Paolo Vescovi
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View article: Er:YAG Laser in QSP Modality for Treatment of Indirect Adhesive Restoration Build-Up: Surface Roughness Analysis and Morphology Assessment by Environmental Scanning Electron Microscopy (ESEM)
Er:YAG Laser in QSP Modality for Treatment of Indirect Adhesive Restoration Build-Up: Surface Roughness Analysis and Morphology Assessment by Environmental Scanning Electron Microscopy (ESEM) Open
Background/Objectives: Sandblasting build-ups before applying the acid and adhesive significantly improves the bond strength. The aim of this study is to evaluate, for the first time, the effectiveness of an Er:YAG laser used in QSP mode t…
View article: Correlation between tooth decay and insulin resistance in normal weight males prompts a role for myo-inositol as a regenerative factor in dentistry and oral surgery: a feasibility study
Correlation between tooth decay and insulin resistance in normal weight males prompts a role for myo-inositol as a regenerative factor in dentistry and oral surgery: a feasibility study Open
Background In an era of precision and stratified medicine, homogeneity in population-based cohorts, stringent causative entry, and pattern analysis of datasets are key elements to investigate medical treatments. Adhering to these principle…
View article: Extraoral photobiomodulation to prevent hyposalivation in patients treated with head and neck radiotherapy: randomized double-blind clinical trial
Extraoral photobiomodulation to prevent hyposalivation in patients treated with head and neck radiotherapy: randomized double-blind clinical trial Open
Purpose To evaluate the efficacy of extraoral photobiomodulation in preventing hyposalivation in patients treated with radiotherapy for head and neck cancers. Methods 52 patients divided into an intervention group (23 patients) and a contr…
View article: Salivary Diagnosis of Dental Caries: A Systematic Review
Salivary Diagnosis of Dental Caries: A Systematic Review Open
The activity of dental caries, combined with its multifactorial etiology, alters salivary molecule composition. The present systematic review was developed to answer the following question: “Are salivary biomarkers reliable for diagnosis o…
View article: Italian position paper ( <scp>SIPMO‐SICMF</scp> ) on medication‐related osteonecrosis of the jaw ( <scp>MRONJ</scp> )
Italian position paper ( <span>SIPMO‐SICMF</span> ) on medication‐related osteonecrosis of the jaw ( <span>MRONJ</span> ) Open
Objective This paper aims to describe the 2023 update position paper on MRONJ developed by the Italian Societies of Oral Pathology and Medicine (SIPMO) and of Maxillofacial Surgery (SICMF). Methods This is the second update following the 2…
View article: Italian Position Paper (SIPMO-SICMF) on Medication-Related Osteonecrosis of the Jaw (MRONJ)
Italian Position Paper (SIPMO-SICMF) on Medication-Related Osteonecrosis of the Jaw (MRONJ) Open
Despite being one of the most recently studied oral diseases, MRONJ remains a condition with uncertain and controversial issues. The aim of this updated version of the position paper on MRONJ developed by the Italian Societies of Oral Path…
View article: Prevalence of late stage in 507 Medication-related osteonecrosis of the jaws (MRONJ) sites: comparison between cancer and osteometabolic patients
Prevalence of late stage in 507 Medication-related osteonecrosis of the jaws (MRONJ) sites: comparison between cancer and osteometabolic patients Open
The present retrospective study we compared 507 sites of MRONJ occurred in 394 patients to highlight possible differences between cancer and non-cancer patients with stage III MRONJ. Five hundred and seven sites of MRONJ were observed betw…
View article: MRONJ and implants: the risk of developing necrosis away from surgery
MRONJ and implants: the risk of developing necrosis away from surgery Open
This study aimed to evaluate the prevalence of MRONJ in patients treated with prosthetic implant rehabilitation. We evaluated the risk of MRONJ genesis comparing implant surgery with the development of necrosis after correct implant osteoi…
View article: “Drug holiday” in DRONJ (Denosumab Related Osteonecrosis of the Jaws) patients : real benefit in surgical or non surgical therapeutic approach ?
