Explanipedia

Multitarget-Directed Multiple Ligands in Anti-VEGF Resistant Glioblastoma Therapeutics: An in Silico Approach to Identify Potential Phytochemicals Open

Kesavan R. Arya, Sasikumar J. Soumya, Anuroopa G. Nadh, Thankamani R. Aswathy, B Vijayalakshmi , et al. · 2025

Angiogenesis is an important process in tumor progression. Vascular endothelial growth factor (VEGF) is the key factor regulating angiogenesis, and hence, anti-VEGF therapy is considered a useful therapeutic approach in tumor conditions. H…

Multi-target and natural product-based multi-drug approach for anti-VEGF resistance in glioblastoma Open

Sasikumar J. Soumya, Kesavan R. Arya, Chandran S. Abhinand, P. Sunitha, A. P. Athira , et al. · 2024

Glioblastoma (GBM) remains a formidable challenge in neuro-oncology due to its aggressive nature and propensity for therapeutic resistance. Anti-vascular endothelial growth factor (VEGF) therapies, although promising, often encounter resis…

Designing Lsa46-Based Multi-Epitope Peptide Vaccine Against Leptospirosis: Immunoinformatic Approach Open

Junaida M. Ibrahim, Padikara Kutty Satheeshkumar, Achuthsankar S. Nair, Oommen V. Oommen, P. R. Sudhakaran · 2024

Leptospirosis represents a significant global public health problem due to its epidemiological impact, complex pathogen biology, and diverse clinical manifestations. Effective treatment, management, and preventive measures, including vacci…

Temporal phosphoproteomic analysis of VEGF-A signaling in HUVECs: an insight into early signaling events associated with angiogenesis Open

Chandran S. Abhinand, Josephine Galipon, Masaru Mori, Poornima Ramesh, Thottethodi Subrahmanya Keshava Prasad , et al. · 2023

Vascular endothelial growth factor-A (VEGF-A) is one of the primary factors promoting angiogenesis in endothelial cells. Although defects in VEGF-A signaling are linked to diverse pathophysiological conditions, the early phosphorylation-de…

Intermittent cold exposure upregulates regulators of cardiac mitochondrial biogenesis and function in mice Open

Mithra Sudha Mohan, Aswani Sukumaran Sreedevi, Aparna Nandakumaran Sakunthala, Puthenpura T. Boban, P. R. Sudhakaran , et al. · 2023

Hypothermic conditions enhance the incidence of cardiovascular diseases due to increased blood pressure. Cold-induced adaptive thermogenesis increased mitochondrial biogenesis and function in skeletal muscles and adipocytes. Here, we studi…

In silico screening and epitope mapping of leptospiral outer membrane protein—Lsa46 Open

Junaida M. Ibrahim, A. Shanitha, Achuthsankar S. Nair, Oommen V. Oommen, P. R. Sudhakaran · 2022

Leptospirosis is one of the neglected diseases caused by the spirochete, Leptospira interrogans. Leptospiral surface adhesion (Lsa) proteins are surface exposed outer membrane proteins present in the pathogen. It acts as laminin and…

SARS-CoV-2 variants infectivity prediction and therapeutic peptide design using computational approaches Open

Chandran S. Abhinand, Athira A. Prabhakaran, Anand Krishnamurthy, Rajesh Raju, Thottethodi Subrahmanya Keshava Prasad , et al. · 2022

The outbreak of severe acute respiratory coronavirus 2 (SARS-CoV-2) has created a public health emergency globally. SARS-CoV-2 enters the human cell through the binding of the spike protein to human angiotensin converting enzyme 2 (ACE2) r…

Black Palm Squirrel (Funambulus palmarum Linn.) from India: Association with a Frame Shift Mutation in the MC1R Gene Open

Dileepkumar Raveendran, K. Anaswara, V. Navya, S. Beena, A. E. Jacob , et al. · 2021

This study shows that the dominant mutation of Extension locus in the recessive locus of the agouti Indian three-striped palm squirrel results in constituting an active or hyperactive receptor.This is not inhibited by the agouti antagonist…

Identification of Hub Genes and Key Pathways Associated with Anti-VEGF Resistant Glioblastoma Using Gene Expression Data Analysis Open

Kesavan R. Arya, Ramachandran P. Bharath Chand, Chandran S. Abhinand, Achuthsankar S. Nair, Oommen V. Oommen , et al. · 2021

