Andrew Nguyen
YOU?
Author Swipe
Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors Open
Solid tumors often suppress antitumor immune responses by promoting various dysfunctional CD8+ T cell states, which limit the effectiveness of T‐cell‐based immunotherapy. However, the mechanisms that promote these states have not been full…
Biological and Biologically Inspired Functional Nanostructures: Insights into Structural, Optical, Thermal, and Sensing Applications Open
Biological materials developed over millennia consist of simple biogenic materials, yet exhibit exceptional functional properties. Leveraging design features from these structures with engineered nanomaterial components can lead to bio‐ins…
590 Feasibility of the MyIBD care plan to improve care quality in pediatric IBD practice Open
Objectives/Goals: Youth with IBD have preventive, psychosocial, and acute care needs beyond those of peers, yet receipt of services does not match those needs. Our objectives are to assess the feasibility of (1) an individualized care plan…
Did the United States smokeless tobacco industry use cigarette industry strategies to sponsor and manipulate research? Open
Background and aim The cigarette industry in the United States (US) laid the foundation for sponsoring research to improve public relations and defend against product liability cases. Fewer threats of litigation facing the US smokeless tob…
Figure S3 from Level of Expression of MHCI-Presented Neoepitopes Influences Tumor Rejection by Neoantigen-Specific CD8<sup>+</sup> T Cells Open
Comparison of Adpgk-specific CD8 T cell responses induced by VSV-Adpgk and the Adpgk neoantigen peptide vaccine.
Data from Level of Expression of MHCI-Presented Neoepitopes Influences Tumor Rejection by Neoantigen-Specific CD8<sup>+</sup> T Cells Open
Neoantigen-targeted therapy holds an array of benefits for cancer immunotherapy, but the identification of peptide targets with tumor rejection capacity remains a limitation. To better define the criteria dictating tumor rejection potentia…
Figure S1 from Level of Expression of MHCI-Presented Neoepitopes Influences Tumor Rejection by Neoantigen-Specific CD8<sup>+</sup> T Cells Open
IFNγ pre-treatment driven enhanced MHCI expression fails to make MC38 cells susceptible to prophylactic Adpgk vaccination.
Figure S2 from Level of Expression of MHCI-Presented Neoepitopes Influences Tumor Rejection by Neoantigen-Specific CD8<sup>+</sup> T Cells Open
Tumor regression rescued with enhanced expression of neoantigen target peptide.
Table S1 from Level of Expression of MHCI-Presented Neoepitopes Influences Tumor Rejection by Neoantigen-Specific CD8<sup>+</sup> T Cells Open
Information on DNA Sequences and Primers
The convergent design evolution of multiscale biomineralized structures in extinct and extant organisms Open
Evolution has generated a sophisticated convergence of material components, ultrastructural designs, and fabrication processes in response to similar selective pressures across a diverse array of extinct and extant species. This review exp…
Figure S2 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S2: Differentially expressed genes when comparing ACT+MS-275- to ACT-treated T cells
Figure S1 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S1: Transferred T-cell proliferation and cell death over time
Table S1 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Table S1: Gene lists of T cell signatures
Figure S4 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S4: HAVCR2/DUSP22-pathway correlation
Figure S3 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S3: CEMiTool module analysis and hub gene identification
Figure S1 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S1: Transferred T-cell proliferation and cell death over time
Table S1 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Table S1: Gene lists of T cell signatures
Figure S5 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S5: PD-1/Tim-3 expression during combination immunotherapy
Figure S2 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S2: Differentially expressed genes when comparing ACT+MS-275- to ACT-treated T cells
Figure S5 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S5: PD-1/Tim-3 expression during combination immunotherapy
Figure S4 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S4: HAVCR2/DUSP22-pathway correlation
Table S2 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Table S2: Overrepresented GO terms associated with Module 2 (M2)
Figure S3 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Figure S3: CEMiTool module analysis and hub gene identification
Data from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Purpose: T-cell exhaustion limits immunotherapy for the treatment of solid tumors. While immune checkpoint blockade and adoptive T cell therapy (ACT) can mediate tumor regression, their potency is often determined by tumor burden. Here, we…
Table S2 from HDACi-dependent microenvironmental normalization overcomes tumor burden-induced T-cell exhaustion Open
Table S2: Overrepresented GO terms associated with Module 2 (M2)
A surprising lack of consequences when constraining language Open
Introduction Labels considered normatively appropriate for specific social identity groups change. Researchers have examined the effects of censorship and slur usage, but minimal research examines the psychological consequences of imposing…
376 Overcoming tumor heterogeneity – Clinical trial assays to prospectively assign patients customized multiplexed TCR-T cell therapy in Phase 1 Open
Background TCR-engineered T cell therapy has shown encouraging response rates in solid tumors, but complete responses are rare and partial responses are often short-lived. We submit that the primary reason underlying these results is that …