Patrick W. Serruys
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View article: Coronary revascularization: a long-term perspective
Coronary revascularization: a long-term perspective Open
This paper will forecast advancements in coronary revascularization by 2040, drawing on historical trends and recent breakthroughs. Having forecasted in 2000 the impact of innovations like drug-eluting stents, coronary computed tomography …
View article: Implications of computed tomography reconstruction algorithms on coronary atheroma composition: A head-to-head comparison with multimodality near-infrared spectroscopy intravascular ultrasound imaging
Implications of computed tomography reconstruction algorithms on coronary atheroma composition: A head-to-head comparison with multimodality near-infrared spectroscopy intravascular ultrasound imaging Open
CTA reconstruction parameters influence plaque composition analysis. The combination of an intermediate-strength IR, thin slice thickness, and fixed HU cutoffs yields the most accurate tissue characterization compared to NIRS-IVUS as the r…
View article: Prognostic value of SYNTAX score, intravascular ultrasound and near-infrared spectroscopy in coronary disease: 12-year follow-up of ATHEROREMO
Prognostic value of SYNTAX score, intravascular ultrasound and near-infrared spectroscopy in coronary disease: 12-year follow-up of ATHEROREMO Open
Background and aims This study aims to investigate the very long-term predictive value of the SYNTAX score and plaque characteristics derived by intravascular ultrasound (IVUS) as well as near-infrared spectroscopy (NIRS), for all-cause mo…
View article: Percutaneous endocardial alginate–hydrogel injection in the treatment of heart failure: First‐in‐human study
Percutaneous endocardial alginate–hydrogel injection in the treatment of heart failure: First‐in‐human study Open
Aims Despite the potential of alginate hydrogel intramyocardial injections in the treatment of heart failure (HF), minimally invasive implantation techniques remain scarce. This study evaluated the safety and feasibility of percutaneous tr…
View article: Quantitative videodensitometric assessment of aortic regurgitation in Myval, Sapien, and Evolut THV series: Results from the LANDMARK trial
Quantitative videodensitometric assessment of aortic regurgitation in Myval, Sapien, and Evolut THV series: Results from the LANDMARK trial Open
The QVDA highlights the superior performance of the Myval THV series compared to the Evolut THV series, with the lowest rate of moderate/severe RF among the three THV series, and could be used with echocardiography to help in detecting cas…
View article: Aspirin-Free Prasugrel Monotherapy After Percutaneous Coronary Intervention in Patients With Non-ST Elevation Acute Coronary Syndrome
Aspirin-Free Prasugrel Monotherapy After Percutaneous Coronary Intervention in Patients With Non-ST Elevation Acute Coronary Syndrome Open
Low-dose (3.75 mg/day) prasugrel monotherapy started immediately after SYNERGY stent deployment was feasible and safe in selected NSTE-ACS patients.
View article: Comparative 30-day echocardiographic outcomes of Myval vs. Sapien and Evolut THVs: insights from LANDMARK trial
Comparative 30-day echocardiographic outcomes of Myval vs. Sapien and Evolut THVs: insights from LANDMARK trial Open
Aims Several factors, including device design, annulus size, and sizing strategies, influence transcatheter heart valve (THV) haemodynamic outcomes in patients with aortic stenosis (AS). This sub-study evaluates early (30-day) echocardiogr…
View article: Diagnostic performance of exercise stress testing findings and coronary microvascular dysfunction in patients with angina with non-obstructive coronary artery disease
Diagnostic performance of exercise stress testing findings and coronary microvascular dysfunction in patients with angina with non-obstructive coronary artery disease Open
Background Coronary microvascular dysfunction (CMD) is common among patients with angina with non-obstructive coronary artery disease (ANOCA) and leads to poorer clinical outcomes. Exercise stress testing (EST) was shown to have a high spe…
View article: Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening: The VICTORION-PLAQUE primary prevention trial
Design and rationale of a randomized clinical trial assessing the effect of inclisiran on atherosclerotic plaque in individuals without previous cardiovascular event and without flow- limiting lesions identified in an in-hospital screening: The VICTORION-PLAQUE primary prevention trial Open
ClinicalTrials.gov. Identifier: NCT05360446.
