P. Vineeth Daniel
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View article: ER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity-influenced enhancer
ER stress upregulates S100A11 in steatohepatitis models via epigenetic modifications within the lipotoxicity-influenced enhancer Open
Metabolic dysfunction-associated steatohepatitis (MASH) is a progressive liver disease characterized by complex interactions between lipotoxicity, ER stress responses, and immune-mediated inflammation. We identified enrichment of the proin…
View article: Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH
Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH Open
Background: Immune cell–driven inflammation is a key mediator of metabolic dysfunction–associated steatohepatitis (MASH) progression. We have previously demonstrated that pharmacological sphingosine 1-phosphate (S1P) receptor modulation am…
View article: Macrophage RAGE activation is proinflammatory in NASH
Macrophage RAGE activation is proinflammatory in NASH Open
Intrahepatic macrophages in nonalcoholic steatohepatitis (NASH) are heterogenous and include proinflammatory recruited monocyte-derived macrophages. The receptor for advanced glycation endproducts (RAGE) is expressed on macrophages and can…
View article: Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis
Effects of apolipoprotein H downregulation on lipid metabolism, fatty liver disease, and gut microbiota dysbiosis Open
View article: Foreseeing Alcohol-Associated Liver Disease through Proteomic Biomarkers
Foreseeing Alcohol-Associated Liver Disease through Proteomic Biomarkers Open
Journal Article Foreseeing Alcohol-Associated Liver Disease through Proteomic Biomarkers Get access P Vineeth Daniel, P Vineeth Daniel Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA Sea…
View article: Liver-Derived S100A6 Propels β-Cell Dysfunction in NAFLD
Liver-Derived S100A6 Propels β-Cell Dysfunction in NAFLD Open
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess liver fat content and β-cell function remain equivocal. Sp…
View article: Liver derived S100A6 propels β cell dysfunction in NAFLD
Liver derived S100A6 propels β cell dysfunction in NAFLD Open
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess liver fat content and β-cell function remain equivocal. Sp…
View article: Liver derived S100A6 propels β cell dysfunction in NAFLD
Liver derived S100A6 propels β cell dysfunction in NAFLD Open
Nonalcoholic fatty liver disease (NAFLD) is an independent predictor of systemic insulin resistance and type 2 diabetes mellitus (T2DM). However, converse correlates between excess liver fat content and β-cell function remain equivocal. Sp…
View article: Molecular pathways dysregulated by Pb2+ exposure prompts pancreatic beta-cell dysfunction
Molecular pathways dysregulated by Pb2+ exposure prompts pancreatic beta-cell dysfunction Open
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by reduced insulin sensitivity and dysfunction of β-cells. Although the increasing prevalence of diabetes worldwide is largely attributed to genetic predisposition or lif…
View article: NF-κB p65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet
NF-κB p65 regulates hepatic lipogenesis by promoting nuclear entry of ChREBP in response to a high carbohydrate diet Open
View article: Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders
Causative and Sanative dynamicity of ChREBP in Hepato-Metabolic disorders Open
ChREBP is the master regulator of carbohydrate dependent glycolytic and lipogenic flux within metabolic tissues. It plays a vital role in hyper-calorific milieu by activating glycolysis, lipogenesis along with pentose phosphate shunt and g…
View article: Chronic exposure to Pb<sup>2+</sup> perturbs Ch<scp>REBP</scp> transactivation and coerces hepatic dyslipidemia
Chronic exposure to Pb<sup>2+</sup> perturbs Ch<span>REBP</span> transactivation and coerces hepatic dyslipidemia Open
Dysregulated hepatic de novo lipogenesis contributes to the pathogenesis of nonalcoholic fatty liver disease in both humans and rodents. Clinical evidence suggests fatty liver to have a positive correlation with serum lead (Pb 2+ ) levels.…
View article: CCDC 1559082: Experimental Crystal Structure Determination
CCDC 1559082: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …