Paul D. Veith
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View article: OmpA_C‐Like Domain of PorE Is Essential for PorE Function in the Type IX Secretion System (T9SS) of <i>Porphyromonas gingivalis</i> and Some T9SS Cargo Proteins Are Secreted in a PorE‐Independent Manner
OmpA_C‐Like Domain of PorE Is Essential for PorE Function in the Type IX Secretion System (T9SS) of <i>Porphyromonas gingivalis</i> and Some T9SS Cargo Proteins Are Secreted in a PorE‐Independent Manner Open
The periodontal pathogen Porphyromonas gingivalis secretes gingipains, highly hydrolytic proteases, to the cell surface or external environment via a type IX secretion system (T9SS). PorE is one of the T9SS component proteins essential for…
View article: <scp>PorA</scp> of the Type <scp>IX</scp> Secretion Is a Ligand of the <scp>PorXY</scp> Two‐Component Regulatory System in <scp><i>Porphyromonas gingivalis</i></scp>
<span>PorA</span> of the Type <span>IX</span> Secretion Is a Ligand of the <span>PorXY</span> Two‐Component Regulatory System in <span><i>Porphyromonas gingivalis</i></span> Open
Porphyromonas gingivalis is an important bacterium associated with chronic periodontitis. The type IX secretion system (T9SS) in P. gingivalis secretes conserved C‐terminal domain (CTD) containing proteins, which are also called T9SS cargo…
View article: Near-atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provide mechanistic insights into the type IX secretion system
Near-atomic structure of the PorKN rings, disulfide bonded to PorG and bound to Attachment Complexes, provide mechanistic insights into the type IX secretion system Open
The Type IX Secretion System exports proteins across the outer membrane (OM) of bacteria in the Bacteroidota phylum, however, the mechanistic details remain unknown. Here, we present a ∼3.5Å cryo-EM structure of the periplasmic rings compr…
View article: C-terminal glycosylation of type IX secretion system cargo proteins in <i>Prevotella intermedia</i> with both short and long secretion signals
C-terminal glycosylation of type IX secretion system cargo proteins in <i>Prevotella intermedia</i> with both short and long secretion signals Open
Prevotella intermedia is a Gram-negative bacterium that is associated with periodontitis and acute necrotizing ulcerative gingivitis. P. intermedia utilizes the type IX secretion system (T9SS) to secrete and anchor virulence factors to the…
View article: Analyses of biosynthesis mutants reveal that the fifth and sixth sugars of the Porphyromonas gingivalis O-glycan are L-fucose and N-acetylgalactosamine respectively
Analyses of biosynthesis mutants reveal that the fifth and sixth sugars of the Porphyromonas gingivalis O-glycan are L-fucose and N-acetylgalactosamine respectively Open
The oral pathogen, Porphyromonas gingivalis has a general O-glycosylation system which it utilises to modify hundreds of proteins localised outside of the cytoplasm. The O-glycan is a heptasaccharide that includes a putative L-fucose and N…
View article: Cell-to-cell interactions revealed by cryo-tomography of a DPANN co-culture system
Cell-to-cell interactions revealed by cryo-tomography of a DPANN co-culture system Open
DPANN is a widespread and diverse group of archaea characterized by their small size, reduced genome, limited metabolic pathways, and symbiotic existence. Known DPANN species are predominantly obligate ectosymbionts that depend on their ho…
View article: Novel cell-to-cell interactions revealed by cryotomography of a DPANN coculture system
Novel cell-to-cell interactions revealed by cryotomography of a DPANN coculture system Open
DPANN is a widespread and highly diverse group of archaea characterised by their small size, reduced genome, limited metabolic pathways, and symbiotic existence. Known DPANN species are predominantly obligate ectosymbionts that depend on t…
View article: Ultrastructural and glycoproteomic characterization of <i>Prevotella intermedia</i>: Insights into <i>O</i>‐glycosylation and outer membrane vesicles
Ultrastructural and glycoproteomic characterization of <i>Prevotella intermedia</i>: Insights into <i>O</i>‐glycosylation and outer membrane vesicles Open
Prevotella intermedia , a Gram‐negative bacterium from the Bacteroidota phylum, is associated with periodontitis. Other species within this phylum are known to possess the general O ‐glycosylation system. The O ‐glycoproteome has been char…
View article: Characterization of the <i>O</i> -Glycoproteome of Flavobacterium johnsoniae
Characterization of the <i>O</i> -Glycoproteome of Flavobacterium johnsoniae Open
Flavobacterium johnsoniae is a Gram-negative bacterium that is found in soil and water. It is frequently used as a model species for studying gliding motility and the T9SS.
