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View article: Deciphering Resistance: Beyond the Androgen Paradigm; Report From the 2025 Coffey‐Holden Prostate Cancer Academy Meeting
Deciphering Resistance: Beyond the Androgen Paradigm; Report From the 2025 Coffey‐Holden Prostate Cancer Academy Meeting Open
Introduction The 12th Annual 2025 Coffey—Holden Prostate Cancer Academy (CHPCA) Meeting, “Deciphering Resistance: Beyond the Androgen Paradigm,” was held at the University of California, Los Angeles (UCLA), Luskin Conference Center, in Los…
View article: Standardizing caloric restriction for preclinical cancer research
Standardizing caloric restriction for preclinical cancer research Open
Despite increasing rates of metabolic syndrome, cancer treatment regimens often ignore the underlying metabolic dysfunction in patients. A high proportion of cancer patients have metabolic dysfunction, and caloric restriction has shown the…
View article: Prediction of metastasis-free survival in patients with localized prostate adenocarcinoma using primary tumor and lymph node radiomics from pre-treatment PSMA-PET/CT scans
Prediction of metastasis-free survival in patients with localized prostate adenocarcinoma using primary tumor and lymph node radiomics from pre-treatment PSMA-PET/CT scans Open
This is one of the first studies to explore the prognostic value of pre-treatment PSMA-PET, a relatively recent advancement in the care of prostate adenocarcinoma patients. Results demonstrated the potential of using imaging biomarkers fro…
View article: 3D Segment Anything Model (SAM) for 3D Protoacoustic Imaging Enhancement and In Vivo Dose Verification in Proton Therapy
3D Segment Anything Model (SAM) for 3D Protoacoustic Imaging Enhancement and In Vivo Dose Verification in Proton Therapy Open
View article: Genomic Predictors of Response to Metastasis-directed Therapy With or Without Androgen Deprivation Therapy
Genomic Predictors of Response to Metastasis-directed Therapy With or Without Androgen Deprivation Therapy Open
Metastasis-directed therapy (MDT) is an emerging treatment option for metachronous oligometastatic castration-sensitive prostate cancer (omCSPC) and can delay time to progression and the need to initiate androgen deprivation therapy (ADT).…
View article: Evaluating Molecular Response Using 68Ga-PSMA-PET/CT in Prostate Cancer Patients with Pelvic Lymph Node Metastasis Undergoing Definitive Radiotherapy: Clinical Significance and Implications
Evaluating Molecular Response Using 68Ga-PSMA-PET/CT in Prostate Cancer Patients with Pelvic Lymph Node Metastasis Undergoing Definitive Radiotherapy: Clinical Significance and Implications Open
View article: Graph feature selection for enhancing radiomic stability and reproducibility across multiple institutions in head and neck cancer
Graph feature selection for enhancing radiomic stability and reproducibility across multiple institutions in head and neck cancer Open
Radiomic biomarkers offer promise for precision oncology. However, their clinical utility is limited by variability from differing imaging protocols and the high dimensionality of radiomics data. Feature selection is key for better interpr…
View article: Enhancing Radiation Oncology Training through Patient Advocate Integration
Enhancing Radiation Oncology Training through Patient Advocate Integration Open
Purpose Patient advocates represent the voice of the patient community and bring a unique perspective to research. We hypothesized that including patient advocates in research training would increase trainees ability to communicate their s…
View article: External validation of a digital pathology-based multimodal artificial intelligence-derived prognostic model in patients with advanced prostate cancer starting long-term androgen deprivation therapy: a post-hoc ancillary biomarker study of four phase 3 randomised controlled trials of the STAMPEDE platform protocol
External validation of a digital pathology-based multimodal artificial intelligence-derived prognostic model in patients with advanced prostate cancer starting long-term androgen deprivation therapy: a post-hoc ancillary biomarker study of four phase 3 randomised controlled trials of the STAMPEDE platform protocol Open
Prostate Cancer UK, UK Medical Research Council, Cancer Research UK, John Black Charitable Foundation, Prostate Cancer Foundation, Sanofi Aventis, Janssen, Astellas, Novartis, Artera.
