Peter W. Macfarlane
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View article: Recent-onset atrial fibrillation: challenges and opportunities
Recent-onset atrial fibrillation: challenges and opportunities Open
Atrial fibrillation (AF) is increasingly diagnosed early, close to its first occurrence due to: (i) increased public awareness with self-screening; (ii) health care initiatives including population screening and opportunistic case finding;…
View article: Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST‐Segment–Elevation Myocardial Infarction
Latent Cytomegalovirus Infection Is Associated With Impaired Left Ventricular Function After ST‐Segment–Elevation Myocardial Infarction Open
Background Human cytomegalovirus is a herpes virus that affects most individuals globally and may increase the risk of cardiovascular disease. Whether cytomegalovirus influences outcomes after ST‐segment–elevation myocardial infarction (ST…
View article: A new QRS detector stress test combining temporal jitter and F-score (JF) reveals significant performance differences amongst popular detectors
A new QRS detector stress test combining temporal jitter and F-score (JF) reveals significant performance differences amongst popular detectors Open
QRS detection within an electrocardiogram (ECG) is the basis of virtually any further processing and any error caused by this detection will propagate to further processing stages. However, standard benchmarking procedures of QRS detectors…
View article: Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial
Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial Open
BACKGROUND: Microvascular angina is associated with dysregulation of the endothelin system and impairments in myocardial blood flow, exercise capacity, and health-related quality of life. The G allele of the noncoding single nucleotide pol…
View article: Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19
Clinical Significance of Myocardial Injury in Patients Hospitalized for COVID-19 Open
Myocardial injury in severe hospitalized COVID-19 survivors is nonprogressive. Medium-term outcomes show a low incidence of major adverse cardiovascular events and improved quality of life. (COVID-19 Effects on the Heart; ISRCTN58667920).
View article: Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease Open
The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide a…
View article: Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis Open
British Heart Foundation, UK Medical Research Council, and Australian National Health and Medical Research Council.
View article: 12 Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19
12 Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19 Open
Introduction We aimed to understand the impact of being a healthcare worker on the progression and outcomes of illness in individuals hospitalised because of post-COVID-19 complications. Materials and Methods The CISCO-19 study included pa…
View article: Precision Pharmacotherapy With Zibotentan in Microvascular Angina: a randomized, placebo-controlled, cross-over trial.
Precision Pharmacotherapy With Zibotentan in Microvascular Angina: a randomized, placebo-controlled, cross-over trial. Open
Microvascular angina, linked to endothelin system dysregulation, was the focus of this double-blind, placebo-controlled, randomized, sequential crossover trial (NCT04097314). The trial compared zibotentan, an oral endothelin A receptor sel…
View article: Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study
Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study Open
Background: The multisystem associations between baseline mental health status and coronavirus disease-19 (COVID)-19 illness trajectory are uncertain. Objectives: This article will investigate the associations between baseline mental healt…
View article: Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy
Microstructural and Microvascular Phenotype of Sarcomere Mutation Carriers and Overt Hypertrophic Cardiomyopathy Open
BACKGROUND: In hypertrophic cardiomyopathy (HCM), myocyte disarray and microvascular disease (MVD) have been implicated in adverse events, and recent evidence suggests that these may occur early. As novel therapy provides promise for disea…
View article: A NOVEL ELECTROCARDIOGRAPHIC PREDICTION MODEL FOR DIAGNOSING CONCEALED BRUGADA SYNDROME: RESULTS FROM A CLINICAL TRIAL OF AJMALINE PROVOCATION IN HEALTHY SUBJECTS
A NOVEL ELECTROCARDIOGRAPHIC PREDICTION MODEL FOR DIAGNOSING CONCEALED BRUGADA SYNDROME: RESULTS FROM A CLINICAL TRIAL OF AJMALINE PROVOCATION IN HEALTHY SUBJECTS Open
Background Clinical, electrocardiographic, and genomic factors have been associated with the drug-induced type 1 Brugada pattern (DI-T1BP), in response to sodium channel blocker provocation (SCBP). However, prior analyses have been concern…
View article: Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19
Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19 Open
Background We investigated the associations of healthcare worker status with multisystem illness trajectory in hospitalised post-COVID-19 individuals. Methods and results One hundred and sixty-eight patients were evaluated 28–60 days after…
View article: Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study
Myocardial Involvement After Hospitalization for COVID-19 Complicated by Troponin Elevation: A Prospective, Multicenter, Observational Study Open
Background: Acute myocardial injury in hospitalized patients with coronavirus disease 2019 (COVID-19) has a poor prognosis. Its associations and pathogenesis are unclear. Our aim was to assess the presence, nature, and extent of myocardial…
View article: Consumer-Led Screening for Atrial Fibrillation: Frontier Review of the AF-SCREEN International Collaboration
Consumer-Led Screening for Atrial Fibrillation: Frontier Review of the AF-SCREEN International Collaboration Open
The technological evolution and widespread availability of wearables and handheld ECG devices capable of screening for atrial fibrillation (AF), and their promotion directly to consumers, has focused attention of health care professionals …
View article: Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials
Effect of statin therapy on muscle symptoms: an individual participant data meta-analysis of large-scale, randomised, double-blind trials Open
British Heart Foundation, Medical Research Council, Australian National Health and Medical Research Council.
View article: Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium
Resting heart rate and incident atrial fibrillation: A stratified Mendelian randomization in the AFGen consortium Open
Background Both elevated and low resting heart rates are associated with atrial fibrillation (AF), suggesting a U-shaped relationship. However, evidence for a U-shaped causal association between genetically-determined resting heart rate an…
View article: The Application of Computer Techniques to ECG Interpretation
The Application of Computer Techniques to ECG Interpretation Open
This book presents some of the latest available information on automated ECG analysis written by many of the leading researchers in the field. It contains a historical introduction, an outline of the latest international standards for sign…
View article: The Application of Computer Techniques to ECG Interpretation
The Application of Computer Techniques to ECG Interpretation Open
It is over 120 years since Einthoven introduced the electrocardiogram [...]