Anti-VEGF therapy is considered to be a useful therapeutic approach in many tumors, but the low efficacy and drug resistance limit its therapeutic potential and promote tumor growth through alternative mechanisms. We reanalyzed the gene ex…

Potential protease inhibitors and their combinations to block SARS-CoV-2 Open

Chandran S. Abhinand, Achuthsankar S. Nair, Anand Krishnamurthy, Oommen V. Oommen, P. R. Sudhakaran · 2020

COVID-19, which has emerged recently as a pandemic viral infection caused by SARS-coronavirus 2 has spread rapidly around the world, creating a public health emergency. The current situation demands an effective therapeutic strategy to con…

Multiple Targets Directed Multiple Ligands: An In Silico and In Vitro Approach to Evaluating the Effect of Triphala on Angiogenesis Open

Chandran S. Abhinand, P Athira, Sasikumar J. Soumya, P. R. Sudhakaran · 2020

Angiogenesis is critical in both physiological and pathological conditions and targeting angiogenesis is a promising strategy for the development of therapies against cancer; however, cells develop resistance to anti-angiogenic therapy, ne…

Temporal VEGFA responsive genes in HUVECs: Gene signatures and potential ligands/receptors fine-tuning angiogenesis Open

P. Sunitha, Rajesh Raju, C. K. Sajil, Chandran S. Abhinand, Achuthsankar S. Nair , et al. · 2019

Vascular Endothelial Growth Factor-A (VEGFA) signaling is crucial to the cellular processes involved in angiogenesis. Previously, we assembled a network of molecular reactions induced by VEGFA in human umbilical vein endothelial cell popul…

Value of VKORC1 (−1639G>A) rs9923231 genotyping in predicting warfarin dose: A replication study in South Indian population Open

S Harikrishnan, Linda Koshy, Ram Subramanian, G. Sanjay, Chithra Vineeth , et al. · 2018

Expression of Leptospira membrane proteins Signal Peptidase (SP) and Leptospira Endostatin like A (Len A) in BL-21(DE3) is toxic to the host cells Open

Padikara Kutty Satheeshkumar, Prasannan V. Anu, Mohmed I. Junaida, Madathiparambil Gopalakrishnan Madanan, Tennison Jebasingh , et al. · 2018

Heterologous expression of Integral Membrane Proteins (IMPs) is reported to be toxic to the host system in many studies. Even though there are reports on various concerns like transformation efficiency, growth properties, protein toxicity,…

Identification of genes responsible for anti-VEGF resistance in tumor cells Open

Kesavan R. Arya, Achuthsankar S. Nair, P. R. Sudhakaran · 2017

Angiogenesis is the process of formation of new blood vessels from pre-existing vessels, which plays a key role in physiological as well as pathological conditions. It is a tightly regulated process involving the interplay of a number of p…

Identification of differentially expressed snoRNAs in Ovarian Cancer from RNA-Seq data Open

P. Sunitha, Jiffy John, Prathwiraj Umesh, Sugunan V.S., Oommen V. Oommen , et al. · 2017

Non-coding RNAs (ncRNAs) are a large class of important regulatory molecules involved in many physiological and cellular processes. Small nucleolar RNAs (snoRNAs), a subset of the small ncRNAs, are molecules located in the cell nucleolus. …

VEGF-A/VEGFR2 signaling network in endothelial cells relevant to angiogenesis Open

Chandran S. Abhinand, Rajesh Raju, Sasikumar J. Soumya, Prabha S. Arya, P. R. Sudhakaran · 2016

Vascular endothelial growth factor-A (VEGF-A) is essential for endothelial cell functions associated with angiogenesis. Signal transduction networks initiated by VEGFA/VEGFR2, the most prominent ligand-receptor complex in the VEGF system, …

ANTI-HEPATOTOXIC PROPERTY OF ROOTS AND LEAVES OF CHASSALIA CURVIFLORA (WALL.) THWAITES AGAINST CCL4 INDUCED LIVER DAMAGE IN RATS Open

G. Rajeswari Gopal, G. I. Anuja, P. Latha, A. Jayakumaran Nair, A. Gangaprasad , et al. · 2016

In the present study the roots and leaf ethanolic extracts of Chassalia curviflora were screened for their anti hepatotoxic and anti oxidant effects in experimentally induced liver injury by carbon tetra chloride. Liver serum marker enzyme…

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