P. Wildy
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Detection of herpes simplex virus-specific DNA sequences in latently infected mice and in humans Open
Herpes simplex virus-specific DNA sequences have been detected by Southern hybridization analysis in both central and peripheral nervous system tissues of latently infected mice. We have detected virus-specific sequences corresponding to t…
Clonal analysis of T-cell responses to herpes simplex virus: isolation, characterization and antiviral properties of an antigen-specific helper T-cell clone. Open
A herpes simplex virus (HSV)-specific long-term T-cell clone has been established from the draining lymph node cells of BALB/c mice; the cells required repeated in vitro restimulation with UV-irradiated virus. The established T-cell clone …
Inhibition of herpes simplex virus multiplication by activated macrophages: a role for arginase? Open
Proteose-peptone-activated mouse macrophages can prevent productive infection by herpes simplex virus in neighboring cells in vitro whether or not those cells belong to the same animal species. The effect does not require contact between t…
Tolerance and immunity in mice infected with herpes simplex virus: studies on the mechanism of tolerance to delayed-type hypersensitivity. Open
Tolerance to delayed-type hypersensitivity is produced in mice following an intravenous injection of herpes simplex virus. This form of tolerance is produced early on, following simultaneous injections of virus subcutaneously and intraveno…
Properties of Cells Carrying the Herpes Simplex Virus Type 2 Thymidine Kinase Gene: Mechanisms of Reversion to a Thymidine Kinase-Negative Phenotype Open
We have isolated cells with a thymidine kinase-negative (tk − ) phenotype from cells which carry the herpes simplex virus type 2 tk gene by selection in 5-bromodeoxyuridine or 9-(2-hydroxyethoxymethyl)guanine. Both selection routines gener…
Effect of Acycloguanosine Treatment on Acute and Latent Herpes Simplex Infections in Mice Open
Systemic treatment of mice with the nucleoside analog 9-(2-hydroxyethoxymethyl)guanine (acycloguanosine [aciclovir]) was found to be highly effective against acute type 1 herpes simplex virus infection of the pinna. The drug ablated clinic…
The pathogenicity of thymidine kinase-deficient mutants of herpes simplex virus in mice Open
Summary The pathogenicity for mice of two mutants of herpes simplex virus (type 1 and type 2), which fail to induce thymidine kinase, were compared with their respective parent strains. The mutants were much less virulent than the parents …
Association between Psychopathic Disorder and Serum Antibody to Herpes Simplex Virus (Type 1) Open
The sera of a small of patients has been examined for herpes simplex virus antibody. Three clinically-defined groups of patients were compared: ( a ) aggressive psychopaths, ( b ) psychiatric controls, and ( c ) general hospital patients. …
The progression of herpes simplex virus to the central nervous system of the mouse Open
1. The strain HFEM of herpes simplex virus is highly virulent for the 5-week-old mouse when inoculated intracerebrally; the LD50 and the ID50 both being close to the egg infectious unit. It is also virulent when given intraspinally. 2. Whe…
Virus specific antigens in mammalian cells infected with herpes simplex virus. Open
Antisera to specific proteins in herpes simplex infected cells were produced by immunization of rabbits with infected rabbit kidney cells. These antisera were highly virus specific and produced up to twelve lines in immunodiffusion tests a…
CYTOCHEMICAL STUDIES OF THE NUCLEOPROTEINS OF HELA CELLS INFECTED WITH HERPES VIRUS Open
The morphological and cytochemical changes in HeLa cells infected with herpes virus have been studied at frequent intervals during infection and related to the growth of virus and the multiplicity of the virus inoculum. Infection with a hi…
The anaerobic cocci: gas formation, fermentation reactions, sensitivity to antibiotics and sulphonamides. Classification Open
1. A total of ninety-nine strains of anaerobic cocci from human beings have been studied and six groups demarcated on the basis of gas formation and fermentation reactions. 2.Gas formation by strains of group I is due to fermentation of gl…
A Simple Method for Detecting Streptomycin-resistant Tubercle Bacilli Open
Since theadvent ofstreptomycin therapy intuberculosis, theneedhasarisen for arapid, simple methodfordetecting theemergence ofresistant strains ofMyco. tuberculosis. Methods sofardescribed, forexample, that oftheM.R.C. (1948), are mostly de…