Philipp Sewerin
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View article: Comparison of radiographic spinal changes and their progression in patients with axial spondyloarthritis vs. psoriatic arthritis with inflammatory axial involvement
Comparison of radiographic spinal changes and their progression in patients with axial spondyloarthritis vs. psoriatic arthritis with inflammatory axial involvement Open
Background Psoriatic arthritis with inflammatory axial involvement (PsA-ax) and axial spondyloarthritis (axSpA) are distinct entities within the spectrum of spondyloarthritides. Despite overlapping clinical and imaging features, the extent…
View article: Efficacy of Risankizumab across distinct PsA phenotypes identified with machine learning analytics using data from biologic DMARD-Naïve patients in two phase 3 clinical trials
Efficacy of Risankizumab across distinct PsA phenotypes identified with machine learning analytics using data from biologic DMARD-Naïve patients in two phase 3 clinical trials Open
Background The development of personalized approaches in psoriatic arthritis (PsA) is challenging due to unclear patient phenotypes and trajectories. Machine learning (ML) could help to identify homogeneous patient groups. The objective of…
View article: The impact of MRI slice thickness on the detection of spinal syndesmophytes in axial spondyloarthritis
The impact of MRI slice thickness on the detection of spinal syndesmophytes in axial spondyloarthritis Open
Background Radiography is commonly used in clinical practice for detecting syndesmophytes in radiographic axial Spondyloarthritis (r-axSpA), while the ability of magnetic resonance imaging (MRI) to detect such bony structures is questionab…
View article: Real-World Evidence for Ixekizumab in the Treatment of Psoriasis, Psoriatic Arthritis, and Axial Spondyloarthritis: Systematic Literature Review 2022–2023
Real-World Evidence for Ixekizumab in the Treatment of Psoriasis, Psoriatic Arthritis, and Axial Spondyloarthritis: Systematic Literature Review 2022–2023 Open
Real-world ixekizumab use for PsO and PsA is effective and safe, with a positive impact on patient quality of life. More data are needed to draw conclusions for real-world ixekizumab use in axSpA.
View article: The impact of MRI slice thickness on the detection of spinal syndesmophytes in axial spondyloarthritis
The impact of MRI slice thickness on the detection of spinal syndesmophytes in axial spondyloarthritis Open
Background Conventional radiographs (CR) are the gold standard for detecting syndesmophytes in radiographic axial Spondyloarthritis (r-axSpA), while the ability of magnetic resonance imaging (MRI) to detect such bony structures is question…
View article: P166 Effectiveness of b/tsDMARDs including ixekizumab per line of therapy and concomitant csDMARD in psoriatic arthritis: real-world data from a prospective observational study
P166 Effectiveness of b/tsDMARDs including ixekizumab per line of therapy and concomitant csDMARD in psoriatic arthritis: real-world data from a prospective observational study Open
Background/Aims Treatment (tx) guidelines for PsA recommend biologic DMARDs (bDMARDs) or targeted synthetic (ts) DMARDs after inadequate response to conventional synthetic DMARDs (csDMARDs). In clinical studies, ixekizumab (IXE) has shown …
View article: Prevalence and associations of kinesiophobia with patient reported outcomes and mobility measures in axial spondyloarthritis
Prevalence and associations of kinesiophobia with patient reported outcomes and mobility measures in axial spondyloarthritis Open
Kinesiophobia seems to be a clinically relevant problem of axSpA patients, since the mobility of patients with moderate to high TSK and FABQ scores was much more impaired in this study. Of interest, the level of kinesiophobia showed strong…
View article: Real-World Prevalence, Incidence and Management of Systemic Lupus Erythematosus in Germany: A Retrospective Claims Data Analysis
Real-World Prevalence, Incidence and Management of Systemic Lupus Erythematosus in Germany: A Retrospective Claims Data Analysis Open
Our data demonstrate an increased prevalence of SLE with stable incidence in Germany, suggesting improved survival of affected patients. Nevertheless, suboptimal treatment patterns, including limited use of biologics, reflect a high unmet …
View article: Sustained response to guselkumab regardless of baseline characteristics in patients with active psoriatic arthritis and inadequate response to TNF inhibitors: results from the phase 3b COSMOS clinical trial
Sustained response to guselkumab regardless of baseline characteristics in patients with active psoriatic arthritis and inadequate response to TNF inhibitors: results from the phase 3b COSMOS clinical trial Open
Objectives To prospectively evaluate the effect of guselkumab through 48 weeks across various clinical outcomes in subgroups of patients with psoriatic arthritis (PsA) and inadequate response to tumour necrosis factor inhibitors (TNFi-IR) …
View article: Identification of a machine learning-based diagnostic model for axial spondyloarthritis in rheumatological routine care using a random forest approach