“Drug holiday” in DRONJ (Denosumab Related Osteonecrosis of the Jaws) patients : real benefit in surgical or non surgical therapeutic approach ? Open
One of the most frequent monoclonal antibodies linked to MRONJ is Denosumab. In our study, attention was focused on different therapeutic approaches considering patients treated only with Denosumab or in combination with other drugs associ…
View article: Clinical validation of 13‐gene <scp>DNA</scp> methylation analysis in oral brushing samples for detection of oral carcinoma: Italian multicenter study
Clinical validation of 13‐gene <span>DNA</span> methylation analysis in oral brushing samples for detection of oral carcinoma: Italian multicenter study Open
Background The aim of this Italian multicenter study was to evaluate the diagnostic performance of a minimally invasive method for the detection of oral squamous cell carcinoma (OSCC) based on 13‐gene DNA methylation analysis in oral brush…
View article: Clinicopathological Features Associated with Fluorescence Alteration: Analysis of 108 Oral Malignant and Potentially Malignant Lesions
Clinicopathological Features Associated with Fluorescence Alteration: Analysis of 108 Oral Malignant and Potentially Malignant Lesions Open
Background: Several noninvasive diagnostic tools have been developed to aid the early detection of oral cancer and for evaluation before definitive biopsy. Among these, devices evaluating a tissues autofluorescence (AF) are emerging. In pa…
View article: Aesthetic Treatment Outcomes of Capillary Hemangioma, Venous Lake, and Venous Malformation of the Lip Using Different Surgical Procedures and Laser Wavelengths (Nd:YAG, Er,Cr:YSGG, CO2, and Diode 980 nm)
Aesthetic Treatment Outcomes of Capillary Hemangioma, Venous Lake, and Venous Malformation of the Lip Using Different Surgical Procedures and Laser Wavelengths (Nd:YAG, Er,Cr:YSGG, CO2, and Diode 980 nm) Open
Different approaches with different clinical outcomes have been found in treating capillary hemangioma (CH), venous lake (VL), or venous malformations (VM) of the lips. This retrospective study aims to assess scar quality, recurrence rate,…
View article: Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020
Medication-Related Osteonecrosis of Jaws (MRONJ) Prevention and Diagnosis: Italian Consensus Update 2020 Open
The Medication-Related Osteonecrosis of Jaws (MRONJ) diagnosis process and its prevention play a role of great and rising importance, not only on the Quality of Life (QoL) of patients, but also on the decision-making process by the majorit…
View article: A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser
A Single Case Report of Granular Cell Tumor of the Tongue Successfully Treated through 445 nm Diode Laser Open
Oral granular cell tumor (GCT) is a relatively rare, benign lesion that can easily be misdiagnosed. Particularly, the presence of pseudoepitheliomatous hyperplasia might, in some cases, lead to the hypothesis of squamous cell carcinoma. Su…
View article: Histopathological determinants of autofluorescence patterns in oral carcinoma
Histopathological determinants of autofluorescence patterns in oral carcinoma Open
Biological tissues (including oral mucosa) can absorb and re‐emit specific light wavelengths, detectable through spectrophotometric devices. Such a phenomenon is known as “autofluorescence” ( AF ). Several devices evaluating tissue AF have…
View article: Salivary MicroRNA for Diagnosis of Cancer and Systemic Diseases: A Systematic Review
Salivary MicroRNA for Diagnosis of Cancer and Systemic Diseases: A Systematic Review Open
: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malign…
View article: Salivary Metabolic Analysis in Healthy Subjects and Perspectives for Patients with Oral Cancer: Pilot Study and Systematic Review
Salivary Metabolic Analysis in Healthy Subjects and Perspectives for Patients with Oral Cancer: Pilot Study and Systematic Review Open
Oral squamous-cell carcinoma, the most frequent malignant neoplasm of the oral cavity, has a poor 5 years survival rate. [...]
