Lionel Rostaing
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View article: Outcome of hemodialysis patients in one poorest country in the world: the Zinder experience.
Outcome of hemodialysis patients in one poorest country in the world: the Zinder experience. Open
Background/Objectives Chronic hemodialysis therapy is a well-recognized supportive therapy for patients with end-stage kidney disease. However, this therapy is poorly implemented in low-income countries due to its high cost. We herein repo…
View article: Optimizing HLA desensitization: serum dilution strategies and platform-specific MFI thresholds for antibody-mediated rejection risk in kidney transplantation
Optimizing HLA desensitization: serum dilution strategies and platform-specific MFI thresholds for antibody-mediated rejection risk in kidney transplantation Open
Introduction Highly sensitized kidney transplant (KT) candidates are at increased risk of antibody-mediated rejection (ABMR), particularly in the context of desensitization protocols. Accurate quantification of donor-specific antibodies (D…
View article: The Effectiveness of a Sofosbuvir/Daclatasvir Combination in the Treatment of HCV Infection in Patients from Mauritania Undergoing Chronic Hemodialysis
The Effectiveness of a Sofosbuvir/Daclatasvir Combination in the Treatment of HCV Infection in Patients from Mauritania Undergoing Chronic Hemodialysis Open
Background and Objectives: Hepatitis C virus (HCV) infection is highly prevalent among patients undergoing chronic hemodialysis in emerging countries and is associated with significant morbidity and mortality in this population. The object…
View article: Use of HLA desensitization in the management of renal transplant recipients in Europe
Use of HLA desensitization in the management of renal transplant recipients in Europe Open
A significant challenge in kidney transplantation is overcoming immunological barriers such as human leukocyte antigen (HLA) incompatibilities. The presence of anti-HLA antibodies in the transplant candidate is referred to as HLA sensitiza…
View article: From Pandemic to Resistance: Addressing Multidrug-Resistant Urinary Tract Infections in the Balkans
From Pandemic to Resistance: Addressing Multidrug-Resistant Urinary Tract Infections in the Balkans Open
Background/Objectives: The rise in urinary tract infections caused by multidrug-resistant (MDR) bacteria presents a serious public health challenge across the Balkans, a region already burdened by aging populations, healthcare resource lim…
View article: Identification of Donor–recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study
Identification of Donor–recipient Interactions for a Relative Appraisal of Kidney Graft Marginality: A French Multicentric Cohort-based Study Open
Background. Kidney marginality criteria consider the impact of donor characteristics on graft failure risk. To evaluate graft quality according to both the donor and recipient, we identified recipient characteristics that may modify the pr…
View article: Antibody-mediated rejection—treatment standard
Antibody-mediated rejection—treatment standard Open
Antibody-mediated rejection (AMR) remains a major cause of graft failure, with significant health and economic burden. Despite being recognized >25 years ago, AMR treatment remains unstandardized, and no therapy has gained robust regula…
View article: Summary Report of the CTS-TIREX Expert Meeting 2024 “Innovative Approaches to Immunogenetics and Organ Transplantation”
Summary Report of the CTS-TIREX Expert Meeting 2024 “Innovative Approaches to Immunogenetics and Organ Transplantation” Open
View article: Impact of Corticosteroid-Free Regimen on Interstitial Fibrosis Following Kidney Transplantation
Impact of Corticosteroid-Free Regimen on Interstitial Fibrosis Following Kidney Transplantation Open
View article: Impact of tacrolimus on interferon gamma ELISpot assay results for the assessment of T-cell immunity: Proof-of-concept
Impact of tacrolimus on interferon gamma ELISpot assay results for the assessment of T-cell immunity: Proof-of-concept Open
SOT patients require immunosuppressors to avoid graft rejection. Therapeutic drug monitoring is insufficient to find the optimal balance with immunosuppression. The evaluation of cell-mediated immunity by enzyme-linked immunospot (ELISpot)…
View article: Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for <i>CYP3A5</i>-polymorphism in kidney-transplant recipients
Predictive value of tacrolimus concentration/dose ratio in first post-transplant week for <i>CYP3A5</i>-polymorphism in kidney-transplant recipients Open
BACKGROUND Tacrolimus (TAC) is metabolized primarily by the CYP3A -encoded enzyme family (CYP3A4 , CYP3A5 , and CYP3A7 ). Individuals expressing the CYP3A51 allele are considered fast metabolizers and generally require higher TAC doses to …
View article: Urinary Tract Infections Caused by Klebsiella pneumoniae and Prolonged Treatment with Trimethoprim/Sulfamethoxazole
Urinary Tract Infections Caused by Klebsiella pneumoniae and Prolonged Treatment with Trimethoprim/Sulfamethoxazole Open
Urinary tract infections (UTIs) are among the most prevalent bacterial infections, with Klebsiella pneumoniae emerging as a significant multidrug-resistant pathogen, particularly in healthcare settings. The frequent utilization of β-lactam…
View article: Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR
Enhancing individual glomerular filtration rate assessment: can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR Open
View article: Life beyond antibodies: quality of life after desensitization in kidney transplantation
Life beyond antibodies: quality of life after desensitization in kidney transplantation Open
International audience
View article: Effectiveness of complement inhibitors against refractory antibody-mediated rejection of lung transplantation: Two clinical cases
Effectiveness of complement inhibitors against refractory antibody-mediated rejection of lung transplantation: Two clinical cases Open
Antibody-mediated rejection (AMR) has been recognized as a significant cause of acute and chronic lung allograft dysfunction after lung transplantation. Some treatments, eculizumab, an anti-complement (C)5 component monoclonal antibody (Ma…
View article: Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants
Timing of rejection events preceded by Covid-19 mRNA vaccination in recipients of solid organ transplants Open
SARS-CoV-2 mRNA vaccination is unlikely to trigger rejection in SOT recipients.