Identification of a machine learning-based diagnostic model for axial spondyloarthritis in rheumatological routine care using a random forest approach Open
Objectives In axial spondyloarthritis (axSpA), early diagnosis is crucial, but diagnostic delay remains long and diagnostic criteria do not exist. We aimed to identify a diagnostic model that distinguishes patients with axSpA from patients…
View article: Performance of standardized patient reported outcomes developed for spondyloarthritis in primary and concomitant forms of fibromyalgia
Performance of standardized patient reported outcomes developed for spondyloarthritis in primary and concomitant forms of fibromyalgia Open
Background In spondyloarthritides (SpA) and fibromyalgia (FM), patients suffer from generalized pain. The impact of FM on PRO validated in SpA has not been systematically studied. Objective Study the performance of PROs developed for SpA i…
View article: No difference in clinical parameters and drug retention in PsA patients receiving b/tsDMARD monotherapy versus combination with methotrexate: data from the RABBIT-SpA registry
No difference in clinical parameters and drug retention in PsA patients receiving b/tsDMARD monotherapy versus combination with methotrexate: data from the RABBIT-SpA registry Open
Background The potential benefit of methotrexate (MTX) in combination with biologic (b) and targeted synthetic (ts) disease modifying anti-rheumatic drugs (DMARDs) in psoriatic arthritis (PsA) is still a matter of debate. Objectives To com…
View article: Quantitative and Compositional MRI of the Articular Cartilage: A Narrative Review
Quantitative and Compositional MRI of the Articular Cartilage: A Narrative Review Open
This review examines the latest advancements in compositional and quantitative cartilage MRI techniques, addressing both their potential and challenges. The integration of these advancements promises to improve disease detection, treatment…
View article: Performance of standardized patient reported outcomes developed for spondyloarthritis in primary and concomitant forms of fibromyalgia
Performance of standardized patient reported outcomes developed for spondyloarthritis in primary and concomitant forms of fibromyalgia Open
Background. In spondyloarthritides (SpA) and fibromyalgia (FM), patients suffer from generalized pain. The impact of FM on PRO validated in SpA has not been systematically studied. Objective. Study the performance of PROs developed for SpA…
View article: Clinically relevant differences in spinal mobility related to daytime performance in patients with axial spondyloarthritis
Clinically relevant differences in spinal mobility related to daytime performance in patients with axial spondyloarthritis Open
Objective Patients with axial spondyloarthritis (axSpA) suffer from clinical symptoms like morning stiffness and back pain. Mobility of patients with axSpA is often impaired. The aim of this study is to compare the performance of patients …
View article: Impact of daily physical therapy over 2 weeks on spinal mobility including objective electronic measurements and function in patients with axial spondyloarthritis
Impact of daily physical therapy over 2 weeks on spinal mobility including objective electronic measurements and function in patients with axial spondyloarthritis Open
Background: Patients with axial spondyloarthritis (axSpA) are often compromised by impaired function and mobility. The standardized 2-week inpatient program ‘multimodal rheumatologic complex treatment’ (MRCT) was designed for patients with…
View article: Efficient Management of Multiple Domains in Psoriatic Arthritis: Target Treatment Goals and Streamlined Clinical Assessment in a Short Session
Efficient Management of Multiple Domains in Psoriatic Arthritis: Target Treatment Goals and Streamlined Clinical Assessment in a Short Session Open
Psoriatic arthritis (PsA) is a chronic, immune-mediated, inflammatory arthropathy that presents with inflammation of the joints and entheses, including those of the axial skeleton, and is associated with increased mortality from cardiovasc…
View article: High Frequency of Osteophytes Detected by High-Resolution Ultrasound at the Finger Joints of Asymptomatic Factory Workers
High Frequency of Osteophytes Detected by High-Resolution Ultrasound at the Finger Joints of Asymptomatic Factory Workers Open
Hand Osteoarthritis (HOA) is a frequently occurring musculoskeletal disease that impacts health. Diagnostic criteria often incorporate osteophytes documented through imaging procedures. Radiographic imaging is considered the gold standard;…
View article: ‘Status Quo’ on Different Aspects of Gender Distribution in Rheumatology in Germany—Results from a Nationwide Online Survey among Physicians
‘Status Quo’ on Different Aspects of Gender Distribution in Rheumatology in Germany—Results from a Nationwide Online Survey among Physicians Open
Objectives: Despite the increasing number of female medical students and fellows in Europe, women are still under-represented in higher academic careers and positions in medicine. The aim of this survey was to assess the ‘status quo’ on ge…