the en…
View article: Application of Synthetic Biology Approaches to High-Yield Production of Mycosporine-like Amino Acids
Application of Synthetic Biology Approaches to High-Yield Production of Mycosporine-like Amino Acids Open
Ultraviolet (UV) radiation reaching the Earth’s surface is a major societal concern, and therefore, there is a significant consumer demand for cosmetics formulated to mitigate the harmful effects of UV radiation. Synthetic sunscreens being…
View article: Recent Developments and Future Perspectives of Vaccines and Therapeutic Agents against SARS-CoV2 Using the BCOV_S1_CTD of the S Protein
Recent Developments and Future Perspectives of Vaccines and Therapeutic Agents against SARS-CoV2 Using the BCOV_S1_CTD of the S Protein Open
Since the onset of the coronavirus disease 2019 (COVID-19) pandemic, the virus kept developing and mutating into different variants over time, which also gained increased transmissibility and spread in populations at a higher pace, culmina…
View article: Novel Antiviral Therapeutic Against SARS-CoV-2 and its Variants: Recent Developments and Future Perspectives
Novel Antiviral Therapeutic Against SARS-CoV-2 and its Variants: Recent Developments and Future Perspectives Open
Since the onset of coronavirus disease 2019 (COVID-19) pandemic, the virus kept developing and mutating into different variants over time that also gained increased transmissibility and spread in populations at a higher pace, culminating i…
View article: Influence of Microorganisms on Thermal Conductivity of Soils and its Potential Impact on Soil Aggregation
Influence of Microorganisms on Thermal Conductivity of Soils and its Potential Impact on Soil Aggregation Open
Thermal conductivity of soil is one of the phenomenon which measure the amount of heat passing per cross-sectional area. Thermal conductivity of soils depends on various factors. In this study the influence of presence of Microorganisms on…
View article: Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging
Natural Sun-Screening Compounds and DNA-Repair Enzymes: Photoprotection and Photoaging Open
Ultraviolet radiation (UVR) has been scientifically proven to cause skin disorders such as sunburn, skin cancer and the symptoms of chronic exposure. Natural sun screening compounds have recently gained tremendous attention from the cosmet…
View article: Evolutionary aspects of mutation in functional motif and post-translational modifications in SARS-CoV-2 3CLpro (Mpro): an in-silico study
Evolutionary aspects of mutation in functional motif and post-translational modifications in SARS-CoV-2 3CLpro (Mpro): an in-silico study Open
View article: Collegial Effects of Salt and Ultraviolet Radiation on Rice-Field Cyanobacterium Nostochopsis lobatus HKAR-21
Collegial Effects of Salt and Ultraviolet Radiation on Rice-Field Cyanobacterium Nostochopsis lobatus HKAR-21 Open
Cyanobacteria are a primitive group of photosynthetic oxygen-evolving, Gram-negative prokaryotes. Similar to eukaryotic algae and higher plants, it engages in photosynthesis-dependent oxygen evolution with water as a proton source. Cyanoba…
View article: Therapeutic Strategies against Biofilm Infections
Therapeutic Strategies against Biofilm Infections Open
A biofilm is an aggregation of surface-associated microbial cells that is confined in an extracellular polymeric substance (EPS) matrix. Infections caused by microbes that form biofilms are linked to a variety of animals, including insects…
View article: Extraction and Purification of Lectin from Soybean Seeds (Glycine max)
Extraction and Purification of Lectin from Soybean Seeds (Glycine max) Open
In this study, the effectiveness of the ion exchange column packed with anionic resin DEAE-Sephadex®-A-50 in purifying lectin isolated by conventional saline buffer method was investigated. After the lectin extraction, the purification eff…
View article: Exploration of Novel Lichen Compounds as Inhibitors of SARS-CoV-2 Mpro: Ligand-Based Design, Molecular Dynamics, and ADMET Analyses
Exploration of Novel Lichen Compounds as Inhibitors of SARS-CoV-2 Mpro: Ligand-Based Design, Molecular Dynamics, and ADMET Analyses Open
View article: Identification of Cyanobacteria-Based Natural Inhibitors Against SARS-CoV-2 Druggable Target ACE2 Using Molecular Docking Study, ADME and Toxicity Analysis
Identification of Cyanobacteria-Based Natural Inhibitors Against SARS-CoV-2 Druggable Target ACE2 Using Molecular Docking Study, ADME and Toxicity Analysis Open
View article: Responses of antioxidants for resilience to temporal variations in the cyanobacterium Microcystis aeruginosa
Responses of antioxidants for resilience to temporal variations in the cyanobacterium Microcystis aeruginosa Open
The responses of antioxidants and photosynthetic pigments to temporal variations in the bloom- forming cyanobacterium Microcystis aeruginosa dominating the eutrophic pond were investigated. Native-PAGE of superoxide dismutase (SOD) enzyme …
View article: Cyanobacterial Blooms and Their Implications in the Changing Environment