View article: Integrating Clinical and Histopathological Data to Predict Delayed Graft Function in Kidney Transplant Recipients Using Machine Learning Techniques
Integrating Clinical and Histopathological Data to Predict Delayed Graft Function in Kidney Transplant Recipients Using Machine Learning Techniques Open
Background: Given the significant impact of delayed graft function (DGF) on transplant outcomes, the aim of this study was to develop and validate machine learning (ML) models capable of predicting the risk of DGF in deceased-donor kidney …
View article: Outcomes of ABO-incompatible kidney transplants with very high isoagglutinin titers: a single-center experience and literature review
Outcomes of ABO-incompatible kidney transplants with very high isoagglutinin titers: a single-center experience and literature review Open
Background ABO-incompatible kidney transplantation (ABOi-KTx) represents a possible solution to address the shortage of kidney donors. However, these transplants present immunological challenges, particularly when isoagglutinin titers are …
View article: Corrigendum: Glycolysis Changes in Alloreactive Memory B Cells in Highly Sensitized Kidney Transplant Recipients Undergoing Desensitization Therapy
Corrigendum: Glycolysis Changes in Alloreactive Memory B Cells in Highly Sensitized Kidney Transplant Recipients Undergoing Desensitization Therapy Open
[This corrects the article DOI: 10.3389/ti.2024.13029.].
View article: Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate
Comparison between the EKFC-equation and machine learning models to predict Glomerular Filtration Rate Open
View article: Early screening for chronic liver disease: impact of a FIB-4 first integrated care pathway to identify patients with significant fibrosis
Early screening for chronic liver disease: impact of a FIB-4 first integrated care pathway to identify patients with significant fibrosis Open
View article: Estimating glomerular filtration in young people
Estimating glomerular filtration in young people Open
Background Creatinine-based equations are the most used to estimate glomerular filtration rate (eGFR). The Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI), the re-expressed Lund-Malmö Revised (r-LMR) and the European Kidney Fun…
View article: SLC34 mutation: Personal experience with six families and literature review
SLC34 mutation: Personal experience with six families and literature review Open
Background Mutations in SLC34A1 and SLC34A2 genes, which encode co-transporters NaPi2a and NaPi2c, respectively, can lead hypophosphatemia due to renal phosphate loss. This condition results in hypercalcitriolemia and hypercalciuria, leadi…
View article: A Randomized Trial Comparing Imlifidase to Plasmapheresis in Kidney Transplant Recipients With Antibody‐Mediated Rejection
A Randomized Trial Comparing Imlifidase to Plasmapheresis in Kidney Transplant Recipients With Antibody‐Mediated Rejection Open
Background Antibody‐mediated rejection (ABMR) poses a barrier to long‐term graft survival and is one of the most challenging events after kidney transplantation. Removing donor specific antibodies (DSA) through therapeutic plasma exchange …
View article: Immunoadsorption and Plasma Exchange are Comparable in Anti-Neutrophil Cytoplasmic Antibodies or Anti-Glomerular Basement Membrane Removal Kinetics
Immunoadsorption and Plasma Exchange are Comparable in Anti-Neutrophil Cytoplasmic Antibodies or Anti-Glomerular Basement Membrane Removal Kinetics Open
View article: Calcium-Free Dialysate Hemodialysis: A Simplified Approach
Calcium-Free Dialysate Hemodialysis: A Simplified Approach Open
Intermittent hemodialysis (HD) in high-bleeding-risk patients presents a challenge as circuit anticoagulation using heparin is contraindicated in such cases. Recently, the use of calcium-free citrate-containing dialysate with calcium suppl…
View article: Unraveling complexity: morbidity factors in elderly kidney transplant recipients
Unraveling complexity: morbidity factors in elderly kidney transplant recipients Open
Background The rising prevalence of end-stage renal failure in the elderly has led to an increased number of kidney transplantations in older individuals. While age does not solely determine transplant eligibility, frailty in elderly recip…
View article: Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) for Patients—3-Year Follow-Up of Patients with Chronic Kidney Disease
Post-Acute Sequelae of SARS-CoV-2 Infection (PASC) for Patients—3-Year Follow-Up of Patients with Chronic Kidney Disease Open
Post-acute sequelae of SARS-CoV-2 (PASC) is a significant health concern, particularly for patients with chronic kidney disease (CKD). This study investigates the long-term outcomes of individuals with CKD who were infected with COVID-19, …
View article: Impact of donor-specific antibody with low mean fluorescence intensity on allograft outcomes in kidney transplant
Impact of donor-specific antibody with low mean fluorescence intensity on allograft outcomes in kidney transplant Open
Low MFI DSA values after transplantation may be associated with a higher incidence of rejection, but this finding did not show differences in allograft and patient survival in this study's analysis.
View article: Is Lack of Consensus on the Management of Chronic Active Antibody-Mediated Rejection Harming Renal Transplant Recipients?
Is Lack of Consensus on the Management of Chronic Active Antibody-Mediated Rejection Harming Renal Transplant Recipients? Open
In 2022, over 92,000 kidney transplants were performed globally. With advancements in transplant science, 1-year graft survival rates have reached 94.3% for deceased donor kidney transplant recipients, and 97.8% for living recipients. Howe…