View article: Clinical Validation of 13-gene DNA Methylation Analysis from Oral Brushing: A Non Invasive Sampling Procedure for Early Detection of Oral Squamous Cell Carcinoma. A Multicentric Study
Clinical Validation of 13-gene DNA Methylation Analysis from Oral Brushing: A Non Invasive Sampling Procedure for Early Detection of Oral Squamous Cell Carcinoma. A Multicentric Study Open
1. Introduction In a recent study our research group described a non-invasive sampling procedure based on DNA methylation analysis of a set of 13 genes with a high level of accuracy (sensitivity 96.6%, specificity 100%) in the detection of…
View article: Recurrent p16-Positive Human Papillomavirus (HPV) Associated Oral Lesions Treated with a Diode Laser: A Case Report Oral Lesions Treated with a Diode Laser: A Case Report
Recurrent p16-Positive Human Papillomavirus (HPV) Associated Oral Lesions Treated with a Diode Laser: A Case Report Oral Lesions Treated with a Diode Laser: A Case Report Open
Human papilloma virus (HPV) family include approximately 150 known subtypes of viruses that can infect humans and other animals. Among these, HPV-16 is known for its association with oral squamous cell carcinoma (OSCC), particularly within…
View article: Absorption Capability of a 645-nm Diode Laser on Swine Soft Tissue Samples: a Preliminary Study in an Ex-Vivo Model Tissue Samples: a Preliminary Study in an Ex-Vivo Mo
Absorption Capability of a 645-nm Diode Laser on Swine Soft Tissue Samples: a Preliminary Study in an Ex-Vivo Model Tissue Samples: a Preliminary Study in an Ex-Vivo Mo Open
Most published articles have highlighted several positive effects of low-level laser therapy on tissues; however, to our knowledge, no studies have investigated the depth to which a light beam penetrates cell layers of an irradiated tissue…
View article: Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case
Self-healing CD30- T-clonal proliferation of the tongue: report of an extremely rare case Open
In view of the very peculiar clinical and histological features, a retrospective diagnosis of a TUGSE with scarce eosinophilic infiltrate (possibly in regression), displaying CD30- T-clonal proliferation was eventually rendered. The patien…
View article: Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Society of Oral Pathology and Medicine (SIPMO) Ancona, 20 October 2018 - Part I
Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Society of Oral Pathology and Medicine (SIPMO) Ancona, 20 October 2018 - Part I Open
On 20 October 2018 a Closed Round Table brought together a wide range of stakeholders from several medical disciplines, including academic experts, dentists, oncologists, maxillo-facial surgeons, oral surgeons, radiologists, under the tech…
View article: Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Society of Oral Pathology and Medicine (SIPMO) Ancona, 20 October 2018 - Part II
Proceedings of the Closed Round Table and Italian Consensus on the Medication-Related Osteonecrosis of Jaws (MRONJ) at the Symposium of Italian Society of Oral Pathology and Medicine (SIPMO) Ancona, 20 October 2018 - Part II Open
On 20 October 2018 a Closed Round Table brought together a wide range of stakeholders from several medical disciplines, including academic experts, dentists, oncologists, maxillo-facial surgeons, oral surgeons, radiologists, under the tech…
View article: Auto-Fluorescence and Histopathologic Evaluation of Medication-Related Osteonecrosis of the Jaws: Perspectives for Treatment
Auto-Fluorescence and Histopathologic Evaluation of Medication-Related Osteonecrosis of the Jaws: Perspectives for Treatment Open
Auto-fluorescence (AF) of healthy bone tissue has recently been described. Loss of AF (LAF) has, on the contrary, been reported in necrotic bone. Further, the use of LAF as a possible guidance to distinguish viable from necrotic bone durin…
View article: Osteonecrosis of the Jaw (ONJ) in Osteoporosis Patients: Report of Delayed Diagnosis of a Multisite Case and Commentary about Risks Coming from a Restricted ONJ Definition
Osteonecrosis of the Jaw (ONJ) in Osteoporosis Patients: Report of Delayed Diagnosis of a Multisite Case and Commentary about Risks Coming from a Restricted ONJ Definition Open
Osteonecrosis of the jaws (ONJ) in osteoporosis patients has been defined as rare, but the number of reported cases is increasing. We report a case of delayed ONJ diagnosis in a patient, who was being treated with alendronate, developing b…