View article: Protein interactome mapping of <i>Porphyromonas gingivalis</i> provides insights into the formation of the PorQ‐Z complex of the type IX secretion system
Protein interactome mapping of <i>Porphyromonas gingivalis</i> provides insights into the formation of the PorQ‐Z complex of the type IX secretion system Open
Porphyromonas gingivalis is an anaerobic Gram‐negative human oral pathogen highly associated with the more severe forms of periodontal disease. Porphyromonas gingivalis utilises the type IX secretion system (T9SS) to transport ∼30 cargo pr…
View article: Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage
Type B CTD Proteins Secreted by the Type IX Secretion System Associate with PorP-like Proteins for Cell Surface Anchorage Open
The Bacteroidetes type IX secretion system (T9SS) consists of at least 20 components that translocate proteins with type A or type B C-terminal domain (CTD) signals across the outer membrane (OM). While type A CTD proteins are anchored to …
View article: Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon
Protein Interactome Analysis of the Type IX Secretion System Identifies PorW as the Missing Link between the PorK/N Ring Complex and the Sov Translocon Open
The T9SS is a newly identified protein secretion system of the Fibrobacteres - Chlorobi - Bacteroidetes superphylum used by pathogens associated with diseases of humans, fish, and poultry for the secretion and cell surface attachment of vi…
View article: Characterization of the O-Glycoproteome of Porphyromonas gingivalis
Characterization of the O-Glycoproteome of Porphyromonas gingivalis Open
Porphyromonas gingivalis is an oral pathogen primarily associated with severe periodontal disease and further associated with rheumatoid arthritis, dementia, cardiovascular disease, and certain cancers. Protein glycosylation can be importa…
View article: The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis
The Type IX Secretion System and Its Role in Bacterial Function and Pathogenesis Open
Porphyromonas, Tannerella, and Prevotella species found in severe periodontitis use the Type IX Secretion System (T9SS) to load their outer membrane surface with an array of virulence factors. These virulence factors are then released on o…
View article: Characterization of the O-Glycoproteome of Tannerella forsythia
Characterization of the O-Glycoproteome of Tannerella forsythia Open
Tannerella forsythia is an oral pathogen associated with severe forms of periodontal disease characterized by destruction of the tooth’s supporting tissues, including the bone. The bacterium releases a variety of proteins associated with v…
View article: Complementation in <i>trans</i> of Porphyromonas gingivalis Lipopolysaccharide Biosynthetic Mutants Demonstrates Lipopolysaccharide Exchange
Complementation in <i>trans</i> of Porphyromonas gingivalis Lipopolysaccharide Biosynthetic Mutants Demonstrates Lipopolysaccharide Exchange Open
Porphyromonas gingivalis is a keystone pathogen contributing to periodontitis in humans, leading to tooth loss. The oral microbiota is essential in this pathogenic process and changes from predominantly Gram-positive (health) to predominan…
View article: Towards defining the outer membrane proteome of <i>Porphyromonas gingivalis</i>
Towards defining the outer membrane proteome of <i>Porphyromonas gingivalis</i> Open
Porphyromonas gingivalis is a Gram‐negative anaerobic pathogen found in subgingival plaque associated with progressive periodontitis. Proteins associated with the outer membrane (OM) of Gram‐negative pathogens are particularly important fo…
View article: Type IX Secretion System Cargo Proteins Are Glycosylated at the C Terminus with a Novel Linking Sugar of the Wbp/Vim Pathway
Type IX Secretion System Cargo Proteins Are Glycosylated at the C Terminus with a Novel Linking Sugar of the Wbp/Vim Pathway Open
Porphyromonas gingivalis and Tannerella forsythia , two pathogens associated with severe gum disease, use the type IX secretion system (T9SS) to secrete and attach toxic arrays of virulence factor proteins to their cell surfaces. The prote…
View article: The Type IX Secretion System: Advances in Structure, Function and Organisation