View article: The Anatomy of Coronary Risk: How Artery Geometry Shapes Coronary Artery Disease through Blood Flow Haemodynamics -- Latest Methods, Insights and Clinical Implications
The Anatomy of Coronary Risk: How Artery Geometry Shapes Coronary Artery Disease through Blood Flow Haemodynamics -- Latest Methods, Insights and Clinical Implications Open
Despite tremendous advances in cardiovascular medicine, significant opportunities remain to improve coronary artery disease (CAD) prevention and treatment strategies. The key limitation lies in the understanding of disease formation and pr…
View article: Impact of elevated lipoprotein(a) on epicardial coronary flow conductance and endoluminal atherosclerotic disease distribution
Impact of elevated lipoprotein(a) on epicardial coronary flow conductance and endoluminal atherosclerotic disease distribution Open
In this PIONEER IV sub-study (NCT04923191), we investigated the effect of elevated lipoprotein(a) [Lp(a)] on epicardial coronary flow and endoluminal disease distribution. We analyzed 392 vessels from 75 propensity-matched pairs using Quan…
View article: Extended reality in cardiovascular care: a systematic review
Extended reality in cardiovascular care: a systematic review Open
Extended reality (XR) is an emerging technology currently finding its way into various medical fields. This systematic review aimed to compile a comprehensive overview of the current data on XR in cardiovascular medicine. To identify the c…
View article: Precision and Accuracy of Dimensional Assessment of Luminal Contours by Commercially Available Quantitative Angiography Software as a Prerequisite to Angiography Based FFR and Other Derived Parametrics
Precision and Accuracy of Dimensional Assessment of Luminal Contours by Commercially Available Quantitative Angiography Software as a Prerequisite to Angiography Based FFR and Other Derived Parametrics Open
Background Accurate dimensional measurements are critical for quantitative coronary angiography (QCA) and serve as the first step in angiography‐based fractional flow reserve (FFR) calculations. Aims To compare minimum lumen diameter (MLD)…
View article: Effectiveness and Safety of Myval Versus Other Transcatheter Valves in Patients Undergoing TAVI: A Meta‐Analysis
Effectiveness and Safety of Myval Versus Other Transcatheter Valves in Patients Undergoing TAVI: A Meta‐Analysis Open
Transcatheter aortic valve implantation (TAVI) has changed the treatment of aortic stenosis. The Myval transcatheter heart valve (THV), a novel balloon‐expandable THV, has shown promising outcomes. Our aim is to compare the comparative saf…
View article: Win ratio analysis of the LANDMARK trial
Win ratio analysis of the LANDMARK trial Open
The LANDMARK trial reported the non-inferiority of the Myval transcatheter heart valve (THV) series compared with the contemporary standard THV series (Sapien and Evolut) for a 30-day composite endpoint in patients with severe aortic steno…
View article: Definitions and standardized endpoints for the use of drug-coated balloon in coronary artery disease: consensus document of the Drug Coated Balloon Academic Research Consortium
Definitions and standardized endpoints for the use of drug-coated balloon in coronary artery disease: consensus document of the Drug Coated Balloon Academic Research Consortium Open
The Drug Coated Balloon Academic Research Consortium project originated from the lack of standardization and comparability between studies using drug-coated balloons in the treatment of obstructive coronary artery disease. This document is…
View article: Diagnostic Performance of Angiography‐Based Vessel‐Fractional Flow Reserve Compared with Various Wire‐Based Physiological Assessments
Diagnostic Performance of Angiography‐Based Vessel‐Fractional Flow Reserve Compared with Various Wire‐Based Physiological Assessments Open
Background Although considered the gold standard, pressure wire‐derived fractional flow reserve (PW‐FFR) and instantaneous wave‐free ratio (PW‐iFR) are not sufficiently adopted. Vessel fractional flow reserve (vFFR) is a potentially less i…
View article: Trimethylamine N-Oxide as a Biomarker for Left Ventricular Diastolic Dysfunction and Functional Remodeling After STEMI
