Simon Travis
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View article: Acute upper gastrointestinal bleeding in the UK: 2022 audit update
Acute upper gastrointestinal bleeding in the UK: 2022 audit update Open
Background Acute upper gastrointestinal bleeding (AUGIB) is a common medical emergency with evolving demographics and management strategies, particularly in medical/endoscopic therapy and transfusion strategies. Objective To provide key da…
View article: Bowel Urgency in Crohn's Disease: Bridging the Gap Between Patients and Healthcare Providers
Bowel Urgency in Crohn's Disease: Bridging the Gap Between Patients and Healthcare Providers Open
Bowel urgency (BU) is a prevalent and highly burdensome symptom among patients with inflammatory bowel disease. While BU is now recognized as a key symptom of ulcerative colitis, in the case of Crohn's disease (CD), it is often under-recog…
Broad Impact of Bowel Urgency in Ulcerative Colitis and Crohn’s Disease: US, European, and Japanese Patient and Healthcare Professional Perspectives from the Communicating Needs and Features of IBD Experiences (CONFIDE) Survey Open
Bowel urgency affects the emotions and daily life of patients with UC or CD in the US, Europe, and Japan. A multidisciplinary approach is required to enhance care and develop suitable treatment strategies.
View article: Bowel Urgency in Crohn’s Disease: Effects of Mirikizumab in a Randomized Controlled Phase 3 Study
Bowel Urgency in Crohn’s Disease: Effects of Mirikizumab in a Randomized Controlled Phase 3 Study Open
gov, Number: NCT03926130.
Bowel urgency in ulcerative colitis: effect of baseline urgency and change in urgency in response to mirikizumab Open
Background Mirikizumab has demonstrated efficacy in moderately to severely active ulcerative colitis. A 1–2-point change in Urgency Numeric Rating Scale (NRS) score can be meaningful for patients. In these post-hoc analyses, we evaluated t…
View article: Evaluation and Management of Glucocorticoid-Induced Adrenal Insufficiency in IBD: An Expert Opinion
Evaluation and Management of Glucocorticoid-Induced Adrenal Insufficiency in IBD: An Expert Opinion Open
Background and Aims Glucocorticoid-induced adrenal insufficiency (GC-AI) is a potentially life-threatening side effect of glucocorticoid therapy. Currently, there is no consensus on monitoring and treating GC-AI in inflammatory bowel disea…
Magnetic resonance enterography to predict subsequent disabling Crohn’s disease in newly diagnosed patients (METRIC-EF)—multivariable prediction model, multicentre diagnostic inception cohort Open
Objectives Magnetic resonance enterography (MRE) is a first-line investigation to diagnose Crohn’s disease (CD), but its role for prognostication is unknown. Accordingly, we assessed the predictive ability of prognostic models including MR…
Fecal Calprotectin and C-Reactive Protein Association With Histologic and Endoscopic Endpoints in Mirikizumab-Treated Patients With Ulcerative Colitis Open
Background Fecal calprotectin (FC) and C-reactive protein (CRP) are noninvasive biomarkers used in ulcerative colitis (UC) clinical trials; however, thresholds defined as “normal” in trials may be higher than “normal” thresholds typically …
MRI assessment of body composition for prediction of therapeutic response to biologic agents in patients with Crohn’s disease Open
Objectives Altered body fat and muscle mass in Crohn’s disease (CD) have been linked to adverse disease course and outcomes. Prediction of treatment response or remission (RoR) of small bowel CD (SBCD) to biologic therapy remains challengi…
US and European Patient and Health Care Professional Perspectives on Fatigue in Ulcerative Colitis and Crohn’s Disease: Results From the Communicating Needs and Features of Inflammatory Bowel Disease Experiences Survey Open
Background Fatigue is a burdensome symptom of Crohn’s disease (CD) and ulcerative colitis (UC). The Communicating Needs and Features of Inflammatory Bowel Disease Experiences (CONFIDE) study investigated how patients and health care profes…
View article: Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn’s Disease Commencing Biological Therapy: The Motility Study
Small Bowel Motility Quantified by Cine MRI to Predict Longer-Term Response in Patients with Crohn’s Disease Commencing Biological Therapy: The Motility Study Open
Background Small bowel Crohn’s disease (SBCD) is increasingly treated with biological therapies. Predicting response or remission (RoR) for individual patients is difficult and complicates treatment strategy. We aimed to determine if motil…
CROHN’S DISEASE AND BOWEL URGENCY: US AND EUROPEAN PATIENT AND HEALTHCARE PROFESSIONAL PERSPECTIVES FROM THE COMMUNICATING NEEDS AND FEATURES OF IBD EXPERIENCES (CONFIDE) SURVEY Open
BACKGROUND Bowel urgency (BU) is a disruptive symptom for patients with Crohn’s disease (CD) and affects their quality of life. This study used data from the Communicating Needs and Features of IBD Experiences (CONFIDE) survey to explore p…