The Type IX Secretion System: Advances in Structure, Function and Organisation Open
The type IX secretion system (T9SS) is specific to the Bacteroidetes phylum. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilises the T9SS to transport many proteins—including its gingipain virulence factors—across the…
View article: <i>In situ</i>structure and organisation of the type IX secretion system
<i>In situ</i>structure and organisation of the type IX secretion system Open
The Bacteroidetes type IX secretion system (T9SS) consists of at least 19 components that translocate proteins with a type A or type B C-terminal domain (CTD) signal across the outer membrane. The overall organisation and architecture of t…
View article: Quantitative proteomic analysis of the type IX secretion system mutants in <i>Porphyromonas gingivalis</i>
Quantitative proteomic analysis of the type IX secretion system mutants in <i>Porphyromonas gingivalis</i> Open
Porphyromonas gingivalis is an anaerobic, gram‐negative human oral pathogen highly associated with chronic periodontitis. P. gingivalis utilizes the type IX secretion system (T9SS) to transport many of its virulence factors including the g…
View article: The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis
The Role of Treponema denticola Motility in Synergistic Biofilm Formation With Porphyromonas gingivalis Open
Chronic periodontitis has a polymicrobial biofilm etiology and interactions between key oral bacterial species, such as Porphyromonas gingivalis and Treponema denticola contribute to disease progression. P. gingivalis and T. denticola are …
View article: The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates
The Bacteroidetes Q-Rule: Pyroglutamate in Signal Peptidase I Substrates Open
Bacteroidetes feature prominently in the human microbiome, as major colonizers of the gut and clinically relevant pathogens elsewhere. Here, we reveal a new Bacteroidetes specific feature in the otherwise widely conserved Sec/SPI (Sec tran…
View article: PorV is an Outer Membrane Shuttle Protein for the Type IX Secretion System
PorV is an Outer Membrane Shuttle Protein for the Type IX Secretion System Open
Porphyromonas gingivalis is a keystone pathogen associated with chronic periodontitis. Major virulence factors named gingipains (cysteine proteinases, RgpA, RgpB and Kgp) are secreted via the Type IX Secretion System (T9SS). These, togethe…
View article: Type IX secretion: the generation of bacterial cell surface coatings involved in virulence, gliding motility and the degradation of complex biopolymers
Type IX secretion: the generation of bacterial cell surface coatings involved in virulence, gliding motility and the degradation of complex biopolymers Open
Summary The Type IX secretion system (T9SS) is present in over 1000 sequenced species/strains of the Fibrobacteres‐Chlorobi‐Bacteroidetes superphylum. Proteins secreted by the T9SS have an N‐terminal signal peptide for translocation across…
View article: PG1058 Is a Novel Multidomain Protein Component of the Bacterial Type IX Secretion System
PG1058 Is a Novel Multidomain Protein Component of the Bacterial Type IX Secretion System Open
Porphyromonas gingivalis utilises the Bacteroidetes-specific type IX secretion system (T9SS) to export proteins across the outer membrane (OM), including virulence factors such as the gingipains. The secreted proteins have a conserved carb…
View article: Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System
Structural Insights into the PorK and PorN Components of the Porphyromonas gingivalis Type IX Secretion System Open
The type IX secretion system (T9SS) has been recently discovered and is specific to Bacteroidetes species. Porphyromonas gingivalis, a keystone pathogen for periodontitis, utilizes the T9SS to transport many proteins including the gingipai…
View article: The Interactions of CPP–ACP with Saliva
The Interactions of CPP–ACP with Saliva Open
The repair of early dental caries lesions has been demonstrated by the application of the remineralisation technology based on casein phosphopeptide-stabilised amorphous calcium phosphate complexes (CPP–ACP). These complexes consist of an …