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View article: Breaking Barriers for Intensive Care Admission in Patients With Advanced <scp>HCC</scp> on Immunotherapy
Breaking Barriers for Intensive Care Admission in Patients With Advanced <span>HCC</span> on Immunotherapy Open
Background and Aims Intensive Care Unit (ICU) admission is usually denied to patients with advanced hepatocellular carcinoma (HCC) due to the perceived poor prognosis associated with both cirrhosis and liver cancer. However, immunotherapy …
Dietary salt intake worsens the Th17-dependent inflammatory profile of patients with cirrhosis Open
BACKGROUNDLiver cirrhosis is characterized by chronic inflammation and fibrosis, with Th17 cells playing a crucial role in its progression. Recent evidence suggests that dietary salt influences immune diseases by modulating Th17 differenti…
Cytomegalovirus Reactivation Is Associated With Lower Rates of Hepatocellular Carcinoma Recurrence After Liver Transplantation Open
In patients with hepatocellular carcinoma (HCC), undergoing liver transplantation (LT), cytomegalovirus reactivation (CMVr) may modulate the immune system to prevent tumor recurrence. In this multicenter retrospective study (2010–2015) inv…
An assessment of circulating biomarkers and germline genetic variants in predicting chemotherapy associated mucositis in Ewing sarcoma Open
Background: Treatment of Ewing sarcoma is associated with severe toxicities including chemotherapy-induced mucositis. Here we investigated the role of circulating biomarkers and genetic factors in predicting mucositis severity in Ewing sar…
Burnout Among Physicians of Specialties Dedicated to Liver Transplantation Open
Burnout is increasingly relevant among healthcare professionals. The aim of this study is to describe the prevalence of burnout and other parameters of professional satisfaction among different specialists dedicated to Liver Transplantatio…
<span><i>Cassia angustifolia</i></span> and tacrolimus interaction in a liver transplant patient, a case report Open
Cassia angustifolia is a species of plant from the Senna family that has traditionally been used as a laxative in different herbal products and commercial medicines. Even though there are few documented drug–plant interactions, the use of …
Liver transplantation for diffuse epithelioid hemangioendothelioma Open
Hepatic epithelioid hemangioendothelioma (HEHE) is an extremely rare vascular tumor of unclear etiology. The diagnosis is difficult due to the absence of specific clinical characteristics, laboratory tests results and radiological findings…
Immune changes over time and survival in patients with cirrhosis treated with non-selective beta-blockers: A prospective longitudinal study Open
Chronic treatment with NSBB in patients with stable cirrhosis gives rise to a different state of immune activation, characterized by lower concentrations of IL-6 over time, and it is associated with a reduced risk of adverse event (death, …
View article: Outcome of liver cancer patients with SARS‐CoV‐2 infection: An International, Multicentre, Cohort Study
Outcome of liver cancer patients with SARS‐CoV‐2 infection: An International, Multicentre, Cohort Study Open
Background & Aims Information about the impact of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in patients with liver cancer is lacking. This study characterizes the outcomes and mortality risk in this population. Methods M…
Changes in humoral immune response after SARS-CoV-2 infection in liver transplant recipients compared to immunocompetent patients Open
The protective capacity and duration of humoral immunity after SARS-CoV-2 infection are not yet understood in solid organ transplant recipients. A prospective multicenter study was performed to evaluate the persistence of anti-nucleocapsid…
View article: Fast‐Track Liver Transplantation: Six‐year Prospective Cohort Study with an Enhanced Recovery After Surgery (ERAS) Protocol
Fast‐Track Liver Transplantation: Six‐year Prospective Cohort Study with an Enhanced Recovery After Surgery (ERAS) Protocol Open
Introduction Enhanced recovery after surgery (ERAS) has been shown to facilitate discharge, decrease length of stay, improve outcomes and reduce costs. We used this concept to design a comprehensive fast‐track pathway (OR‐to‐discharge) bef…
International and multicenter real‐world study of sorafenib‐treated patients with hepatocellular carcinoma under dialysis Open
Background & Aims Information on safety and efficacy of systemic treatment in patients with hepatocellular carcinoma (HCC) under dialysis are limited due to patient exclusion from clinical trials. Thus, we aimed to evaluate the rate, preva…
Surveillance and diagnosis of hepatocellular carcinoma: A systematic review Open
The evidence supports the recommendation of performing surveillance of HCC in patients with cirrhosis susceptible of treatment, using ultrasonography every 6 mo. The diagnosis evaluation of HCC can be established based on noninvasive imagi…
Bacterial DNA translocation contributes to systemic inflammation and to minor changes in the clinical outcome of liver transplantation Open
Bacterial (bact)DNA is an immunogenic product that frequently translocates into the blood in cirrhosis. We evaluated bactDNA clearance in patients undergoing liver transplantation (LT) and its association with inflammation and clinically r…
Treatment with non‐selective beta‐blockers affects the systemic inflammatory response to bacterial<span>DNA</span>in patients with cirrhosis Open
Background & Aims The use of non‐selective beta‐blockers has been associated with lower rates of infection and reduced infection‐associated morbidity in patients with cirrhosis. However, it is unknown if these drugs modify the systemic inf…
Clinical characteristics of hepatocellular carcinoma in Spain. Comparison with the 2008–2009 period and analysis of the causes of diagnosis out of screening programs. Analysis of 686 cases in 73 centers Open
In 2010 we published that 53% of cases of hepatocellular carcinoma (HCC) detected in Spain were diagnosed outside the context of standard screening programs, which consequently leads to lower survival rates. The aim of this study was to an…
View article: Efficacy and safety of daclatasvir-based antiviral therapy in hepatitis C virus recurrence after liver transplantation. Role of cirrhosis and genotype 3. A multicenter cohort study
Efficacy and safety of daclatasvir-based antiviral therapy in hepatitis C virus recurrence after liver transplantation. Role of cirrhosis and genotype 3. A multicenter cohort study Open
Direct-acting antiviral agents (DAA) combining daclatasvir (DCV) have reported good outcomes in the recurrence of hepatitis C virus (HCV) infection after liver transplant (LT). However, its effect on the severe recurrence and the risk of d…
New advances in hepatocellular carcinoma Open
Hepatocellular carcinoma (HCC) is the leading cause of deaths in cirrhotic patients and the third cause of cancer related deaths. Most HCC are associated with well known underlying risk factors, in fact, HCC arise in cirrhotic patients in …