Trimethylamine N-Oxide as a Biomarker for Left Ventricular Diastolic Dysfunction and Functional Remodeling After STEMI Open
Despite successful primary percutaneous coronary intervention (PPCI), the incidence of heart failure (HF) following ST-elevation myocardial infarction (STEMI) remains high. We investigated using Trimethylamine N-oxide (TMAO), a gut microbi…
View article: Impact of lesion preparation and stent optimisation on lesion-oriented events in PCI with drug-eluting stents: 5-year results from the AIDA trial
Impact of lesion preparation and stent optimisation on lesion-oriented events in PCI with drug-eluting stents: 5-year results from the AIDA trial Open
Background Meticulous implantation strategies (i.e. lesion predilatation, stent sizing and postdilatation) are known to decrease lesion-oriented adverse events (LOCE) following percutaneous coronary intervention (PCI) with bioresorbable sc…
View article: Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model
Histological assessment of a novel restorative coronary artery bypass graft in a chronic ovine model Open
Background Although prosthetic conduits for coronary artery bypass grafting (CABG) are increasingly needed because of the limited availability and patency of autologous conduits, no alternatives have succeeded. Methods Sixteen sheep underw…
View article: What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?
What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition? Open
Accurate evaluation of coronary artery pathology is essential for risk stratification and tailoring appropriate treatment. Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque charac…
View article: Glimpse Into the Hemodynamic Performance of Myval Series vs Sapien 3 Ultra Resilia
Glimpse Into the Hemodynamic Performance of Myval Series vs Sapien 3 Ultra Resilia Open
•The Myval series are novel balloon-expandable transcatheter heart valves.•The postprocedural effective orifice area and mean pressure gradient of the Myval series were compared with those of the Sapien 3 Ultra Resilia using published data…
View article: Diffuseness of coronary artery disease impacts on immediate hemodynamic and predicted clinical outcomes
Diffuseness of coronary artery disease impacts on immediate hemodynamic and predicted clinical outcomes Open
Diffuse coronary artery disease (CAD) impacts the immediate hemodynamic and clinical outcomes of percutaneous coronary intervention (PCI). We evaluated whether the diffuse pattern of CAD derived from angiographic Quantitative flow ratio (Q…
View article: Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy?
Parsimonious versus extensive bleeding score: can we simplify risk stratification after percutaneous coronary intervention and reduce bleeding events by de-escalation of the antiplatelet strategy? Open
Background and aims Due to the multitude of risk factors outlined in the guidelines, personalised dual antiplatelet therapy (DAPT) guidance after percutaneous coronary intervention (PCI) is complex. A simplified method was created to facil…
View article: Fractal Laws for Bifurcation Quantitative Coronary Angiography to Assess Left Main Bifurcation Lesions
Fractal Laws for Bifurcation Quantitative Coronary Angiography to Assess Left Main Bifurcation Lesions Open
Background: Visual angiographic assessment of left main (LM) bifurcation lesions is fraught with major limitations. Bifurcation‐dedicated quantitative coronary angiography (Bif‐QCA) assessment provides higher accuracy than standard QCA in …
View article: Early outcomes of the novel Myval THV series compared to SAPIEN THV series and Evolut THV series in individuals with severe aortic stenosis
Early outcomes of the novel Myval THV series compared to SAPIEN THV series and Evolut THV series in individuals with severe aortic stenosis Open
ClinicalTrials.gov: NCT04275726; EudraCT number 2020-000,137-40.
View article: Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial
Long-term prognostic impact of the left anterior descending coronary artery as the STEMI-related culprit vessel: subanalysis of the EXAMINATION-EXTEND trial Open
Introduction and objectives: There is limited data on the impact of the culprit vessel on very long-term outcomes after ST-elevation myocardial infarction (STEMI). The aim was to analyze the impact of the left anterior descending coronary …