View article: Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1
Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1 Open
Non-small cell lung carcinoma (NSCLC) is a major cause of cancer mortality. High expression of the epithelial-to-mesenchymal transition transcription factor (EMT-TF) Twist1 is strongly associated with metastatic cancers and with treatment …
View article: Table S2 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S2 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Depositor communications, describing input from data depositors
View article: Table S1 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S1 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Current collection of LCAMGDB datasets
View article: Figure S1 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S1 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Identification of data redundancy by hierarchical clustering
View article: Figure S8 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S8 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Samples colored by data source
View article: Figure S2 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S2 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Top 100 frequent genetic mutations in realworld lung cancer patients
View article: Data from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Data from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed…
View article: Table S5 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S5 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Dataset table, summarizing input datasets for LCMAGDB
View article: Table S3 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S3 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Additional datasets, to be included in the next update of LCMAGDB
View article: Figure S7 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S7 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Ascl1 expression across reprocessed RNA-seq datasets
View article: Table S6 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S6 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Sample table, providing sample characteristics
View article: Figure S6 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S6 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Dotplot of Ezh2 expression across various samples profiled by the Mouse430_2 microarray platform
View article: Table S7 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S7 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Genotype table, harmonized genotype descriptions
View article: Figure S4 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S4 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
User interface of the GEMMs table in the LCAMGDB web application
View article: Table S4 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Table S4 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Table descriptions, explaining variables included in the data tables
View article: Figure S3 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S3 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
PCA of reprocessed Mouse430_2 microarray data
View article: Figure S5 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
Figure S5 from The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Custom sample filtering and selection
View article: Outcomes of Radium-223 and Stereotactic Ablative Radiotherapy Versus Stereotactic Ablative Radiotherapy for Oligometastatic Prostate Cancers: The RAVENS Phase II Randomized Trial
Outcomes of Radium-223 and Stereotactic Ablative Radiotherapy Versus Stereotactic Ablative Radiotherapy for Oligometastatic Prostate Cancers: The RAVENS Phase II Randomized Trial Open
PURPOSE Randomized clinical trials (RCTs) have shown progression-free survival (PFS) benefits of metastasis-directed therapy (MDT) without androgen deprivation therapy for oligometastatic castration-sensitive prostate cancer (omCSPC). Most…
View article: Assessing Algorithmic Fairness With a Multimodal Artificial Intelligence Model in Men of African and Non-African Origin on NRG Oncology Prostate Cancer Phase III Trials
Assessing Algorithmic Fairness With a Multimodal Artificial Intelligence Model in Men of African and Non-African Origin on NRG Oncology Prostate Cancer Phase III Trials Open
PURPOSE Artificial intelligence (AI) tools could improve clinical decision making or exacerbate inequities because of bias. African American (AA) men reportedly have a worse prognosis for prostate cancer (PCa) and are underrepresented in t…
View article: The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models
The Lung Cancer Autochthonous Model Gene Expression Database Enables Cross-Study Comparisons of the Transcriptomic Landscapes Across Mouse Models Open
Lung cancer, the leading cause of cancer mortality, exhibits diverse histologic subtypes and genetic complexities. Numerous preclinical mouse models have been developed to study lung cancer, but data from these models are disparate, siloed…
View article: Supplementary Figure S7 from PSMA<sup>+</sup> Extracellular Vesicles Are a Biomarker for SABR in Oligorecurrent Prostate Cancer: Analysis from the STOMP-like and ORIOLE Trial Cohorts
Supplementary Figure S7 from PSMA<sup>+</sup> Extracellular Vesicles Are a Biomarker for SABR in Oligorecurrent Prostate Cancer: Analysis from the STOMP-like and ORIOLE Trial Cohorts Open
Progression-free survival stratified by baseline PSA DT levels