View article: TRANSLATING 5-HT4R AGONISM INTO MENTAL ILLNESS: POTENTIAL CLINICAL APPLICATIONS FOR MOOD DISORDER AND COGNITIVE IMPAIRMENT
TRANSLATING 5-HT4R AGONISM INTO MENTAL ILLNESS: POTENTIAL CLINICAL APPLICATIONS FOR MOOD DISORDER AND COGNITIVE IMPAIRMENT Open
Background Depression is common and costly. First-line antidepressants are ineffective for many and have little impact against cognitive deficits. Stimulating 5-HT4 receptors (5-HT4R) rapidly improves learning and has antidepressant-like e…
Navigating Chronic Pouchitis: Pathogenesis, Diagnosis, and Management. Open
Chronic pouchitis affects 13% to 17% of patients with ileal pouch-anal anastomosis and ulcerative colitis, and 20% with a history of acute pouchitis. It is classified by antibiotic responsiveness into chronic antibiotic-dependent pouchitis…
P0371 Building a Robust Artificial Intelligence Solution for Use in Ulcerative Colitis Clinical Trials Open
Background Artificial Intelligence (AI) is increasingly used to assess Ulcerative Colitis (UC) disease activity in clinical trials, with the goal of matching or exceeding expert performance in a reproducible manner. Certai has been created…
View article: DOP094 Improvement in biomarkers in patients with ulcerative colitis treated with vedolizumab: Results from the continuing VERDICT trial
DOP094 Improvement in biomarkers in patients with ulcerative colitis treated with vedolizumab: Results from the continuing VERDICT trial Open
Background Treatment targets in ulcerative colitis (UC) include symptomatic remission, endoscopic remission, and histologic remission. The ongoing VERDICT trial (NCT04259138) aims to determine the optimal treatment target in patients with …
The Urgency Numeric Rating Scale: Psychometric Evaluation in Adults with Crohn’s Disease Open
Clinicaltrials.gov, NCT03926130. Registered 23 April 2019, https://clinicaltrials.gov/study/NCT03926130 .
Hypercoagulation After Hospital Discharge in Acute Severe Ulcerative Colitis: A Prospective Study Open
Global measures of hemostasis demonstrated that patients with ASUC were prothrombotic compared with control subjects with quiescent colitis. This difference was maintained 8-12 weeks after the initial presentation, supporting clinical obse…
View article: Gaps in acute upper GI bleed (AUGIB) endoscopy training: a UK trainees and trainers’ survey
Gaps in acute upper GI bleed (AUGIB) endoscopy training: a UK trainees and trainers’ survey Open
Introduction Trainees report inadequate exposure and training barriers in acute upper gastrointestinal bleed (AUGIB) endoscopic management. This UK-wide survey evaluated the experiences of trainees and trainers in AUGIB endoscopy training.…
View article: Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD
Dye-based chromoendoscopy detects more neoplasia than white light endoscopy in patients with primary sclerosing cholangitis and IBD Open
Background and study aims Patients with primary sclerosing cholangitis and inflammatory bowel disease (IBD) have a high risk of colorectal cancer. There is no agreement on the best technique for surveillance for colorectal neoplasia. We ai…
View article: Association between a selective 5-HT<sub>4</sub> receptor agonist and incidence of major depressive disorder: emulated target trial
Association between a selective 5-HT<sub>4</sub> receptor agonist and incidence of major depressive disorder: emulated target trial Open
Background The serotonin 4 receptor (5-HT 4 R) is a promising target for the treatment of depression. Highly selective 5-HT 4 R agonists, such as prucalopride, have antidepressant-like and procognitive effects in preclinical models, but th…
View article: Development of an index to define overall disease severity in IBD
Development of an index to define overall disease severity in IBD Open
BACKGROUND AND AIM: Disease activity for Crohn's disease (CD) and UC is typically defined based on symptoms at a moment in time, and ignores the long-term burden of disease. The aims of this study were to select the attributes determining …
Neutralizing Autoantibodies against Interleukin-10 in Inflammatory Bowel Disease Open
We discovered high-titer neutralizing autoantibodies against interleukin-10 in a child with infantile-onset inflammatory bowel disease (IBD), a phenocopy of inborn errors of interleukin-10 signaling. After B-cell-depletion therapy and an a…
The continuing value of mesalazine as first-line therapy for patients with moderately active ulcerative colitis Open
Mesalazine is an established and recommended first-line treatment for mild-to-moderate ulcerative colitis (UC). For patients with moderately active UC, the choice to use mesalazine or to initiate treatment with an oral corticosteroid or an…
Value of Engagement in Digital Health Technology Research: Evidence Across 6 Unique Cohort Studies Open
Background Wearable digital health technologies and mobile apps (personal digital health technologies [DHTs]) hold great promise for transforming health research and care. However, engagement in personal DHT research is poor. Objective The…