Cyanobacterial Blooms and Their Implications in the Changing Environment Open
Cyanobacteria are the most ancient phytoplankton that first appeared at least 2.5 billion years ago and have a prolonged evolutionary history. They can form impenetrable and toxic blooms in aquatic ecosystems such as freshwater and marine …
View article: Diagnostic Approaches for Covid-19: Present Status and Future Prospects
Diagnostic Approaches for Covid-19: Present Status and Future Prospects Open
During this COVID-19 outbreak, diagnostic tests were crucial in controlling its spread. This pandemic, which was caused by the SARS-CoV-2 virus, has created an urgent need for rapid diagnostic testing to enable efficient treatment and cont…
View article: UV-induced physiological changes and biochemical characterization of mycosporine-like amino acid in a rice-field cyanobacterium Fischerella sp. strain HKAR-13
UV-induced physiological changes and biochemical characterization of mycosporine-like amino acid in a rice-field cyanobacterium Fischerella sp. strain HKAR-13 Open
Mycosporine-like amino acids (MAAs) are valuable secondary metabolite with notable photoprotective potential. The present study investigateS the imрасts of рhоtоsynthetiс асtive rаdiаtiоn (РАR) and ultraviolet radiation (UVR) on various ph…
View article: Development of a colloidal Gold nanoparticle-based lateral-flow assay for rapid detection of SARS-CoV-2 showing enhanced sensitivity and specificity
Development of a colloidal Gold nanoparticle-based lateral-flow assay for rapid detection of SARS-CoV-2 showing enhanced sensitivity and specificity Open
Astaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive reviewJinu Medhi, Mohan Chandra Kalita
View article: Computational studies on photolyase (Phr) proteins of cyanobacteria
Computational studies on photolyase (Phr) proteins of cyanobacteria Open
Photolyases (Phrs) are enzymes that utilize the blue/ultraviolet (UV-A) region of light for repairing UV-induced cyclopyramidine dimers. We studied Phr groups by bioinformatic analyses as well as active-site and structural modeling. Analys…
View article: Ultraviolet Radiation and Salinity-Induced Physiological Changes and Scytonemin Induction in Cyanobacteria Isolated from Diverse Habitats
Ultraviolet Radiation and Salinity-Induced Physiological Changes and Scytonemin Induction in Cyanobacteria Isolated from Diverse Habitats Open
A novel series of transition metal (II) complexes (5a-h) were conveniently synthesized via reaction of important transition metals (Co, Cu, Zn, Ni) with (E)-N-(4-methylbenzylidene)-2-((Z)-(4-methylbenzylidene)amino)benzamide Schiff base (3…
View article: Synthesis and Characterization of Gold Nanoparticles from Nostoc sp. strain HKAR-2 and their In Vitro Antibacterial, Antifungal, and Antitumor Potentials
Synthesis and Characterization of Gold Nanoparticles from Nostoc sp. strain HKAR-2 and their In Vitro Antibacterial, Antifungal, and Antitumor Potentials Open
In the present study, gold nanoparticles (AuNPs) have been synthesized through biological methods using the cell-free extracts of cyanobacterium Nostoc sp. strain HKAR-2 isolated from the hot spring of India. To determine morphological, st…
View article: Novel Coronavirus (2019-nCoV) pandemic: How Far or How Close is the Solution?
Novel Coronavirus (2019-nCoV) pandemic: How Far or How Close is the Solution? Open
Novel coronavirus (2019-nCoV) is a transmissible disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was first identified in December 2019 in the capital of China's Hubei province, Wuhan. It has spre…
View article: BIOPROSPECTION OF UV-SCREENING COMPOUNDS FROM LICHENS INHABITING THE INDIAN STATE OF SIKKIM
BIOPROSPECTION OF UV-SCREENING COMPOUNDS FROM LICHENS INHABITING THE INDIAN STATE OF SIKKIM Open
Lichens show mutualistic relationship between algae/cyanobacteria and fungi and are found in diverse environmental conditions ranging from sea levels to high alpine elevations. They can tolerate and survive in harsh environmental condition…
View article: Responses of a hot spring cyanobacterium under ultraviolet and photosynthetically active radiation: photosynthetic performance, antioxidative enzymes, mycosporine-like amino acid profiling and its antioxidative potentials
Responses of a hot spring cyanobacterium under ultraviolet and photosynthetically active radiation: photosynthetic performance, antioxidative enzymes, mycosporine-like amino acid profiling and its antioxidative potentials Open
View article: Mycosporine-like Amino Acids and Antioxidative Enzymes Activity in Acytonema SP. under Cumulative Stress of UV Radiation and Salinity
Mycosporine-like Amino Acids and Antioxidative Enzymes Activity in Acytonema SP. under Cumulative Stress of UV Radiation and Salinity Open
We have studied the cumulative effects of ultraviolet radiation (UVR), photosynthetically active radiation (PAR), and varying concentrations of NaCl (50, 150 and 200 mM) on the induction of mycosporine-like amino acids (MAAs) and antioxida…